iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-31	105.4	937	974
UBD/Beta-Prp	2.70e-53	182.0	865	1032

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           gH + v+c++  s+ +++++++Dgt+k+WD+rt+ ++ 
   Q: 937  GHDSQVSCVKMlSGERVLTAAHDGTVKMWDVRTDMCVA 974
           8*********98889*******************9975 PP

UBD/Beta-Prp

   S: 62   pdgkilvtgseDrtikvwdls..tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsG 155
           +d+ ++++gs+D ++k+wd+s   ++   tlkgh+ +v+++s+++   k+vsGs+d  + vwd +t q le  l+ghd+ v+cv++ + g  + ++
   Q: 865  EDAGFFISGSTDCLVKIWDPSlrGSELRATLKGHTGTVRAISSDR--GKIVSGSDDLSVIVWDKQTTQLLE-ELKGHDSQVSCVKMLS-GERVLTA 956
           34459*************766669*********************..***********************9.**************99.99***** PP
   S: 156  slDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfsp 232
           + D+tv++Wd++t+ ++ t      +++ sl++d++   l+++++d+  ++wd+++g+ +++l+ght++++s+r+ +
   Q: 957  AHDGTVKMWDVRTDMCVATVGR-CSSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVE 1032
           ********************66.99************************************************9875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Involved in growth and development through its role in cytokinesis and polarized cell expansion (PubMed:12874123). Required for plasma membrane internalization. May function in clathrin-mediated membrane trafficking, including plasma membrane endocytosis, essential to both cytokinesis and cell expansion (PubMed:24179130). Acts as a negative regulator of basal resistance against bacteria (PubMed:20472560).

Protein Sequence
(Fasta)

MGRIFEYFVV CGLGPEMRTV DGDLGFHGMQ TFYLPALLDQ FPPTDQSPYP APPPQLPTCV 60
LPAGVEFHSS GFVSSDPASF PRSYPIVLTE GDGSKIFVSC IAFRDRVCED IIEAYRLPPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAAACAAA TTGCGTTCGA CCCGTAGGAT TATTTTCCCA CGAACGACTT GGCCAAAAAA 60
ACAAAGGAGG CCGAATTGAA GCAACTACTT TTCTCCATCA TCATCACCAT CGGCGAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0341--Growth regulation
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005112--dDENN_dom
IPR001194--DENN_dom
IPR020472--G-protein_beta_WD-40_rep
IPR005113--uDENN_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50947--DDENN
PS50211--DENN
PS50946--UDENN
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02141--DENN
PF03456--uDENN
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00801--dDENN
SM00799--DENN
SM00800--uDENN
SM00320--WD40

Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005886--C:plasma membrane
GO:0000911--P:cytokinesis by cell plate formation
GO:0010235--P:guard mother cell cytokinesis
GO:0009825--P:multidimensional cell growth
GO:0045824--P:negative regulation of innate immune response
GO:0040008--P:regulation of growth

KEGG

ath:AT1G49040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002593	Amborella trichopoda	72.09	0.00e+00	1655.00
IUUC-Aly-005508	Arabidopsis lyrata	98.06	0.00e+00	2269.00
IUUC-Bdi-014863	Brachypodium distachyon	69.95	0.00e+00	1655.00
IUUC-Bol-015997	Brassica oleracea	93.01	0.00e+00	2184.00
IUUC-Bra-017065	Brassica rapa	93.01	0.00e+00	2184.00
IUUC-Gma-042682	Glycine max	73.06	0.00e+00	1751.00
IUUC-Hvu-047377	Hordeum vulgare	80.06	3.00e-152	530.00
IUUC-Lpe-051109	Leersia perrieri	69.08	0.00e+00	1554.00
IUUC-Mor-057076	Magnaporthe oryzae	31.88	2.00e-28	120.00
IUUC-Mpo-057423	Magnaporthe poae	26.39	1.00e-27	117.00
IUUC-Mtr-058651	Medicago truncatula	72.84	0.00e+00	1736.00
IUUC-Mac-065420	Musa acuminata	72.14	0.00e+00	1722.00
IUUC-Ncr-068688	Neurospora crassa	26.91	5.00e-28	118.00
IUUC-Oba-075961	Oryza barthii	66.56	0.00e+00	1206.00
IUUC-Obr-076806	Oryza brachyantha	70.27	0.00e+00	1658.00
IUUC-Ogu-078716	Oryza glumaepatula	66.33	0.00e+00	1501.00
IUUC-Oin-079809	Oryza indica	58.89	0.00e+00	1256.00
IUUC-Olo-080386	Oryza longistaminata	66.09	0.00e+00	1561.00
IUUC-Ome-081107	Oryza meridionalis	67.94	0.00e+00	1576.00
IUUC-Oni-082213	Oryza nivara	64.39	0.00e+00	1445.00
IUUC-Opu-083850	Oryza punctata	64.87	0.00e+00	1420.00
IUUC-Oru-084982	Oryza rufipogon	68.20	0.00e+00	1512.00
IUUC-Osa-086141	Oryza sativa	70.35	0.00e+00	1633.00
IUUC-Olu-087744	Ostreococcus lucimarinus	31.78	1.00e-38	155.00
IUUC-Ppa-095259	Physcomitrella patens	53.10	0.00e+00	1239.00
IUUC-Pop-099233	Populus trichocarpa	76.72	0.00e+00	1803.00
IUUC-Ppe-101883	Prunus persica	73.26	0.00e+00	1419.00
IUUC-Smo-109566	Selaginella moellendorffii	57.21	0.00e+00	1362.00
IUUC-Sit-109736	Setaria italica	70.70	0.00e+00	1679.00
IUUC-Sly-111483	Solanum lycopersicum	72.59	0.00e+00	1746.00
IUUC-Sbi-113820	Sorghum bicolor	70.70	0.00e+00	1672.00
IUUC-Sre-114901	Sporisorium reilianum	30.51	2.00e-27	117.00
IUUC-Tca-121657	Theobroma cacao	76.88	0.00e+00	1807.00
IUUC-Tae-124598	Triticum aestivum	68.93	0.00e+00	1664.00
IUUC-Tur-126080	Triticum urartu	68.60	0.00e+00	1064.00
IUUC-Uma-129449	Ustilago maydis	31.11	2.00e-28	121.00
IUUC-Vvi-131550	Vitis vinifera	75.74	0.00e+00	1767.00
IUUC-Yli-134429	Yarrowia lipolytica	34.51	3.00e-33	135.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence