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Tag Content
iUUCD ID IUUC-Cja-019335
Ensembl Protein ID ENSCJAP00000021906.2
UniProt Accession F6PQH9; F6PQH9_CALJA
Genbank Protein ID ENSCJAP00000021906
Protein Name Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47
Genbank Nucleotide ID ACFV01054050
Gene Name EIF3F; EIF3S5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000011903.2 ENSCJAT00000023147.2 ENSCJAP00000021895.2
ENSCJAG00000011903.2 ENSCJAT00000023158.2 ENSCJAP00000021906.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 100.00 2.00e-163 572.00 IUUC-Hsa-046860
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Callithrix jacchus
Functional Description
(View)

Functional Description



     Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Protein Sequence
(Fasta)
LNALVSAPVA FFLDKMATPA VSPSAPPATP APAPVAAPVS APTSVPAPAP TPAQAAAPPS 60
AGTPASSSDS AAAAATTAAP GQTSASAQAP AQTPAPALPG PALPGPFPGG RVVRLHPVIL 120
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Protein Fasta Sequence



>IUUC-Cja-019335|DUB,JAMM|Callithrix jacchus
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Nucleotide Sequence
(Fasta)
CTAAGTTCTC CTTCTTGCTC ATTGCAGCCT CAAGCTCCTG GGCTCAAACA ATCGTTCTGC 60
CTCGGTCTCC CAAAGTGCTG GGATTACAGG GGTGAGCCAC CGCGCCCGGC CTTAAAATGC 120
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Nucleotide Fasta Sequence



>IUUC-Cja-019335|DUB,JAMM|Callithrix jacchus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001150 Aegilops tauschii 35.81 4.00e-47 181.00
IUUC-Aml-001527 Ailuropoda melanoleuca 100.00 4.00e-162 563.00
IUUC-Atr-002686 Amborella trichopoda 41.06 6.00e-50 190.00
IUUC-Apl-003977 Anas platyrhynchos 91.07 2.00e-122 431.00
IUUC-Aca-004335 Anolis carolinensis 90.74 6.00e-149 520.00
IUUC-Aly-005945 Arabidopsis lyrata 38.78 5.00e-50 191.00
IUUC-Ath-007045 Arabidopsis thaliana 39.16 4.00e-50 191.00
IUUC-Acl-008365 Aspergillus clavatus 34.80 4.00e-41 162.00
IUUC-Afl-008742 Aspergillus flavus 35.53 3.00e-40 159.00
IUUC-Afu-009030 Aspergillus fumigatus 34.43 8.00e-41 160.00
IUUC-Ani-009212 Aspergillus nidulans 35.42 1.00e-41 163.00
IUUC-Ang-009712 Aspergillus niger 34.43 7.00e-40 157.00
IUUC-Aor-009885 Aspergillus oryzae 35.53 7.00e-42 164.00
IUUC-Ate-010315 Aspergillus terreus 35.53 1.00e-39 156.00
IUUC-Ame-010801 Astyanax mexicanus 54.07 5.00e-67 247.00
IUUC-Bgr-011982 Blumeria graminis 35.41 2.00e-40 159.00
IUUC-Bta-012804 Bos taurus 98.93 2.00e-168 584.00
IUUC-Bci-013891 Botrytis cinerea 34.91 4.00e-35 142.00
IUUC-Bdi-014328 Brachypodium distachyon 39.62 2.00e-48 185.00
IUUC-Bol-015446 Brassica oleracea 39.16 4.00e-51 194.00
IUUC-Bra-016862 Brassica rapa 39.54 1.00e-51 196.00
IUUC-Cel-018171 Caenorhabditis elegans 35.19 9.00e-47 180.00
IUUC-Cfa-020138 Canis familiaris 99.63 9.00e-162 562.00
IUUC-Cpo-022109 Cavia porcellus 87.64 4.00e-137 480.00
IUUC-Cre-022664 Chlamydomonas reinhardtii 38.43 7.00e-58 217.00
IUUC-Csa-023994 Chlorocebus sabaeus 100.00 6.00e-165 573.00
IUUC-Cho-024351 Choloepus hoffmanni 76.84 2.00e-115 408.00
IUUC-Cin-025801 Ciona intestinalis 56.51 2.00e-88 318.00
IUUC-Csv-025805 Ciona savignyi 55.39 3.00e-86 311.00
IUUC-Cgl-026643 Colletotrichum gloeosporioides 31.87 2.00e-35 142.00
IUUC-Cne-026868 Cryptococcus neoformans 29.15 3.00e-28 119.00
IUUC-Cme-027328 Cyanidioschyzon merolae 27.22 2.00e-22 100.00
IUUC-Dre-028085 Danio rerio 80.30 9.00e-130 456.00
IUUC-Dno-030099 Dasypus novemcinctus 99.63 5.00e-159 553.00
IUUC-Dor-030324 Dipodomys ordii 91.04 5.00e-141 493.00
IUUC-Dse-031314 Dothistroma septosporum 35.74 1.00e-44 173.00
IUUC-Dme-031926 Drosophila melanogaster 49.26 5.00e-77 280.00
IUUC-Ete-032569 Echinops telfairi 93.17 2.00e-153 534.00
IUUC-Eca-033502 Equus caballus 94.66 6.00e-156 543.00
IUUC-Eeu-034883 Erinaceus europaeus 82.16 4.00e-83 300.00
IUUC-Fca-035873 Felis catus 100.00 3.00e-162 563.00
IUUC-Fal-036921 Ficedula albicollis 92.22 5.00e-150 523.00
IUUC-Fox-037765 Fusarium oxysporum 32.73 5.00e-30 124.00
IUUC-Fso-038240 Fusarium solani 33.09 3.00e-32 132.00
IUUC-Gmo-038864 Gadus morhua 78.44 9.00e-130 455.00
IUUC-Ggr-039862 Gaeumannomyces graminis 31.52 5.00e-30 125.00
IUUC-Gga-040952 Gallus gallus 92.28 2.00e-151 527.00
IUUC-Gac-041677 Gasterosteus aculeatus 79.55 6.00e-130 456.00
IUUC-Gma-043061 Glycine max 41.06 1.00e-49 189.00
IUUC-Ggo-045591 Gorilla gorilla 100.00 1.00e-162 565.00
IUUC-Hsa-046860 Homo sapiens 100.00 6.00e-165 573.00
IUUC-Hvu-047410 Hordeum vulgare 31.08 3.00e-20 90.50
IUUC-Itr-048211 Ictidomys tridecemlineatus 99.63 1.00e-161 562.00
IUUC-Lch-049410 Latimeria chalumnae 74.27 2.00e-87 315.00
IUUC-Lpe-051102 Leersia perrieri 40.00 3.00e-47 182.00
IUUC-Loc-052016 Lepisosteus oculatus 69.20 1.00e-114 405.00
IUUC-Lma-053157 Leptosphaeria maculans 34.26 4.00e-43 168.00
IUUC-Laf-054568 Loxodonta africana 99.26 2.00e-164 571.00
IUUC-Mcc-054613 Macaca mulatta 100.00 2.00e-162 565.00
IUUC-Meu-056832 Macropus eugenii 72.86 1.00e-82 298.00
IUUC-Mor-057104 Magnaporthe oryzae 31.32 4.00e-30 125.00
IUUC-Mtr-058445 Medicago truncatula 40.68 3.00e-58 218.00
IUUC-Mla-059038 Melampsora laricipopulina 31.12 3.00e-32 132.00
IUUC-Mga-059548 Meleagris gallopavo 91.95 8.00e-130 455.00
IUUC-Mvi-060520 Microbotryum violaceum 27.95 4.00e-22 98.60
IUUC-Mdo-062376 Monodelphis domestica 94.40 4.00e-151 527.00
IUUC-Mmu-063254 Mus musculus 99.25 6.00e-161 560.00
IUUC-Mac-065635 Musa acuminata 41.09 3.00e-52 198.00
IUUC-Mpu-066314 Mustela putorius furo 100.00 3.00e-162 563.00
IUUC-Mlu-067512 Myotis lucifugus 98.13 5.00e-160 556.00
IUUC-Nfi-068262 Neosartorya fischeri 34.43 9.00e-41 160.00
IUUC-Ncr-068872 Neurospora crassa 32.36 8.00e-33 134.00
IUUC-Nle-070118 Nomascus leucogenys 100.00 1.00e-159 555.00
IUUC-Opr-071228 Ochotona princeps 99.57 2.00e-141 494.00
IUUC-Ont-072600 Oreochromis niloticus 80.67 1.00e-132 465.00
IUUC-Oan-073584 Ornithorhynchus anatinus 93.64 1.00e-133 468.00
IUUC-Ocu-074542 Oryctolagus cuniculus 99.63 2.00e-161 561.00
IUUC-Oba-075923 Oryza barthii 38.93 1.00e-50 192.00
IUUC-Obr-076313 Oryza brachyantha 40.00 1.00e-48 186.00
IUUC-Ogl-076932 Oryza glaberrima 38.93 1.00e-50 192.00
IUUC-Ogu-078152 Oryza glumaepatula 38.93 1.00e-50 192.00
IUUC-Oin-079528 Oryza indica 38.93 1.00e-50 192.00
IUUC-Olo-080401 Oryza longistaminata 38.93 1.00e-50 192.00
IUUC-Ome-081553 Oryza meridionalis 38.57 4.00e-50 191.00
IUUC-Oni-082090 Oryza nivara 38.93 1.00e-50 192.00
IUUC-Opu-083583 Oryza punctata 40.00 4.00e-48 184.00
IUUC-Oru-084492 Oryza rufipogon 38.93 1.00e-50 192.00
IUUC-Osa-085383 Oryza sativa 38.93 1.00e-50 192.00
IUUC-Ola-086835 Oryzias latipes 79.55 2.00e-129 454.00
IUUC-Olu-087716 Ostreococcus lucimarinus 29.70 2.00e-28 119.00
IUUC-Oga-088886 Otolemur garnettii 99.25 4.00e-161 560.00
IUUC-Oar-090079 Ovis aries 98.58 8.00e-169 585.00
IUUC-Ptr-091457 Pan troglodytes 100.00 6.00e-165 573.00
IUUC-Pan-092317 Papio anubis 100.00 5.00e-109 386.00
IUUC-Psi-093129 Pelodiscus sinensis 85.71 1.00e-130 458.00
IUUC-Pma-094488 Petromyzon marinus 72.35 1.00e-124 439.00
IUUC-Pno-095049 Phaeosphaeria nodorum 34.26 2.00e-43 169.00
IUUC-Ppa-095341 Physcomitrella patens 41.57 3.00e-64 238.00
IUUC-Pfo-096286 Poecilia formosa 76.33 1.00e-130 459.00
IUUC-Pab-097765 Pongo abelii 100.00 6.00e-165 573.00
IUUC-Pop-099131 Populus trichocarpa 40.68 2.00e-54 205.00
IUUC-Pca-100524 Procavia capensis 82.91 1.00e-108 385.00
IUUC-Ppe-101934 Prunus persica 41.83 4.00e-59 221.00
IUUC-Pva-102577 Pteropus vampyrus 99.25 2.00e-161 561.00
IUUC-Pgr-103521 Puccinia graminis 30.19 1.00e-31 130.00
IUUC-Pte-104304 Pyrenophora teres 34.95 8.00e-44 170.00
IUUC-Pyt-104563 Pyrenophora triticirepentis 34.95 5.00e-44 171.00
IUUC-Rno-105717 Rattus norvegicus 99.63 1.00e-161 561.00
IUUC-Sha-107190 Sarcophilus harrisii 94.64 2.00e-147 514.00
IUUC-Sja-107918 Schizosaccharomyces japonicus 35.89 1.00e-45 176.00
IUUC-Spo-108355 Schizosaccharomyces pombe 35.84 9.00e-46 177.00
IUUC-Smo-109374 Selaginella moellendorffii 44.28 1.00e-68 253.00
IUUC-Sit-110119 Setaria italica 39.54 4.00e-49 188.00
IUUC-Sly-111570 Solanum lycopersicum 37.34 5.00e-46 177.00
IUUC-Stu-112308 Solanum tuberosum 39.66 3.00e-52 198.00
IUUC-Sar-113515 Sorex araneus 97.87 2.00e-52 197.00
IUUC-Sbi-114605 Sorghum bicolor 39.16 5.00e-49 188.00
IUUC-Sre-114906 Sporisorium reilianum 39.78 6.00e-52 197.00
IUUC-Tgu-117087 Taeniopygia guttata 90.25 2.00e-127 447.00
IUUC-Tru-117700 Takifugu rubripes 79.18 9.00e-130 456.00
IUUC-Tni-120470 Tetraodon nigroviridis 79.93 1.00e-130 458.00
IUUC-Tca-121109 Theobroma cacao 39.92 6.00e-48 184.00
IUUC-Tre-122095 Trichoderma reesei 33.94 4.00e-32 132.00
IUUC-Tvi-122580 Trichoderma virens 33.57 2.00e-31 129.00
IUUC-Tae-125129 Triticum aestivum 37.93 1.00e-51 196.00
IUUC-Tur-126658 Triticum urartu 34.94 1.00e-42 166.00
IUUC-Tme-127043 Tuber melanosporum 38.87 7.00e-48 184.00
IUUC-Tbe-127927 Tupaia belangeri 100.00 3.00e-162 563.00
IUUC-Ttr-129231 Tursiops truncatus 99.63 9.00e-162 562.00
IUUC-Uma-129578 Ustilago maydis 39.42 5.00e-51 194.00
IUUC-Vda-129730 Verticillium dahliae 32.36 7.00e-37 147.00
IUUC-Vpa-130677 Vicugna pacos 64.75 4.00e-42 165.00
IUUC-Vvi-130968 Vitis vinifera 41.44 1.00e-53 202.00
IUUC-Xtr-132203 Xenopus tropicalis 84.76 4.00e-137 480.00
IUUC-Xma-133972 Xiphophorus maculatus 78.81 5.00e-130 456.00
IUUC-Yli-134553 Yarrowia lipolytica 36.33 6.00e-40 157.00
IUUC-Zma-134941 Zea mays 38.78 2.00e-44 172.00
Created Date 25-Jun-2017

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