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Tag Content
iUUCD ID IUUC-Gac-042111
Ensembl Protein ID ENSGACP00000022979.1
UniProt Accession G3PZD9; G3PZD9_GASAC
Protein Name Ubiquitin-related modifier 1
Gene Name urm1; URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGACG00000017389.1 ENSGACT00000023022.1 ENSGACP00000022979.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 39.39 1.00e-15 75.90 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Gasterosteus aculeatus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPIAIHLE FGGGAELLFN GVKKHHVDLP SQSEPWDVKQ LLVWIQRNLL RERPELFVQG 60
DSVRPGILVL INDADWELMG ELDYQLQDQD NVVFISTLHG G 101
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Protein Fasta Sequence


>IUUC-Gac-042111|ULD,UBQ_Other|Gasterosteus aculeatus
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Nucleotide Sequence
(Fasta)
ATGGCAGCGC CCATAGCAAT TCACCTGGAG TTTGGGTAGG CGAATATCAG ACTCTTTATG 60
ATAATATAGT TTGCGAGTTG TGTTGCTCAG TGAGCCGTTG TGAGGGAAAA GCTTTTTATC 120
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Nucleotide Fasta Sequence


>IUUC-Gac-042111|ULD,UBQ_Other|Gasterosteus aculeatus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 78.22 3.00e-46 175.00
IUUC-Atr-003089 Amborella trichopoda 56.57 6.00e-31 124.00
IUUC-Apl-003382 Anas platyrhynchos 82.42 4.00e-41 158.00
IUUC-Aca-004981 Anolis carolinensis 83.17 1.00e-47 180.00
IUUC-Aly-005517 Arabidopsis lyrata 55.43 2.00e-27 113.00
IUUC-Ath-006718 Arabidopsis thaliana 55.00 4.00e-24 102.00
IUUC-Ago-007917 Ashbya gossypii 40.40 2.00e-18 83.60
IUUC-Acl-008054 Aspergillus clavatus 68.00 7.00e-16 74.70
IUUC-Afl-008704 Aspergillus flavus 53.33 1.00e-20 90.10
IUUC-Aor-009890 Aspergillus oryzae 51.96 4.00e-24 102.00
IUUC-Bta-012448 Bos taurus 79.21 2.00e-46 176.00
IUUC-Bci-013865 Botrytis cinerea 47.52 1.00e-21 94.40
IUUC-Bdi-014980 Brachypodium distachyon 57.65 5.00e-24 102.00
IUUC-Bol-016055 Brassica oleracea 55.00 1.00e-24 103.00
IUUC-Bra-016845 Brassica rapa 55.00 1.00e-24 103.00
IUUC-Cel-018485 Caenorhabditis elegans 34.95 4.00e-11 59.30
IUUC-Cja-019587 Callithrix jacchus 80.20 2.00e-46 176.00
IUUC-Cfa-020653 Canis familiaris 78.22 3.00e-46 176.00
IUUC-Cpo-021622 Cavia porcellus 80.20 2.00e-46 176.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 55.10 2.00e-26 110.00
IUUC-Csa-023756 Chlorocebus sabaeus 75.95 7.00e-34 135.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 43.56 9.00e-21 91.70
IUUC-Cne-026953 Cryptococcus neoformans 54.37 1.00e-27 115.00
IUUC-Cme-027314 Cyanidioschyzon merolae 46.46 7.00e-21 91.70
IUUC-Dre-027884 Danio rerio 83.17 2.00e-47 179.00
IUUC-Dno-029262 Dasypus novemcinctus 77.50 4.00e-35 140.00
IUUC-Dor-030601 Dipodomys ordii 53.47 2.00e-23 100.00
IUUC-Dme-031893 Drosophila melanogaster 60.78 2.00e-31 126.00
IUUC-Ete-032773 Echinops telfairi 78.22 2.00e-43 166.00
IUUC-Eca-034187 Equus caballus 79.21 2.00e-46 176.00
IUUC-Eeu-034808 Erinaceus europaeus 75.25 8.00e-45 171.00
IUUC-Fca-036107 Felis catus 78.22 1.00e-46 177.00
IUUC-Fal-036607 Ficedula albicollis 80.22 2.00e-40 155.00
IUUC-Fox-037698 Fusarium oxysporum 45.19 2.00e-21 93.60
IUUC-Gmo-039492 Gadus morhua 85.15 9.00e-48 181.00
IUUC-Ggr-039965 Gaeumannomyces graminis 46.15 7.00e-20 89.40
IUUC-Gga-041268 Gallus gallus 80.20 4.00e-46 175.00
IUUC-Gma-043240 Glycine max 65.62 6.00e-23 98.20
IUUC-Ggo-045176 Gorilla gorilla 74.68 5.00e-27 113.00
IUUC-Hsa-046077 Homo sapiens 78.22 1.00e-39 154.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 82.02 3.00e-34 135.00
IUUC-Kpa-049157 Komagataella pastoris 46.46 3.00e-19 85.90
IUUC-Lch-049889 Latimeria chalumnae 79.21 3.00e-47 179.00
IUUC-Lpe-050783 Leersia perrieri 56.63 2.00e-22 97.10
IUUC-Loc-052400 Lepisosteus oculatus 84.16 4.00e-48 182.00
IUUC-Lma-053259 Leptosphaeria maculans 46.53 1.00e-20 91.30
IUUC-Laf-053596 Loxodonta africana 79.61 1.00e-45 173.00
IUUC-Mcc-054845 Macaca mulatta 75.51 5.00e-41 158.00
IUUC-Meu-055968 Macropus eugenii 80.20 3.00e-47 179.00
IUUC-Mor-057126 Magnaporthe oryzae 43.27 1.00e-17 81.60
IUUC-Mpo-057311 Magnaporthe poae 47.52 3.00e-21 94.00
IUUC-Mtr-058266 Medicago truncatula 51.81 8.00e-22 94.70
IUUC-Mla-058847 Melampsora laricipopulina 40.78 7.00e-13 65.50
IUUC-Mga-059468 Meleagris gallopavo 82.42 3.00e-41 159.00
IUUC-Mvi-060235 Microbotryum violaceum 35.76 1.00e-18 85.50
IUUC-Mdo-061948 Monodelphis domestica 80.20 9.00e-47 177.00
IUUC-Mmu-063946 Mus musculus 79.21 4.00e-46 175.00
IUUC-Mac-064812 Musa acuminata 57.83 4.00e-25 105.00
IUUC-Mpu-066763 Mustela putorius furo 78.22 2.00e-45 172.00
IUUC-Mlu-066970 Myotis lucifugus 77.22 3.00e-34 135.00
IUUC-Ncr-068824 Neurospora crassa 47.52 7.00e-20 88.60
IUUC-Nle-069849 Nomascus leucogenys 75.95 7.00e-34 135.00
IUUC-Opr-070227 Ochotona princeps 80.20 2.00e-46 176.00
IUUC-Ont-072530 Oreochromis niloticus 95.05 6.00e-52 194.00
IUUC-Oan-073191 Ornithorhynchus anatinus 83.15 2.00e-41 159.00
IUUC-Ocu-074460 Oryctolagus cuniculus 78.57 7.00e-45 171.00
IUUC-Oba-075499 Oryza barthii 58.33 1.00e-22 98.60
IUUC-Obr-076896 Oryza brachyantha 55.95 2.00e-21 95.90
IUUC-Ogl-077834 Oryza glaberrima 59.76 3.00e-23 99.40
IUUC-Ogu-078622 Oryza glumaepatula 59.76 3.00e-23 99.40
IUUC-Oin-079358 Oryza indica 56.82 1.00e-22 99.00
IUUC-Olo-081035 Oryza longistaminata 55.56 2.00e-24 104.00
IUUC-Oni-082425 Oryza nivara 59.76 3.00e-23 99.40
IUUC-Opu-083461 Oryza punctata 58.02 5.00e-22 96.70
IUUC-Oru-084875 Oryza rufipogon 60.56 8.00e-21 91.30
IUUC-Oga-089128 Otolemur garnettii 79.21 2.00e-46 176.00
IUUC-Oar-089896 Ovis aries 79.21 2.00e-46 176.00
IUUC-Ptr-091618 Pan troglodytes 74.68 6.00e-27 112.00
IUUC-Pan-092238 Papio anubis 75.95 7.00e-34 135.00
IUUC-Psi-093879 Pelodiscus sinensis 78.22 2.00e-45 172.00
IUUC-Pma-094484 Petromyzon marinus 77.23 4.00e-35 139.00
IUUC-Ppa-095801 Physcomitrella patens 57.14 3.00e-22 96.30
IUUC-Pfo-097192 Poecilia formosa 90.10 4.00e-51 192.00
IUUC-Pab-098203 Pongo abelii 78.22 2.00e-39 153.00
IUUC-Pop-099614 Populus trichocarpa 57.14 4.00e-24 102.00
IUUC-Pca-100507 Procavia capensis 75.95 3.00e-34 135.00
IUUC-Ppe-101174 Prunus persica 57.58 8.00e-30 121.00
IUUC-Pva-102735 Pteropus vampyrus 78.22 1.00e-42 164.00
IUUC-Pgr-103510 Puccinia graminis 37.86 3.00e-11 60.10
IUUC-Ptt-103918 Puccinia triticina 35.92 2.00e-10 57.40
IUUC-Pte-104173 Pyrenophora teres 50.49 2.00e-23 100.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 50.49 1.00e-23 100.00
IUUC-Rno-105820 Rattus norvegicus 79.21 5.00e-46 174.00
IUUC-Sce-106366 Saccharomyces cerevisiae 39.39 4.00e-16 75.90
IUUC-Sja-107727 Schizosaccharomyces japonicus 44.79 1.00e-17 81.30
IUUC-Spo-108074 Schizosaccharomyces pombe 42.00 2.00e-10 56.60
IUUC-Smo-108944 Selaginella moellendorffii 62.92 6.00e-27 111.00
IUUC-Sit-110277 Setaria italica 60.71 8.00e-25 104.00
IUUC-Sly-111505 Solanum lycopersicum 53.57 1.00e-23 100.00
IUUC-Stu-112076 Solanum tuberosum 54.76 4.00e-24 102.00
IUUC-Sbi-114274 Sorghum bicolor 67.19 3.00e-23 99.80
IUUC-Sre-114953 Sporisorium reilianum 58.82 2.00e-27 113.00
IUUC-Ssc-115418 Sus scrofa 80.20 2.00e-46 176.00
IUUC-Tgu-117311 Taeniopygia guttata 80.22 3.00e-40 155.00
IUUC-Tru-118598 Takifugu rubripes 88.76 2.00e-42 162.00
IUUC-Tni-120109 Tetraodon nigroviridis 87.25 2.00e-47 180.00
IUUC-Tca-120942 Theobroma cacao 55.42 9.00e-24 100.00
IUUC-Tre-122099 Trichoderma reesei 47.31 3.00e-15 72.40
IUUC-Tvi-122285 Trichoderma virens 47.12 2.00e-18 83.60
IUUC-Tae-125193 Triticum aestivum 58.33 7.00e-23 98.20
IUUC-Tur-126677 Triticum urartu 51.04 3.00e-20 89.70
IUUC-Tme-127120 Tuber melanosporum 46.15 4.00e-24 102.00
IUUC-Tbe-128050 Tupaia belangeri 59.41 1.00e-28 117.00
IUUC-Ttr-129019 Tursiops truncatus 76.24 5.00e-43 165.00
IUUC-Uma-129483 Ustilago maydis 57.84 3.00e-25 106.00
IUUC-Vda-129690 Verticillium dahliae 41.07 1.00e-16 78.20
IUUC-Vvi-131174 Vitis vinifera 56.63 1.00e-23 100.00
IUUC-Xma-133862 Xiphophorus maculatus 90.10 4.00e-51 192.00
IUUC-Yli-134398 Yarrowia lipolytica 47.47 6.00e-19 85.10
IUUC-Zma-134964 Zea mays 54.12 1.00e-22 97.80
Created Date 25-Jun-2017

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