iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006610

UUCD1 version

UUC-ArT-00420

Ensembl Protein ID

AT2G46280.2

UniProt Accession

Q38884; O82342; Q94K09; Q9C5Z0; EIF3I_ARATH

Genbank Protein ID

AAC49079.1; AAG53616.1; AAC62878.1; AEC10670.1; AEC10671.1; AAK43862.1; AAL47346.1

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; eIF-3-beta; eIF3 p36

Genbank Nucleotide ID

U36765; AF285835; AC005397; CP002685; CP002685; AF370485; AY064633

Gene Name

TIF3I1; At2g46280; T3F17.7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G46280	AT2G46280.3	AT2G46280.3
AT2G46280	AT2G46280.2	AT2G46280.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-28	97.3	50	87
UBD/Beta-Prp	7.20e-40	137.9	7	320

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++   d  +l++Gs D t k+WD+++g+ l
   Q: 50   GHNGAVWCCDVsRDsSRLITGSADQTAKLWDVKSGKEL 87
           8***********77799****************99875 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee............... 131
           +ghe + t ++++++g++l ++++D+t  +w  ++g+ + t++gh+  v+++++s+++++l++Gs+d+t+++wd+++g++l +               
   Q: 7    KGHERPLTFLRYNREGDLLFSCAKDHTPTLWFADNGERLGTYRGHNGAVWCCDVSRDSSRLITGSADQTAKLWDVKSGKELFTfkfnaptrsvdfavg 104
           45555555555555555555555555555555555555555555555555555555555555555555555555555555555555555555555555 PP
   S: 132  .......................................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvyslsf 188
                                                  + +g++  +n +v+ p ++ +vsG+ D+++r+Wd +tgkll++   + gh+++++sl  
   Q: 105  drlavittdhfvdrtaaihvkriaedpeeqdaesvlvlhCPDGKK-RINRAVWGPLNQTIVSGGEDKVIRIWDAETGKLLKQSdeEVGHKKDITSLCK 201
           555555555555555555555555566666688888886777776.7788899999***************************99667********** PP
   S: 189  dsngkelvsgsldgtvklwdlqtgec.......................................................vrtlnghtdnvksvrfs 231
             +  ++++gsld+t klwd++t +                                                        +  ++gh  +++ ++f 
   Q: 202  AADDSHFLTGSLDKTAKLWDMRTLTLlktyttvvpvnavslspllnhvvlgggqdasavtttdhragkfeakfydkilqeeIGGVKGHFGPINALAFN 299
           **********************8887222233333444444444444444444444433444444444444444444444444444444666666666 PP
   S: 232  pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           p+++ + sg++Dg +r++                                            ++
   Q: 300  PDGKSFSSGGEDGYVRLH-------------------------------------------HFD 320
           666666666666666665...........................................333 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Protein Sequence
(Fasta)

MRPILMKGHE RPLTFLRYNR EGDLLFSCAK DHTPTLWFAD NGERLGTYRG HNGAVWCCDV 60
SRDSSRLITG SADQTAKLWD VKSGKELFTF KFNAPTRSVD FAVGDRLAVI TTDHFVDRTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGAGAAA GGAAAAAAAC AAAATAGGCG CAACGGGCGA GGTTCGAACT CATCAAATAG 60
GGAAGAAGCT AAAAACGCTG AAGCCACTGA GCTTTGCTAA ACTGTGGCAT CTCGAGTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0046686--P:response to cadmium ion
GO:0009651--P:response to salt stress

KEGG

ath:AT2G46280

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence