iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025709

UUCD1 version

UUC-CiI-00435

Ensembl Protein ID

ENSCINP00000000504.3

UniProt Accession

F6ZZZ6; F6ZZZ6_CIOIN

Protein Name

Uncharacterized protein

Gene Name

ci-zf(zz)-8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000000272.3	ENSCINT00000000504.3	ENSCINP00000000504.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-79	265.8	1934	2262

Active Site

Position(s)	Description	Evidence
2231	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrl 87
           +r++ v+f+gE++ d+gG  +e ++++++elqn +++l+  ++n++ +   n+d ++ n       h+k+F+flG+l+g+a+++g +
   Q: 1934 HRIWkVKFLGESVDDCGGGYSESITEICDELQNGSVPLLSGTPNGRDESGANRDCFILNSttsseTHIKMFKFLGILIGIAMRTGSP 2020
           56677**********************************99999999999999998888788888********************** PP
   S: 88   ldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYv 174
           l ++++++++k+l g k  l+d++e+d++++    +i++ + +++e   ++++f +++     +  ee+  g+ +  Vt +N++eY+
   Q: 2021 LSINMAEPVWKQLAGIKPCLKDISEIDKHFVPKSVFIRDCEADELES--MQIQFATHS-----ACGEEIPLGSTHQVVTAQNRNEYI 2100
           **************************************996544444..677776333.....45566888889999********** PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseer 261
           +l ++yrl+e ++++v+a+reG++ vip  llslFt++ele+ +cG+++i ++ lk+  + kg ++++++ i+wFwe+le+fs+e+r
   Q: 2101 RLAIQYRLHE-FDQMVAAVREGMSFVIPVPLLSLFTASELETTVCGSPDIPLHLLKSVSTCKG-ISPNDELIRWFWETLESFSDEQR 2185
           **********.**********************************************999966.*********************** PP
   S: 262  kafLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           + fL+Fv+g+ rlP + +a+++ r fvi+        d+ lP+s TCf++LkLP+Ys k +l+ekL yAi+ +k++++
   Q: 2186 SLFLRFVWGRTRLP-RSIADFRGRDFVIQVpdkyHPPDHYLPESYTCFFMLKLPRYSCKPVLEEKLKYAIHFCKSIDT 2262
           **************.8*************9999777789**********************************99875 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MYKKPHDFND NDDYARYVRD NITIGMMVCC CRTYEEVEEG DIGQVLRLDK DGIQDLNVQA 60
SWINKGGTYW VRYIHVELIA SPSDGALPST SQTRTIKVGD KVQVKRSITI PRYKWGSVKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTATAAGA AACCACATGA TTTCAACGAT AATGATGATT ATGCACGCTA TGTGAGGGAT 60
AATATCACTG TGAGTATTCA TCGTGTACTT ATTTACTGTA ACCTTCAGTT CGCCTGAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS51284--DOC
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00632--HECT
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	57.56	0.00e+00	1461.00
IUUC-Atr-003065	Amborella trichopoda	32.78	2.00e-43	169.00
IUUC-Apl-003983	Anas platyrhynchos	57.46	0.00e+00	1461.00
IUUC-Aca-004300	Anolis carolinensis	54.80	0.00e+00	2304.00
IUUC-Aly-006545	Arabidopsis lyrata	31.65	3.00e-41	162.00
IUUC-Ame-010621	Astyanax mexicanus	54.42	0.00e+00	2296.00
IUUC-Bta-013067	Bos taurus	54.62	0.00e+00	2307.00
IUUC-Bdi-014093	Brachypodium distachyon	32.62	1.00e-47	183.00
IUUC-Bol-015203	Brassica oleracea	31.38	4.00e-44	172.00
IUUC-Bra-017584	Brassica rapa	30.46	3.00e-39	155.00
IUUC-Cja-019687	Callithrix jacchus	57.49	0.00e+00	1442.00
IUUC-Cfa-020672	Canis familiaris	57.49	0.00e+00	1461.00
IUUC-Cpo-021819	Cavia porcellus	52.02	0.00e+00	2137.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	37.37	2.00e-45	174.00
IUUC-Csa-023817	Chlorocebus sabaeus	57.63	0.00e+00	1447.00
IUUC-Cho-024387	Choloepus hoffmanni	56.77	0.00e+00	775.00
IUUC-Csv-026336	Ciona savignyi	74.75	0.00e+00	3374.00
IUUC-Dre-027717	Danio rerio	59.07	0.00e+00	1456.00
IUUC-Dno-029296	Dasypus novemcinctus	54.78	0.00e+00	2320.00
IUUC-Dor-030979	Dipodomys ordii	66.67	0.00e+00	768.00
IUUC-Dme-032171	Drosophila melanogaster	49.45	0.00e+00	1244.00
IUUC-Ete-032687	Echinops telfairi	45.20	0.00e+00	813.00
IUUC-Eca-034046	Equus caballus	57.58	0.00e+00	1459.00
IUUC-Eeu-034859	Erinaceus europaeus	52.74	0.00e+00	779.00
IUUC-Fca-036262	Felis catus	54.43	0.00e+00	2299.00
IUUC-Fal-037562	Ficedula albicollis	57.46	0.00e+00	1459.00
IUUC-Gmo-038739	Gadus morhua	61.01	0.00e+00	709.00
IUUC-Gga-040359	Gallus gallus	57.39	0.00e+00	1457.00
IUUC-Gac-041879	Gasterosteus aculeatus	60.14	0.00e+00	724.00
IUUC-Gma-043616	Glycine max	35.69	2.00e-43	168.00
IUUC-Ggo-044692	Gorilla gorilla	54.11	0.00e+00	2240.00
IUUC-Hsa-045995	Homo sapiens	54.61	0.00e+00	2285.00
IUUC-Hvu-047529	Hordeum vulgare	31.83	6.00e-44	171.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	37.40	3.00e-177	614.00
IUUC-Lch-049808	Latimeria chalumnae	53.38	0.00e+00	1873.00
IUUC-Lpe-051165	Leersia perrieri	31.76	3.00e-42	164.00
IUUC-Loc-052685	Lepisosteus oculatus	54.64	0.00e+00	2324.00
IUUC-Laf-053372	Loxodonta africana	54.90	0.00e+00	2313.00
IUUC-Mcc-054693	Macaca mulatta	57.81	0.00e+00	1449.00
IUUC-Meu-056660	Macropus eugenii	64.57	0.00e+00	1278.00
IUUC-Mtr-058277	Medicago truncatula	34.01	3.00e-46	177.00
IUUC-Mga-059371	Meleagris gallopavo	57.38	0.00e+00	1453.00
IUUC-Mmr-060787	Microcebus murinus	54.89	0.00e+00	2308.00
IUUC-Mdo-062518	Monodelphis domestica	51.59	0.00e+00	2131.00
IUUC-Mmu-063690	Mus musculus	54.71	0.00e+00	2300.00
IUUC-Mpu-066478	Mustela putorius furo	57.49	0.00e+00	1460.00
IUUC-Mlu-067596	Myotis lucifugus	49.88	0.00e+00	1392.00
IUUC-Nle-069633	Nomascus leucogenys	36.91	3.00e-173	603.00
IUUC-Opr-070990	Ochotona princeps	59.31	0.00e+00	1437.00
IUUC-Ont-072285	Oreochromis niloticus	53.86	0.00e+00	2296.00
IUUC-Oan-072721	Ornithorhynchus anatinus	57.08	0.00e+00	1448.00
IUUC-Ocu-074273	Oryctolagus cuniculus	54.78	0.00e+00	2313.00
IUUC-Oba-075262	Oryza barthii	31.17	9.00e-42	162.00
IUUC-Obr-076115	Oryza brachyantha	31.23	3.00e-41	160.00
IUUC-Ogl-077586	Oryza glaberrima	31.17	1.00e-41	162.00
IUUC-Ogu-078796	Oryza glumaepatula	30.92	4.00e-41	160.00
IUUC-Oin-079298	Oryza indica	30.92	3.00e-41	161.00
IUUC-Olo-080629	Oryza longistaminata	34.21	6.00e-42	164.00
IUUC-Ome-081908	Oryza meridionalis	30.20	3.00e-41	161.00
IUUC-Oni-082049	Oryza nivara	30.92	4.00e-41	160.00
IUUC-Opu-083608	Oryza punctata	31.74	3.00e-41	161.00
IUUC-Oru-084712	Oryza rufipogon	30.92	4.00e-41	160.00
IUUC-Osa-086078	Oryza sativa	30.92	4.00e-41	160.00
IUUC-Ola-087346	Oryzias latipes	63.17	0.00e+00	853.00
IUUC-Oga-088742	Otolemur garnettii	54.61	0.00e+00	2288.00
IUUC-Oar-090093	Ovis aries	54.78	0.00e+00	2311.00
IUUC-Ptr-091034	Pan troglodytes	50.15	0.00e+00	1182.00
IUUC-Pan-092783	Papio anubis	57.81	0.00e+00	1448.00
IUUC-Psi-094027	Pelodiscus sinensis	57.35	0.00e+00	1459.00
IUUC-Pma-094275	Petromyzon marinus	39.15	7.00e-59	221.00
IUUC-Pfo-096208	Poecilia formosa	48.45	0.00e+00	1300.00
IUUC-Pab-097760	Pongo abelii	37.40	4.00e-180	625.00
IUUC-Pop-099121	Populus trichocarpa	31.56	3.00e-44	172.00
IUUC-Pca-100705	Procavia capensis	53.08	3.00e-167	583.00
IUUC-Ppe-101345	Prunus persica	33.33	3.00e-46	179.00
IUUC-Pva-103147	Pteropus vampyrus	56.84	0.00e+00	772.00
IUUC-Rno-105458	Rattus norvegicus	57.81	0.00e+00	1469.00
IUUC-Sha-106959	Sarcophilus harrisii	52.89	0.00e+00	1261.00
IUUC-Smo-108827	Selaginella moellendorffii	33.68	2.00e-44	173.00
IUUC-Sit-109917	Setaria italica	32.20	5.00e-45	174.00
IUUC-Sly-110961	Solanum lycopersicum	34.47	1.00e-47	183.00
IUUC-Stu-112166	Solanum tuberosum	32.41	6.00e-46	178.00
IUUC-Sar-113532	Sorex araneus	48.60	2.00e-134	474.00
IUUC-Sbi-114352	Sorghum bicolor	31.73	2.00e-46	179.00
IUUC-Ssc-116304	Sus scrofa	67.52	0.00e+00	674.00
IUUC-Tgu-116789	Taeniopygia guttata	57.38	0.00e+00	1454.00
IUUC-Tru-118129	Takifugu rubripes	54.57	0.00e+00	2293.00
IUUC-Tsy-119302	Tarsius syrichta	44.90	2.00e-126	447.00
IUUC-Tni-120374	Tetraodon nigroviridis	54.65	0.00e+00	2290.00
IUUC-Tca-121094	Theobroma cacao	32.02	7.00e-43	167.00
IUUC-Tae-124157	Triticum aestivum	32.98	3.00e-46	179.00
IUUC-Tur-126300	Triticum urartu	31.83	2.00e-44	173.00
IUUC-Tbe-128137	Tupaia belangeri	63.94	3.00e-161	563.00
IUUC-Ttr-128273	Tursiops truncatus	51.47	0.00e+00	1855.00
IUUC-Vpa-130471	Vicugna pacos	47.15	7.00e-132	465.00
IUUC-Xtr-132185	Xenopus tropicalis	53.35	0.00e+00	2181.00
IUUC-Xma-133233	Xiphophorus maculatus	54.32	0.00e+00	2273.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence