iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tme-126909

Ensembl Protein ID

CAZ81908

UniProt Accession

D5GBQ8; D5GBQ8_TUBMM

Genbank Protein ID

CAZ81908.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

FN430097

Gene Name

GSTUM_00005527001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSTUM_00005527001	CAZ81908	CAZ81908

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.90e-53	178.1	303	787
UBD/Alpha-Helix/UBA	1.30e-19	68.3	656	694

Active Site

Position(s)	Description	Evidence
312	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
743	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.............wkskkk..........avsprellkalk 78
           tGlkNlgN+CY+ S+LQcL+++p + + ++     +l+e+    p  +l ++l+kl   l                  +            +p ++++ ++
   Q: 303  TGLKNLGNSCYLASILQCLFALPVFEKRYNL---PDLPES--LAPADDLETQLRKLADGLlsgrysrpdpdvaA----SeyspeiqhqrGLAPAMFKALIG 394
           7************************999988...555554..66888999999999999955555555555440....044444555559*********** PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           k +eefs+++qqDa E+l +l++ ++++                           ++   ++++   F++ l+++++c  c++v  r++    +s+pvp k
   Q: 395  KGHEEFSTMRQQDAFELLLHLFKLISRSH--------------------------HPGDLEDPV-SEFRFALEQRLQCMGCGKVRYRTDIQDNMSVPVPAK 468
           **************************988..........................455555555.56********************************** PP
   S: 180  eetkke......................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
           +   ++                      ++++cL+ ft+ e +     ++c++c k+ +a+k++ +k+lPevL ++  Rf++   +++++k++  v + +e
   Q: 469  RIPTESldvkmreggnekdknkdvfepvTIKECLDIFTAVEIVG----FNCPSCGKNAKATKRHAFKTLPEVLAVNARRFEYI--NWVPTKLDVPVAVGDE 563
           *987779***********************************98....9*******************************885..5*************** PP
   S: 259  .Ldlspfctspeekqke.................................................................................... 274
            + l+ ++++p ++++e                                                                                    
   Q: 564  pFLLDDYLAKPHSADEEllpedeepgfqadegivgqleamgfprmraekalyhtgnkdseaamnwlfahmddpdidaqmsfapkkdsagtepdeekvsmlg 664
           **********7777777788888888888888888888888888888888888888888888888888888888888888888888888888888888888 PP
   S: 275  ..........................................................kkkYeLiavvvHsG.slssGHYvayvkn...ekgk...Wllfd 310
                                                                     +  +eL+++v+H+G s++ GHYva++++      +   W+lf+
   Q: 665  amgftasqakkalketggdveravewlfshpddmgddevmgesvdpcapkkepgrgekPAPFELHSIVCHKGgSIHAGHYVAFIRKdveG--EgkvWVLFN 763
           8888888888889999999999999999999999999999999999999999999999****************************5542..1458***** PP
   S: 311  DskVtevkeeevleetgstaYvlfYkr 337
           D+kV + +  +v e++ + aYv+f+kr
   Q: 764  DEKVVKAS--DVGEMK-KFAYVYFFKR 787
           ***98885..555533.79******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           de+k+  l +MGF+ ++a++aL ++++++e+Ave+L+++
   Q: 656  DEEKVSMLGAMGFTASQAKKALKETGGDVERAVEWLFSH 694
           89***********************************97 PP

Organism

Tuber melanosporum

Protein Sequence
(Fasta)

MNCQHVSASR LTPPRASQAV HREDCTQCFD GIDDPEGLNV CLSCFNGGCA GERNHALLHH 60
KLSQHPLTLN IRRTKKPRAE RAEPPKKISK LVIEAESEND KYDTHTAVIC YMCGGKEVER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTGCC AACACGTCTC TGCGTCTCGT AGGTTCATCG GTCCAGCTTT AGGGGGGAAA 60
TTTTAACCTT GATAGGCCTT ACCCCACCAA GAGCGAGCCA GGCAGTCCAT AGAGAGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

tml:GSTUM_00005527001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.44	1.00e-92	332.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.14	3.00e-123	434.00
IUUC-Atr-002580	Amborella trichopoda	33.64	2.00e-105	375.00
IUUC-Apl-003774	Anas platyrhynchos	34.44	1.00e-119	422.00
IUUC-Aca-005368	Anolis carolinensis	35.13	8.00e-127	446.00
IUUC-Aly-005727	Arabidopsis lyrata	33.70	3.00e-107	380.00
IUUC-Ath-006974	Arabidopsis thaliana	34.06	1.00e-108	385.00
IUUC-Ago-007890	Ashbya gossypii	31.69	1.00e-109	389.00
IUUC-Acl-008057	Aspergillus clavatus	55.80	0.00e+00	881.00
IUUC-Afl-008547	Aspergillus flavus	56.35	0.00e+00	773.00
IUUC-Afu-008805	Aspergillus fumigatus	53.93	0.00e+00	804.00
IUUC-Ani-009441	Aspergillus nidulans	53.51	0.00e+00	745.00
IUUC-Ang-009720	Aspergillus niger	58.56	0.00e+00	904.00
IUUC-Aor-010111	Aspergillus oryzae	56.98	0.00e+00	932.00
IUUC-Ate-010531	Aspergillus terreus	52.99	0.00e+00	820.00
IUUC-Ame-011893	Astyanax mexicanus	35.30	1.00e-105	375.00
IUUC-Bgr-012183	Blumeria graminis	57.20	0.00e+00	882.00
IUUC-Bta-013179	Bos taurus	34.18	4.00e-123	433.00
IUUC-Bci-013858	Botrytis cinerea	61.06	0.00e+00	985.00
IUUC-Bdi-014904	Brachypodium distachyon	33.54	3.00e-97	347.00
IUUC-Bol-015296	Brassica oleracea	34.10	1.00e-111	395.00
IUUC-Bra-017939	Brassica rapa	34.70	1.00e-112	398.00
IUUC-Cel-018625	Caenorhabditis elegans	31.97	4.00e-84	303.00
IUUC-Cja-019063	Callithrix jacchus	34.10	1.00e-121	428.00
IUUC-Cfa-020976	Canis familiaris	34.55	6.00e-125	439.00
IUUC-Cpo-022265	Cavia porcellus	35.39	1.00e-124	439.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	33.13	9.00e-70	256.00
IUUC-Csa-024177	Chlorocebus sabaeus	34.73	1.00e-112	399.00
IUUC-Cho-024702	Choloepus hoffmanni	32.99	2.00e-75	275.00
IUUC-Cin-025411	Ciona intestinalis	33.09	6.00e-101	360.00
IUUC-Csv-026347	Ciona savignyi	32.34	4.00e-100	357.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	60.85	0.00e+00	898.00
IUUC-Cne-026831	Cryptococcus neoformans	46.38	0.00e+00	657.00
IUUC-Cme-027335	Cyanidioschyzon merolae	34.46	7.00e-63	233.00
IUUC-Dre-027982	Danio rerio	33.45	6.00e-105	373.00
IUUC-Dno-029034	Dasypus novemcinctus	34.22	3.00e-125	440.00
IUUC-Dor-030479	Dipodomys ordii	36.71	1.00e-54	206.00
IUUC-Dse-031467	Dothistroma septosporum	54.61	0.00e+00	843.00
IUUC-Dme-032075	Drosophila melanogaster	33.57	5.00e-104	370.00
IUUC-Ete-032865	Echinops telfairi	31.29	7.00e-101	359.00
IUUC-Eca-034059	Equus caballus	34.22	2.00e-121	427.00
IUUC-Eeu-035304	Erinaceus europaeus	35.52	5.00e-114	403.00
IUUC-Fca-035515	Felis catus	34.57	2.00e-124	438.00
IUUC-Fal-037271	Ficedula albicollis	35.64	1.00e-118	418.00
IUUC-Fox-037745	Fusarium oxysporum	61.59	0.00e+00	945.00
IUUC-Fso-038158	Fusarium solani	61.38	0.00e+00	932.00
IUUC-Gmo-039071	Gadus morhua	35.05	3.00e-117	414.00
IUUC-Ggr-040098	Gaeumannomyces graminis	59.35	0.00e+00	882.00
IUUC-Gga-040635	Gallus gallus	34.38	9.00e-125	439.00
IUUC-Gac-042528	Gasterosteus aculeatus	34.81	7.00e-116	409.00
IUUC-Gma-043614	Glycine max	32.89	1.00e-99	355.00
IUUC-Ggo-044602	Gorilla gorilla	34.72	3.00e-124	437.00
IUUC-Hsa-045959	Homo sapiens	34.72	3.00e-124	437.00
IUUC-Hvu-047563	Hordeum vulgare	36.57	3.00e-97	347.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.33	2.00e-125	441.00
IUUC-Kpa-049156	Komagataella pastoris	40.37	2.00e-168	583.00
IUUC-Lch-049648	Latimeria chalumnae	34.48	5.00e-121	426.00
IUUC-Lpe-051523	Leersia perrieri	32.82	6.00e-97	346.00
IUUC-Loc-052520	Lepisosteus oculatus	31.32	2.00e-95	342.00
IUUC-Lma-053216	Leptosphaeria maculans	62.07	0.00e+00	932.00
IUUC-Laf-054327	Loxodonta africana	33.64	1.00e-122	432.00
IUUC-Mcc-055443	Macaca mulatta	34.34	5.00e-123	433.00
IUUC-Meu-056298	Macropus eugenii	35.01	2.00e-86	311.00
IUUC-Mor-057106	Magnaporthe oryzae	60.33	0.00e+00	937.00
IUUC-Mpo-057589	Magnaporthe poae	59.03	0.00e+00	877.00
IUUC-Mtr-058680	Medicago truncatula	34.41	2.00e-108	385.00
IUUC-Mla-058903	Melampsora laricipopulina	42.84	4.00e-174	603.00
IUUC-Mga-059669	Meleagris gallopavo	34.24	9.00e-119	419.00
IUUC-Mvi-060476	Microbotryum violaceum	44.44	2.00e-172	597.00
IUUC-Mmr-060575	Microcebus murinus	34.22	2.00e-123	434.00
IUUC-Mdo-062183	Monodelphis domestica	34.75	7.00e-127	446.00
IUUC-Mmu-063592	Mus musculus	34.26	3.00e-123	434.00
IUUC-Mac-065634	Musa acuminata	31.32	9.00e-92	329.00
IUUC-Mpu-066082	Mustela putorius furo	34.74	2.00e-123	434.00
IUUC-Mlu-067345	Myotis lucifugus	34.03	3.00e-122	430.00
IUUC-Nfi-068558	Neosartorya fischeri	56.89	0.00e+00	870.00
IUUC-Ncr-068960	Neurospora crassa	60.12	0.00e+00	895.00
IUUC-Nle-070173	Nomascus leucogenys	35.60	5.00e-125	440.00
IUUC-Opr-070556	Ochotona princeps	34.60	5.00e-124	436.00
IUUC-Ont-071502	Oreochromis niloticus	35.42	4.00e-116	410.00
IUUC-Oan-072959	Ornithorhynchus anatinus	40.18	2.00e-45	173.00
IUUC-Ocu-074861	Oryctolagus cuniculus	34.31	8.00e-125	439.00
IUUC-Oba-075109	Oryza barthii	32.49	5.00e-101	360.00
IUUC-Obr-076292	Oryza brachyantha	34.06	2.00e-101	362.00
IUUC-Ogl-077065	Oryza glaberrima	33.05	7.00e-106	376.00
IUUC-Ogu-078776	Oryza glumaepatula	33.25	7.00e-104	369.00
IUUC-Oin-080048	Oryza indica	33.49	7.00e-106	376.00
IUUC-Olo-080711	Oryza longistaminata	32.35	8.00e-96	342.00
IUUC-Ome-081506	Oryza meridionalis	33.04	1.00e-96	345.00
IUUC-Oni-082320	Oryza nivara	31.85	1.00e-99	355.00
IUUC-Opu-083801	Oryza punctata	32.29	6.00e-95	340.00
IUUC-Oru-085139	Oryza rufipogon	31.85	1.00e-99	355.00
IUUC-Osa-085713	Oryza sativa	33.17	5.00e-107	380.00
IUUC-Ola-086951	Oryzias latipes	33.29	4.00e-108	384.00
IUUC-Olu-087822	Ostreococcus lucimarinus	32.15	9.00e-92	329.00
IUUC-Oga-088625	Otolemur garnettii	33.49	6.00e-122	429.00
IUUC-Oar-089995	Ovis aries	34.03	7.00e-124	436.00
IUUC-Ptr-090640	Pan troglodytes	34.88	3.00e-126	444.00
IUUC-Pan-091974	Papio anubis	34.52	1.00e-123	435.00
IUUC-Psi-093957	Pelodiscus sinensis	34.64	3.00e-127	447.00
IUUC-Pma-094242	Petromyzon marinus	38.84	2.00e-66	243.00
IUUC-Pno-094835	Phaeosphaeria nodorum	61.04	0.00e+00	850.00
IUUC-Ppa-095901	Physcomitrella patens	35.91	9.00e-120	422.00
IUUC-Pfo-097148	Poecilia formosa	35.53	9.00e-116	409.00
IUUC-Pab-098068	Pongo abelii	32.91	2.00e-105	374.00
IUUC-Pop-098943	Populus trichocarpa	33.17	1.00e-105	375.00
IUUC-Pca-100738	Procavia capensis	34.19	5.00e-88	317.00
IUUC-Ppe-101315	Prunus persica	34.73	4.00e-110	390.00
IUUC-Pva-102154	Pteropus vampyrus	33.53	6.00e-119	419.00
IUUC-Pgr-103343	Puccinia graminis	42.69	6.00e-143	499.00
IUUC-Ptt-103928	Puccinia triticina	37.77	1.00e-137	481.00
IUUC-Pte-104306	Pyrenophora teres	62.34	0.00e+00	903.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	61.94	0.00e+00	912.00
IUUC-Rno-105801	Rattus norvegicus	34.45	2.00e-123	434.00
IUUC-Sce-106304	Saccharomyces cerevisiae	33.74	3.00e-120	424.00
IUUC-Sha-107635	Sarcophilus harrisii	34.97	3.00e-124	437.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	42.19	1.00e-166	578.00
IUUC-Spo-108144	Schizosaccharomyces pombe	39.58	1.00e-163	567.00
IUUC-Smo-108848	Selaginella moellendorffii	37.21	1.00e-120	425.00
IUUC-Sit-110728	Setaria italica	34.10	2.00e-109	388.00
IUUC-Sly-111523	Solanum lycopersicum	34.70	3.00e-114	404.00
IUUC-Stu-112122	Solanum tuberosum	41.54	2.00e-10	58.50
IUUC-Sar-113733	Sorex araneus	34.15	1.00e-59	222.00
IUUC-Sbi-114419	Sorghum bicolor	34.14	4.00e-111	393.00
IUUC-Sre-115225	Sporisorium reilianum	46.67	0.00e+00	664.00
IUUC-Ssc-115686	Sus scrofa	34.41	7.00e-125	439.00
IUUC-Tgu-117346	Taeniopygia guttata	34.22	7.00e-123	432.00
IUUC-Tru-118350	Takifugu rubripes	32.36	8.00e-110	389.00
IUUC-Tsy-119278	Tarsius syrichta	29.26	2.00e-86	311.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.02	2.00e-105	374.00
IUUC-Tca-121585	Theobroma cacao	33.25	2.00e-105	375.00
IUUC-Tre-122043	Trichoderma reesei	61.65	0.00e+00	916.00
IUUC-Tvi-122303	Trichoderma virens	60.83	0.00e+00	913.00
IUUC-Tae-123798	Triticum aestivum	33.17	1.00e-105	375.00
IUUC-Tur-126732	Triticum urartu	31.74	4.00e-95	340.00
IUUC-Tbe-127261	Tupaia belangeri	31.03	7.00e-69	253.00
IUUC-Ttr-129119	Tursiops truncatus	35.67	1.00e-56	213.00
IUUC-Uma-129599	Ustilago maydis	46.33	0.00e+00	696.00
IUUC-Vda-129688	Verticillium dahliae	60.45	0.00e+00	908.00
IUUC-Vpa-130170	Vicugna pacos	32.56	5.00e-45	174.00
IUUC-Vvi-131116	Vitis vinifera	33.21	1.00e-102	365.00
IUUC-Xtr-131953	Xenopus tropicalis	33.87	3.00e-116	410.00
IUUC-Xma-133837	Xiphophorus maculatus	35.29	5.00e-115	406.00
IUUC-Yli-134510	Yarrowia lipolytica	44.80	7.00e-179	619.00
IUUC-Zma-135786	Zea mays	33.86	4.00e-107	380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence