iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.90e-29	99.6	570	599
UBD/Beta-Prp	2.50e-49	169.0	522	686

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+  +t+++f ++ t l+++s D+tik+WD
   Q: 570  HAHIITDVRFrPNsTQLATSSFDKTIKIWD 599
           8889*******777**************** PP

UBD/Beta-Prp

   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.ktgkllrtltgghtdsv 183
           v+ +++  ++v ++sfs +g+ l+s++hd+ + +w++et q+ + t ++h ++++ v++ p++  l+++s D+t+++Wd    g  lrt +g h  +v
   Q: 522  VSCIRKSASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVES-TPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDAsDPGYFLRTISG-HAAPV 617
           4556677899*********************************9.**********************************9677999****99.***** PP
   S: 184  yslsfdsng.kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
            s++f++++ + l s++ ++++++wd+ + +cvr+++g +++v+   f p++  ++ ++s+++++i+d+++++
   Q: 618  MSIDFHPKKtELLCSCDSNNDIRFWDI-NASCVRAVKGASTQVR---FQPRTGQFLAAASENTVSIFDIENNN 686
           *******9956678*************.566********99887...6666666677777*********9986 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Transcription repressor subunit of the SEU-SLK1 and SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes, by means of an epigenetic process involving histone modification (e.g. H3K9 and H3K14 acetylation), probably by recruiting HDAC, to facilitate the condensation of chromatin thus preventing transcription at the target genes (PubMed:24564815). Can also act as a transcription activator (PubMed:21518777). Implicated in embryo and floral development (PubMed:18390806). Involved in post-synthesis cell wall modifications necessary for mucilage extrusion from seeds upon imbibition, probably by promoting the expression of genes required for mucilage maturation (e.g. MUM2) (PubMed:11706181, PubMed:21362134, PubMed:21402796, PubMed:21518777). Regulates the maintenance on leaf polarity and meristem activity as well as the initiation of embryonic shoot apical meristem (SAM) development (PubMed:19837869).

Protein Sequence
(Fasta)

MAQSNWEADK MLDVYIYDYL VKKKLHNTAK SFMTEGKVSP DPVAIDAPGG FLFEWWSVFW 60
DIFIARTNEK HSEAAAAYIE AQQGKAKEQQ MQIQQLQMMR QAQMQRRDPN HPSLGGPMNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCGATGAT CTCTCCAAAC TCATCAATCT GATCTATCTC TCTCTTCCAG CTGTTTCATG 60
ATCGATTTAC TCTTAACTTA CAGCTGATTA CAATTCACTG TAATCTCTCA AGAACCCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0030154--P:cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071217--P:cellular response to external biotic stimulus
GO:0009908--P:flower development
GO:0010393--P:galacturonan metabolic process
GO:0010073--P:meristem maintenance
GO:0010192--P:mucilage biosynthetic process
GO:0080001--P:mucilage extrusion from seed coat
GO:0048359--P:mucilage metabolic process involved in seed coat development
GO:1901001--P:negative regulation of response to salt stress
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009827--P:plant-type cell wall modification
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045995--P:regulation of embryonic development
GO:0009909--P:regulation of flower development
GO:2000024--P:regulation of leaf development
GO:0047484--P:regulation of response to osmotic stress
GO:1902183--P:regulation of shoot apical meristem development
GO:0009733--P:response to auxin
GO:0009617--P:response to bacterium
GO:0046898--P:response to cycloheximide
GO:0009620--P:response to fungus
GO:0001666--P:response to hypoxia
GO:0009624--P:response to nematode
GO:0006979--P:response to oxidative stress
GO:1902074--P:response to salt
GO:0010272--P:response to silver ion
GO:0009414--P:response to water deprivation
GO:0009611--P:response to wounding
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT2G32700

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000776	Aegilops tauschii	60.80	4.00e-144	505.00
IUUC-Atr-002717	Amborella trichopoda	63.68	5.00e-147	514.00
IUUC-Aly-006471	Arabidopsis lyrata	93.93	0.00e+00	1363.00
IUUC-Bdi-014855	Brachypodium distachyon	59.52	0.00e+00	894.00
IUUC-Bol-016419	Brassica oleracea	82.00	0.00e+00	1207.00
IUUC-Bra-017537	Brassica rapa	79.12	0.00e+00	1165.00
IUUC-Gma-044008	Glycine max	69.14	0.00e+00	1016.00
IUUC-Hvu-047358	Hordeum vulgare	61.24	2.00e-152	531.00
IUUC-Lpe-051527	Leersia perrieri	60.29	0.00e+00	885.00
IUUC-Mtr-058582	Medicago truncatula	71.02	0.00e+00	1003.00
IUUC-Mac-064608	Musa acuminata	58.80	0.00e+00	853.00
IUUC-Oba-075243	Oryza barthii	59.46	0.00e+00	876.00
IUUC-Obr-076847	Oryza brachyantha	59.27	0.00e+00	868.00
IUUC-Ogl-076931	Oryza glaberrima	60.53	0.00e+00	909.00
IUUC-Ogu-077963	Oryza glumaepatula	59.23	0.00e+00	868.00
IUUC-Oin-079144	Oryza indica	60.05	0.00e+00	899.00
IUUC-Olo-080947	Oryza longistaminata	58.06	0.00e+00	835.00
IUUC-Ome-081723	Oryza meridionalis	57.64	0.00e+00	861.00
IUUC-Oni-083067	Oryza nivara	60.05	0.00e+00	904.00
IUUC-Opu-083429	Oryza punctata	60.34	0.00e+00	905.00
IUUC-Oru-084534	Oryza rufipogon	59.47	0.00e+00	870.00
IUUC-Osa-085788	Oryza sativa	60.53	0.00e+00	907.00
IUUC-Pop-099951	Populus trichocarpa	70.57	0.00e+00	1035.00
IUUC-Ppe-101896	Prunus persica	68.60	0.00e+00	963.00
IUUC-Sit-110618	Setaria italica	60.26	0.00e+00	896.00
IUUC-Sly-111127	Solanum lycopersicum	61.03	0.00e+00	867.00
IUUC-Stu-112404	Solanum tuberosum	60.37	0.00e+00	877.00
IUUC-Sbi-114046	Sorghum bicolor	61.78	0.00e+00	919.00
IUUC-Tca-121754	Theobroma cacao	70.37	0.00e+00	1035.00
IUUC-Tae-125446	Triticum aestivum	59.36	0.00e+00	897.00
IUUC-Tur-126636	Triticum urartu	57.91	0.00e+00	797.00
IUUC-Vvi-130936	Vitis vinifera	64.00	0.00e+00	929.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence