iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aor-009914

Ensembl Protein ID

BAE58783

UniProt Accession

Q2UI32; Q2UI32_ASPOR

Genbank Protein ID

BAE58783.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AP007157

Gene Name

AO090023000210

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AO090023000210	BAE58783	BAE58783

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-57	195.3	19	553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagg............lGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlw + +q++l++++vllv+ +g            +G+E+lKnLvl G+g +t+vD +tv+ ++l+ +F++++++ gk++A  +++ lkelnpdv+
   Q: 19   YDRQLRLWAASGQKALEESRVLLVNSDGpwsnqstgvsgvVGVETLKNLVLPGIGGFTIVDPATVTEADLGVNFFLEEQSLGKPRAAETCRLLKELNPDVE 119
           ************************98766666666666669************************************************************ PP
   S: 90   vea.....heesiteleeeiv.FfkkfdvV.vlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.....dppqktiPfctlke 178
           +++     ++ sitel  +++ F+ ++ +V v++ ++r +   + ++  ++++p + +++ G+++  +  ++ l  + + ++     +++++ +P+++l+e
   Q: 120  GSFqskvwDSGSITELLRQDPgFLAQHRLVlVSGPMKRPSLDALCKAASELNIPVLYTRSVGFYSSFSLQLPPLFPIVETHPdpettQDLRLLNPWPELAE 220
           *99333334579999999999*******99345677777776666666666******************9988765555555599999************* PP
   S: 179  tpn..........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks....edeenfeeaieiavkafakttins.ikqllksfecdi 264
             +           ++ ++++  l+ ++le+++++++++ +++++ek+e+++ v+s++++      een++ea+++++k++++++  s +++++++ ec++
   Q: 221  AASriddletlddHQHGHVPYLLLLLHYLEKWKEAHNGNVPSNYKEKSEFREMVRSSARTcnpeGGEENYDEAVAAVLKSLNPFSLRSsTREIFEMEECKN 321
           *999999999999999999*99*************************************987777789********************************* PP
   S: 265  vtkskspfwv.........................................................................sfcsnaealq........ 284
            + ++++fw+                                                                          fc+na+ ++        
   Q: 322  PRADSADFWIiasavreffqqhnvlplpgslpdmkaqsadyvslqniykskakkdveevtnivrriesqigsrsgdipekdieIFCKNAAHIKvirgrsip 422
           ***********************************************************************************999999999966666644 PP
   S: 285  ....vpekvekdeevvkasap.........lylllralerfekk.......kgrkpgelsfekdddsavdlvtaaanlra...eslgiep.kldddlikei 361
               +   ++k  ++     +           ++++al+++ ++       +g+  +e+ +  + d ++      ++l a   ++++  + +  +++i+e+
   Q: 423  eidgE-AQTLKAIRN-----SisipdslipVFIAFQALDNVVTDlqerripSGSIDDEVAWGAQIDRVL------SALTAddqSTIDEDArERISEAIQEL 511
           44431.222222222.....1333345777556666666554431000111344444444554444433......3333332244444555556789999* PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
            +++ ++++ +++  gGl+aqE++Kv++ +++pl+n+ +fd+
   Q: 512  RRTEGGELHNISSLTGGLVAQEALKVITRQYVPLDNTCIFDG 553
           ****************************************97 PP

Organism

Aspergillus oryzae

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MTDAFPSALT GPSSKERKYD RQLRLWAASG QKALEESRVL LVNSDGPWSN QSTGVSGVVG 60
VETLKNLVLP GIGGFTIVDP ATVTEADLGV NFFLEEQSLG KPRAAETCRL LKELNPDVEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTGATG CTTTTCCAAG CGCCCTGACT GGGCCATCTT CCAAAGAAAG GAAATATGAT 60
CGGCAACTGC GGTTATGGGC TGCAAGTGGC CAGAAGGCTC TAGAAGAGTC TCGTGTACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	33.09	7.00e-75	272.00
IUUC-Aml-002333	Ailuropoda melanoleuca	35.17	1.00e-84	305.00
IUUC-Atr-002644	Amborella trichopoda	33.33	4.00e-67	247.00
IUUC-Apl-003446	Anas platyrhynchos	33.45	3.00e-74	270.00
IUUC-Aca-004450	Anolis carolinensis	33.45	4.00e-82	296.00
IUUC-Aly-006187	Arabidopsis lyrata	33.57	5.00e-77	280.00
IUUC-Ath-007600	Arabidopsis thaliana	33.57	4.00e-77	280.00
IUUC-Ago-007900	Ashbya gossypii	25.94	1.00e-33	135.00
IUUC-Acl-008333	Aspergillus clavatus	75.84	0.00e+00	853.00
IUUC-Afl-008529	Aspergillus flavus	98.76	0.00e+00	1092.00
IUUC-Afu-009071	Aspergillus fumigatus	76.73	0.00e+00	865.00
IUUC-Ani-009443	Aspergillus nidulans	72.29	0.00e+00	793.00
IUUC-Ang-009669	Aspergillus niger	78.01	0.00e+00	894.00
IUUC-Ate-010450	Aspergillus terreus	78.33	0.00e+00	890.00
IUUC-Ame-011183	Astyanax mexicanus	35.29	3.00e-88	317.00
IUUC-Bgr-012111	Blumeria graminis	44.80	6.00e-115	405.00
IUUC-Bta-012583	Bos taurus	35.23	2.00e-85	307.00
IUUC-Bci-013892	Botrytis cinerea	50.00	7.00e-134	468.00
IUUC-Bdi-014592	Brachypodium distachyon	33.45	8.00e-74	269.00
IUUC-Bol-016401	Brassica oleracea	33.39	2.00e-79	288.00
IUUC-Bra-017506	Brassica rapa	33.75	3.00e-75	273.00
IUUC-Cel-018456	Caenorhabditis elegans	31.57	4.00e-55	207.00
IUUC-Cja-020007	Callithrix jacchus	35.34	6.00e-83	299.00
IUUC-Cfa-020324	Canis familiaris	35.88	3.00e-85	307.00
IUUC-Cpo-022248	Cavia porcellus	30.63	4.00e-41	160.00
IUUC-Csa-023149	Chlorocebus sabaeus	33.40	1.00e-60	225.00
IUUC-Cho-024537	Choloepus hoffmanni	30.15	2.00e-51	194.00
IUUC-Cin-025763	Ciona intestinalis	35.27	4.00e-80	290.00
IUUC-Csv-026113	Ciona savignyi	34.56	2.00e-82	297.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	44.52	3.00e-118	416.00
IUUC-Cne-026884	Cryptococcus neoformans	29.88	1.00e-61	229.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.00	4.00e-12	64.70
IUUC-Dre-028140	Danio rerio	35.69	6.00e-88	316.00
IUUC-Dno-030033	Dasypus novemcinctus	37.80	8.00e-76	275.00
IUUC-Dor-030513	Dipodomys ordii	49.57	5.00e-24	103.00
IUUC-Dse-031536	Dothistroma septosporum	45.39	6.00e-129	452.00
IUUC-Dme-031683	Drosophila melanogaster	35.50	2.00e-76	278.00
IUUC-Ete-032420	Echinops telfairi	30.56	3.00e-63	234.00
IUUC-Eca-033992	Equus caballus	33.41	5.00e-60	223.00
IUUC-Eeu-034713	Erinaceus europaeus	51.85	1.00e-25	108.00
IUUC-Fca-036548	Felis catus	35.52	4.00e-84	303.00
IUUC-Fal-037600	Ficedula albicollis	33.69	1.00e-72	265.00
IUUC-Fox-038037	Fusarium oxysporum	43.57	1.00e-123	435.00
IUUC-Fso-038387	Fusarium solani	45.33	1.00e-130	457.00
IUUC-Gmo-038562	Gadus morhua	34.22	2.00e-83	301.00
IUUC-Ggr-040005	Gaeumannomyces graminis	47.10	1.00e-131	461.00
IUUC-Gga-041129	Gallus gallus	34.35	6.00e-79	286.00
IUUC-Gac-042558	Gasterosteus aculeatus	34.93	9.00e-82	295.00
IUUC-Gma-043610	Glycine max	34.64	1.00e-73	268.00
IUUC-Ggo-045611	Gorilla gorilla	35.85	1.00e-83	301.00
IUUC-Hsa-046563	Homo sapiens	36.04	2.00e-85	307.00
IUUC-Hvu-047790	Hordeum vulgare	31.64	2.00e-47	181.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	36.23	4.00e-85	306.00
IUUC-Kpa-049309	Komagataella pastoris	35.42	7.00e-75	272.00
IUUC-Lch-050038	Latimeria chalumnae	34.58	2.00e-77	281.00
IUUC-Lpe-051535	Leersia perrieri	31.38	2.00e-55	207.00
IUUC-Loc-051917	Lepisosteus oculatus	33.98	2.00e-76	278.00
IUUC-Lma-053112	Leptosphaeria maculans	50.09	3.00e-154	536.00
IUUC-Laf-053690	Loxodonta africana	35.88	3.00e-86	310.00
IUUC-Mcc-055117	Macaca mulatta	35.10	2.00e-80	291.00
IUUC-Meu-056761	Macropus eugenii	28.62	1.00e-55	209.00
IUUC-Mor-057230	Magnaporthe oryzae	45.95	7.00e-132	462.00
IUUC-Mpo-057514	Magnaporthe poae	47.29	6.00e-125	439.00
IUUC-Mtr-058551	Medicago truncatula	32.04	7.00e-71	259.00
IUUC-Mla-059183	Melampsora laricipopulina	34.78	5.00e-82	296.00
IUUC-Mga-060144	Meleagris gallopavo	33.15	2.00e-74	271.00
IUUC-Mvi-060221	Microbotryum violaceum	34.29	3.00e-73	267.00
IUUC-Mmr-061325	Microcebus murinus	34.97	3.00e-81	293.00
IUUC-Mdo-062532	Monodelphis domestica	35.23	4.00e-85	306.00
IUUC-Mmu-063956	Mus musculus	35.88	2.00e-85	307.00
IUUC-Mac-064521	Musa acuminata	32.68	2.00e-73	268.00
IUUC-Mpu-066716	Mustela putorius furo	37.22	2.00e-75	274.00
IUUC-Mlu-067459	Myotis lucifugus	36.19	5.00e-88	316.00
IUUC-Nfi-068245	Neosartorya fischeri	76.91	0.00e+00	871.00
IUUC-Ncr-068910	Neurospora crassa	46.96	7.00e-145	505.00
IUUC-Nle-070034	Nomascus leucogenys	34.18	1.00e-75	275.00
IUUC-Opr-070552	Ochotona princeps	34.80	5.00e-63	233.00
IUUC-Ont-071426	Oreochromis niloticus	36.45	2.00e-89	320.00
IUUC-Oan-073389	Ornithorhynchus anatinus	32.83	2.00e-54	204.00
IUUC-Ocu-074911	Oryctolagus cuniculus	35.69	1.00e-85	308.00
IUUC-Oba-075437	Oryza barthii	32.01	3.00e-62	230.00
IUUC-Obr-076684	Oryza brachyantha	32.01	9.00e-57	212.00
IUUC-Ogl-077170	Oryza glaberrima	32.01	3.00e-62	230.00
IUUC-Ogu-078844	Oryza glumaepatula	31.58	2.00e-54	204.00
IUUC-Oin-079105	Oryza indica	32.01	3.00e-62	230.00
IUUC-Olo-080943	Oryza longistaminata	28.92	4.00e-48	183.00
IUUC-Oni-082891	Oryza nivara	29.50	8.00e-56	209.00
IUUC-Opu-083457	Oryza punctata	32.19	3.00e-61	227.00
IUUC-Oru-084960	Oryza rufipogon	28.92	4.00e-48	183.00
IUUC-Osa-085358	Oryza sativa	32.01	1.00e-61	229.00
IUUC-Ola-086420	Oryzias latipes	32.63	2.00e-53	201.00
IUUC-Olu-087625	Ostreococcus lucimarinus	25.78	3.00e-42	164.00
IUUC-Oga-088810	Otolemur garnettii	35.65	4.00e-86	310.00
IUUC-Oar-089196	Ovis aries	34.93	6.00e-84	302.00
IUUC-Ptr-090617	Pan troglodytes	36.22	7.00e-86	309.00
IUUC-Pan-092761	Papio anubis	36.06	8.00e-86	309.00
IUUC-Psi-093191	Pelodiscus sinensis	34.12	1.00e-77	281.00
IUUC-Pma-094380	Petromyzon marinus	34.35	4.00e-76	276.00
IUUC-Pno-095084	Phaeosphaeria nodorum	48.05	2.00e-128	451.00
IUUC-Ppa-095798	Physcomitrella patens	32.09	3.00e-73	267.00
IUUC-Pfo-096467	Poecilia formosa	36.19	8.00e-88	315.00
IUUC-Pab-098255	Pongo abelii	37.44	1.00e-75	275.00
IUUC-Pop-099722	Populus trichocarpa	32.86	3.00e-75	273.00
IUUC-Pca-100807	Procavia capensis	36.10	4.00e-26	110.00
IUUC-Ppe-101280	Prunus persica	33.21	9.00e-76	275.00
IUUC-Pva-102333	Pteropus vampyrus	35.21	2.00e-77	281.00
IUUC-Pgr-103401	Puccinia graminis	31.86	9.00e-70	256.00
IUUC-Ptt-103889	Puccinia triticina	31.34	9.00e-68	249.00
IUUC-Pte-104355	Pyrenophora teres	51.90	2.00e-156	544.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	51.56	6.00e-155	538.00
IUUC-Rno-105810	Rattus norvegicus	35.51	1.00e-84	305.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.20	2.00e-28	118.00
IUUC-Sha-106770	Sarcophilus harrisii	38.64	2.00e-46	177.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	30.80	1.00e-70	258.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.05	2.00e-72	265.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	49.29	3.00e-132	463.00
IUUC-Smo-109296	Selaginella moellendorffii	34.11	2.00e-77	281.00
IUUC-Sit-110157	Setaria italica	34.06	6.00e-77	279.00
IUUC-Sly-111105	Solanum lycopersicum	33.16	1.00e-75	275.00
IUUC-Stu-112469	Solanum tuberosum	33.27	5.00e-76	276.00
IUUC-Sar-113083	Sorex araneus	28.35	1.00e-25	109.00
IUUC-Sbi-113813	Sorghum bicolor	33.82	8.00e-76	275.00
IUUC-Sre-115058	Sporisorium reilianum	38.50	4.00e-67	247.00
IUUC-Tgu-116772	Taeniopygia guttata	34.53	2.00e-73	267.00
IUUC-Tru-118686	Takifugu rubripes	34.82	2.00e-86	310.00
IUUC-Tsy-119111	Tarsius syrichta	35.57	7.00e-38	149.00
IUUC-Tni-120231	Tetraodon nigroviridis	31.44	4.00e-71	260.00
IUUC-Tca-121491	Theobroma cacao	32.97	5.00e-71	259.00
IUUC-Tre-122103	Trichoderma reesei	46.61	7.00e-133	465.00
IUUC-Tvi-122672	Trichoderma virens	44.52	2.00e-127	447.00
IUUC-Tae-125684	Triticum aestivum	32.91	1.00e-75	275.00
IUUC-Tur-126487	Triticum urartu	32.12	1.00e-70	258.00
IUUC-Tme-127097	Tuber melanosporum	39.65	3.00e-97	347.00
IUUC-Ttr-128465	Tursiops truncatus	33.92	3.00e-69	254.00
IUUC-Uma-129645	Ustilago maydis	33.70	3.00e-80	290.00
IUUC-Vda-129989	Verticillium dahliae	40.67	6.00e-104	369.00
IUUC-Vpa-130529	Vicugna pacos	34.28	7.00e-73	266.00
IUUC-Vvi-131059	Vitis vinifera	32.08	8.00e-73	266.00
IUUC-Xtr-132002	Xenopus tropicalis	36.09	2.00e-87	314.00
IUUC-Xma-133930	Xiphophorus maculatus	36.01	3.00e-84	303.00
IUUC-Yli-134505	Yarrowia lipolytica	35.14	1.00e-80	291.00
IUUC-Zma-135895	Zea mays	34.00	1.00e-75	275.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence