iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/DCUN1	DCUN1	20832729; 18206966; 19942853
UBD/Alpha-Helix/UBA	UBA	18206966

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	6.80e-05	21.4	14	52

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlve.MGFdreealqaLraannnleaAveyLld 40
           +++++e +++ + +d++  ++ L+++++n++ A+++++d
   Q: 14   EQEAIESFTSlTKCDPKVSRKYLQRNHWNINYALNDYYD 52
           789*******9999**********************986 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.

Protein Sequence
(Fasta)

MSNNKIKRKD ASPEQEAIES FTSLTKCDPK VSRKYLQRNH WNINYALNDY YDKEIGTFTD 60
EVSTVAHPPV YPKELTQVFE HYINNNLFDI DSLVKFIEEL GYNLEDLATL CLAHLLGYKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTATGTT TTTAATTTCG TTTCTTTAGT TCTCAGGCTC TTCAAAGTAC TAACACTTTA 60
TTGGCAAGGG GCGCTCAAAT GTGATGCATC ATTATAGAGT AATAATAAAA TAAAAAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

sce:YLR128W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	23.85	3.00e-19	86.30
IUUC-Aml-001879	Ailuropoda melanoleuca	25.37	1.00e-20	91.30
IUUC-Atr-002697	Amborella trichopoda	32.43	2.00e-10	55.80
IUUC-Apl-003933	Anas platyrhynchos	26.15	4.00e-21	92.80
IUUC-Aca-005269	Anolis carolinensis	25.75	1.00e-20	91.30
IUUC-Aly-006285	Arabidopsis lyrata	33.73	5.00e-19	85.50
IUUC-Ath-007531	Arabidopsis thaliana	26.64	5.00e-21	92.40
IUUC-Ago-007806	Ashbya gossypii	36.05	3.00e-50	189.00
IUUC-Acl-008172	Aspergillus clavatus	23.08	4.00e-17	79.70
IUUC-Afl-008569	Aspergillus flavus	23.02	2.00e-21	93.60
IUUC-Afu-009005	Aspergillus fumigatus	24.86	1.00e-15	74.30
IUUC-Ani-009241	Aspergillus nidulans	19.06	4.00e-16	76.30
IUUC-Ang-009664	Aspergillus niger	22.31	4.00e-18	82.80
IUUC-Aor-009902	Aspergillus oryzae	25.23	8.00e-08	47.40
IUUC-Ate-010414	Aspergillus terreus	24.16	3.00e-22	96.70
IUUC-Ame-011763	Astyanax mexicanus	25.37	2.00e-21	93.60
IUUC-Bgr-011991	Blumeria graminis	26.94	7.00e-17	79.00
IUUC-Bta-013561	Bos taurus	25.40	3.00e-19	86.30
IUUC-Bci-013824	Botrytis cinerea	24.52	2.00e-16	77.00
IUUC-Bdi-014138	Brachypodium distachyon	25.10	3.00e-19	86.70
IUUC-Bol-016110	Brassica oleracea	27.63	6.00e-22	95.50
IUUC-Bra-017111	Brassica rapa	27.13	1.00e-21	94.70
IUUC-Cel-018441	Caenorhabditis elegans	23.47	5.00e-14	69.30
IUUC-Cja-019502	Callithrix jacchus	25.37	7.00e-21	92.00
IUUC-Cfa-020523	Canis familiaris	25.40	3.00e-19	86.30
IUUC-Cpo-022196	Cavia porcellus	25.37	8.00e-21	91.70
IUUC-Cre-022620	Chlamydomonas reinhardtii	22.53	6.00e-19	85.90
IUUC-Csa-023551	Chlorocebus sabaeus	25.37	1.00e-20	91.30
IUUC-Cho-024373	Choloepus hoffmanni	24.25	9.00e-16	75.10
IUUC-Cin-025269	Ciona intestinalis	24.90	4.00e-17	79.70
IUUC-Csv-025976	Ciona savignyi	23.83	5.00e-12	62.40
IUUC-Cgl-026386	Colletotrichum gloeosporioides	26.09	6.00e-18	81.60
IUUC-Cne-026950	Cryptococcus neoformans	26.18	7.00e-20	89.00
IUUC-Cme-027199	Cyanidioschyzon merolae	22.17	6.00e-05	39.30
IUUC-Dre-028247	Danio rerio	25.74	1.00e-22	98.20
IUUC-Dno-028974	Dasypus novemcinctus	25.37	1.00e-20	91.30
IUUC-Dor-030143	Dipodomys ordii	24.31	3.00e-19	86.30
IUUC-Dse-031365	Dothistroma septosporum	23.68	1.00e-18	84.70
IUUC-Dme-032197	Drosophila melanogaster	26.64	2.00e-19	87.00
IUUC-Ete-032371	Echinops telfairi	25.75	6.00e-21	92.00
IUUC-Eca-033242	Equus caballus	25.37	9.00e-21	91.70
IUUC-Eeu-035317	Erinaceus europaeus	25.00	2.00e-20	90.50
IUUC-Fca-036061	Felis catus	25.37	1.00e-20	91.70
IUUC-Fal-036715	Ficedula albicollis	26.15	3.00e-21	93.20
IUUC-Fox-037884	Fusarium oxysporum	25.17	6.00e-12	61.60
IUUC-Fso-038150	Fusarium solani	25.11	4.00e-11	60.10
IUUC-Gmo-038885	Gadus morhua	25.86	2.00e-22	97.10
IUUC-Ggr-039959	Gaeumannomyces graminis	23.76	3.00e-11	61.60
IUUC-Gga-040224	Gallus gallus	25.10	1.00e-20	90.90
IUUC-Gac-041853	Gasterosteus aculeatus	27.52	3.00e-22	96.70
IUUC-Gma-043516	Glycine max	25.76	6.00e-21	92.40
IUUC-Ggo-044972	Gorilla gorilla	23.92	1.00e-19	87.80
IUUC-Hsa-046089	Homo sapiens	25.37	1.00e-20	91.30
IUUC-Hvu-047636	Hordeum vulgare	26.32	9.00e-10	54.70
IUUC-Itr-047902	Ictidomys tridecemlineatus	23.53	7.00e-18	82.00
IUUC-Kpa-049127	Komagataella pastoris	27.17	2.00e-27	113.00
IUUC-Lch-050600	Latimeria chalumnae	26.39	3.00e-21	93.60
IUUC-Lpe-051540	Leersia perrieri	23.60	1.00e-20	91.30
IUUC-Loc-052509	Lepisosteus oculatus	26.24	4.00e-23	99.40
IUUC-Lma-053103	Leptosphaeria maculans	23.51	2.00e-19	87.40
IUUC-Laf-053527	Loxodonta africana	25.75	3.00e-21	93.20
IUUC-Mcc-054700	Macaca mulatta	24.31	7.00e-20	88.60
IUUC-Meu-056791	Macropus eugenii	24.22	1.00e-16	78.20
IUUC-Mor-056909	Magnaporthe oryzae	22.56	2.00e-16	77.80
IUUC-Mpo-057299	Magnaporthe poae	22.14	6.00e-15	72.40
IUUC-Mtr-057964	Medicago truncatula	26.62	7.00e-22	95.10
IUUC-Mla-058990	Melampsora laricipopulina	21.63	8.00e-14	68.90
IUUC-Mga-060072	Meleagris gallopavo	25.77	5.00e-21	92.40
IUUC-Mvi-060312	Microbotryum violaceum	22.39	7.00e-17	79.00
IUUC-Mmr-060851	Microcebus murinus	25.37	1.00e-20	91.30
IUUC-Mdo-063074	Monodelphis domestica	25.00	3.00e-20	92.40
IUUC-Mmu-063954	Mus musculus	25.37	1.00e-20	91.30
IUUC-Mac-065016	Musa acuminata	29.61	1.00e-16	77.80
IUUC-Mpu-066870	Mustela putorius furo	25.40	3.00e-19	86.30
IUUC-Mlu-067701	Myotis lucifugus	26.01	1.00e-19	87.80
IUUC-Nfi-068610	Neosartorya fischeri	25.97	1.00e-16	77.40
IUUC-Ncr-068780	Neurospora crassa	19.67	4.00e-15	73.20
IUUC-Nle-069291	Nomascus leucogenys	25.37	1.00e-20	91.30
IUUC-Opr-070682	Ochotona princeps	30.66	4.00e-09	53.10
IUUC-Ont-071408	Oreochromis niloticus	26.24	1.00e-21	94.70
IUUC-Oan-073031	Ornithorhynchus anatinus	24.81	2.00e-20	90.90
IUUC-Ocu-074648	Oryctolagus cuniculus	25.37	9.00e-21	91.70
IUUC-Oba-074993	Oryza barthii	24.23	2.00e-20	90.50
IUUC-Obr-076341	Oryza brachyantha	24.53	7.00e-21	92.00
IUUC-Ogl-077099	Oryza glaberrima	24.23	2.00e-20	90.50
IUUC-Ogu-078285	Oryza glumaepatula	23.85	3.00e-19	86.70
IUUC-Oin-079441	Oryza indica	24.23	2.00e-20	90.50
IUUC-Olo-081037	Oryza longistaminata	24.23	2.00e-20	90.50
IUUC-Ome-081357	Oryza meridionalis	24.23	2.00e-20	90.50
IUUC-Oni-082632	Oryza nivara	23.85	9.00e-20	88.20
IUUC-Opu-083351	Oryza punctata	24.60	6.00e-19	85.50
IUUC-Oru-084306	Oryza rufipogon	24.23	2.00e-20	90.50
IUUC-Osa-085307	Oryza sativa	24.23	2.00e-20	90.50
IUUC-Ola-086371	Oryzias latipes	27.06	3.00e-21	93.20
IUUC-Olu-087646	Ostreococcus lucimarinus	23.86	1.00e-11	61.60
IUUC-Oga-089015	Otolemur garnettii	25.37	9.00e-21	91.70
IUUC-Oar-090405	Ovis aries	25.37	9.00e-21	91.70
IUUC-Ptr-090735	Pan troglodytes	25.37	9.00e-21	91.70
IUUC-Pan-092825	Papio anubis	24.31	5.00e-20	89.00
IUUC-Psi-093110	Pelodiscus sinensis	26.10	1.00e-18	84.30
IUUC-Pma-094582	Petromyzon marinus	26.67	1.00e-13	67.80
IUUC-Pno-095145	Phaeosphaeria nodorum	25.98	8.00e-17	78.60
IUUC-Ppa-095321	Physcomitrella patens	26.59	8.00e-24	101.00
IUUC-Pfo-097121	Poecilia formosa	25.86	2.00e-21	94.40
IUUC-Pab-098197	Pongo abelii	25.41	7.00e-18	82.00
IUUC-Pop-098821	Populus trichocarpa	36.36	8.00e-16	73.60
IUUC-Pca-100218	Procavia capensis	25.00	8.00e-21	91.70
IUUC-Ppe-102032	Prunus persica	23.57	2.00e-18	84.00
IUUC-Pva-102691	Pteropus vampyrus	25.10	1.00e-19	87.80
IUUC-Pgr-103633	Puccinia graminis	25.54	3.00e-22	96.70
IUUC-Ptt-103979	Puccinia triticina	28.49	3.00e-11	60.50
IUUC-Pyt-104428	Pyrenophora triticirepentis	22.79	9.00e-15	71.60
IUUC-Rno-105554	Rattus norvegicus	25.19	1.00e-20	91.30
IUUC-Sha-106542	Sarcophilus harrisii	25.88	8.00e-22	95.10
IUUC-Sja-107938	Schizosaccharomyces japonicus	23.83	2.00e-11	60.50
IUUC-Spo-108207	Schizosaccharomyces pombe	26.90	5.00e-13	65.90
IUUC-Ssl-108410	Sclerotinia sclerotiorum	23.75	7.00e-17	78.60
IUUC-Smo-108750	Selaginella moellendorffii	25.95	1.00e-21	94.00
IUUC-Sit-110613	Setaria italica	25.00	4.00e-20	89.40
IUUC-Sly-111489	Solanum lycopersicum	23.19	7.00e-19	85.10
IUUC-Stu-112517	Solanum tuberosum	24.90	5.00e-16	75.90
IUUC-Sar-113248	Sorex araneus	28.06	6.00e-13	65.50
IUUC-Sbi-114082	Sorghum bicolor	25.38	1.00e-20	90.90
IUUC-Sre-115221	Sporisorium reilianum	21.23	1.00e-04	38.50
IUUC-Ssc-115547	Sus scrofa	25.37	1.00e-20	91.30
IUUC-Tgu-117196	Taeniopygia guttata	25.88	6.00e-21	92.00
IUUC-Tru-118119	Takifugu rubripes	26.67	1.00e-21	94.70
IUUC-Tsy-119599	Tarsius syrichta	25.37	1.00e-20	91.30
IUUC-Tni-120315	Tetraodon nigroviridis	26.27	2.00e-21	94.00
IUUC-Tca-121033	Theobroma cacao	24.71	1.00e-20	90.90
IUUC-Tre-121986	Trichoderma reesei	25.68	3.00e-14	70.50
IUUC-Tvi-122607	Trichoderma virens	23.17	1.00e-16	78.20
IUUC-Tae-125740	Triticum aestivum	21.12	8.00e-14	68.60
IUUC-Tur-126375	Triticum urartu	20.12	2.00e-12	65.10
IUUC-Tme-126878	Tuber melanosporum	27.24	1.00e-21	94.70
IUUC-Tbe-127937	Tupaia belangeri	27.55	1.00e-12	64.70
IUUC-Ttr-129086	Tursiops truncatus	22.39	3.00e-12	63.20
IUUC-Uma-129364	Ustilago maydis	21.73	2.00e-10	57.80
IUUC-Vda-129929	Verticillium dahliae	27.23	4.00e-14	70.50
IUUC-Vpa-130543	Vicugna pacos	25.65	4.00e-13	66.20
IUUC-Vvi-130834	Vitis vinifera	25.19	4.00e-21	92.80
IUUC-Xtr-131888	Xenopus tropicalis	25.00	8.00e-21	91.70
IUUC-Xma-134122	Xiphophorus maculatus	25.97	1.00e-21	94.70
IUUC-Yli-134595	Yarrowia lipolytica	24.31	8.00e-22	95.10
IUUC-Zma-135642	Zea mays	25.38	4.00e-20	89.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence