iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048731

Ensembl Protein ID

ENSSTOP00000019177.1

UniProt Accession

I3N481; I3N481_ICTTR

Genbank Protein ID

ENSSTOP00000019177

Protein Name

Presenilin

Genbank Nucleotide ID

AGTP01044506

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000025166.1	ENSSTOT00000025107.1	ENSSTOP00000019177.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.00e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSD EEVCNERTSL MSAESPTPRS CQEGRQGLED GENTAQWRSQ DSEEDCEEDP 60
DHYDCSAVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCAGCCGG GCTCTCCGCC AGCGGCGTAA ACTCTTCTGG GGCGCAGCGG CGGAGCAGGT 60
GAGAGAGCGG GCGGGGCTGG GGGCGCGCGG CCCAAGGCTC GAGCCCGCGG CGCTGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	89.06	0.00e+00	627.00
IUUC-Apl-003959	Anas platyrhynchos	77.04	4.00e-162	563.00
IUUC-Aca-005160	Anolis carolinensis	75.91	2.00e-160	558.00
IUUC-Ath-006730	Arabidopsis thaliana	31.63	4.00e-18	85.90
IUUC-Ang-009768	Aspergillus niger	51.85	1.20e-01	31.60
IUUC-Ame-010686	Astyanax mexicanus	79.43	3.00e-147	514.00
IUUC-Bta-013097	Bos taurus	95.99	0.00e+00	723.00
IUUC-Cel-018553	Caenorhabditis elegans	48.47	8.00e-92	330.00
IUUC-Cja-018824	Callithrix jacchus	95.31	0.00e+00	732.00
IUUC-Cfa-020253	Canis familiaris	96.21	0.00e+00	746.00
IUUC-Cpo-021401	Cavia porcellus	95.54	0.00e+00	741.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	5.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	97.32	0.00e+00	754.00
IUUC-Cin-025780	Ciona intestinalis	60.90	3.00e-116	411.00
IUUC-Csv-025967	Ciona savignyi	59.91	2.00e-117	415.00
IUUC-Dre-028526	Danio rerio	70.34	3.00e-144	504.00
IUUC-Dor-031127	Dipodomys ordii	91.52	0.00e+00	690.00
IUUC-Ete-033081	Echinops telfairi	84.40	1.00e-94	339.00
IUUC-Eca-034387	Equus caballus	95.76	0.00e+00	696.00
IUUC-Eeu-034846	Erinaceus europaeus	81.18	3.00e-149	521.00
IUUC-Fca-035396	Felis catus	95.08	0.00e+00	752.00
IUUC-Fal-037457	Ficedula albicollis	76.30	2.00e-160	558.00
IUUC-Gmo-038550	Gadus morhua	82.76	3.00e-105	375.00
IUUC-Gga-040706	Gallus gallus	77.63	1.00e-158	552.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.11	1.00e-129	456.00
IUUC-Ggo-045338	Gorilla gorilla	97.32	0.00e+00	754.00
IUUC-Hsa-046455	Homo sapiens	97.32	0.00e+00	754.00
IUUC-Lch-049638	Latimeria chalumnae	68.09	7.00e-146	509.00
IUUC-Loc-052427	Lepisosteus oculatus	75.33	2.00e-157	548.00
IUUC-Laf-053758	Loxodonta africana	89.38	0.00e+00	728.00
IUUC-Mcc-054755	Macaca mulatta	97.10	0.00e+00	751.00
IUUC-Mmr-060890	Microcebus murinus	95.31	0.00e+00	735.00
IUUC-Mdo-062197	Monodelphis domestica	80.95	1.00e-178	618.00
IUUC-Mmu-063823	Mus musculus	95.31	0.00e+00	745.00
IUUC-Mac-064858	Musa acuminata	43.86	5.00e-23	101.00
IUUC-Mpu-066181	Mustela putorius furo	95.54	0.00e+00	740.00
IUUC-Nle-069596	Nomascus leucogenys	96.96	0.00e+00	705.00
IUUC-Opr-070344	Ochotona princeps	94.64	0.00e+00	748.00
IUUC-Ont-071867	Oreochromis niloticus	71.46	2.00e-134	472.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.60	2.00e-155	541.00
IUUC-Ocu-074652	Oryctolagus cuniculus	95.31	0.00e+00	703.00
IUUC-Obr-076302	Oryza brachyantha	36.96	4.00e-17	82.40
IUUC-Ola-086707	Oryzias latipes	69.84	4.00e-106	377.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.44	8.00e-47	180.00
IUUC-Oga-088560	Otolemur garnettii	95.57	0.00e+00	703.00
IUUC-Oar-089200	Ovis aries	95.32	0.00e+00	697.00
IUUC-Ptr-090569	Pan troglodytes	97.10	0.00e+00	752.00
IUUC-Pan-091742	Papio anubis	97.10	0.00e+00	753.00
IUUC-Psi-093297	Pelodiscus sinensis	75.42	2.00e-132	465.00
IUUC-Pma-094612	Petromyzon marinus	77.84	1.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	1.00e-27	117.00
IUUC-Pfo-097396	Poecilia formosa	67.33	3.00e-127	447.00
IUUC-Pab-098531	Pongo abelii	97.32	0.00e+00	754.00
IUUC-Pca-101120	Procavia capensis	93.75	0.00e+00	721.00
IUUC-Pva-102934	Pteropus vampyrus	86.61	0.00e+00	696.00
IUUC-Rno-106052	Rattus norvegicus	94.64	0.00e+00	759.00
IUUC-Sha-106876	Sarcophilus harrisii	80.39	4.00e-176	610.00
IUUC-Ssc-115380	Sus scrofa	97.77	0.00e+00	779.00
IUUC-Tgu-117280	Taeniopygia guttata	77.39	3.00e-161	561.00
IUUC-Tru-117732	Takifugu rubripes	68.51	9.00e-121	426.00
IUUC-Tni-119852	Tetraodon nigroviridis	64.56	1.00e-112	399.00
IUUC-Tbe-127632	Tupaia belangeri	96.18	0.00e+00	625.00
IUUC-Ttr-129008	Tursiops truncatus	95.09	0.00e+00	731.00
IUUC-Xtr-132756	Xenopus tropicalis	72.87	5.00e-164	570.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence