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Tag Content
UUCD2 ID IUUC-Ocu-074922
UUCD1 version UUC-OrC-00700
Ensembl Protein ID ENSOCUP00000017548.2
UniProt Accession G1TKQ8; G1TKQ8_RABIT
Genbank Protein ID ENSOCUP00000017548
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAGW02050362
Gene Name UBE3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000017465.3 ENSOCUT00000026447.2 ENSOCUP00000017548.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.40e-108 362.0 554 880
Active Site
Position(s) Description Evidence
849 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 554  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 637
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 638  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 724
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 725  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 813
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 814  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 880
           *****************...8888866666**************************************97 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
MATACKRSPG EPQSDDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFHR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG APNNSEIKMN KKEGKGPRID 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074922|E3,HECT|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGGACGCG GGGGGCGACG ACAGGTCAGT GTTGCTGCGG ACGCGGCCAA GGCCGGGCGG 60
CGCTTCCTGC CCTCGGCTGC CTGTGCCCCT CGCCATCCTC AGGGCCTGCT CTGGCAAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074922|E3,HECT|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG ocu:100342825
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 96.98 0.00e+00 1598.00
IUUC-Atr-003144 Amborella trichopoda 45.80 4.00e-96 345.00
IUUC-Apl-003742 Anas platyrhynchos 93.44 0.00e+00 1602.00
IUUC-Aca-004873 Anolis carolinensis 93.04 0.00e+00 1604.00
IUUC-Ame-011166 Astyanax mexicanus 85.53 0.00e+00 1436.00
IUUC-Bta-013286 Bos taurus 94.90 0.00e+00 1595.00
IUUC-Cja-019707 Callithrix jacchus 95.55 0.00e+00 1625.00
IUUC-Cfa-020154 Canis familiaris 95.55 0.00e+00 1617.00
IUUC-Cpo-021292 Cavia porcellus 96.74 0.00e+00 1599.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 49.06 3.00e-82 298.00
IUUC-Csa-023378 Chlorocebus sabaeus 95.81 0.00e+00 1635.00
IUUC-Cho-025059 Choloepus hoffmanni 92.81 0.00e+00 1506.00
IUUC-Cin-025643 Ciona intestinalis 43.76 0.00e+00 714.00
IUUC-Csv-026282 Ciona savignyi 45.29 0.00e+00 673.00
IUUC-Cme-027151 Cyanidioschyzon merolae 44.02 3.00e-101 363.00
IUUC-Dre-027901 Danio rerio 85.07 0.00e+00 1420.00
IUUC-Dno-029320 Dasypus novemcinctus 96.83 0.00e+00 1638.00
IUUC-Dor-030756 Dipodomys ordii 94.57 0.00e+00 752.00
IUUC-Dme-032035 Drosophila melanogaster 43.35 2.00e-164 573.00
IUUC-Eca-033843 Equus caballus 95.01 0.00e+00 1558.00
IUUC-Eeu-035109 Erinaceus europaeus 94.77 0.00e+00 1540.00
IUUC-Fca-036344 Felis catus 96.04 0.00e+00 1631.00
IUUC-Fal-036747 Ficedula albicollis 93.44 0.00e+00 1601.00
IUUC-Gmo-038840 Gadus morhua 63.00 0.00e+00 1100.00
IUUC-Gga-040399 Gallus gallus 93.33 0.00e+00 1599.00
IUUC-Gac-041933 Gasterosteus aculeatus 82.84 0.00e+00 1369.00
IUUC-Ggo-044804 Gorilla gorilla 95.56 0.00e+00 1625.00
IUUC-Hsa-045727 Homo sapiens 95.56 0.00e+00 1625.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 93.83 0.00e+00 1523.00
IUUC-Lch-050197 Latimeria chalumnae 89.29 0.00e+00 1536.00
IUUC-Loc-052743 Lepisosteus oculatus 89.31 0.00e+00 1524.00
IUUC-Lma-053245 Leptosphaeria maculans 33.87 5.00e-57 216.00
IUUC-Laf-053615 Loxodonta africana 95.09 0.00e+00 1585.00
IUUC-Mcc-054934 Macaca mulatta 95.88 0.00e+00 1622.00
IUUC-Meu-056061 Macropus eugenii 88.95 0.00e+00 1406.00
IUUC-Mga-059271 Meleagris gallopavo 91.74 0.00e+00 1559.00
IUUC-Mmr-061288 Microcebus murinus 97.14 0.00e+00 1625.00
IUUC-Mdo-062975 Monodelphis domestica 94.92 0.00e+00 1607.00
IUUC-Mmu-063674 Mus musculus 93.87 0.00e+00 1592.00
IUUC-Mpu-066568 Mustela putorius furo 97.28 0.00e+00 1652.00
IUUC-Mlu-067522 Myotis lucifugus 89.19 0.00e+00 1506.00
IUUC-Nle-069505 Nomascus leucogenys 95.56 0.00e+00 1625.00
IUUC-Opr-070570 Ochotona princeps 92.09 0.00e+00 1497.00
IUUC-Ont-071527 Oreochromis niloticus 84.84 0.00e+00 1456.00
IUUC-Oan-073446 Ornithorhynchus anatinus 89.93 0.00e+00 1052.00
IUUC-Ola-086996 Oryzias latipes 83.94 0.00e+00 1451.00
IUUC-Oga-088261 Otolemur garnettii 97.10 0.00e+00 1600.00
IUUC-Oar-090024 Ovis aries 94.90 0.00e+00 1595.00
IUUC-Ptr-090455 Pan troglodytes 95.56 0.00e+00 1625.00
IUUC-Pan-092509 Papio anubis 93.64 0.00e+00 1456.00
IUUC-Psi-092974 Pelodiscus sinensis 91.40 0.00e+00 1575.00
IUUC-Pma-094643 Petromyzon marinus 71.67 0.00e+00 1253.00
IUUC-Pno-094886 Phaeosphaeria nodorum 35.32 8.00e-58 219.00
IUUC-Pfo-096905 Poecilia formosa 82.43 0.00e+00 1436.00
IUUC-Pab-097840 Pongo abelii 95.24 0.00e+00 1558.00
IUUC-Pca-100869 Procavia capensis 95.48 0.00e+00 1565.00
IUUC-Pva-103040 Pteropus vampyrus 97.02 0.00e+00 666.00
IUUC-Rno-105453 Rattus norvegicus 93.64 0.00e+00 1588.00
IUUC-Sha-107651 Sarcophilus harrisii 94.92 0.00e+00 1607.00
IUUC-Smo-108858 Selaginella moellendorffii 49.88 2.00e-116 412.00
IUUC-Sar-113293 Sorex araneus 95.93 0.00e+00 1583.00
IUUC-Ssc-115979 Sus scrofa 96.40 0.00e+00 1591.00
IUUC-Tgu-116901 Taeniopygia guttata 93.44 0.00e+00 1602.00
IUUC-Tru-118368 Takifugu rubripes 85.07 0.00e+00 1453.00
IUUC-Tsy-119516 Tarsius syrichta 93.03 0.00e+00 1488.00
IUUC-Tni-120143 Tetraodon nigroviridis 83.70 0.00e+00 1450.00
IUUC-Tbe-127484 Tupaia belangeri 90.97 0.00e+00 1093.00
IUUC-Ttr-129078 Tursiops truncatus 94.77 0.00e+00 1569.00
IUUC-Vpa-130312 Vicugna pacos 87.07 0.00e+00 1342.00
IUUC-Xtr-132881 Xenopus tropicalis 89.29 0.00e+00 1541.00
Created Date 25-Jun-2017

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