iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027931

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2N-like; Ubiquitin-conjugating enzyme E2Nb

Genbank Nucleotide ID

CU571163

Gene Name

ube2nb; ube2nl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000045877.4	ENSDART00000067433.4	ENSDARP00000067432.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.50e-47	159.7	7	139

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R+ ke+++l ++p++gi+a+p++  +   ++v+i Gp+d+p+egg+Fkle+ +pe+YP+ +Pkv+f+tki+hPnv++ G++Cl+ilk  
   Q: 7    RIIKETQRLLAEPVPGIKAEPDEG-NARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILK-- 92
           899********************9.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkk 136
           +kWspal++++vllsiq+ll+ pnp++pl +++ae++k+n+++  ++
   Q: 93   DKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKSNEAQAIET 139
           ****************************************9876555 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAGLPRRIIK ETQRLLAEPV PGIKAEPDEG NARYFHVVIA GPQDSPFEGG TFKLELFLPE 60
EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGATGATGA CGGTTTTTTA CCGGAAGACT CACGCGCATG CGCTGTCAAC CTCAACGCGA 60
GGAGCAGGGA GCGGGCCACG GTGCAAACCG CATTAATAAA ACGAGATGGC TGGATTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0005524--F:ATP binding
GO:0043130--F:ubiquitin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0000729--P:DNA double-strand break processing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0016574--P:histone ubiquitination
GO:0045739--P:positive regulation of DNA repair
GO:0031058--P:positive regulation of histone modification
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0033182--P:regulation of histone ubiquitination
GO:0050852--P:T cell receptor signaling pathway

KEGG

dre:393313

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002818	Amborella trichopoda	79.05	1.00e-69	255.00
IUUC-Aly-005804	Arabidopsis lyrata	80.41	1.00e-70	258.00
IUUC-Ath-007639	Arabidopsis thaliana	79.73	4.00e-70	256.00
IUUC-Ago-007837	Ashbya gossypii	75.20	4.00e-54	203.00
IUUC-Acl-008263	Aspergillus clavatus	71.92	8.00e-63	232.00
IUUC-Afu-008946	Aspergillus fumigatus	71.92	8.00e-63	232.00
IUUC-Ate-010254	Aspergillus terreus	71.23	2.00e-62	231.00
IUUC-Bdi-014796	Brachypodium distachyon	80.41	2.00e-70	258.00
IUUC-Bol-016613	Brassica oleracea	80.41	1.00e-70	258.00
IUUC-Bra-016938	Brassica rapa	80.41	1.00e-70	258.00
IUUC-Csv-025952	Ciona savignyi	72.97	4.00e-60	223.00
IUUC-Cne-026809	Cryptococcus neoformans	74.44	8.00e-57	212.00
IUUC-Dse-031505	Dothistroma septosporum	68.03	2.00e-59	221.00
IUUC-Dme-032097	Drosophila melanogaster	81.76	4.00e-72	263.00
IUUC-Fox-037840	Fusarium oxysporum	71.92	1.00e-60	225.00
IUUC-Fso-038118	Fusarium solani	71.92	6.00e-61	226.00
IUUC-Gac-042450	Gasterosteus aculeatus	93.38	6.00e-82	295.00
IUUC-Gma-043982	Glycine max	80.41	1.00e-70	258.00
IUUC-Hvu-047346	Hordeum vulgare	80.41	2.00e-70	257.00
IUUC-Kpa-049285	Komagataella pastoris	70.27	8.00e-63	232.00
IUUC-Lch-050548	Latimeria chalumnae	93.10	3.00e-79	286.00
IUUC-Mpo-057586	Magnaporthe poae	73.29	3.00e-62	230.00
IUUC-Mtr-058552	Medicago truncatula	72.22	1.00e-66	245.00
IUUC-Nfi-068526	Neosartorya fischeri	71.92	8.00e-63	232.00
IUUC-Ola-087083	Oryzias latipes	94.81	5.00e-84	303.00
IUUC-Ppa-095892	Physcomitrella patens	81.08	2.00e-70	257.00
IUUC-Pfo-096074	Poecilia formosa	96.75	8.00e-86	308.00
IUUC-Ppe-101149	Prunus persica	80.41	1.00e-70	258.00
IUUC-Pgr-103654	Puccinia graminis	71.43	2.00e-60	224.00
IUUC-Ptt-103752	Puccinia triticina	70.14	3.00e-58	217.00
IUUC-Rno-105927	Rattus norvegicus	98.03	2.00e-85	307.00
IUUC-Sce-106178	Saccharomyces cerevisiae	68.63	2.00e-61	228.00
IUUC-Sja-107878	Schizosaccharomyces japonicus	67.57	8.00e-57	213.00
IUUC-Sit-110151	Setaria italica	80.41	3.00e-70	258.00
IUUC-Sly-111322	Solanum lycopersicum	80.41	1.00e-70	258.00
IUUC-Stu-112722	Solanum tuberosum	79.73	6.00e-70	256.00
IUUC-Sbi-114864	Sorghum bicolor	79.73	9.00e-70	255.00
IUUC-Tru-117903	Takifugu rubripes	94.04	5.00e-82	296.00
IUUC-Tni-120038	Tetraodon nigroviridis	94.04	5.00e-82	296.00
IUUC-Tae-125309	Triticum aestivum	80.41	2.00e-70	257.00
IUUC-Tur-126687	Triticum urartu	78.17	4.00e-65	239.00
IUUC-Tme-127129	Tuber melanosporum	73.97	7.00e-63	232.00
IUUC-Ttr-128808	Tursiops truncatus	95.39	2.00e-82	297.00
IUUC-Uma-129548	Ustilago maydis	78.77	3.00e-67	247.00
IUUC-Vvi-131416	Vitis vinifera	66.48	1.00e-65	242.00
IUUC-Xma-132986	Xiphophorus maculatus	96.10	2.00e-85	306.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence