iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-45	151.9	148	184
UBD/Beta-Prp	1.90e-77	261.3	11	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWDlrtg 33
           gH d+v+c++f  ++  +++vs+s+D+t+kvW+l+ +
   Q: 148  GHRDWVSCVRFspNTlqPTIVSASWDKTVKVWNLSNC 184
           8***********6445677**************9765 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf.spdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           + +h++ +t+++  +++ ++++++srd++i++w++t+ ++      r+l gh+ +v +v +s+dg++ ++gs D+ +++wdl +g  ++ + gh+++v
   Q: 11   MRAHTDMVTAIATpIDNADIIVSASRDKSIILWKLTKDDKaygvaQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDV 108
           679999*******************************9999***9***************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfds 190
           ls++fs ++  +vs+s+drti++w++  + c ++     +gh+++v+cv+++p++    +vs+s D+tv++W+l++ kl  tl g ht++v  +++++
   Q: 109  LSVAFSLDNRQIVSASRDRTIKLWNTLGE-CKYTiseGGEGHRDWVSCVRFSPNTlqPTIVSASWDKTVKVWNLSNCKLRSTLAG-HTGYVSTVAVSP 204
           ************************87543.33333448899************999789************************99.************ PP
   S: 191  ngkelvsgsldgtvklwdlqtgecvrtlng 220
           +g  ++sg++dg v lwdl +g+ +++l++
   Q: 205  DGSLCASGGKDGVVLLWDLAEGKKLYSLEA 234
           ************************999987 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Major component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes (PubMed:16829549, PubMed:18715992, PubMed:18947417). MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway (PubMed:25731164).

Protein Sequence
(Fasta)

MAEGLVLKGT MRAHTDMVTA IATPIDNADI IVSASRDKSI ILWKLTKDDK AYGVAQRRLT 60
GHSHFVEDVV LSSDGQFALS GSWDGELRLW DLAAGVSTRR FVGHTKDVLS VAFSLDNRQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCCATTTT TAGTTTCTAT CATATAAATA GCTTCTTGTG TTTTTCACGC CCTTCTTCTT 60
TGTATTTCCG CCTCCCCCGA GAAAACGAAA ACCCTAGTTT CAGAGGCATC TCCAGACACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0689--Ribosomal protein
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0009507--C:chloroplast
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0022626--C:cytosolic ribosome
GO:0005634--C:nucleus
GO:0005078--F:MAP-kinase scaffold activity
GO:0032947--F:protein complex scaffold
GO:0004871--F:signal transducer activity
GO:0071215--P:cellular response to abscisic acid stimulus
GO:0010476--P:gibberellin mediated signaling pathway
GO:0009967--P:positive regulation of signal transduction
GO:0006417--P:regulation of translation
GO:0046686--P:response to cadmium ion
GO:0009739--P:response to gibberellin
GO:0009749--P:response to glucose
GO:0042254--P:ribosome biogenesis
GO:0009845--P:seed germination
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT1G18080

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000395	Aegilops tauschii	72.41	7.00e-121	426.00
IUUC-Aly-005806	Arabidopsis lyrata	99.39	0.00e+00	660.00
IUUC-Ago-007720	Ashbya gossypii	48.62	2.00e-87	315.00
IUUC-Acl-008156	Aspergillus clavatus	60.49	4.00e-115	406.00
IUUC-Afu-008867	Aspergillus fumigatus	60.80	7.00e-116	409.00
IUUC-Bgr-012064	Blumeria graminis	61.11	1.00e-116	412.00
IUUC-Bci-013862	Botrytis cinerea	61.42	1.00e-117	415.00
IUUC-Bol-015949	Brassica oleracea	96.33	0.00e+00	641.00
IUUC-Bra-016871	Brassica rapa	96.94	0.00e+00	647.00
IUUC-Cel-018335	Caenorhabditis elegans	56.84	9.00e-99	352.00
IUUC-Cin-025647	Ciona intestinalis	62.23	5.00e-116	409.00
IUUC-Csv-026027	Ciona savignyi	61.92	1.00e-115	408.00
IUUC-Cgl-026718	Colletotrichum gloeosporioides	63.39	3.00e-109	387.00
IUUC-Dme-032118	Drosophila melanogaster	63.38	3.00e-118	417.00
IUUC-Fox-037702	Fusarium oxysporum	62.35	9.00e-119	419.00
IUUC-Fso-038384	Fusarium solani	62.04	4.00e-118	416.00
IUUC-Ggr-039985	Gaeumannomyces graminis	61.73	4.00e-118	416.00
IUUC-Gac-041316	Gasterosteus aculeatus	64.29	5.00e-122	429.00
IUUC-Hvu-047683	Hordeum vulgare	69.94	1.00e-134	472.00
IUUC-Kpa-049214	Komagataella pastoris	51.24	1.00e-86	311.00
IUUC-Lch-049634	Latimeria chalumnae	63.89	2.00e-122	431.00
IUUC-Mor-057107	Magnaporthe oryzae	61.73	2.00e-118	417.00
IUUC-Mpo-057487	Magnaporthe poae	61.42	1.00e-117	415.00
IUUC-Nfi-068344	Neosartorya fischeri	60.80	7.00e-116	409.00
IUUC-Ncr-068722	Neurospora crassa	61.11	2.00e-117	414.00
IUUC-Ont-072287	Oreochromis niloticus	65.74	2.00e-125	441.00
IUUC-Ola-086400	Oryzias latipes	65.43	6.00e-125	439.00
IUUC-Pno-095100	Phaeosphaeria nodorum	64.02	5.00e-82	296.00
IUUC-Pop-099345	Populus trichocarpa	85.58	9.00e-166	575.00
IUUC-Ppe-101743	Prunus persica	85.37	5.00e-165	572.00
IUUC-Sja-107971	Schizosaccharomyces japonicus	60.74	5.00e-113	399.00
IUUC-Ssl-108479	Sclerotinia sclerotiorum	61.42	1.00e-117	415.00
IUUC-Sly-111218	Solanum lycopersicum	82.77	2.00e-159	553.00
IUUC-Stu-112775	Solanum tuberosum	81.85	1.00e-159	554.00
IUUC-Tca-120951	Theobroma cacao	85.93	5.00e-168	582.00
IUUC-Tre-121961	Trichoderma reesei	61.42	2.00e-117	414.00
IUUC-Tvi-122447	Trichoderma virens	61.42	1.00e-117	415.00
IUUC-Tae-123560	Triticum aestivum	69.94	6.00e-135	472.00
IUUC-Tur-126335	Triticum urartu	73.91	2.00e-119	421.00
IUUC-Tme-127105	Tuber melanosporum	58.88	1.00e-108	385.00
IUUC-Vda-129923	Verticillium dahliae	62.04	2.00e-117	414.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence