iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Cullin	Cullin_N_terminal	15618422; 16045478

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	2.20e-225	750.9	32	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrkifayldrtyvkksk 99
           l++a+++i++++++  ++eely+++yn++l+k+g+klY+ l ++++ ++k+++k++ee+++ ++L+ +nr+W++++++l+++r+i++y+drtyv+  +
   Q: 32   LEHAIHEIYNHNASGLSFEELYRNAYNMVLHKYGDKLYTGLVTTMTFHLKEICKSIEEAQGGAFLELLNRKWNDHNKALQMIRDILMYMDRTYVST-T 128
           789*********************************************************************************************.* PP
   S: 100  kvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqenevde 195
           k+++v++L+l+lwr+++v +  i++rll++ll+l+++eR+ge++dr l+++v++++++L+   +++y+++FE++flea++efyk es ef++++++ e
   Q: 129  KKTHVHELGLHLWRDNVVYSskIQTRLLNTLLDLVHKERTGEVIDRVLMRNVIKMFMDLG---ESVYQDDFEKPFLEASAEFYKVESMEFIESCDCGE 223
           ******************9889*************************************9...9********************************** PP
   S: 196  YlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt 289
           Ylkk+e+ l ee er+ +yl++++e k+++vve+e+ia+h+++l+    ++lv++l ++k+ed++rmy+L++rv ngl ++++ ++ h++e+gk+++t
   Q: 224  YLKKAEKPLVEEVERVVNYLDAKSEAKITSVVEREMIANHVQRLVhmenSGLVNMLLNDKYEDMGRMYSLFRRVANGLVTVRDVMTLHLREMGKQLVT 321
           *********************************************99999************************************************ PP
   S: 290  aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyis 387
           ++ek+kdp+++V+rll+ ++k+++++++aFnnd++F++al+++fe+fvn n     ++spE+++ ++D++Lrk++kg+ ee+++ +ldkv+++f+y++
   Q: 322  DPEKSKDPVEFVQRLLDERDKYDRIINMAFNNDKTFQNALNSSFEYFVNLN-----TRSPEFISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRYLQ 414
           ***************************************************.....****************************************** PP
   S: 388  ekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekv 485
           ekdvFekyYk+hLakRLlsgk++s++aE+++i kLk+ecg++ftskLe+Mf+d+k+S+d+   F+  +++ e se+++l v+vL++g+Wpt+++ + +
   Q: 415  EKDVFEKYYKQHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFTSKLEGMFTDMKTSHDTLLGFY--NSHPELSEGPTLVVQVLTTGSWPTQPTIQ-C 509
           *****************************************************************..99***********************9988.* PP
   S: 486  sLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkg.kyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk.kq 581
           +LPae++ ++ekf+++Yl +h+gR+L+Wq+++g+a++ka++ kg k+el+VstfQm+vL++fnns+++s++e+++ate+p+++L+r+lqs++++k k+
   Q: 510  NLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAVFGKGqKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDLKRCLQSMACVKgKN 607
           ********************************************99**************************************************** PP
   S: 582  vlkkepeskeieeedlfsvNqef 604
           vl+kep+skei+eed+f+vN++f
   Q: 608  VLRKEPMSKEIAEEDWFVVNDRF 630
           *********************98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. Functions in distal root patterning, by an ethylene-independent mechanism. Functionally redundant with CUL3A.

Protein Sequence
(Fasta)

MSNQKKRNFQ IEAFKQRVVV DPKYADKTWK ILEHAIHEIY NHNASGLSFE ELYRNAYNMV 60
LHKYGDKLYT GLVTTMTFHL KEICKSIEEA QGGAFLELLN RKWNDHNKAL QMIRDILMYM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTAATC AGAAGAAGAG AAATTTCCAG ATTGAAGCGT TTAAGCAACG AGTCGTCGTT 60
GATCCAAAAT ACGCCGATAA AACTTGGAAG ATCCTTGAAC ATGCGATTCA TGAGATTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G69670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002616	Amborella trichopoda	80.90	0.00e+00	1256.00
IUUC-Cne-027048	Cryptococcus neoformans	36.72	2.00e-118	419.00
IUUC-Kpa-049372	Komagataella pastoris	33.38	3.00e-113	402.00
IUUC-Mla-059055	Melampsora laricipopulina	38.46	1.00e-132	466.00
IUUC-Mvi-060470	Microbotryum violaceum	34.16	1.00e-132	466.00
IUUC-Pgr-103600	Puccinia graminis	36.81	1.00e-107	384.00
IUUC-Ptt-103961	Puccinia triticina	36.59	3.00e-107	382.00
IUUC-Sce-106293	Saccharomyces cerevisiae	24.66	4.00e-58	219.00
IUUC-Spo-108135	Schizosaccharomyces pombe	36.90	1.00e-129	456.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence