iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062220

UUCD1 version

UUC-MoD-01131

Ensembl Protein ID

ENSMODP00000026259.1

UniProt Accession

F6RKK2; F6RKK2_MONDO

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000020994.3	ENSMODT00000026726.1	ENSMODP00000026259.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-88	297.0	196	810

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
746	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...............kkkeklneenp.......kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++  lrell+e               +                  +p g+l++++ ++++e+ ++k++ 
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTLVLRELLKEvkmsgtivkiespdlS---------LtepleinLGPPGPLTSAMCQFLNEMHETKRGI 275
           5******************************8666665555444442.........0444555589999******************** PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+g++qqD+qE+l++lld+++ e  ++ +  + ++ ++ + + +++     +e + kk+ +s+++++F+g+l+
   Q: 276  VTPKELFSQVCKKAVRFKGFQQQDSQELLRYLLDGMRAEEIQRVSAGILTALGSPTGKPDEDlrrriKEHERKKSMPSFVDRIFGGELT 364
           *************************************9998877777777777776655555777779999999999************ PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c++c++vs  +e+fldlslpv ++++ k+                                                        
   Q: 365  STIMCEQCKTVSLVHESFLDLSLPVLDDQSGKNIndknikktkedeskdseeekdnniymkkntippytskhwqkkakkqakklaknqr 453
           *****************************987779****************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  rqqkmqektiqlnnlcmndkpeehphvtdalpeeetdddsnsfsqeeekcqescsnqedisdrespvealpgnageadlpraafsiera 542
           ***************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftke 197
                                                                                        s+++cL +ft++
   Q: 543  gdfngaslggdsedeedlagdlghlqldpllepdegngellndgcpvgakiyevvhdvpetafctlapreaadtdegSIHHCLYQFTSN 631
           ***************************************************************************************** PP
   S: 198  eelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           e+l+g+nk+ c+ c+++q+                 a+k++ +++ P++L+lhLkRf  ++++ +  k+nk+++fp+ +dl+pfct ++
   Q: 632  EKLQGSNKLLCDVCTQRQRpgpkahskgekkcvytdAKKQMLISQAPPILTLHLKRF--QQAGLNLCKVNKHIKFPDVIDLAPFCTIKC 718
           ***************99999*************************************..99999999********************99 PP
   S: 270  ekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevkeeevleetgstaY 331
           ++++e   k+ Y+L++vv HsG+++ GHY+ayvk                         +kg+W++++D++V++v+ ++vl+   s+aY
   Q: 719  KNVAEgntKVLYSLYGVVEHSGTMRWGHYTAYVKTrtsnshlynlvldgtspqefenesTKGQWFHISDTHVQAVPASKVLN---SQAY 804
           999888889**************************9999999999999999999988888999*******************...**** PP
   S: 332  vlfYkr 337
           +lfY+r
   Q: 805  LLFYER 810
           ****98 PP

Organism

Monodelphis domestica

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VLADDDSEIL EPRCRHIKKG LEQSGLKKSL MNVQWNVCQE CKIDNRTNDK 60
PEGENKENPS IWLCLKCGHQ GCGRYSQEQH ALKHYTTPRS EPHCLVLSLY NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGTACAAA GGGAAAAACT GTACTGGCTG ATGATGATTC TGAAATTTTA 60
GGTATAGTCT ATTGGATTTT ATTTATTGAT TGGATGGGAT AATTTTTATG TCCAAAAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.39	7.00e-26	113.00
IUUC-Aml-001931	Ailuropoda melanoleuca	69.57	0.00e+00	1029.00
IUUC-Atr-003015	Amborella trichopoda	29.71	6.00e-36	146.00
IUUC-Apl-004145	Anas platyrhynchos	61.65	0.00e+00	860.00
IUUC-Aca-004314	Anolis carolinensis	57.94	0.00e+00	836.00
IUUC-Aly-006422	Arabidopsis lyrata	29.54	3.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	28.87	2.00e-32	135.00
IUUC-Ame-011659	Astyanax mexicanus	47.09	2.00e-106	380.00
IUUC-Bta-013362	Bos taurus	69.04	0.00e+00	1019.00
IUUC-Bdi-014624	Brachypodium distachyon	30.46	7.00e-26	112.00
IUUC-Bol-015941	Brassica oleracea	28.67	6.00e-31	129.00
IUUC-Bra-016751	Brassica rapa	28.98	5.00e-30	126.00
IUUC-Cja-019177	Callithrix jacchus	69.65	0.00e+00	1047.00
IUUC-Cfa-020051	Canis familiaris	69.41	0.00e+00	1044.00
IUUC-Cpo-021886	Cavia porcellus	65.02	0.00e+00	1006.00
IUUC-Csa-024103	Chlorocebus sabaeus	69.53	0.00e+00	1050.00
IUUC-Cho-024315	Choloepus hoffmanni	60.07	2.00e-87	316.00
IUUC-Csv-026075	Ciona savignyi	47.37	5.00e-53	202.00
IUUC-Dre-028388	Danio rerio	51.42	5.00e-115	409.00
IUUC-Dno-029409	Dasypus novemcinctus	69.29	0.00e+00	1041.00
IUUC-Dor-030443	Dipodomys ordii	64.72	2.00e-143	503.00
IUUC-Ete-032807	Echinops telfairi	69.30	7.00e-162	564.00
IUUC-Eca-033479	Equus caballus	70.50	0.00e+00	1065.00
IUUC-Eeu-034835	Erinaceus europaeus	60.09	4.00e-122	432.00
IUUC-Fca-036320	Felis catus	69.17	0.00e+00	1055.00
IUUC-Fal-037029	Ficedula albicollis	59.55	0.00e+00	816.00
IUUC-Gmo-039480	Gadus morhua	51.82	4.00e-109	389.00
IUUC-Gga-040527	Gallus gallus	62.64	0.00e+00	872.00
IUUC-Gma-043919	Glycine max	30.89	2.00e-33	138.00
IUUC-Ggo-045598	Gorilla gorilla	69.53	0.00e+00	1042.00
IUUC-Hsa-046598	Homo sapiens	69.66	0.00e+00	1047.00
IUUC-Hvu-047146	Hordeum vulgare	29.27	2.00e-26	115.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	69.53	0.00e+00	1051.00
IUUC-Lch-050536	Latimeria chalumnae	57.32	3.00e-124	439.00
IUUC-Lpe-050703	Leersia perrieri	36.73	1.00e-26	115.00
IUUC-Loc-051814	Lepisosteus oculatus	55.04	6.00e-124	438.00
IUUC-Laf-053732	Loxodonta africana	66.91	0.00e+00	1019.00
IUUC-Mcc-054661	Macaca mulatta	69.77	0.00e+00	1051.00
IUUC-Meu-055967	Macropus eugenii	79.24	3.00e-169	588.00
IUUC-Mtr-057945	Medicago truncatula	29.09	5.00e-32	133.00
IUUC-Mga-059551	Meleagris gallopavo	60.45	0.00e+00	882.00
IUUC-Mmr-061747	Microcebus murinus	69.52	0.00e+00	1025.00
IUUC-Mmu-063582	Mus musculus	67.35	0.00e+00	980.00
IUUC-Mpu-066339	Mustela putorius furo	70.01	0.00e+00	1044.00
IUUC-Mlu-067511	Myotis lucifugus	67.35	0.00e+00	1004.00
IUUC-Nle-069252	Nomascus leucogenys	69.53	0.00e+00	1050.00
IUUC-Opr-070969	Ochotona princeps	68.03	0.00e+00	990.00
IUUC-Ont-071786	Oreochromis niloticus	49.76	6.00e-110	391.00
IUUC-Ocu-074704	Oryctolagus cuniculus	69.80	0.00e+00	1026.00
IUUC-Oba-075094	Oryza barthii	36.73	1.00e-26	115.00
IUUC-Obr-076743	Oryza brachyantha	35.71	2.00e-26	114.00
IUUC-Ogl-077739	Oryza glaberrima	36.92	7.00e-27	116.00
IUUC-Ogu-078851	Oryza glumaepatula	36.73	8.00e-27	116.00
IUUC-Oin-079402	Oryza indica	36.73	8.00e-27	116.00
IUUC-Olo-080431	Oryza longistaminata	36.73	7.00e-27	116.00
IUUC-Ome-081580	Oryza meridionalis	36.73	1.00e-26	115.00
IUUC-Oni-082644	Oryza nivara	36.73	8.00e-27	116.00
IUUC-Opu-083452	Oryza punctata	28.66	6.00e-27	116.00
IUUC-Oru-084546	Oryza rufipogon	36.73	8.00e-27	116.00
IUUC-Osa-085858	Oryza sativa	36.73	8.00e-27	116.00
IUUC-Ola-086795	Oryzias latipes	52.35	3.00e-110	392.00
IUUC-Oga-088713	Otolemur garnettii	69.77	0.00e+00	1040.00
IUUC-Oar-089887	Ovis aries	69.77	0.00e+00	1033.00
IUUC-Ptr-091670	Pan troglodytes	69.17	0.00e+00	1041.00
IUUC-Pan-092293	Papio anubis	69.77	0.00e+00	1051.00
IUUC-Psi-093101	Pelodiscus sinensis	61.10	0.00e+00	830.00
IUUC-Ppa-095622	Physcomitrella patens	28.48	1.00e-32	135.00
IUUC-Pfo-097202	Poecilia formosa	52.19	3.00e-117	416.00
IUUC-Pab-098773	Pongo abelii	68.17	0.00e+00	788.00
IUUC-Pop-099136	Populus trichocarpa	30.23	1.00e-37	151.00
IUUC-Pca-101069	Procavia capensis	62.09	2.00e-140	493.00
IUUC-Ppe-101794	Prunus persica	30.56	5.00e-35	143.00
IUUC-Pva-103092	Pteropus vampyrus	59.47	4.00e-122	432.00
IUUC-Rno-105237	Rattus norvegicus	67.71	0.00e+00	988.00
IUUC-Sha-106889	Sarcophilus harrisii	79.15	0.00e+00	1224.00
IUUC-Sit-110283	Setaria italica	30.89	3.00e-26	114.00
IUUC-Sly-111491	Solanum lycopersicum	31.42	5.00e-36	146.00
IUUC-Stu-112820	Solanum tuberosum	29.44	4.00e-38	153.00
IUUC-Sar-113530	Sorex araneus	67.59	0.00e+00	1013.00
IUUC-Sbi-113785	Sorghum bicolor	36.91	4.00e-22	100.00
IUUC-Ssc-116091	Sus scrofa	70.16	0.00e+00	1022.00
IUUC-Tgu-117478	Taeniopygia guttata	59.19	0.00e+00	827.00
IUUC-Tru-118640	Takifugu rubripes	52.58	3.00e-115	409.00
IUUC-Tsy-119042	Tarsius syrichta	56.49	1.00e-174	607.00
IUUC-Tni-120015	Tetraodon nigroviridis	52.06	8.00e-113	401.00
IUUC-Tca-121701	Theobroma cacao	29.28	3.00e-35	144.00
IUUC-Tae-125351	Triticum aestivum	29.57	1.00e-24	108.00
IUUC-Tur-126788	Triticum urartu	28.35	4.00e-24	107.00
IUUC-Tbe-127309	Tupaia belangeri	58.19	0.00e+00	746.00
IUUC-Ttr-128271	Tursiops truncatus	68.52	0.00e+00	1028.00
IUUC-Vpa-130674	Vicugna pacos	68.73	0.00e+00	945.00
IUUC-Xtr-131869	Xenopus tropicalis	48.57	0.00e+00	711.00
IUUC-Xma-134195	Xiphophorus maculatus	52.64	7.00e-116	411.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence