iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011470

Ensembl Protein ID

ENSAMXP00000012233.1

UniProt Accession

W5KXC1; W5KXC1_ASTMX

Genbank Protein ID

ENSAMXP00000012233

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01033361

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000011904.1	ENSAMXT00000012234.1	ENSAMXP00000012233.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-55	186.3	318	855
UBD/Alpha-Helix/UBA	1.30e-20	73.1	712	749

Active Site

Position(s)	Description	Evidence
327	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG++NlgN+CY+  ++Q+L++ipe+++++   + +++ + +p +p+++++++++kl + l                      +k++++ 
   Q: 318  TGIRNLGNSCYLSTTMQVLFSIPEFQRAYVG-NLQRIFDYSPLDPTQDFSTQMAKLGHGLlsgqyskppikselieqvmkeeYKQQHRG 405
           7******************************.7777778889******************9999999999999888877655599999* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ ++++ +e++                              ++++  sd+F++ ++++++c
   Q: 406  ISPRMFKALVSKGHPEFSSNRQQDAQEFFLHFINVVERNS-----------------------------SGSENPSDVFRFVVEERVQC 465
           *************************************999.............................788999************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  ++   + ++lpvp +  t+ e                            ++ cL++ft++e++ +   ++++  ++k+  +
   Q: 466  CQSQKVRYTQRVDYLMQLPVPVEAATNREeliayevkrkdaeenmrappepvrarvPFTACLQAFTEPENVPD---FWSSALQAKSAGV 551
           ******9888888888888887777777778****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++P++++++Lk+f+f  + ++++k++ +v++p+ Ldl++                                            
   Q: 552  KTSRFASFPDYMVVQLKKFTFGVD-WVPKKLDVSVDVPDFLDLNRLRGMglqageeelpdltppivipedtrdssmnnslesleideaa 639
           *********************776.*******************877667888888999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 640  vmqlaemgfpleacrkavyytgnmgaemafnwiiahmeepdfaeplavpaymepdlpspslptatpldnqppeesiailtsmgfprhht 728
           88888777777777777777777777777777777777777777777777777777777777777777776666666666666666666 PP
   S: 268  .....................peekqke..............................................kkkYeLiavvvHsG. 288
                                p     e                                              + +YeL+a ++H+G 
   Q: 729  iralratnnnleraldwifthP-----EseeesealsdmadtepndtsfsnanphsdstlspdqelssprirdgPGRYELFAFISHMGt 812
           6666666666666666666551.....04445566677777777777777888888888889999999999999*************** PP
   S: 289  slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           s+ sGHYv+++k+ +g+W+ ++D++V  +  e+  +   + +Y++fY+r
   Q: 813  STMSGHYVCHIKK-EGRWVIYNDHRVCLS--ERPPR---ELGYIYFYRR 855
           *************.9***********988..55666...68******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ ++ l++MGF+r++ ++aLra+nnnle+A+++++++
   Q: 712  EESIAILTSMGFPRHHTIRALRATNNNLERALDWIFTH 749
           789*********************************98 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MATDLGELLV PFMPTIRVPR TGDRVYKSEC AFSYDSPESD GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK APGAAGGVGP RRRNGKVFLD LELNRDFNGD DYEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCCCACT GACAATGTTT TCATCGTCAT ATCCGAGGGA ATGCGTCCTC GGAGTGATTT 60
AAAAATAACC CCTTAGCCCC GCCACTCACT CTGGACCGCT CACTCCACCT CACCCCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	39.81	1.00e-168	587.00
IUUC-Aml-001356	Ailuropoda melanoleuca	73.57	0.00e+00	1261.00
IUUC-Atr-002580	Amborella trichopoda	41.69	0.00e+00	650.00
IUUC-Apl-003712	Anas platyrhynchos	75.73	0.00e+00	1260.00
IUUC-Aca-004634	Anolis carolinensis	76.11	0.00e+00	1303.00
IUUC-Aly-005727	Arabidopsis lyrata	42.46	0.00e+00	655.00
IUUC-Ath-006974	Arabidopsis thaliana	42.11	0.00e+00	649.00
IUUC-Ago-007890	Ashbya gossypii	25.81	2.00e-61	230.00
IUUC-Ang-009720	Aspergillus niger	31.90	1.00e-104	374.00
IUUC-Bta-013349	Bos taurus	74.74	0.00e+00	1275.00
IUUC-Bdi-014904	Brachypodium distachyon	41.25	5.00e-178	618.00
IUUC-Bol-015296	Brassica oleracea	42.72	0.00e+00	663.00
IUUC-Bra-017939	Brassica rapa	42.84	0.00e+00	666.00
IUUC-Cel-018625	Caenorhabditis elegans	30.11	7.00e-108	385.00
IUUC-Cja-019021	Callithrix jacchus	73.28	0.00e+00	1261.00
IUUC-Cfa-020614	Canis familiaris	73.68	0.00e+00	1259.00
IUUC-Cpo-022484	Cavia porcellus	72.40	0.00e+00	1195.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	36.88	1.00e-102	367.00
IUUC-Csa-024078	Chlorocebus sabaeus	73.57	0.00e+00	1261.00
IUUC-Cho-024522	Choloepus hoffmanni	61.12	0.00e+00	938.00
IUUC-Cin-025411	Ciona intestinalis	45.52	0.00e+00	718.00
IUUC-Csv-026347	Ciona savignyi	41.74	0.00e+00	691.00
IUUC-Cne-026831	Cryptococcus neoformans	32.95	2.00e-113	403.00
IUUC-Dre-027651	Danio rerio	89.42	0.00e+00	1576.00
IUUC-Dno-028975	Dasypus novemcinctus	73.51	0.00e+00	1254.00
IUUC-Dor-030130	Dipodomys ordii	53.74	0.00e+00	823.00
IUUC-Dse-031467	Dothistroma septosporum	32.91	3.00e-107	382.00
IUUC-Dme-032075	Drosophila melanogaster	43.83	0.00e+00	675.00
IUUC-Ete-032251	Echinops telfairi	62.35	0.00e+00	985.00
IUUC-Eca-033568	Equus caballus	73.23	0.00e+00	1197.00
IUUC-Fca-036280	Felis catus	73.23	0.00e+00	1196.00
IUUC-Fal-036610	Ficedula albicollis	75.80	0.00e+00	1237.00
IUUC-Gmo-038906	Gadus morhua	80.07	0.00e+00	1410.00
IUUC-Gga-041215	Gallus gallus	75.20	0.00e+00	1309.00
IUUC-Gac-042441	Gasterosteus aculeatus	80.53	0.00e+00	1448.00
IUUC-Gma-043614	Glycine max	41.00	0.00e+00	631.00
IUUC-Ggo-044446	Gorilla gorilla	73.68	0.00e+00	1269.00
IUUC-Hsa-046546	Homo sapiens	73.57	0.00e+00	1268.00
IUUC-Hvu-047563	Hordeum vulgare	43.72	2.00e-158	552.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	67.78	0.00e+00	1150.00
IUUC-Kpa-049156	Komagataella pastoris	29.91	5.00e-101	362.00
IUUC-Lch-050425	Latimeria chalumnae	74.40	0.00e+00	1326.00
IUUC-Lpe-051523	Leersia perrieri	40.39	4.00e-176	611.00
IUUC-Loc-052072	Lepisosteus oculatus	78.93	0.00e+00	1360.00
IUUC-Laf-053909	Loxodonta africana	72.99	0.00e+00	1245.00
IUUC-Mcc-054686	Macaca mulatta	73.45	0.00e+00	1260.00
IUUC-Meu-056361	Macropus eugenii	67.91	0.00e+00	1149.00
IUUC-Mtr-058680	Medicago truncatula	41.91	0.00e+00	628.00
IUUC-Mga-059972	Meleagris gallopavo	70.63	0.00e+00	1193.00
IUUC-Mmr-060916	Microcebus murinus	73.68	0.00e+00	1259.00
IUUC-Mdo-062302	Monodelphis domestica	74.33	0.00e+00	1327.00
IUUC-Mmu-063639	Mus musculus	73.65	0.00e+00	1253.00
IUUC-Mac-065634	Musa acuminata	38.43	1.00e-168	587.00
IUUC-Mpu-066533	Mustela putorius furo	73.57	0.00e+00	1260.00
IUUC-Mlu-067786	Myotis lucifugus	69.21	0.00e+00	1182.00
IUUC-Nle-069997	Nomascus leucogenys	72.96	0.00e+00	1191.00
IUUC-Ont-071859	Oreochromis niloticus	82.39	0.00e+00	1473.00
IUUC-Oan-072959	Ornithorhynchus anatinus	78.33	6.00e-113	399.00
IUUC-Ocu-074265	Oryctolagus cuniculus	73.22	0.00e+00	1256.00
IUUC-Oba-075109	Oryza barthii	41.56	0.00e+00	634.00
IUUC-Obr-076292	Oryza brachyantha	41.56	3.00e-179	622.00
IUUC-Ogl-077065	Oryza glaberrima	42.51	0.00e+00	658.00
IUUC-Ogu-078776	Oryza glumaepatula	40.75	0.00e+00	645.00
IUUC-Oin-080048	Oryza indica	41.70	0.00e+00	648.00
IUUC-Olo-080711	Oryza longistaminata	39.83	6.00e-167	581.00
IUUC-Ome-081506	Oryza meridionalis	40.78	3.00e-170	592.00
IUUC-Oni-082320	Oryza nivara	40.70	0.00e+00	627.00
IUUC-Opu-083801	Oryza punctata	41.09	1.00e-178	620.00
IUUC-Oru-085139	Oryza rufipogon	40.82	2.00e-180	625.00
IUUC-Osa-085713	Oryza sativa	42.62	0.00e+00	660.00
IUUC-Ola-087344	Oryzias latipes	80.11	0.00e+00	1471.00
IUUC-Olu-087822	Ostreococcus lucimarinus	37.67	7.00e-155	541.00
IUUC-Oga-088734	Otolemur garnettii	73.58	0.00e+00	1247.00
IUUC-Oar-089636	Ovis aries	74.21	0.00e+00	1240.00
IUUC-Ptr-090982	Pan troglodytes	73.57	0.00e+00	1268.00
IUUC-Pan-091991	Papio anubis	73.57	0.00e+00	1261.00
IUUC-Psi-093509	Pelodiscus sinensis	76.73	0.00e+00	1330.00
IUUC-Ppa-095901	Physcomitrella patens	41.34	0.00e+00	665.00
IUUC-Pfo-096029	Poecilia formosa	85.43	0.00e+00	1545.00
IUUC-Pab-098672	Pongo abelii	69.89	0.00e+00	1177.00
IUUC-Pop-098943	Populus trichocarpa	41.83	0.00e+00	634.00
IUUC-Pca-100738	Procavia capensis	57.78	0.00e+00	724.00
IUUC-Ppe-101315	Prunus persica	41.23	0.00e+00	642.00
IUUC-Pva-102545	Pteropus vampyrus	73.84	0.00e+00	1066.00
IUUC-Ptt-103928	Puccinia triticina	29.18	1.00e-96	347.00
IUUC-Rno-105210	Rattus norvegicus	73.76	0.00e+00	1246.00
IUUC-Sce-106304	Saccharomyces cerevisiae	26.23	2.00e-56	214.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.23	1.00e-104	374.00
IUUC-Smo-108848	Selaginella moellendorffii	41.69	0.00e+00	637.00
IUUC-Sit-110728	Setaria italica	41.76	0.00e+00	677.00
IUUC-Sly-111523	Solanum lycopersicum	42.13	0.00e+00	681.00
IUUC-Sar-113733	Sorex araneus	76.98	0.00e+00	627.00
IUUC-Sbi-114419	Sorghum bicolor	42.00	0.00e+00	667.00
IUUC-Tgu-116591	Taeniopygia guttata	75.20	0.00e+00	1307.00
IUUC-Tru-118627	Takifugu rubripes	81.25	0.00e+00	1492.00
IUUC-Tsy-119278	Tarsius syrichta	65.28	0.00e+00	1068.00
IUUC-Tni-120804	Tetraodon nigroviridis	83.33	0.00e+00	1508.00
IUUC-Tca-121585	Theobroma cacao	41.25	1.00e-177	616.00
IUUC-Tae-125686	Triticum aestivum	42.15	0.00e+00	650.00
IUUC-Tur-126732	Triticum urartu	39.67	5.00e-175	607.00
IUUC-Tbe-127699	Tupaia belangeri	61.02	0.00e+00	691.00
IUUC-Ttr-128295	Tursiops truncatus	67.06	0.00e+00	1140.00
IUUC-Uma-129599	Ustilago maydis	32.39	2.00e-110	393.00
IUUC-Vpa-130170	Vicugna pacos	65.40	0.00e+00	1018.00
IUUC-Vvi-131116	Vitis vinifera	41.37	1.00e-175	610.00
IUUC-Xtr-132809	Xenopus tropicalis	69.97	0.00e+00	1219.00
IUUC-Xma-134273	Xiphophorus maculatus	84.62	0.00e+00	1535.00
IUUC-Yli-134510	Yarrowia lipolytica	33.10	5.00e-111	395.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence