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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045660
UUCD1 version UUC-HoS-00182
Ensembl Protein ID ENSP00000391529.2
UniProt Accession Q7Z3V4; A5D8Z3; Q05BX9; Q659F7; Q7Z7Q1; Q9BXZ4; UBE3B_HUMAN; UBE3B_v1; UBE3B_v2
Genbank Protein ID AAK28419.2; CAH56410.1; CAD97645.1; AAH32301.1; AAH51266.1; AAH68221.1; AAI08706.1; AAI41881.1
Protein Name Ubiquitin-protein ligase E3B; HECT-type ubiquitin transferase E3B
Genbank Nucleotide ID AF251046; AL096740; BX537403; AC007570; BC051266; BC068221; BC108705; BC141880
Gene Name UBE3B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000151148.13 ENST00000434735.6 ENSP00000391529.2
ENSG00000151148.13 ENST00000536398.5 ENSP00000440585.1
ENSG00000151148.13 ENST00000449510.6 ENSP00000395802.2
ENSG00000151148.13 ENST00000537063.1 ENSP00000437694.1
ENSG00000151148.13 ENST00000605142.1 ENSP00000474360.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 12689446
Classification
Family E-value Score Start End
E3 activity/HECT 1.40e-113 381.4 703 1068
Active Site
Position(s) Description Evidence
1036 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka+++g 
   Q: 703  QHAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGI 790
           7899********************************************99987665.59*******76.********************* PP
   S: 87   lldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
           ++d+p++++f+++llg+       s+++l+++d+e+yk+l++ik++ + di++lgl+l++  +e+++g+  ++eL+pgG++ipVtneNk 
   Q: 791  VVDVPFASFFLSQLLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDITDLGLTLSY--DEDVMGQLVCHELIPGGKTIPVTNENKI 877
           *****************777777999********************.7899998777776..5899************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevl.eefsse 259
           +Y++l++++r++++ik+q++a+ +Gf+++i++e++++F++ el+ li+G+ +eid+edlkk+t y gg++ ++++i+w+w++l ++f+ +
   Q: 878  SYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDnAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILaSDFTPD 967
           **************************************************9********************************99***** PP
   S: 260  erkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLly 325
           er++fL+FvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Ys+k++l+ekL+y
   Q: 968  ERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRY 1057
           ********************************************************8888****************************** PP
   S: 326  AieetkgFels 336
           Ai++++gFels
   Q: 1058 AISMNTGFELS 1068
           ********985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MFTLSQTSRA WFIDRARQAR EERLVQKERE RAAVVIQAHV RSFLCRSRLQ RDIRREIDDF 60
FKADDPESTK RSALCIFKIA RKLLFLFRIK EDNERFEKLC RSILSSMDAE NEPKVWYVSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045660|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACGTCTTAA GCCGTCCGTT GTGCGCCTAG GGGCCAGTTT TCTTTCCAGC CTCCCCGGCC 60
GGAGTGGGTT CCAGCTTTTC TCGGCTGGGG AGGGCATTTA TCCCACCTCC GCTATTTCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045660|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
PROSITE

PS50237--HECT
PS50096--IQ
Pfam

PF00632--HECT
SMART

SM00119--HECTc
SM00015--IQ
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
KEGG hsa:89910
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000128 Aegilops tauschii 36.23 4.00e-106 380.00
IUUC-Aml-002107 Ailuropoda melanoleuca 96.72 0.00e+00 2095.00
IUUC-Atr-003017 Amborella trichopoda 38.48 1.00e-109 391.00
IUUC-Apl-003328 Anas platyrhynchos 88.21 0.00e+00 1850.00
IUUC-Aly-005794 Arabidopsis lyrata 38.93 3.00e-109 390.00
IUUC-Ath-007269 Arabidopsis thaliana 39.29 9.00e-112 398.00
IUUC-Bta-013547 Bos taurus 95.60 0.00e+00 2095.00
IUUC-Bdi-014502 Brachypodium distachyon 39.15 2.00e-109 390.00
IUUC-Bol-015093 Brassica oleracea 40.00 5.00e-113 402.00
IUUC-Bra-016722 Brassica rapa 40.00 1.00e-113 405.00
IUUC-Cel-018447 Caenorhabditis elegans 37.57 0.00e+00 679.00
IUUC-Cja-019855 Callithrix jacchus 98.50 0.00e+00 2128.00
IUUC-Cfa-020066 Canis familiaris 96.31 0.00e+00 2070.00
IUUC-Cpo-021504 Cavia porcellus 94.94 0.00e+00 2077.00
IUUC-Csa-023579 Chlorocebus sabaeus 98.69 0.00e+00 2138.00
IUUC-Cho-024430 Choloepus hoffmanni 85.79 0.00e+00 1547.00
IUUC-Cin-025750 Ciona intestinalis 47.34 0.00e+00 979.00
IUUC-Csv-026016 Ciona savignyi 48.04 0.00e+00 1022.00
IUUC-Dre-028271 Danio rerio 81.31 0.00e+00 1758.00
IUUC-Dno-029054 Dasypus novemcinctus 96.07 0.00e+00 2080.00
IUUC-Dor-030938 Dipodomys ordii 87.45 0.00e+00 1858.00
IUUC-Dme-031602 Drosophila melanogaster 48.11 0.00e+00 969.00
IUUC-Ete-033041 Echinops telfairi 76.60 0.00e+00 1372.00
IUUC-Eca-034411 Equus caballus 96.72 0.00e+00 2068.00
IUUC-Eeu-035201 Erinaceus europaeus 84.91 0.00e+00 806.00
IUUC-Fca-036594 Felis catus 95.22 0.00e+00 2044.00
IUUC-Fal-037317 Ficedula albicollis 84.48 0.00e+00 1860.00
IUUC-Gmo-039412 Gadus morhua 77.46 0.00e+00 1720.00
IUUC-Gga-040149 Gallus gallus 87.94 0.00e+00 1878.00
IUUC-Gac-042088 Gasterosteus aculeatus 79.93 0.00e+00 1804.00
IUUC-Gma-042728 Glycine max 40.67 2.00e-111 397.00
IUUC-Ggo-045279 Gorilla gorilla 99.53 0.00e+00 2151.00
IUUC-Hvu-047102 Hordeum vulgare 36.23 2.00e-106 380.00
IUUC-Itr-048021 Ictidomys tridecemlineatus 94.14 0.00e+00 1056.00
IUUC-Lch-050664 Latimeria chalumnae 82.26 0.00e+00 1816.00
IUUC-Lpe-050755 Leersia perrieri 37.04 4.00e-98 353.00
IUUC-Loc-052791 Lepisosteus oculatus 82.50 0.00e+00 1777.00
IUUC-Laf-053902 Loxodonta africana 96.16 0.00e+00 2085.00
IUUC-Mcc-054730 Macaca mulatta 98.60 0.00e+00 2138.00
IUUC-Meu-056527 Macropus eugenii 79.76 0.00e+00 1668.00
IUUC-Mtr-057671 Medicago truncatula 39.43 2.00e-111 397.00
IUUC-Mga-059260 Meleagris gallopavo 87.69 0.00e+00 1879.00
IUUC-Mmr-060804 Microcebus murinus 94.57 0.00e+00 2006.00
IUUC-Mdo-062575 Monodelphis domestica 84.03 0.00e+00 1791.00
IUUC-Mmu-063636 Mus musculus 91.50 0.00e+00 1941.00
IUUC-Mac-064989 Musa acuminata 39.54 2.00e-107 384.00
IUUC-Mpu-066677 Mustela putorius furo 96.22 0.00e+00 1961.00
IUUC-Mlu-067952 Myotis lucifugus 95.42 0.00e+00 1992.00
IUUC-Nle-069153 Nomascus leucogenys 99.16 0.00e+00 2146.00
IUUC-Opr-070554 Ochotona princeps 94.59 0.00e+00 1877.00
IUUC-Ont-071372 Oreochromis niloticus 81.10 0.00e+00 1786.00
IUUC-Oan-073327 Ornithorhynchus anatinus 70.83 0.00e+00 732.00
IUUC-Ocu-074183 Oryctolagus cuniculus 94.95 0.00e+00 2040.00
IUUC-Oba-075213 Oryza barthii 38.65 3.00e-106 380.00
IUUC-Obr-076320 Oryza brachyantha 35.38 2.00e-109 390.00
IUUC-Ogl-077093 Oryza glaberrima 38.82 7.00e-109 389.00
IUUC-Ogu-078947 Oryza glumaepatula 37.28 4.00e-110 392.00
IUUC-Oin-080058 Oryza indica 39.09 1.00e-108 388.00
IUUC-Olo-080742 Oryza longistaminata 35.18 4.00e-108 387.00
IUUC-Ome-081741 Oryza meridionalis 34.72 6.00e-102 365.00
IUUC-Oni-082385 Oryza nivara 37.28 5.00e-110 392.00
IUUC-Opu-083529 Oryza punctata 35.22 6.00e-109 389.00
IUUC-Oru-085128 Oryza rufipogon 36.69 2.00e-95 344.00
IUUC-Osa-085557 Oryza sativa 39.36 2.00e-108 386.00
IUUC-Ola-087337 Oryzias latipes 80.45 0.00e+00 1724.00
IUUC-Oga-088342 Otolemur garnettii 95.32 0.00e+00 1984.00
IUUC-Oar-090234 Ovis aries 95.46 0.00e+00 2068.00
IUUC-Ptr-091661 Pan troglodytes 99.44 0.00e+00 2149.00
IUUC-Pan-092728 Papio anubis 98.41 0.00e+00 2132.00
IUUC-Psi-093251 Pelodiscus sinensis 87.59 0.00e+00 1749.00
IUUC-Pma-094195 Petromyzon marinus 69.74 0.00e+00 1442.00
IUUC-Ppa-095544 Physcomitrella patens 37.87 5.00e-110 393.00
IUUC-Pfo-097472 Poecilia formosa 80.73 0.00e+00 1790.00
IUUC-Pab-098570 Pongo abelii 99.06 0.00e+00 2143.00
IUUC-Pca-100110 Procavia capensis 83.43 0.00e+00 1739.00
IUUC-Ppe-101281 Prunus persica 39.01 3.00e-107 384.00
IUUC-Pva-102887 Pteropus vampyrus 91.21 0.00e+00 1943.00
IUUC-Rno-106028 Rattus norvegicus 88.42 0.00e+00 1842.00
IUUC-Sha-107331 Sarcophilus harrisii 85.07 0.00e+00 1810.00
IUUC-Smo-109488 Selaginella moellendorffii 36.96 1.00e-105 378.00
IUUC-Sit-109811 Setaria italica 35.75 4.00e-111 396.00
IUUC-Sly-111362 Solanum lycopersicum 35.50 6.00e-102 365.00
IUUC-Sar-113287 Sorex araneus 85.48 0.00e+00 731.00
IUUC-Sbi-114433 Sorghum bicolor 35.66 9.00e-112 398.00
IUUC-Ssc-116103 Sus scrofa 96.35 0.00e+00 2056.00
IUUC-Tgu-117275 Taeniopygia guttata 87.57 0.00e+00 1867.00
IUUC-Tru-118681 Takifugu rubripes 79.70 0.00e+00 1798.00
IUUC-Tsy-118985 Tarsius syrichta 91.90 0.00e+00 1043.00
IUUC-Tni-120850 Tetraodon nigroviridis 91.48 0.00e+00 776.00
IUUC-Tca-121770 Theobroma cacao 39.18 2.00e-111 397.00
IUUC-Tae-125466 Triticum aestivum 36.82 8.00e-109 388.00
IUUC-Tur-126086 Triticum urartu 36.23 2.00e-105 377.00
IUUC-Tbe-127461 Tupaia belangeri 91.39 0.00e+00 1897.00
IUUC-Ttr-129269 Tursiops truncatus 95.51 0.00e+00 2040.00
IUUC-Vpa-130523 Vicugna pacos 76.36 4.00e-127 449.00
IUUC-Vvi-131524 Vitis vinifera 39.04 4.00e-109 389.00
IUUC-Xtr-132146 Xenopus tropicalis 83.30 0.00e+00 1830.00
IUUC-Xma-133526 Xiphophorus maculatus 80.45 0.00e+00 1783.00
Created Date 25-Jun-2017

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