iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-63	215.9	326	855
UBD/Alpha-Helix/UBA	3.70e-23	81.3	725	762

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpalesgdgeqvpeQKEVQDGIA 413
           7******************************.99999999********************66666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekvalpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 647
           *******************997.*******************98888788888888888888888888888888888888777777777 PP
   S: 268  .................................................................................peekqke. 274
                                                                                                  + 
   Q: 648  ssptspmldesvviqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvA-----Ti 731
           7777777777777777777777777777777776666666666666666666666666666666665555555555555550.....05 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a ++H+G s+ +GHYv
   Q: 732  vsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYV 820
           555555555555566666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 821  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed ++ +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 725  EDCVATIVSMGFSRDQALKALRATNNSLERAVDWIFSH 762
           899*********************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDSSAGTGD PPRKKPTRLA IGVEGGFDLT EDKFEYDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGGACGCG GCTGCGGTGG GGGGGGTACT AGGTACAGTG GGAGCTGCCG TGTGAGGAGG 60
AGCTGCTGCC GGTGTCATGG CGGAGCTGAG TGAGGAGGCG CTGCTGTCAG TGTTACCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:297593

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.55	0.00e+00	652.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.53	0.00e+00	1638.00
IUUC-Atr-002580	Amborella trichopoda	46.20	0.00e+00	743.00
IUUC-Apl-003774	Anas platyrhynchos	91.43	0.00e+00	1530.00
IUUC-Aca-005368	Anolis carolinensis	86.01	0.00e+00	1508.00
IUUC-Aly-005727	Arabidopsis lyrata	47.16	0.00e+00	733.00
IUUC-Ath-006974	Arabidopsis thaliana	47.38	0.00e+00	733.00
IUUC-Ago-007890	Ashbya gossypii	29.18	2.00e-82	300.00
IUUC-Acl-008057	Aspergillus clavatus	34.04	2.00e-125	442.00
IUUC-Afl-008547	Aspergillus flavus	36.68	3.00e-119	422.00
IUUC-Afu-008805	Aspergillus fumigatus	34.52	2.00e-115	410.00
IUUC-Ani-009441	Aspergillus nidulans	32.48	5.00e-99	355.00
IUUC-Ang-009720	Aspergillus niger	34.34	3.00e-120	426.00
IUUC-Aor-010111	Aspergillus oryzae	34.34	2.00e-129	456.00
IUUC-Ate-010531	Aspergillus terreus	32.57	3.00e-105	376.00
IUUC-Ame-011893	Astyanax mexicanus	65.36	0.00e+00	998.00
IUUC-Bgr-012183	Blumeria graminis	33.68	2.00e-122	433.00
IUUC-Bta-013179	Bos taurus	97.87	0.00e+00	1644.00
IUUC-Bci-013858	Botrytis cinerea	34.96	3.00e-131	462.00
IUUC-Bdi-014904	Brachypodium distachyon	47.32	0.00e+00	717.00
IUUC-Bol-015296	Brassica oleracea	47.67	0.00e+00	746.00
IUUC-Bra-017939	Brassica rapa	47.67	0.00e+00	749.00
IUUC-Cel-018625	Caenorhabditis elegans	34.85	4.00e-135	475.00
IUUC-Cja-019063	Callithrix jacchus	96.71	0.00e+00	1617.00
IUUC-Cfa-020976	Canis familiaris	95.40	0.00e+00	1591.00
IUUC-Cpo-022265	Cavia porcellus	95.64	0.00e+00	1588.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.51	2.00e-112	399.00
IUUC-Csa-024177	Chlorocebus sabaeus	94.80	0.00e+00	1451.00
IUUC-Cho-024702	Choloepus hoffmanni	89.12	0.00e+00	989.00
IUUC-Cin-025411	Ciona intestinalis	50.65	0.00e+00	835.00
IUUC-Csv-026347	Ciona savignyi	46.64	0.00e+00	796.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.80	5.00e-114	405.00
IUUC-Cne-026831	Cryptococcus neoformans	35.65	4.00e-130	458.00
IUUC-Dre-027982	Danio rerio	67.36	0.00e+00	1103.00
IUUC-Dno-029034	Dasypus novemcinctus	97.87	0.00e+00	1660.00
IUUC-Dor-030479	Dipodomys ordii	94.92	0.00e+00	724.00
IUUC-Dse-031467	Dothistroma septosporum	36.18	4.00e-132	465.00
IUUC-Dme-032075	Drosophila melanogaster	49.60	0.00e+00	805.00
IUUC-Ete-032865	Echinops telfairi	86.95	0.00e+00	1467.00
IUUC-Eca-034059	Equus caballus	98.01	0.00e+00	1660.00
IUUC-Eeu-035304	Erinaceus europaeus	92.09	0.00e+00	1495.00
IUUC-Fca-035515	Felis catus	98.11	0.00e+00	1649.00
IUUC-Fal-037271	Ficedula albicollis	87.93	0.00e+00	1429.00
IUUC-Fox-037745	Fusarium oxysporum	35.24	3.00e-129	455.00
IUUC-Fso-038158	Fusarium solani	36.01	2.00e-128	453.00
IUUC-Gmo-039071	Gadus morhua	65.53	0.00e+00	1080.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.14	1.00e-119	424.00
IUUC-Gga-040635	Gallus gallus	91.14	0.00e+00	1600.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.61	0.00e+00	1094.00
IUUC-Gma-043614	Glycine max	46.85	0.00e+00	709.00
IUUC-Ggo-044602	Gorilla gorilla	98.23	0.00e+00	1649.00
IUUC-Hsa-045959	Homo sapiens	98.23	0.00e+00	1649.00
IUUC-Hvu-047563	Hordeum vulgare	47.38	1.00e-168	586.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.35	0.00e+00	1651.00
IUUC-Kpa-049156	Komagataella pastoris	32.95	8.00e-115	408.00
IUUC-Lch-049648	Latimeria chalumnae	82.01	0.00e+00	1379.00
IUUC-Lpe-051523	Leersia perrieri	47.00	0.00e+00	721.00
IUUC-Loc-052520	Lepisosteus oculatus	63.16	0.00e+00	1021.00
IUUC-Lma-053216	Leptosphaeria maculans	34.68	1.00e-114	408.00
IUUC-Laf-054327	Loxodonta africana	97.40	0.00e+00	1641.00
IUUC-Mcc-055443	Macaca mulatta	97.87	0.00e+00	1641.00
IUUC-Meu-056298	Macropus eugenii	93.75	0.00e+00	1066.00
IUUC-Mor-057106	Magnaporthe oryzae	35.30	5.00e-131	461.00
IUUC-Mpo-057589	Magnaporthe poae	34.80	5.00e-124	438.00
IUUC-Mtr-058680	Medicago truncatula	48.20	0.00e+00	740.00
IUUC-Mla-058903	Melampsora laricipopulina	32.46	3.00e-120	426.00
IUUC-Mga-059669	Meleagris gallopavo	90.30	0.00e+00	1517.00
IUUC-Mvi-060476	Microbotryum violaceum	34.88	7.00e-121	428.00
IUUC-Mmr-060575	Microcebus murinus	98.35	0.00e+00	1653.00
IUUC-Mdo-062183	Monodelphis domestica	92.09	0.00e+00	1538.00
IUUC-Mmu-063592	Mus musculus	99.17	0.00e+00	1664.00
IUUC-Mac-065634	Musa acuminata	43.12	0.00e+00	691.00
IUUC-Mpu-066082	Mustela putorius furo	94.81	0.00e+00	1577.00
IUUC-Mlu-067345	Myotis lucifugus	95.76	0.00e+00	1608.00
IUUC-Nfi-068558	Neosartorya fischeri	35.30	4.00e-124	438.00
IUUC-Ncr-068960	Neurospora crassa	35.12	1.00e-117	417.00
IUUC-Nle-070173	Nomascus leucogenys	95.40	0.00e+00	1584.00
IUUC-Opr-070556	Ochotona princeps	97.52	0.00e+00	1642.00
IUUC-Ont-071502	Oreochromis niloticus	65.38	0.00e+00	1090.00
IUUC-Ocu-074861	Oryctolagus cuniculus	95.16	0.00e+00	1586.00
IUUC-Oba-075109	Oryza barthii	46.72	0.00e+00	724.00
IUUC-Obr-076292	Oryza brachyantha	48.01	0.00e+00	717.00
IUUC-Ogl-077065	Oryza glaberrima	48.01	0.00e+00	754.00
IUUC-Ogu-078776	Oryza glumaepatula	46.72	0.00e+00	736.00
IUUC-Oin-080048	Oryza indica	47.55	0.00e+00	747.00
IUUC-Olo-080711	Oryza longistaminata	44.90	0.00e+00	666.00
IUUC-Ome-081506	Oryza meridionalis	45.96	0.00e+00	679.00
IUUC-Oni-082320	Oryza nivara	46.16	0.00e+00	723.00
IUUC-Opu-083801	Oryza punctata	46.90	0.00e+00	716.00
IUUC-Oru-085139	Oryza rufipogon	46.16	0.00e+00	723.00
IUUC-Osa-085713	Oryza sativa	48.13	0.00e+00	757.00
IUUC-Ola-086951	Oryzias latipes	66.12	0.00e+00	1090.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.50	5.00e-180	624.00
IUUC-Oga-088625	Otolemur garnettii	97.29	0.00e+00	1631.00
IUUC-Oar-089995	Ovis aries	95.18	0.00e+00	1613.00
IUUC-Ptr-090640	Pan troglodytes	95.51	0.00e+00	1626.00
IUUC-Pan-091974	Papio anubis	96.94	0.00e+00	1623.00
IUUC-Psi-093957	Pelodiscus sinensis	90.12	0.00e+00	1600.00
IUUC-Pma-094242	Petromyzon marinus	71.92	2.00e-165	574.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.90	2.00e-108	386.00
IUUC-Ppa-095901	Physcomitrella patens	49.60	0.00e+00	785.00
IUUC-Pfo-097148	Poecilia formosa	66.51	0.00e+00	1100.00
IUUC-Pab-098068	Pongo abelii	90.55	0.00e+00	1468.00
IUUC-Pop-098943	Populus trichocarpa	47.09	0.00e+00	716.00
IUUC-Pca-100738	Procavia capensis	97.84	0.00e+00	1136.00
IUUC-Ppe-101315	Prunus persica	47.33	0.00e+00	727.00
IUUC-Pva-102154	Pteropus vampyrus	96.58	0.00e+00	1620.00
IUUC-Pgr-103343	Puccinia graminis	34.16	2.00e-110	393.00
IUUC-Ptt-103928	Puccinia triticina	30.44	3.00e-107	383.00
IUUC-Pte-104306	Pyrenophora teres	32.16	3.00e-104	372.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.26	6.00e-107	382.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.00	5.00e-72	265.00
IUUC-Sha-107635	Sarcophilus harrisii	91.97	0.00e+00	1545.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.48	2.00e-110	393.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.23	1.00e-113	404.00
IUUC-Smo-108848	Selaginella moellendorffii	48.18	0.00e+00	740.00
IUUC-Sit-110728	Setaria italica	48.48	0.00e+00	774.00
IUUC-Sly-111523	Solanum lycopersicum	47.62	0.00e+00	762.00
IUUC-Sbi-114419	Sorghum bicolor	47.72	0.00e+00	756.00
IUUC-Sre-115225	Sporisorium reilianum	35.28	5.00e-127	448.00
IUUC-Ssc-115686	Sus scrofa	97.05	0.00e+00	1635.00
IUUC-Tgu-117346	Taeniopygia guttata	90.69	0.00e+00	1567.00
IUUC-Tru-118350	Takifugu rubripes	65.62	0.00e+00	1117.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.47	0.00e+00	1096.00
IUUC-Tca-121585	Theobroma cacao	47.74	0.00e+00	725.00
IUUC-Tre-122043	Trichoderma reesei	33.95	8.00e-120	424.00
IUUC-Tvi-122303	Trichoderma virens	34.84	1.00e-126	447.00
IUUC-Tae-125686	Triticum aestivum	47.42	0.00e+00	734.00
IUUC-Tur-126732	Triticum urartu	44.95	0.00e+00	689.00
IUUC-Tme-126909	Tuber melanosporum	34.68	1.00e-118	421.00
IUUC-Tbe-127261	Tupaia belangeri	90.68	0.00e+00	1031.00
IUUC-Uma-129599	Ustilago maydis	34.35	4.00e-131	462.00
IUUC-Vda-129688	Verticillium dahliae	33.72	4.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	47.39	0.00e+00	705.00
IUUC-Xtr-131953	Xenopus tropicalis	79.51	0.00e+00	1357.00
IUUC-Xma-133837	Xiphophorus maculatus	66.74	0.00e+00	1104.00
IUUC-Yli-134510	Yarrowia lipolytica	35.93	4.00e-131	462.00
IUUC-Zma-135786	Zea mays	47.84	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence