iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028277.13	ENSMUST00000124992.7	ENSMUSP00000118333.1
ENSMUSG00000028277.13	ENSMUST00000135924.1	ENSMUSP00000115757.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.10e-25	90.2	14	119

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.e 88
           Rl+ke++el kdp+++++a+p ++ +l+ew++++ Gp+d+ ++ggv++ +i +p++YP+kPP++ +lt   ++ ++   k+Clsi + +
   Q: 14   RLMKEAAEL-KDPTDHYHAQPLED-NLFEWHFTVRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTA--NGRFEVGKKICLSISGhH 98
           9*******9.99************.9******************************************9..9999999********549 PP
   S: 89   eekWspalsvesvllsiqsll 109
           +e+W+p +s+++ ll+i+ ++
   Q: 99   PETWQPSWSIRTALLAIIGFM 119
           ******************998 PP

Organism

Mus musculus

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Protein Sequence
(Fasta)

METRYNLKSP AVKRLMKEAA ELKDPTDHYH AQPLEDNLFE WHFTVRGPPD SDFDGGVYHG 60
RIVLPPEYPM KPPSIILLTA NGRFEVGKKI CLSISGHHPE TWQPSWSIRT ALLAIIGFMP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACGCCCCG GCGCCCGGCC GGCCCTCAGG GAGGCGGACC CCGCGGCACG CACCTCGCCC 60
GCGGTCGGGC TGGACTGGGC GGTGTCAGCG GAGGCCCTCG CTAGGCGCGT CCGCCGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904153--P:negative regulation of retrograde protein transport, ER to cytosol
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0042534--P:regulation of tumor necrosis factor biosynthetic process
GO:0007286--P:spermatid development
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:56228

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001180	Aegilops tauschii	34.26	7.00e-35	141.00
IUUC-Aml-002404	Ailuropoda melanoleuca	92.45	1.00e-149	522.00
IUUC-Atr-002806	Amborella trichopoda	63.70	3.00e-55	208.00
IUUC-Apl-003507	Anas platyrhynchos	75.56	8.00e-120	423.00
IUUC-Aca-004697	Anolis carolinensis	72.59	5.00e-111	393.00
IUUC-Aly-005556	Arabidopsis lyrata	61.81	4.00e-54	204.00
IUUC-Ath-007477	Arabidopsis thaliana	60.27	8.00e-54	203.00
IUUC-Acl-008101	Aspergillus clavatus	56.46	3.00e-46	178.00
IUUC-Afl-008466	Aspergillus flavus	56.13	4.00e-45	174.00
IUUC-Afu-009109	Aspergillus fumigatus	53.46	1.00e-40	159.00
IUUC-Ani-009343	Aspergillus nidulans	53.85	4.00e-42	165.00
IUUC-Ang-009509	Aspergillus niger	57.94	1.00e-40	158.00
IUUC-Aor-010210	Aspergillus oryzae	56.13	4.00e-45	174.00
IUUC-Ate-010571	Aspergillus terreus	46.95	7.00e-39	155.00
IUUC-Ame-010806	Astyanax mexicanus	80.83	2.00e-86	312.00
IUUC-Bgr-012063	Blumeria graminis	45.96	8.00e-50	190.00
IUUC-Bta-012638	Bos taurus	90.82	1.00e-145	509.00
IUUC-Bci-013709	Botrytis cinerea	43.14	1.00e-49	189.00
IUUC-Bdi-014694	Brachypodium distachyon	60.42	1.00e-51	196.00
IUUC-Bol-015399	Brassica oleracea	60.27	1.00e-53	202.00
IUUC-Bra-017645	Brassica rapa	60.27	1.00e-53	203.00
IUUC-Cel-018452	Caenorhabditis elegans	59.61	1.00e-69	256.00
IUUC-Cja-019087	Callithrix jacchus	91.82	9.00e-148	516.00
IUUC-Cfa-020218	Canis familiaris	91.88	4.00e-142	497.00
IUUC-Cpo-022552	Cavia porcellus	92.14	1.00e-155	541.00
IUUC-Cre-022888	Chlamydomonas reinhardtii	60.14	4.00e-54	203.00
IUUC-Csa-024028	Chlorocebus sabaeus	91.82	5.00e-148	516.00
IUUC-Cho-024606	Choloepus hoffmanni	67.30	5.00e-94	337.00
IUUC-Cin-025631	Ciona intestinalis	69.52	2.00e-77	281.00
IUUC-Csv-026321	Ciona savignyi	68.95	6.00e-76	277.00
IUUC-Cgl-026755	Colletotrichum gloeosporioides	47.31	3.00e-49	188.00
IUUC-Cne-026839	Cryptococcus neoformans	50.31	5.00e-41	161.00
IUUC-Cme-027189	Cyanidioschyzon merolae	60.13	3.00e-45	175.00
IUUC-Dre-027569	Danio rerio	82.98	2.00e-91	328.00
IUUC-Dno-029214	Dasypus novemcinctus	92.14	5.00e-150	523.00
IUUC-Dor-030145	Dipodomys ordii	59.83	1.00e-48	186.00
IUUC-Dse-031537	Dothistroma septosporum	53.49	2.00e-52	199.00
IUUC-Ete-033083	Echinops telfairi	90.25	1.00e-138	485.00
IUUC-Eca-034179	Equus caballus	90.91	9.00e-146	509.00
IUUC-Eeu-035115	Erinaceus europaeus	76.42	7.00e-110	389.00
IUUC-Fca-036083	Felis catus	92.77	2.00e-150	525.00
IUUC-Fal-037289	Ficedula albicollis	69.84	1.00e-110	392.00
IUUC-Fox-038027	Fusarium oxysporum	58.04	2.00e-40	159.00
IUUC-Fso-038254	Fusarium solani	52.53	2.00e-50	192.00
IUUC-Ggr-039884	Gaeumannomyces graminis	55.92	1.00e-49	190.00
IUUC-Gga-041156	Gallus gallus	75.16	9.00e-124	436.00
IUUC-Gac-041807	Gasterosteus aculeatus	38.60	7.00e-43	167.00
IUUC-Gma-044356	Glycine max	63.27	2.00e-56	212.00
IUUC-Ggo-044450	Gorilla gorilla	92.45	9.00e-149	519.00
IUUC-Hsa-046496	Homo sapiens	92.45	2.00e-148	518.00
IUUC-Hvu-047328	Hordeum vulgare	59.72	5.00e-51	194.00
IUUC-Itr-048629	Ictidomys tridecemlineatus	93.71	1.00e-152	532.00
IUUC-Lch-050348	Latimeria chalumnae	68.92	6.00e-109	387.00
IUUC-Lpe-050862	Leersia perrieri	60.42	5.00e-52	197.00
IUUC-Loc-052465	Lepisosteus oculatus	79.67	3.00e-85	308.00
IUUC-Lma-053257	Leptosphaeria maculans	51.08	1.00e-52	200.00
IUUC-Laf-053830	Loxodonta africana	91.82	8.00e-153	532.00
IUUC-Mcc-054880	Macaca mulatta	91.51	8.00e-149	519.00
IUUC-Mor-057183	Magnaporthe oryzae	50.91	2.00e-49	189.00
IUUC-Mpo-057391	Magnaporthe poae	55.63	2.00e-50	192.00
IUUC-Mtr-058479	Medicago truncatula	61.90	9.00e-56	210.00
IUUC-Mga-059321	Meleagris gallopavo	74.36	1.00e-117	416.00
IUUC-Mvi-060366	Microbotryum violaceum	59.48	2.00e-50	192.00
IUUC-Mmr-061717	Microcebus murinus	92.83	5.00e-144	503.00
IUUC-Mdo-061865	Monodelphis domestica	82.87	1.00e-121	429.00
IUUC-Mac-064669	Musa acuminata	58.90	3.00e-52	198.00
IUUC-Mpu-066177	Mustela putorius furo	92.41	2.00e-140	491.00
IUUC-Mlu-067037	Myotis lucifugus	90.26	1.00e-140	492.00
IUUC-Nfi-068283	Neosartorya fischeri	46.35	4.00e-43	168.00
IUUC-Ncr-068645	Neurospora crassa	46.29	3.00e-49	188.00
IUUC-Nle-069166	Nomascus leucogenys	92.14	3.00e-149	521.00
IUUC-Opr-070562	Ochotona princeps	97.67	5.00e-19	88.60
IUUC-Ont-072096	Oreochromis niloticus	64.91	2.00e-103	368.00
IUUC-Oan-073369	Ornithorhynchus anatinus	81.45	3.00e-110	391.00
IUUC-Ocu-074815	Oryctolagus cuniculus	91.19	4.00e-146	510.00
IUUC-Oba-075649	Oryza barthii	60.42	5.00e-52	197.00
IUUC-Obr-076169	Oryza brachyantha	61.11	1.00e-52	200.00
IUUC-Ogl-077144	Oryza glaberrima	60.42	5.00e-52	197.00
IUUC-Ogu-078255	Oryza glumaepatula	60.42	5.00e-52	197.00
IUUC-Oin-079510	Oryza indica	61.11	6.00e-51	194.00
IUUC-Olo-080589	Oryza longistaminata	47.03	1.00e-45	177.00
IUUC-Ome-081849	Oryza meridionalis	55.41	4.00e-49	188.00
IUUC-Oni-082959	Oryza nivara	60.42	6.00e-52	197.00
IUUC-Opu-083736	Oryza punctata	60.69	7.00e-52	197.00
IUUC-Oru-084215	Oryza rufipogon	60.42	5.00e-52	197.00
IUUC-Osa-085722	Oryza sativa	60.42	5.00e-52	197.00
IUUC-Ola-086717	Oryzias latipes	82.97	5.00e-92	330.00
IUUC-Olu-087750	Ostreococcus lucimarinus	66.06	3.00e-41	159.00
IUUC-Oga-088848	Otolemur garnettii	80.82	2.00e-124	438.00
IUUC-Oar-090134	Ovis aries	91.88	5.00e-143	500.00
IUUC-Ptr-091314	Pan troglodytes	92.45	9.00e-149	519.00
IUUC-Pan-092103	Papio anubis	91.82	3.00e-148	517.00
IUUC-Psi-093668	Pelodiscus sinensis	79.41	1.00e-105	375.00
IUUC-Pno-094982	Phaeosphaeria nodorum	56.38	8.00e-49	187.00
IUUC-Ppa-095836	Physcomitrella patens	62.11	4.00e-59	221.00
IUUC-Pfo-096964	Poecilia formosa	63.58	6.00e-101	360.00
IUUC-Pab-097857	Pongo abelii	91.51	3.00e-147	514.00
IUUC-Pop-099025	Populus trichocarpa	63.01	8.00e-56	210.00
IUUC-Pca-101108	Procavia capensis	89.12	7.00e-99	353.00
IUUC-Ppe-101444	Prunus persica	61.38	2.00e-54	206.00
IUUC-Pva-102297	Pteropus vampyrus	80.19	3.00e-117	414.00
IUUC-Pte-104112	Pyrenophora teres	54.27	5.00e-52	197.00
IUUC-Pyt-104824	Pyrenophora triticirepentis	56.06	7.00e-44	170.00
IUUC-Rno-105336	Rattus norvegicus	98.59	5.00e-125	439.00
IUUC-Sha-107324	Sarcophilus harrisii	84.06	4.00e-127	447.00
IUUC-Smo-109549	Selaginella moellendorffii	68.75	2.00e-60	225.00
IUUC-Sit-110794	Setaria italica	60.00	2.00e-51	196.00
IUUC-Sly-111585	Solanum lycopersicum	64.19	4.00e-57	214.00
IUUC-Stu-111996	Solanum tuberosum	64.19	5.00e-57	214.00
IUUC-Sar-113063	Sorex araneus	90.55	7.00e-139	486.00
IUUC-Sbi-114593	Sorghum bicolor	60.00	1.00e-51	196.00
IUUC-Sre-115043	Sporisorium reilianum	52.84	3.00e-50	192.00
IUUC-Ssc-115523	Sus scrofa	91.51	1.00e-142	499.00
IUUC-Tgu-116966	Taeniopygia guttata	73.98	6.00e-123	433.00
IUUC-Tru-117737	Takifugu rubripes	62.05	5.00e-100	357.00
IUUC-Tsy-119190	Tarsius syrichta	100.00	9.00e-62	229.00
IUUC-Tni-120283	Tetraodon nigroviridis	94.59	1.00e-40	157.00
IUUC-Tca-120992	Theobroma cacao	64.38	3.00e-56	212.00
IUUC-Tre-122028	Trichoderma reesei	48.39	1.00e-49	189.00
IUUC-Tvi-122637	Trichoderma virens	54.04	1.00e-50	193.00
IUUC-Tae-124782	Triticum aestivum	59.72	3.00e-51	195.00
IUUC-Tme-126962	Tuber melanosporum	42.17	2.00e-52	199.00
IUUC-Tbe-127743	Tupaia belangeri	90.88	2.00e-140	491.00
IUUC-Ttr-129193	Tursiops truncatus	89.90	2.00e-139	488.00
IUUC-Uma-129586	Ustilago maydis	54.66	9.00e-50	190.00
IUUC-Vda-129959	Verticillium dahliae	54.43	2.00e-50	192.00
IUUC-Vpa-130404	Vicugna pacos	92.18	4.00e-143	500.00
IUUC-Vvi-130893	Vitis vinifera	62.33	3.00e-55	208.00
IUUC-Xtr-131832	Xenopus tropicalis	70.19	3.00e-104	371.00
IUUC-Zma-135443	Zea mays	60.42	6.00e-52	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence