iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007646

UUCD1 version

UUC-ArT-01594

Ensembl Protein ID

AT2G46030.3

UniProt Accession

P42750; O49739; O82365; Q4TZ03; UBC6_ARATH

Genbank Protein ID

AAA32901.1; CAA50503.1; AAY44847.1; AAC62907.1; AEC10634.1; ANM62735.1; AAO63272.1; BAF00193.1

Protein Name

Ubiquitin-conjugating enzyme E2 6; E2 ubiquitin-conjugating enzyme 6; Ubiquitin carrier protein 6; Ubiquitin-conjugating enzyme E2-21 kDa 3; Ubiquitin-protein ligase 6

Genbank Nucleotide ID

L19355; X71381; DQ027021; AC005397; CP002685; CP002685; BT005208; AK228245

Gene Name

UBC6; At2g46030; T3F17.32

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G46030	AT2G46030.4	AT2G46030.4
AT2G46030	AT2G46030.3	AT2G46030.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	3.60e-33	115.1	83	212

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 8    elekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvlls 104
           +++k  ++ +++++v++ dl+ + v++ Gp+d+ Y+ggv+k+++e+pe YP+k+P+v f++ki+hPnv+e+ G+vCl++++  ++Wsp+ ++ +v+ s
   Q: 83   DMMKLMMSDYKVDTVND-DLQMFYVTFHGPTDSLYQGGVWKIKVELPEAYPYKSPSVGFVNKIYHPNVDESsGAVCLDVIN--QTWSPMFDLINVFES 177
           34566678889999999.9***************************************************99********9..*************66 PP
   S: 105  .iqsllaepnpesplneeaaellkknreeykkkvr 138
            + +ll  pnp++p n eaa+ll ++r++y+ kv+
   Q: 178  fLPQLLLYPNPSDPFNGEAASLLMRDRAAYELKVK 212
           378999*************************9997 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MNELIFWRRL EIGRFRRKRS VLTGELFLLL RVLLKEIGFN LMRRLDILGG SINYLRILNR 60
RRRRRRGKEK SAMASPSKRR EMDMMKLMMS DYKVDTVNDD LQMFYVTFHG PTDSLYQGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATATATTA GTCAATATTA ACTAAATGTT CTTTCACATA GACTTATATT GAAAAATATA 60
ATATATGTCC ATTTTGATTT TTAAAAAAGT AACTACAGTA TATGGAAAGT AGATTAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G46030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005904	Arabidopsis lyrata	98.68	3.00e-88	316.00
IUUC-Bra-017091	Brassica rapa	96.05	4.00e-86	309.00
IUUC-Cne-027006	Cryptococcus neoformans	68.66	5.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence