iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007647

UUCD1 version

UUC-ArT-01588

Ensembl Protein ID

AT5G53300.2

UniProt Accession

P35133; P56617; Q4TZ00; Q8LCR4; UBC10_ARATH

Genbank Protein ID

CAA78715.1; AAA32895.1; AAY44850.1; BAB09792.1; AED96334.1; AED96335.1; AED96337.1; AAG40069.1; AAG40357.1; AAG41454.1; AAK62621.1; AAL57693.1; AAM44985.1; AAM91074.1; AAM63450.1

Protein Name

Ubiquitin-conjugating enzyme E2 10; E2 ubiquitin-conjugating enzyme 10; Ubiquitin carrier protein 10/12; Ubiquitin-conjugating enzyme E2-17 kDa 10/12; Ubiquitin-protein ligase 10/12

Genbank Nucleotide ID

Z14991; L00640; Z14993; AB013388; CP002688; CP002688; CP002688; AF324718; AF325005; AF326872; AY039566; AY065059; AY113937; AY129488; AY086447

Gene Name

UBC10; UBC12; At5g53300; K19E1.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G53300	AT5G53300.3	AT5G53300.3
AT5G53300	AT5G53300.2	AT5G53300.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20435904; 18643997; 16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	2.80e-56	190.0	5	139
UBD/UBC-like/UBD_UBC	3.20e-74	248.4	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R+ kelk+l+kdpp+++sa+pv e d+++w+++i+Gp+++pY+ggvF ++i+fp+dYPfkPPkv f tk+fhPn+++nG++Cl+ilk  e+Wspal++
   Q: 5    RILKELKDLQKDPPTSCSAGPVAE-DMFHWQATIMGPSESPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILK--EQWSPALTI 99
           899*********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vllsi+sll++pnp++pl  e+a+++k+++++y++++r
   Q: 100  SKVLLSICSLLTDPNPDDPLVPEIAHMYKTDKNKYESTAR 139
           ************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskv 98
           ri kelkdl++d+++ +sa++v +d+f+++ati+gp++spy ggvf +ti++p dypfkppkvaf tk++hpninsngsicldil++qws+alt+skv
   Q: 5    RILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPSESPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKV 102
           899*********************************************************************************************** PP
   S: 99   llslcslladaepddplvaeiariyktdkekykriarewt 138
           lls+csll+d++pddplv+eia++yktdk+ky+ +ar wt
   Q: 103  LLSICSLLTDPNPDDPLVPEIAHMYKTDKNKYESTARSWT 142
           ***************************************8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.

Protein Sequence
(Fasta)

MASKRILKEL KDLQKDPPTS CSAGPVAEDM FHWQATIMGP SESPYAGGVF LVTIHFPPDY 60
PFKPPKVAFR TKVFHPNINS NGSICLDILK EQWSPALTIS KVLLSICSLL TDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCTCTCTA ATACGAGAAG AAAAAGGCGA AAACCTCGCC AATCCGATTA CGCGAAAAAT 60
CAAAGGTATT GTCTCTGTAG CTTTTGGATC TATTACTTAT ATTTCTCACG GATTTATAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G53300

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002861	Amborella trichopoda	97.30	9.00e-85	304.00
IUUC-Aly-006230	Arabidopsis lyrata	100.00	3.00e-86	309.00
IUUC-Bdi-014712	Brachypodium distachyon	94.59	3.00e-83	299.00
IUUC-Bol-016243	Brassica oleracea	98.65	2.00e-85	306.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	84.46	3.00e-75	272.00
IUUC-Gma-043923	Glycine max	97.97	1.00e-84	303.00
IUUC-Hvu-047546	Hordeum vulgare	94.59	2.00e-82	296.00
IUUC-Lch-050109	Latimeria chalumnae	77.55	1.00e-68	251.00
IUUC-Laf-053580	Loxodonta africana	80.00	1.00e-67	247.00
IUUC-Mtr-058257	Medicago truncatula	95.95	9.00e-84	301.00
IUUC-Mac-065077	Musa acuminata	96.62	6.00e-84	301.00
IUUC-Oba-075251	Oryza barthii	95.27	8.00e-83	298.00
IUUC-Ogl-077124	Oryza glaberrima	96.62	7.00e-84	301.00
IUUC-Ogu-078338	Oryza glumaepatula	95.27	8.00e-83	298.00
IUUC-Oin-080092	Oryza indica	96.62	7.00e-84	301.00
IUUC-Olo-080786	Oryza longistaminata	93.92	2.00e-82	296.00
IUUC-Ome-081987	Oryza meridionalis	95.27	8.00e-83	298.00
IUUC-Oni-082631	Oryza nivara	95.27	8.00e-83	298.00
IUUC-Opu-083833	Oryza punctata	96.62	7.00e-84	301.00
IUUC-Oru-085020	Oryza rufipogon	95.27	8.00e-83	298.00
IUUC-Osa-086291	Oryza sativa	95.95	3.00e-83	299.00
IUUC-Ppa-095564	Physcomitrella patens	97.30	6.00e-84	301.00
IUUC-Ppe-101688	Prunus persica	97.97	5.00e-85	305.00
IUUC-Smo-108911	Selaginella moellendorffii	96.62	4.00e-83	299.00
IUUC-Sit-109936	Setaria italica	93.92	6.00e-83	299.00
IUUC-Sly-110885	Solanum lycopersicum	97.30	2.00e-84	303.00
IUUC-Stu-111944	Solanum tuberosum	97.30	2.00e-84	303.00
IUUC-Sbi-114749	Sorghum bicolor	95.27	8.00e-83	298.00
IUUC-Tca-121008	Theobroma cacao	97.30	3.00e-84	302.00
IUUC-Tae-123745	Triticum aestivum	95.95	6.00e-84	301.00
IUUC-Vvi-131700	Vitis vinifera	96.62	9.00e-84	301.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence