iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000007375.1	ENSAMET00000008123.1	ENSAMEP00000007796.1
ENSAMEG00000007375.1	ENSAMET00000008126.1	ENSAMEP00000007799.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.60e-15	57.0	3	64
E3 adaptor/Cullin RING/DCX/DWD	1.90e-29	100.5	392	425
UBD/Beta-Prp	1.30e-51	175.7	234	463

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 392  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 425
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd+
   Q: 234  ADTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 322
           57899************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+
   Q: 323  LLSSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLA 410
           *********************997777777789************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           ++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 411  TAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 463
           **************999999999866527*******************99987 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCCTGA TCTGCTCGAG TGAGTGTCGC CTGCGGCCGA TCGCAGGTCG CAGGGGGCCG 60
GAGCGCGGAG CGGGAGGAGC TGCGGGCCGC TGCGGCGCCG GGGTCGGGGC GGAGGCGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	38.78	6.00e-91	329.00
IUUC-Atr-002594	Amborella trichopoda	42.59	5.00e-113	401.00
IUUC-Apl-003686	Anas platyrhynchos	84.42	0.00e+00	692.00
IUUC-Aca-005272	Anolis carolinensis	94.19	0.00e+00	945.00
IUUC-Aly-005586	Arabidopsis lyrata	43.16	3.00e-113	402.00
IUUC-Ath-007696	Arabidopsis thaliana	43.64	2.00e-109	389.00
IUUC-Acl-008335	Aspergillus clavatus	34.91	5.00e-67	248.00
IUUC-Afl-008527	Aspergillus flavus	37.50	9.00e-73	267.00
IUUC-Afu-008957	Aspergillus fumigatus	38.20	5.00e-79	288.00
IUUC-Ani-009280	Aspergillus nidulans	37.30	6.00e-66	244.00
IUUC-Ang-009746	Aspergillus niger	36.34	7.00e-66	244.00
IUUC-Aor-009905	Aspergillus oryzae	37.30	2.00e-76	279.00
IUUC-Ate-010412	Aspergillus terreus	36.88	1.00e-64	240.00
IUUC-Ame-011561	Astyanax mexicanus	80.58	2.00e-101	362.00
IUUC-Bgr-012283	Blumeria graminis	32.52	2.00e-55	209.00
IUUC-Bta-013242	Bos taurus	96.39	0.00e+00	960.00
IUUC-Bci-013901	Botrytis cinerea	33.33	8.00e-63	234.00
IUUC-Bdi-014277	Brachypodium distachyon	43.75	3.00e-117	415.00
IUUC-Bol-016207	Brassica oleracea	44.81	3.00e-112	399.00
IUUC-Bra-017902	Brassica rapa	42.58	1.00e-110	393.00
IUUC-Cel-018271	Caenorhabditis elegans	50.10	1.00e-142	499.00
IUUC-Cja-019879	Callithrix jacchus	95.80	0.00e+00	951.00
IUUC-Cfa-020175	Canis familiaris	96.79	0.00e+00	962.00
IUUC-Cpo-022379	Cavia porcellus	95.99	0.00e+00	957.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.36	2.00e-95	343.00
IUUC-Csa-023500	Chlorocebus sabaeus	96.19	0.00e+00	959.00
IUUC-Cho-025065	Choloepus hoffmanni	82.11	9.00e-136	476.00
IUUC-Cin-025699	Ciona intestinalis	67.27	1.00e-169	588.00
IUUC-Csv-026128	Ciona savignyi	64.08	0.00e+00	644.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.72	3.00e-64	239.00
IUUC-Cne-026860	Cryptococcus neoformans	37.96	2.00e-90	326.00
IUUC-Dre-028187	Danio rerio	82.60	0.00e+00	818.00
IUUC-Dno-029453	Dasypus novemcinctus	95.99	0.00e+00	957.00
IUUC-Dor-030150	Dipodomys ordii	92.08	6.00e-116	410.00
IUUC-Dse-031220	Dothistroma septosporum	30.86	2.00e-57	216.00
IUUC-Dme-031906	Drosophila melanogaster	65.40	0.00e+00	637.00
IUUC-Ete-033035	Echinops telfairi	98.19	1.00e-131	462.00
IUUC-Eca-033478	Equus caballus	96.19	0.00e+00	958.00
IUUC-Eeu-034974	Erinaceus europaeus	94.75	0.00e+00	627.00
IUUC-Fca-036194	Felis catus	95.98	0.00e+00	952.00
IUUC-Fal-037417	Ficedula albicollis	94.19	0.00e+00	944.00
IUUC-Fox-037922	Fusarium oxysporum	33.20	4.00e-61	228.00
IUUC-Fso-038256	Fusarium solani	34.74	2.00e-63	236.00
IUUC-Gmo-038713	Gadus morhua	83.40	0.00e+00	831.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.62	2.00e-52	200.00
IUUC-Gga-041143	Gallus gallus	94.19	0.00e+00	946.00
IUUC-Gac-042129	Gasterosteus aculeatus	82.83	0.00e+00	850.00
IUUC-Gma-044273	Glycine max	45.05	1.00e-115	410.00
IUUC-Ggo-045262	Gorilla gorilla	96.19	0.00e+00	959.00
IUUC-Hsa-046036	Homo sapiens	96.19	0.00e+00	959.00
IUUC-Hvu-047442	Hordeum vulgare	41.43	2.00e-62	232.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	95.59	0.00e+00	916.00
IUUC-Lch-050105	Latimeria chalumnae	87.58	0.00e+00	892.00
IUUC-Lpe-050976	Leersia perrieri	43.95	2.00e-113	402.00
IUUC-Loc-052042	Lepisosteus oculatus	74.19	0.00e+00	654.00
IUUC-Lma-053143	Leptosphaeria maculans	34.02	5.00e-62	233.00
IUUC-Laf-053451	Loxodonta africana	93.02	0.00e+00	948.00
IUUC-Mcc-055786	Macaca mulatta	96.19	0.00e+00	959.00
IUUC-Meu-056161	Macropus eugenii	91.77	6.00e-128	450.00
IUUC-Mor-057215	Magnaporthe oryzae	33.13	3.00e-53	202.00
IUUC-Mpo-057419	Magnaporthe poae	31.65	3.00e-49	189.00
IUUC-Mtr-057756	Medicago truncatula	43.36	3.00e-111	395.00
IUUC-Mla-059085	Melampsora laricipopulina	37.86	2.00e-82	300.00
IUUC-Mga-060158	Meleagris gallopavo	87.04	0.00e+00	830.00
IUUC-Mvi-060441	Microbotryum violaceum	37.55	8.00e-76	277.00
IUUC-Mmr-061085	Microcebus murinus	96.19	0.00e+00	959.00
IUUC-Mdo-061804	Monodelphis domestica	95.79	0.00e+00	955.00
IUUC-Mmu-063608	Mus musculus	92.47	0.00e+00	943.00
IUUC-Mac-064972	Musa acuminata	43.88	4.00e-111	394.00
IUUC-Mpu-065700	Mustela putorius furo	96.79	0.00e+00	963.00
IUUC-Mlu-068223	Myotis lucifugus	92.23	0.00e+00	939.00
IUUC-Nfi-068504	Neosartorya fischeri	36.88	1.00e-78	286.00
IUUC-Ncr-068729	Neurospora crassa	36.31	5.00e-61	228.00
IUUC-Nle-069754	Nomascus leucogenys	96.19	0.00e+00	959.00
IUUC-Opr-070621	Ochotona princeps	91.87	0.00e+00	892.00
IUUC-Ont-071377	Oreochromis niloticus	82.80	0.00e+00	825.00
IUUC-Oan-073498	Ornithorhynchus anatinus	67.89	6.00e-110	390.00
IUUC-Ocu-074182	Oryctolagus cuniculus	92.31	0.00e+00	945.00
IUUC-Oba-075509	Oryza barthii	43.22	3.00e-115	408.00
IUUC-Obr-076480	Oryza brachyantha	44.14	7.00e-117	414.00
IUUC-Ogl-077052	Oryza glaberrima	43.22	3.00e-115	408.00
IUUC-Ogu-078919	Oryza glumaepatula	43.22	3.00e-115	408.00
IUUC-Oin-079357	Oryza indica	42.50	2.00e-108	386.00
IUUC-Olo-080376	Oryza longistaminata	42.80	2.00e-103	369.00
IUUC-Ome-081973	Oryza meridionalis	42.44	4.00e-103	368.00
IUUC-Oni-082849	Oryza nivara	43.41	6.00e-116	411.00
IUUC-Opu-083243	Oryza punctata	43.02	1.00e-114	406.00
IUUC-Oru-084613	Oryza rufipogon	43.55	1.00e-115	409.00
IUUC-Osa-085407	Oryza sativa	43.22	3.00e-115	408.00
IUUC-Ola-086566	Oryzias latipes	81.98	0.00e+00	816.00
IUUC-Olu-087757	Ostreococcus lucimarinus	40.56	2.00e-92	333.00
IUUC-Oga-089010	Otolemur garnettii	95.57	0.00e+00	952.00
IUUC-Oar-089638	Ovis aries	96.39	0.00e+00	960.00
IUUC-Ptr-091141	Pan troglodytes	96.19	0.00e+00	959.00
IUUC-Pan-092662	Papio anubis	96.19	0.00e+00	959.00
IUUC-Psi-093777	Pelodiscus sinensis	93.48	0.00e+00	769.00
IUUC-Pno-095115	Phaeosphaeria nodorum	34.02	1.00e-62	233.00
IUUC-Ppa-095841	Physcomitrella patens	43.88	5.00e-114	404.00
IUUC-Pfo-096390	Poecilia formosa	82.00	0.00e+00	824.00
IUUC-Pab-098250	Pongo abelii	94.46	0.00e+00	904.00
IUUC-Pop-099854	Populus trichocarpa	44.25	8.00e-115	407.00
IUUC-Pca-100553	Procavia capensis	95.59	0.00e+00	949.00
IUUC-Ppe-101383	Prunus persica	42.83	3.00e-107	382.00
IUUC-Pva-102189	Pteropus vampyrus	96.19	0.00e+00	959.00
IUUC-Pgr-103304	Puccinia graminis	36.71	8.00e-82	297.00
IUUC-Ptt-103984	Puccinia triticina	37.60	5.00e-87	315.00
IUUC-Pte-104385	Pyrenophora teres	32.77	3.00e-66	245.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.19	2.00e-67	249.00
IUUC-Rno-105581	Rattus norvegicus	95.99	0.00e+00	957.00
IUUC-Sha-107071	Sarcophilus harrisii	91.75	0.00e+00	942.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.01	2.00e-35	143.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.48	2.00e-45	176.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.85	9.00e-61	227.00
IUUC-Smo-109648	Selaginella moellendorffii	43.77	3.00e-115	408.00
IUUC-Sit-109873	Setaria italica	43.27	3.00e-113	402.00
IUUC-Sly-111673	Solanum lycopersicum	45.60	2.00e-109	389.00
IUUC-Stu-112125	Solanum tuberosum	45.21	3.00e-108	385.00
IUUC-Sbi-114696	Sorghum bicolor	42.83	6.00e-106	377.00
IUUC-Sre-115134	Sporisorium reilianum	32.25	4.00e-69	255.00
IUUC-Ssc-116260	Sus scrofa	96.19	0.00e+00	959.00
IUUC-Tgu-116533	Taeniopygia guttata	94.19	0.00e+00	945.00
IUUC-Tru-117800	Takifugu rubripes	81.80	0.00e+00	847.00
IUUC-Tsy-118980	Tarsius syrichta	90.85	0.00e+00	879.00
IUUC-Tni-120334	Tetraodon nigroviridis	61.80	6.00e-174	603.00
IUUC-Tca-121807	Theobroma cacao	43.16	3.00e-113	402.00
IUUC-Tre-121920	Trichoderma reesei	33.47	1.00e-61	230.00
IUUC-Tvi-122294	Trichoderma virens	32.91	2.00e-53	203.00
IUUC-Tae-125713	Triticum aestivum	43.75	6.00e-117	414.00
IUUC-Tur-126664	Triticum urartu	39.86	7.00e-110	391.00
IUUC-Tme-127026	Tuber melanosporum	34.08	7.00e-67	248.00
IUUC-Tbe-127582	Tupaia belangeri	94.44	4.00e-180	624.00
IUUC-Ttr-128313	Tursiops truncatus	95.99	0.00e+00	950.00
IUUC-Uma-129626	Ustilago maydis	33.77	2.00e-71	263.00
IUUC-Vda-129699	Verticillium dahliae	35.52	3.00e-66	245.00
IUUC-Vpa-130593	Vicugna pacos	95.39	0.00e+00	860.00
IUUC-Vvi-131668	Vitis vinifera	43.66	7.00e-114	404.00
IUUC-Xtr-132186	Xenopus tropicalis	82.77	0.00e+00	735.00
IUUC-Xma-133212	Xiphophorus maculatus	81.80	0.00e+00	819.00
IUUC-Yli-134607	Yarrowia lipolytica	57.58	2.00e-41	160.00
IUUC-Zma-135662	Zea mays	44.53	8.00e-116	410.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence