iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006653

Ensembl Protein ID

AT3G57130.1

UniProt Accession

Q9M1I7; NPR6_ARATH

Genbank Protein ID

CAB72183.1; AEE79617.1; AAY78777.1; ABH04470.1; BAH30493.1

Protein Name

Regulatory protein NPR6; BTB/POZ domain-containing protein NPR6; Protein BLADE-ON-PETIOLE 1

Genbank Nucleotide ID

AL138655; CP002686; DQ056629; BT026363; AB493655

Gene Name

NPR6; BOP1; At3g57130; F24I3.210

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G57130	AT3G57130.1	AT3G57130.1
AT3G57130	AT3G57130.2	AT3G57130.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.20e-12	46.9	27	109

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmelees................ksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+g+ ++ah+++Laa+S +F++ f +++ + +                  ++ + ++ v +evf  ll+FlY+g++++
   Q: 27   SDVTFSVEGRLVHAHRCILAARSLFFRKFFcESDPS-QpgaepanqtgsgaraaAVGGVIPVNSVGYEVFLLLLQFLYSGQVSI 109
           6*****************************544444.458**************559************************975 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones and suppression of bract formation.

Protein Sequence
(Fasta)

MSNTFEESLK SMSLDYLNLL INGQAFSDVT FSVEGRLVHA HRCILAARSL FFRKFFCESD 60
PSQPGAEPAN QTGSGARAAA VGGVIPVNSV GYEVFLLLLQ FLYSGQVSIV PHKHEPRSNC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCTAAACA CTATAGTCTC TCTCTCTCTT CTTCATCTTC TCCATAAGCT TCTAAAGATA 60
TATAAAAGCT TGTGACTCTT CTTCACTTAA AGAAATATTT GCTTACGAAA GAAAACCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR024228--NPR_central_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF12796--Ank_2
PF00651--BTB
PF11900--DUF3420

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0010434--P:bract formation
GO:0010582--P:floral meristem determinacy
GO:0010227--P:floral organ abscission
GO:0048439--P:flower morphogenesis
GO:0009864--P:induced systemic resistance, jasmonic acid mediated signaling pathway
GO:0009965--P:leaf morphogenesis
GO:0010022--P:meristem determinacy
GO:0010254--P:nectary development
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0009954--P:proximal/distal pattern formation
GO:0030162--P:regulation of proteolysis

KEGG

ath:AT3G57130

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006156	Arabidopsis lyrata	97.77	0.00e+00	862.00
IUUC-Bol-016208	Brassica oleracea	89.20	0.00e+00	758.00
IUUC-Bra-017182	Brassica rapa	89.43	0.00e+00	761.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence