iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	15772280

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.50e-07	32.5	25	96
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.50e-12	46.5	131	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmele..esksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv ++   ++ ++ah  +La+ S+v+ + +++  +   + sk+ ++i +v +++++++++FlY+ +++ene
   Q: 25   TDVEIITSgRRSIPAHSGILASVSPVLTNIIEKPRKihGGSSKKVIKILGVPCDAVSVFVRFLYSPSVTENE 96
           699999988**********************9999973446678888889*****************99997 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eN+++il++A+l+d+pdL++++++fi++ Fk
   Q: 131  ENVVDILQLARLCDAPDLCLKCMRFIHYKFK 161
           9***************************997 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Also targeted for degradation by the 26S proteasome pathway. May be involved in gametophyte development.

Protein Sequence
(Fasta)

MAITATQNDG VSLNANKISY DLVETDVEII TSGRRSIPAH SGILASVSPV LTNIIEKPRK 60
IHGGSSKKVI KILGVPCDAV SVFVRFLYSP SVTENEMEKY GIHLLALSHV YMVTQLKQRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGTTATTA ACAAGTAATC AAAAAGGACC AGACTTCGTT GAGCTGTGTC TATAAAATCC 60
AGAGAAGCAA TGCCCTCAAG CTTCTCCATC ATCAAATTAA AACCCTCCAG CCTCCAACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR000197--Znf_TAZ

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF02135--zf-TAZ

SMART

SM00225--BTB
SM00551--ZnF_TAZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005516--F:calmodulin binding
GO:0004402--F:histone acetyltransferase activity
GO:0003712--F:transcription cofactor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0009553--P:embryo sac development
GO:0009555--P:pollen development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009733--P:response to auxin
GO:0042542--P:response to hydrogen peroxide
GO:0009751--P:response to salicylic acid

KEGG

ath:AT5G63160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002535	Amborella trichopoda	53.38	4.00e-82	297.00
IUUC-Aly-005594	Arabidopsis lyrata	94.51	0.00e+00	646.00
IUUC-Bdi-014937	Brachypodium distachyon	44.20	2.00e-64	238.00
IUUC-Bol-015246	Brassica oleracea	89.47	1.00e-170	591.00
IUUC-Bra-017225	Brassica rapa	88.59	0.00e+00	626.00
IUUC-Hvu-047854	Hordeum vulgare	45.49	5.00e-58	217.00
IUUC-Pno-094901	Phaeosphaeria nodorum	24.00	1.10e-02	33.10
IUUC-Pop-099980	Populus trichocarpa	62.20	3.00e-114	404.00
IUUC-Ppe-101438	Prunus persica	64.76	3.00e-112	397.00
IUUC-Stu-112519	Solanum tuberosum	66.01	5.00e-106	376.00
IUUC-Tae-124430	Triticum aestivum	46.94	4.00e-66	244.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence