iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120231

UUCD1 version

UUC-TeN-01091

Ensembl Protein ID

ENSTNIP00000012293.1

UniProt Accession

H3CVK9; H3CVK9_TETNG

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000009423.1	ENSTNIT00000012484.1	ENSTNIP00000012293.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.20e-95	318.6	39	526

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 29   lGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeeiv.FfkkfdvVvla 116
           + +E+ Kn   +G g +t++D++tv+ ++++++F+++  ++gk++A++a e l+eln+dv++ ++ees+++l ++++ Ff +f++V++a
   Q: 39   ITTETXKNGDFSGMGAFTMFDGHTVTGEDVGNNFFLSNNSIGKNRAQAATELLQELNSDVSGNFVEESPDKLLDNDPeFFHRFSIVITA 127
           77899999999****************************************************************************** PP
   S: 117  ldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiewavlf 193
           + ++++ +++ ++++na+vp+++++t+Gl+G++r +++++t+++s++d   +++++++Pf +lk+++          +++++++w+ ++
   Q: 128  QLPESTCLRLGSVLWNACVPFLICKTYGLIGYMRLVVQEHTVIESHPDnalEDLRLDKPFAELKNHVKscdldnmdkKDHSHTPWIIIV 216
           ******************************************************************88888888998************ PP
   S: 194  nklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv. 274
           +k+le++ +e++ + ++++++ke++++ +++++++      edeenfeeai+ +++a+++t i+s i++l++s +c+ +t+++++fwv 
   Q: 217  AKYLEKWLSEHSYQFPKTYKDKEAFRQYIREGIRKnehdvpEDEENFEEAIKSVNTALNPTKIPSlIEDLFNSEQCNSLTSQTPSFWVm 305
           ***************************************************************************************** PP
   S: 275  .............................................................................sfcsnaealqvp 286
                                                                                         fc+n++ l+v 
   Q: 306  lqavkavkafvlnerngslpvrgtipdmiadsqkfiklqniyrtkamqdaeavskhverllhsigkppdsiseqdikLFCKNSSFLRVV 394
           ***************************************************************************************66 PP
   S: 287  ...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlik 359
                      ++v+kde+ + +++p     +yl+lra++rf ++++r+pg+ ++++++d + +l+  + +l  ++++++ +++dd+++
   Q: 395  ycrsladeysvDSVNKDEISSCMDNPdsemvFYLMLRAVDRFYQQHSRYPGVYNYQVEED-ISKLKLCVNSLL-QEYNLNVNIKDDYVH 481
           6666666666689999988888888889999*****************************.888888888887.*************** PP
   S: 360  eiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           e++++++++ + ++a++gG aaqE+iK++s++f+p+ n+f+++a+
   Q: 482  EFCRYGAAEPHMVAAFLGGSAAQEAIKIISQQFVPFSNTFIYNAM 526
           ******************************************997 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAASKASKEQ KYDRQLRLHK NPVYLHMLQI YFGIVLSEIT TETXKNGDFS GMGAFTMFDG 60
HTVTGEDVGN NFFLSNNSIG KNRAQAATEL LQELNSDVSG NFVEESPDKL LDNDPEFFHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGCCT CCAAAGCGTC TAAAGAACAA AAATACGACA GACAGCTGAG GTAATTTTAA 60
ACCATACCAC AGACTCCACA AAAACCCTGT TTATTTACAC ATGTTGCAAA TTTATTTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	37.83	9.00e-106	377.00
IUUC-Aml-002333	Ailuropoda melanoleuca	66.36	0.00e+00	751.00
IUUC-Atr-002644	Amborella trichopoda	36.79	6.00e-96	344.00
IUUC-Apl-003446	Anas platyrhynchos	69.09	0.00e+00	725.00
IUUC-Aca-004450	Anolis carolinensis	65.22	0.00e+00	734.00
IUUC-Aly-005466	Arabidopsis lyrata	37.57	1.00e-107	383.00
IUUC-Ath-007600	Arabidopsis thaliana	37.90	6.00e-109	387.00
IUUC-Ago-007900	Ashbya gossypii	24.49	5.00e-26	111.00
IUUC-Acl-008333	Aspergillus clavatus	30.40	7.00e-66	244.00
IUUC-Afl-008529	Aspergillus flavus	31.54	2.00e-71	263.00
IUUC-Afu-009071	Aspergillus fumigatus	31.25	4.00e-69	255.00
IUUC-Ani-009443	Aspergillus nidulans	30.76	8.00e-67	247.00
IUUC-Ang-009669	Aspergillus niger	30.18	9.00e-71	261.00
IUUC-Aor-009914	Aspergillus oryzae	31.44	4.00e-70	258.00
IUUC-Ate-010450	Aspergillus terreus	31.43	2.00e-72	266.00
IUUC-Ame-011183	Astyanax mexicanus	73.32	0.00e+00	836.00
IUUC-Bgr-012111	Blumeria graminis	29.01	2.00e-45	176.00
IUUC-Bta-012583	Bos taurus	66.79	0.00e+00	754.00
IUUC-Bci-013892	Botrytis cinerea	28.73	1.00e-54	207.00
IUUC-Bdi-014592	Brachypodium distachyon	39.51	5.00e-110	391.00
IUUC-Bol-016399	Brassica oleracea	38.33	2.00e-110	392.00
IUUC-Bra-017506	Brassica rapa	36.79	2.00e-104	372.00
IUUC-Cel-018456	Caenorhabditis elegans	34.19	9.00e-84	304.00
IUUC-Cja-020007	Callithrix jacchus	66.29	0.00e+00	748.00
IUUC-Cfa-020324	Canis familiaris	66.60	0.00e+00	754.00
IUUC-Cpo-022248	Cavia porcellus	56.62	3.00e-113	401.00
IUUC-Csa-023149	Chlorocebus sabaeus	67.72	0.00e+00	689.00
IUUC-Cho-024537	Choloepus hoffmanni	60.99	2.00e-171	594.00
IUUC-Cin-025763	Ciona intestinalis	44.34	4.00e-135	474.00
IUUC-Csv-026113	Ciona savignyi	41.10	7.00e-123	434.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.37	3.00e-54	206.00
IUUC-Cne-026884	Cryptococcus neoformans	27.22	4.00e-59	222.00
IUUC-Dre-028140	Danio rerio	75.56	0.00e+00	850.00
IUUC-Dno-030033	Dasypus novemcinctus	64.76	0.00e+00	643.00
IUUC-Dor-030513	Dipodomys ordii	49.37	4.00e-80	291.00
IUUC-Dse-031536	Dothistroma septosporum	29.23	6.00e-65	241.00
IUUC-Dme-031683	Drosophila melanogaster	39.15	8.00e-109	387.00
IUUC-Ete-032420	Echinops telfairi	58.79	9.00e-176	609.00
IUUC-Eca-033992	Equus caballus	69.80	0.00e+00	676.00
IUUC-Eeu-034713	Erinaceus europaeus	58.37	1.00e-85	310.00
IUUC-Fca-036548	Felis catus	65.48	0.00e+00	739.00
IUUC-Fal-037600	Ficedula albicollis	68.89	0.00e+00	708.00
IUUC-Fox-038037	Fusarium oxysporum	30.24	4.00e-59	222.00
IUUC-Fso-038387	Fusarium solani	31.65	1.00e-63	237.00
IUUC-Gmo-038562	Gadus morhua	74.72	0.00e+00	838.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.12	1.00e-61	230.00
IUUC-Gga-041129	Gallus gallus	66.73	0.00e+00	731.00
IUUC-Gac-042558	Gasterosteus aculeatus	79.93	0.00e+00	885.00
IUUC-Gma-043610	Glycine max	36.82	2.00e-100	359.00
IUUC-Ggo-045611	Gorilla gorilla	66.11	0.00e+00	749.00
IUUC-Hsa-046563	Homo sapiens	66.23	0.00e+00	751.00
IUUC-Hvu-047790	Hordeum vulgare	38.25	3.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	65.85	0.00e+00	745.00
IUUC-Kpa-049309	Komagataella pastoris	31.77	8.00e-68	250.00
IUUC-Lch-050038	Latimeria chalumnae	66.85	0.00e+00	755.00
IUUC-Lpe-051535	Leersia perrieri	38.57	4.00e-95	341.00
IUUC-Loc-051917	Lepisosteus oculatus	68.81	0.00e+00	748.00
IUUC-Lma-053112	Leptosphaeria maculans	29.96	8.00e-71	261.00
IUUC-Laf-053690	Loxodonta africana	66.79	0.00e+00	759.00
IUUC-Mcc-055117	Macaca mulatta	64.80	0.00e+00	733.00
IUUC-Meu-056761	Macropus eugenii	54.56	2.00e-168	585.00
IUUC-Mor-057230	Magnaporthe oryzae	30.67	4.00e-64	238.00
IUUC-Mpo-057514	Magnaporthe poae	31.26	1.00e-59	223.00
IUUC-Mtr-058551	Medicago truncatula	35.45	4.00e-98	352.00
IUUC-Mla-059183	Melampsora laricipopulina	33.15	4.00e-83	301.00
IUUC-Mga-060144	Meleagris gallopavo	69.09	0.00e+00	715.00
IUUC-Mvi-060221	Microbotryum violaceum	30.81	8.00e-64	238.00
IUUC-Mmr-061325	Microcebus murinus	64.93	0.00e+00	730.00
IUUC-Mdo-062532	Monodelphis domestica	67.35	0.00e+00	766.00
IUUC-Mmu-063956	Mus musculus	66.04	0.00e+00	750.00
IUUC-Mac-064521	Musa acuminata	36.59	1.00e-102	366.00
IUUC-Mpu-066716	Mustela putorius furo	65.47	0.00e+00	699.00
IUUC-Mlu-067459	Myotis lucifugus	65.98	0.00e+00	744.00
IUUC-Nfi-068245	Neosartorya fischeri	32.04	1.00e-70	260.00
IUUC-Ncr-068910	Neurospora crassa	30.63	8.00e-64	237.00
IUUC-Nle-070034	Nomascus leucogenys	67.47	0.00e+00	722.00
IUUC-Opr-070552	Ochotona princeps	59.88	9.00e-173	599.00
IUUC-Ont-071426	Oreochromis niloticus	80.78	0.00e+00	900.00
IUUC-Oan-073389	Ornithorhynchus anatinus	69.35	0.00e+00	647.00
IUUC-Ocu-074911	Oryctolagus cuniculus	66.42	0.00e+00	752.00
IUUC-Oba-075437	Oryza barthii	39.32	4.00e-103	368.00
IUUC-Obr-076684	Oryza brachyantha	39.32	2.00e-98	353.00
IUUC-Ogl-077170	Oryza glaberrima	39.32	4.00e-103	368.00
IUUC-Ogu-078844	Oryza glumaepatula	39.41	4.00e-95	341.00
IUUC-Oin-079105	Oryza indica	39.32	1.00e-102	366.00
IUUC-Olo-080943	Oryza longistaminata	40.27	3.00e-91	328.00
IUUC-Oni-082891	Oryza nivara	40.00	3.00e-97	348.00
IUUC-Opu-083457	Oryza punctata	39.32	1.00e-102	367.00
IUUC-Oru-084960	Oryza rufipogon	37.98	6.00e-92	331.00
IUUC-Osa-085358	Oryza sativa	39.09	1.00e-102	366.00
IUUC-Ola-086420	Oryzias latipes	84.57	0.00e+00	659.00
IUUC-Olu-087625	Ostreococcus lucimarinus	28.67	5.00e-54	205.00
IUUC-Oga-088810	Otolemur garnettii	66.42	0.00e+00	752.00
IUUC-Oar-089196	Ovis aries	66.79	0.00e+00	751.00
IUUC-Ptr-090617	Pan troglodytes	66.42	0.00e+00	754.00
IUUC-Pan-092761	Papio anubis	66.42	0.00e+00	753.00
IUUC-Psi-093191	Pelodiscus sinensis	68.74	0.00e+00	747.00
IUUC-Pma-094380	Petromyzon marinus	55.04	9.00e-169	586.00
IUUC-Pno-095084	Phaeosphaeria nodorum	28.57	1.00e-59	225.00
IUUC-Ppa-095798	Physcomitrella patens	37.62	2.00e-102	365.00
IUUC-Pfo-096467	Poecilia formosa	78.85	0.00e+00	875.00
IUUC-Pab-098255	Pongo abelii	64.33	2.00e-175	608.00
IUUC-Pop-099722	Populus trichocarpa	37.90	6.00e-108	384.00
IUUC-Pca-100807	Procavia capensis	57.46	1.00e-73	270.00
IUUC-Ppe-101280	Prunus persica	37.20	1.00e-106	380.00
IUUC-Pva-102333	Pteropus vampyrus	64.43	0.00e+00	720.00
IUUC-Pgr-103401	Puccinia graminis	30.95	6.00e-70	258.00
IUUC-Ptt-103889	Puccinia triticina	25.75	3.00e-48	186.00
IUUC-Pte-104355	Pyrenophora teres	32.50	5.00e-76	278.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.50	3.00e-77	282.00
IUUC-Rno-105810	Rattus norvegicus	66.23	0.00e+00	744.00
IUUC-Sce-106397	Saccharomyces cerevisiae	22.92	6.00e-22	98.60
IUUC-Sha-106770	Sarcophilus harrisii	65.47	2.00e-108	384.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	29.21	4.00e-59	222.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.41	1.00e-63	237.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	29.04	5.00e-58	218.00
IUUC-Smo-109296	Selaginella moellendorffii	37.59	2.00e-103	369.00
IUUC-Sit-110157	Setaria italica	39.96	3.00e-113	402.00
IUUC-Sly-111105	Solanum lycopersicum	35.10	1.00e-100	360.00
IUUC-Stu-112469	Solanum tuberosum	35.28	7.00e-102	364.00
IUUC-Sar-113083	Sorex araneus	51.11	3.00e-149	521.00
IUUC-Sbi-113813	Sorghum bicolor	40.15	5.00e-112	397.00
IUUC-Sre-115058	Sporisorium reilianum	32.23	1.00e-61	231.00
IUUC-Tgu-116772	Taeniopygia guttata	65.47	0.00e+00	711.00
IUUC-Tru-118686	Takifugu rubripes	84.33	0.00e+00	936.00
IUUC-Tsy-119111	Tarsius syrichta	58.93	4.00e-91	328.00
IUUC-Tca-121491	Theobroma cacao	36.07	2.00e-99	355.00
IUUC-Tre-122103	Trichoderma reesei	31.51	1.00e-66	246.00
IUUC-Tvi-122672	Trichoderma virens	31.01	6.00e-60	224.00
IUUC-Tae-125316	Triticum aestivum	38.37	2.00e-107	382.00
IUUC-Tur-126487	Triticum urartu	38.97	5.00e-104	371.00
IUUC-Tme-127097	Tuber melanosporum	33.87	9.00e-77	280.00
IUUC-Ttr-128465	Tursiops truncatus	61.94	0.00e+00	685.00
IUUC-Uma-129645	Ustilago maydis	30.13	7.00e-71	261.00
IUUC-Vda-129989	Verticillium dahliae	27.32	5.00e-43	168.00
IUUC-Vpa-130529	Vicugna pacos	63.99	0.00e+00	711.00
IUUC-Vvi-131059	Vitis vinifera	36.82	2.00e-102	365.00
IUUC-Xtr-132002	Xenopus tropicalis	63.81	0.00e+00	730.00
IUUC-Xma-133930	Xiphophorus maculatus	79.48	0.00e+00	880.00
IUUC-Yli-134505	Yarrowia lipolytica	29.36	2.00e-65	243.00
IUUC-Zma-135895	Zea mays	40.34	7.00e-111	394.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence