iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012583

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

DAAA02046678

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010132.5	ENSBTAT00000013367.5	ENSBTAP00000013367.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-133	446.1	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++A++a+e+l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMEFLQELNNDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTIVVATQLSESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIVAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengtpEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk+++ fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPTFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyslDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************99*****9996667777777777*************************************************9999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t+++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTSFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           99***999....********************************************************9776 PP

Organism

Bos taurus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM EFLQELNNDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCGGTGG CAGTTTTCGG TAGTGGCCCG GCGGTTCTCC GTGGGGCGGG CGCGGCCATG 60
GCGCAGCCGG GGAAGCTGCT TAAGGAGCAG AAGTACGACC GGCAGCTGAG GTGAGCCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

KEGG

bta:614491

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.72	7.00e-127	447.00
IUUC-Aml-002333	Ailuropoda melanoleuca	97.20	0.00e+00	1086.00
IUUC-Atr-002644	Amborella trichopoda	40.94	2.00e-114	406.00
IUUC-Apl-003446	Anas platyrhynchos	84.39	0.00e+00	921.00
IUUC-Aca-004450	Anolis carolinensis	80.68	0.00e+00	920.00
IUUC-Aly-006187	Arabidopsis lyrata	40.19	3.00e-126	445.00
IUUC-Ath-007600	Arabidopsis thaliana	40.93	3.00e-128	451.00
IUUC-Ago-007900	Ashbya gossypii	25.92	2.00e-39	156.00
IUUC-Acl-008333	Aspergillus clavatus	34.53	7.00e-82	298.00
IUUC-Afl-008529	Aspergillus flavus	35.73	5.00e-87	315.00
IUUC-Afu-009071	Aspergillus fumigatus	33.75	2.00e-81	296.00
IUUC-Ani-009443	Aspergillus nidulans	33.51	1.00e-78	286.00
IUUC-Ang-009669	Aspergillus niger	33.51	1.00e-82	300.00
IUUC-Aor-009914	Aspergillus oryzae	35.05	5.00e-84	305.00
IUUC-Ate-010450	Aspergillus terreus	34.71	4.00e-85	308.00
IUUC-Ame-011183	Astyanax mexicanus	72.02	0.00e+00	830.00
IUUC-Bgr-012111	Blumeria graminis	33.09	4.00e-66	245.00
IUUC-Bci-013892	Botrytis cinerea	33.27	7.00e-66	244.00
IUUC-Bdi-014592	Brachypodium distachyon	43.51	3.00e-129	455.00
IUUC-Bol-016399	Brassica oleracea	40.46	3.00e-125	441.00
IUUC-Bra-017506	Brassica rapa	39.18	1.00e-121	429.00
IUUC-Cel-018456	Caenorhabditis elegans	35.79	9.00e-94	337.00
IUUC-Cja-020007	Callithrix jacchus	97.21	0.00e+00	1090.00
IUUC-Cfa-020324	Canis familiaris	97.75	0.00e+00	1090.00
IUUC-Cpo-022248	Cavia porcellus	66.73	0.00e+00	648.00
IUUC-Csa-023149	Chlorocebus sabaeus	97.79	0.00e+00	927.00
IUUC-Cho-024537	Choloepus hoffmanni	85.47	0.00e+00	808.00
IUUC-Cin-025763	Ciona intestinalis	49.72	3.00e-156	545.00
IUUC-Csv-026113	Ciona savignyi	46.48	7.00e-147	513.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.28	1.00e-66	247.00
IUUC-Cne-026884	Cryptococcus neoformans	30.26	1.00e-72	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.56	1.00e-19	91.30
IUUC-Dre-028140	Danio rerio	73.41	0.00e+00	852.00
IUUC-Dno-030033	Dasypus novemcinctus	97.89	0.00e+00	963.00
IUUC-Dor-030513	Dipodomys ordii	69.33	7.00e-117	414.00
IUUC-Dse-031536	Dothistroma septosporum	35.29	2.00e-86	313.00
IUUC-Dme-031683	Drosophila melanogaster	44.65	4.00e-128	451.00
IUUC-Ete-032420	Echinops telfairi	83.72	0.00e+00	894.00
IUUC-Eca-033992	Equus caballus	97.98	0.00e+00	915.00
IUUC-Eeu-034713	Erinaceus europaeus	79.53	4.00e-117	415.00
IUUC-Fca-036548	Felis catus	97.38	0.00e+00	1084.00
IUUC-Fal-037600	Ficedula albicollis	81.03	0.00e+00	889.00
IUUC-Fox-038037	Fusarium oxysporum	33.81	4.00e-76	278.00
IUUC-Fso-038387	Fusarium solani	35.03	2.00e-78	286.00
IUUC-Gmo-038562	Gadus morhua	71.78	0.00e+00	828.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.30	1.00e-73	270.00
IUUC-Gga-041129	Gallus gallus	85.23	0.00e+00	952.00
IUUC-Gac-042558	Gasterosteus aculeatus	73.07	0.00e+00	835.00
IUUC-Gma-043610	Glycine max	41.15	1.00e-121	429.00
IUUC-Ggo-045611	Gorilla gorilla	97.21	0.00e+00	1086.00
IUUC-Hsa-046563	Homo sapiens	97.75	0.00e+00	1090.00
IUUC-Hvu-047790	Hordeum vulgare	38.62	5.00e-78	284.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	97.94	0.00e+00	1095.00
IUUC-Kpa-049309	Komagataella pastoris	35.78	1.00e-83	303.00
IUUC-Lch-050038	Latimeria chalumnae	76.60	0.00e+00	857.00
IUUC-Lpe-051535	Leersia perrieri	41.25	5.00e-111	394.00
IUUC-Loc-051917	Lepisosteus oculatus	69.93	0.00e+00	799.00
IUUC-Lma-053112	Leptosphaeria maculans	34.76	2.00e-88	320.00
IUUC-Laf-053690	Loxodonta africana	96.25	0.00e+00	1082.00
IUUC-Mcc-055117	Macaca mulatta	95.91	0.00e+00	1074.00
IUUC-Meu-056761	Macropus eugenii	77.37	0.00e+00	831.00
IUUC-Mor-057230	Magnaporthe oryzae	34.29	3.00e-79	289.00
IUUC-Mpo-057514	Magnaporthe poae	33.82	1.00e-72	267.00
IUUC-Mtr-058551	Medicago truncatula	40.29	9.00e-119	420.00
IUUC-Mla-059183	Melampsora laricipopulina	36.78	2.00e-97	350.00
IUUC-Mga-060144	Meleagris gallopavo	83.52	0.00e+00	922.00
IUUC-Mvi-060221	Microbotryum violaceum	35.99	7.00e-84	304.00
IUUC-Mmr-061325	Microcebus murinus	95.34	0.00e+00	1065.00
IUUC-Mdo-062532	Monodelphis domestica	91.37	0.00e+00	1027.00
IUUC-Mmu-063956	Mus musculus	97.19	0.00e+00	1088.00
IUUC-Mac-064521	Musa acuminata	40.75	1.00e-123	436.00
IUUC-Mpu-066716	Mustela putorius furo	97.21	0.00e+00	1025.00
IUUC-Mlu-067459	Myotis lucifugus	95.52	0.00e+00	1066.00
IUUC-Nfi-068245	Neosartorya fischeri	33.93	1.00e-81	296.00
IUUC-Ncr-068910	Neurospora crassa	34.73	5.00e-79	288.00
IUUC-Nle-070034	Nomascus leucogenys	95.24	0.00e+00	1045.00
IUUC-Opr-070552	Ochotona princeps	87.62	0.00e+00	893.00
IUUC-Ont-071426	Oreochromis niloticus	73.91	0.00e+00	855.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.60	0.00e+00	776.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.63	0.00e+00	1088.00
IUUC-Oba-075437	Oryza barthii	43.13	2.00e-119	422.00
IUUC-Obr-076684	Oryza brachyantha	43.32	3.00e-114	405.00
IUUC-Ogl-077170	Oryza glaberrima	43.13	2.00e-119	422.00
IUUC-Ogu-078844	Oryza glumaepatula	43.91	2.00e-112	399.00
IUUC-Oin-079105	Oryza indica	43.13	7.00e-119	421.00
IUUC-Olo-080943	Oryza longistaminata	40.64	3.00e-107	382.00
IUUC-Oni-082891	Oryza nivara	40.27	1.00e-112	400.00
IUUC-Opu-083457	Oryza punctata	43.13	9.00e-119	420.00
IUUC-Oru-084960	Oryza rufipogon	40.64	3.00e-107	382.00
IUUC-Osa-085358	Oryza sativa	43.32	2.00e-119	422.00
IUUC-Ola-086420	Oryzias latipes	72.12	1.00e-169	588.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.06	4.00e-62	232.00
IUUC-Oga-088810	Otolemur garnettii	96.07	0.00e+00	1078.00
IUUC-Oar-089196	Ovis aries	99.07	0.00e+00	1106.00
IUUC-Ptr-090617	Pan troglodytes	97.94	0.00e+00	1092.00
IUUC-Pan-092761	Papio anubis	97.94	0.00e+00	1096.00
IUUC-Psi-093191	Pelodiscus sinensis	86.85	0.00e+00	964.00
IUUC-Pma-094380	Petromyzon marinus	61.46	0.00e+00	659.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.03	1.00e-76	281.00
IUUC-Ppa-095875	Physcomitrella patens	40.23	9.00e-121	427.00
IUUC-Pfo-096467	Poecilia formosa	72.78	0.00e+00	834.00
IUUC-Pab-098255	Pongo abelii	97.52	0.00e+00	912.00
IUUC-Pop-099722	Populus trichocarpa	40.75	1.00e-125	443.00
IUUC-Pca-100807	Procavia capensis	79.62	1.00e-119	423.00
IUUC-Ppe-101280	Prunus persica	40.41	2.00e-124	439.00
IUUC-Pva-102333	Pteropus vampyrus	93.11	0.00e+00	1026.00
IUUC-Pgr-103401	Puccinia graminis	31.61	4.00e-81	295.00
IUUC-Ptt-103889	Puccinia triticina	27.50	6.00e-59	221.00
IUUC-Pte-104355	Pyrenophora teres	35.77	6.00e-91	328.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.54	3.00e-92	332.00
IUUC-Rno-105810	Rattus norvegicus	96.07	0.00e+00	1077.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.39	1.00e-37	150.00
IUUC-Sha-106770	Sarcophilus harrisii	90.46	3.00e-155	540.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.58	6.00e-77	281.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.90	5.00e-84	305.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.97	2.00e-68	253.00
IUUC-Smo-109296	Selaginella moellendorffii	42.42	4.00e-124	438.00
IUUC-Sit-110157	Setaria italica	44.59	8.00e-136	477.00
IUUC-Sly-111105	Solanum lycopersicum	40.44	2.00e-123	435.00
IUUC-Stu-112469	Solanum tuberosum	40.26	4.00e-124	437.00
IUUC-Sar-113083	Sorex araneus	73.64	0.00e+00	757.00
IUUC-Sbi-113813	Sorghum bicolor	44.59	5.00e-135	474.00
IUUC-Sre-115058	Sporisorium reilianum	39.11	4.00e-86	312.00
IUUC-Tgu-116772	Taeniopygia guttata	80.83	0.00e+00	889.00
IUUC-Tru-118686	Takifugu rubripes	72.02	0.00e+00	837.00
IUUC-Tsy-119111	Tarsius syrichta	89.75	3.00e-150	525.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.79	0.00e+00	754.00
IUUC-Tca-121491	Theobroma cacao	40.41	3.00e-117	415.00
IUUC-Tre-122103	Trichoderma reesei	35.98	2.00e-82	300.00
IUUC-Tvi-122672	Trichoderma virens	36.83	3.00e-76	279.00
IUUC-Tae-125679	Triticum aestivum	43.32	6.00e-129	454.00
IUUC-Tur-126487	Triticum urartu	41.98	1.00e-122	433.00
IUUC-Tme-127097	Tuber melanosporum	39.09	1.00e-95	343.00
IUUC-Ttr-128465	Tursiops truncatus	90.50	0.00e+00	1000.00
IUUC-Uma-129645	Ustilago maydis	34.33	4.00e-92	332.00
IUUC-Vda-129989	Verticillium dahliae	31.28	3.00e-58	219.00
IUUC-Vpa-130529	Vicugna pacos	93.30	0.00e+00	1034.00
IUUC-Vvi-131059	Vitis vinifera	41.53	1.00e-123	436.00
IUUC-Xtr-132002	Xenopus tropicalis	78.75	0.00e+00	902.00
IUUC-Xma-133930	Xiphophorus maculatus	73.19	0.00e+00	839.00
IUUC-Yli-134505	Yarrowia lipolytica	36.00	3.00e-88	319.00
IUUC-Zma-135895	Zea mays	44.85	3.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence