iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069406

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

ADFV01128020

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000022.1	ENSNLET00000000029.1	ENSNLEP00000000026.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.10e-42	139.2	103	135
UBD/Beta-Prp	2.70e-58	197.5	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+++v ++a+ ++ +ll+++s+D+++ vW+++
   Q: 103  GHENEVKSVAWaPSgNLLATCSRDKSVWVWEVD 135
           8***********666****************86 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d++i++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPTGTLLASCGGDRRIRIWGTEGDSWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*********************9877654566689******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATL 190
           *********************************9987776566*********************************9977754499*** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklw 207
           +g h++ v sl+fd++g++l+s+s+d+tv++w
   Q: 191  EG-HESTVWSLAFDPSGQRLASCSDDRTVRIW 221
           *9.***************************** PP

Organism

Nomascus leucogenys

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLGR VPAHPDSRCW FLAWNPTGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAGTTCT CGGGGTGACC CAGGTCCTTC GGCGGAAGCG GGAGCCTCTG TCGGCAGCAG 60
AAGCCTGGAG TGAGCGGTGC GCAGACGCGC GCAGTGAGAC CCGCTGTCTG CGCAGCGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	41.81	1.00e-66	248.00
IUUC-Aml-001317	Ailuropoda melanoleuca	94.69	2.00e-177	614.00
IUUC-Atr-003029	Amborella trichopoda	51.32	2.00e-91	328.00
IUUC-Apl-004042	Anas platyrhynchos	72.73	1.00e-51	194.00
IUUC-Aly-006458	Arabidopsis lyrata	47.54	4.00e-83	301.00
IUUC-Ath-006671	Arabidopsis thaliana	47.54	8.00e-83	300.00
IUUC-Ago-007820	Ashbya gossypii	39.71	3.00e-56	211.00
IUUC-Acl-008042	Aspergillus clavatus	30.88	9.00e-47	181.00
IUUC-Afl-008639	Aspergillus flavus	31.43	3.00e-49	189.00
IUUC-Afu-008899	Aspergillus fumigatus	34.38	3.00e-45	176.00
IUUC-Ani-009453	Aspergillus nidulans	31.43	3.00e-47	182.00
IUUC-Ang-009758	Aspergillus niger	33.67	1.00e-47	183.00
IUUC-Aor-010212	Aspergillus oryzae	31.43	3.00e-49	189.00
IUUC-Ate-010314	Aspergillus terreus	31.65	5.00e-49	188.00
IUUC-Ame-010676	Astyanax mexicanus	76.05	9.00e-153	532.00
IUUC-Bgr-012095	Blumeria graminis	29.50	3.00e-34	139.00
IUUC-Bta-012884	Bos taurus	91.45	9.00e-171	592.00
IUUC-Bci-013622	Botrytis cinerea	31.41	6.00e-34	138.00
IUUC-Bdi-014614	Brachypodium distachyon	47.93	4.00e-83	301.00
IUUC-Bol-016439	Brassica oleracea	46.47	1.00e-79	290.00
IUUC-Bra-016830	Brassica rapa	46.02	2.00e-79	289.00
IUUC-Cel-018709	Caenorhabditis elegans	39.14	4.00e-59	221.00
IUUC-Cja-019822	Callithrix jacchus	96.76	0.00e+00	630.00
IUUC-Cfa-020823	Canis familiaris	95.58	3.00e-179	620.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	47.13	2.00e-78	285.00
IUUC-Csa-023754	Chlorocebus sabaeus	97.35	0.00e+00	632.00
IUUC-Cin-025395	Ciona intestinalis	56.42	5.00e-113	400.00
IUUC-Csv-025943	Ciona savignyi	54.35	1.00e-108	385.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	32.67	3.00e-33	136.00
IUUC-Cne-026939	Cryptococcus neoformans	32.44	4.00e-47	182.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.93	8.00e-45	174.00
IUUC-Dre-028172	Danio rerio	74.55	1.00e-149	521.00
IUUC-Dno-029472	Dasypus novemcinctus	93.52	8.00e-148	516.00
IUUC-Dor-031134	Dipodomys ordii	83.48	1.00e-148	518.00
IUUC-Dse-031535	Dothistroma septosporum	29.86	1.00e-43	170.00
IUUC-Dme-032020	Drosophila melanogaster	57.58	1.00e-112	399.00
IUUC-Eca-033700	Equus caballus	95.58	2.00e-179	620.00
IUUC-Eeu-035010	Erinaceus europaeus	92.33	6.00e-172	596.00
IUUC-Fca-036309	Felis catus	86.47	5.00e-166	576.00
IUUC-Fal-037243	Ficedula albicollis	73.68	4.00e-82	296.00
IUUC-Fox-038058	Fusarium oxysporum	32.31	4.00e-40	159.00
IUUC-Fso-038459	Fusarium solani	34.44	6.00e-36	145.00
IUUC-Gmo-039375	Gadus morhua	74.33	7.00e-136	476.00
IUUC-Ggr-040002	Gaeumannomyces graminis	33.94	5.00e-39	155.00
IUUC-Gga-040294	Gallus gallus	81.42	1.00e-124	439.00
IUUC-Gac-042499	Gasterosteus aculeatus	73.59	6.00e-134	469.00
IUUC-Gma-043543	Glycine max	48.08	2.00e-84	305.00
IUUC-Ggo-045181	Gorilla gorilla	97.35	0.00e+00	632.00
IUUC-Hsa-046528	Homo sapiens	97.35	0.00e+00	632.00
IUUC-Hvu-047341	Hordeum vulgare	56.91	2.00e-55	208.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	95.58	3.00e-179	620.00
IUUC-Kpa-049353	Komagataella pastoris	36.26	9.00e-53	200.00
IUUC-Lch-049763	Latimeria chalumnae	79.34	3.00e-156	544.00
IUUC-Lpe-051500	Leersia perrieri	43.94	8.00e-80	290.00
IUUC-Loc-052021	Lepisosteus oculatus	78.74	4.00e-148	516.00
IUUC-Lma-053331	Leptosphaeria maculans	34.25	2.00e-51	197.00
IUUC-Laf-054558	Loxodonta africana	93.22	1.00e-174	605.00
IUUC-Mcc-055374	Macaca mulatta	97.05	0.00e+00	629.00
IUUC-Meu-056042	Macropus eugenii	75.52	7.00e-108	382.00
IUUC-Mor-057187	Magnaporthe oryzae	33.80	4.00e-36	145.00
IUUC-Mtr-058072	Medicago truncatula	48.21	1.00e-82	299.00
IUUC-Mla-059108	Melampsora laricipopulina	30.68	5.00e-48	185.00
IUUC-Mga-059370	Meleagris gallopavo	62.87	2.00e-96	345.00
IUUC-Mvi-060495	Microbotryum violaceum	36.39	4.00e-54	205.00
IUUC-Mmr-060902	Microcebus murinus	95.28	2.00e-178	617.00
IUUC-Mdo-062510	Monodelphis domestica	91.74	2.00e-166	578.00
IUUC-Mmu-063575	Mus musculus	92.92	6.00e-175	606.00
IUUC-Mac-065322	Musa acuminata	49.85	7.00e-88	317.00
IUUC-Mpu-065925	Mustela putorius furo	94.40	7.00e-177	612.00
IUUC-Mlu-067755	Myotis lucifugus	94.69	2.00e-177	614.00
IUUC-Nfi-068327	Neosartorya fischeri	30.32	5.00e-45	175.00
IUUC-Ncr-068845	Neurospora crassa	37.70	4.00e-29	122.00
IUUC-Opr-070416	Ochotona princeps	74.34	5.00e-128	450.00
IUUC-Ont-071936	Oreochromis niloticus	74.48	8.00e-138	483.00
IUUC-Oan-073452	Ornithorhynchus anatinus	91.82	2.00e-71	261.00
IUUC-Ocu-074791	Oryctolagus cuniculus	93.51	2.00e-175	607.00
IUUC-Oba-075636	Oryza barthii	48.66	4.00e-86	311.00
IUUC-Obr-076742	Oryza brachyantha	48.25	5.00e-75	274.00
IUUC-Ogl-077766	Oryza glaberrima	48.66	4.00e-86	311.00
IUUC-Ogu-079039	Oryza glumaepatula	48.66	2.00e-86	312.00
IUUC-Oin-079315	Oryza indica	48.63	1.00e-75	276.00
IUUC-Olo-080669	Oryza longistaminata	43.23	3.00e-78	285.00
IUUC-Ome-081490	Oryza meridionalis	48.66	3.00e-86	311.00
IUUC-Oni-082572	Oryza nivara	48.66	4.00e-86	311.00
IUUC-Opu-083732	Oryza punctata	48.81	3.00e-86	311.00
IUUC-Oru-084763	Oryza rufipogon	48.66	4.00e-86	311.00
IUUC-Osa-085372	Oryza sativa	48.66	4.00e-86	311.00
IUUC-Ola-087379	Oryzias latipes	72.06	2.00e-133	468.00
IUUC-Olu-087801	Ostreococcus lucimarinus	35.12	1.00e-42	166.00
IUUC-Oga-089076	Otolemur garnettii	94.69	1.00e-177	615.00
IUUC-Oar-090022	Ovis aries	90.86	1.00e-169	588.00
IUUC-Ptr-090809	Pan troglodytes	97.35	0.00e+00	632.00
IUUC-Pan-091685	Papio anubis	97.35	0.00e+00	639.00
IUUC-Psi-093046	Pelodiscus sinensis	86.65	2.00e-164	571.00
IUUC-Pma-094181	Petromyzon marinus	62.61	4.00e-127	447.00
IUUC-Pno-094882	Phaeosphaeria nodorum	34.54	4.00e-52	198.00
IUUC-Ppa-095172	Physcomitrella patens	46.80	2.00e-82	299.00
IUUC-Pfo-096396	Poecilia formosa	70.92	4.00e-134	470.00
IUUC-Pab-098427	Pongo abelii	97.64	0.00e+00	632.00
IUUC-Pop-100016	Populus trichocarpa	51.04	1.00e-87	315.00
IUUC-Pca-101048	Procavia capensis	93.81	3.00e-175	607.00
IUUC-Ppe-102050	Prunus persica	46.29	1.00e-83	303.00
IUUC-Pva-103117	Pteropus vampyrus	94.10	3.00e-176	610.00
IUUC-Pgr-103307	Puccinia graminis	33.33	8.00e-54	204.00
IUUC-Ptt-103938	Puccinia triticina	37.37	1.00e-46	180.00
IUUC-Pte-104315	Pyrenophora teres	32.85	2.00e-52	199.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	32.13	2.00e-51	196.00
IUUC-Rno-105523	Rattus norvegicus	92.92	1.00e-174	605.00
IUUC-Sce-106297	Saccharomyces cerevisiae	41.32	2.00e-61	229.00
IUUC-Sha-106981	Sarcophilus harrisii	90.44	8.00e-138	482.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	39.31	8.00e-55	208.00
IUUC-Spo-108214	Schizosaccharomyces pombe	39.19	5.00e-54	205.00
IUUC-Smo-109034	Selaginella moellendorffii	44.51	7.00e-79	287.00
IUUC-Sit-110663	Setaria italica	49.56	2.00e-87	315.00
IUUC-Sly-110898	Solanum lycopersicum	46.51	8.00e-79	286.00
IUUC-Stu-112647	Solanum tuberosum	51.54	5.00e-67	247.00
IUUC-Sbi-114288	Sorghum bicolor	47.21	6.00e-83	300.00
IUUC-Sre-115065	Sporisorium reilianum	42.53	2.00e-71	263.00
IUUC-Ssc-115960	Sus scrofa	87.24	5.00e-173	600.00
IUUC-Tru-118382	Takifugu rubripes	70.03	3.00e-142	497.00
IUUC-Tsy-119585	Tarsius syrichta	86.73	6.00e-158	549.00
IUUC-Tni-120133	Tetraodon nigroviridis	73.94	4.00e-139	487.00
IUUC-Tca-121167	Theobroma cacao	48.66	2.00e-78	285.00
IUUC-Tre-122119	Trichoderma reesei	28.64	2.00e-37	150.00
IUUC-Tae-124500	Triticum aestivum	47.48	9.00e-80	290.00
IUUC-Tur-126682	Triticum urartu	47.78	8.00e-65	239.00
IUUC-Tme-127095	Tuber melanosporum	35.41	7.00e-58	217.00
IUUC-Tbe-128004	Tupaia belangeri	94.69	7.00e-178	615.00
IUUC-Ttr-129284	Tursiops truncatus	89.77	6.00e-166	576.00
IUUC-Uma-129527	Ustilago maydis	42.02	3.00e-70	259.00
IUUC-Vda-129854	Verticillium dahliae	30.57	3.00e-35	142.00
IUUC-Vpa-130681	Vicugna pacos	97.41	9.00e-50	190.00
IUUC-Vvi-131004	Vitis vinifera	53.15	1.00e-85	309.00
IUUC-Xtr-131928	Xenopus tropicalis	80.12	3.00e-150	524.00
IUUC-Xma-134290	Xiphophorus maculatus	69.73	2.00e-130	457.00
IUUC-Yli-134364	Yarrowia lipolytica	42.57	2.00e-63	235.00
IUUC-Zma-135658	Zea mays	48.66	4.00e-84	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence