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Tag Content
iUUCD ID IUUC-Tca-120942
Ensembl Protein ID EOX96118
UniProt Accession A0A061E1H8; A0A061E1H8_THECC
Genbank Protein ID EOX96118.1
Protein Name Ubiquitin-related modifier 1 homolog
Genbank Nucleotide ID CM001879
Gene Name TCM_005444
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
TCM_005444 EOX96118 EOX96118
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 37.35 4.00e-12 63.90 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Theobroma cacao
Functional Description
(View)

Functional Description



     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MQLTLEFGGG LELLCESVKV HNVNIDLPKG ADKLTMRYLL SWVRTDLIKE RPEMFMKGES 60
VRPGVLVLVN DCDWELTGQL DTTLEEKDVV VFISTLHGG 99
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Protein Fasta Sequence



>IUUC-Tca-120942|ULD,UBQ_Other|Theobroma cacao
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Nucleotide Sequence
(Fasta)
GCAAAATCCC GAGTAAGGGT TTTTGAGTTT CTGCGGAAAT TTGTTCAGAA TGCAATTGAC 60
TCTTGAGTTT GGGTAAGTTT TCTACTTCCT TTCCTGTCTT TAATCAAAAC TGATTATCAG 120
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Nucleotide Fasta Sequence



>IUUC-Tca-120942|ULD,UBQ_Other|Theobroma cacao
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 54.55 3.00e-28 115.00
IUUC-Atr-003089 Amborella trichopoda 67.68 2.00e-37 146.00
IUUC-Apl-003382 Anas platyrhynchos 59.14 2.00e-28 115.00
IUUC-Aca-004981 Anolis carolinensis 56.70 9.00e-29 117.00
IUUC-Aly-005517 Arabidopsis lyrata 79.35 9.00e-41 156.00
IUUC-Ath-006718 Arabidopsis thaliana 81.82 7.00e-38 147.00
IUUC-Ago-007917 Ashbya gossypii 35.64 4.00e-17 78.60
IUUC-Acl-008054 Aspergillus clavatus 54.00 2.00e-12 62.40
IUUC-Afl-008704 Aspergillus flavus 48.48 1.00e-14 70.10
IUUC-Aor-009890 Aspergillus oryzae 43.14 1.00e-18 84.00
IUUC-Bta-012448 Bos taurus 55.56 2.00e-28 115.00
IUUC-Bci-013865 Botrytis cinerea 37.86 6.00e-17 77.80
IUUC-Bdi-014980 Brachypodium distachyon 68.18 8.00e-29 117.00
IUUC-Bol-016055 Brassica oleracea 75.29 9.00e-37 143.00
IUUC-Bra-016845 Brassica rapa 75.29 9.00e-37 143.00
IUUC-Cel-018485 Caenorhabditis elegans 34.95 2.00e-11 59.30
IUUC-Cja-019587 Callithrix jacchus 54.55 3.00e-28 115.00
IUUC-Cfa-020653 Canis familiaris 54.55 2.00e-28 115.00
IUUC-Cpo-021622 Cavia porcellus 54.55 3.00e-28 115.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 51.52 2.00e-28 115.00
IUUC-Csa-023756 Chlorocebus sabaeus 51.32 3.00e-19 86.70
IUUC-Cgl-026518 Colletotrichum gloeosporioides 35.64 8.00e-15 71.20
IUUC-Cne-026953 Cryptococcus neoformans 48.57 2.00e-24 103.00
IUUC-Cme-027314 Cyanidioschyzon merolae 48.98 7.00e-21 90.90
IUUC-Dre-027884 Danio rerio 59.79 1.00e-30 123.00
IUUC-Dno-029262 Dasypus novemcinctus 50.63 4.00e-19 86.70
IUUC-Dor-030601 Dipodomys ordii 54.69 5.00e-15 71.20
IUUC-Dme-031893 Drosophila melanogaster 49.49 4.00e-25 105.00
IUUC-Ete-032773 Echinops telfairi 53.61 9.00e-27 110.00
IUUC-Eca-034187 Equus caballus 53.54 4.00e-28 115.00
IUUC-Eeu-034808 Erinaceus europaeus 51.52 2.00e-27 112.00
IUUC-Fca-036107 Felis catus 53.54 6.00e-28 114.00
IUUC-Fal-036607 Ficedula albicollis 56.99 7.00e-27 110.00
IUUC-Fox-037698 Fusarium oxysporum 34.65 3.00e-14 69.30
IUUC-Gmo-039492 Gadus morhua 58.76 7.00e-29 117.00
IUUC-Ggr-039965 Gaeumannomyces graminis 36.63 4.00e-14 69.70
IUUC-Gga-041268 Gallus gallus 58.76 6.00e-30 120.00
IUUC-Gac-042111 Gasterosteus aculeatus 55.56 4.00e-29 118.00
IUUC-Gma-043240 Glycine max 77.65 3.00e-36 142.00
IUUC-Ggo-045176 Gorilla gorilla 51.32 4.00e-14 69.70
IUUC-Hsa-046077 Homo sapiens 53.54 4.00e-23 98.20
IUUC-Itr-048111 Ictidomys tridecemlineatus 56.04 3.00e-21 91.70
IUUC-Kpa-049157 Komagataella pastoris 38.61 8.00e-16 73.90
IUUC-Lch-049889 Latimeria chalumnae 56.57 2.00e-28 115.00
IUUC-Lpe-050783 Leersia perrieri 68.67 2.00e-30 122.00
IUUC-Loc-052400 Lepisosteus oculatus 55.56 5.00e-29 118.00
IUUC-Lma-053259 Leptosphaeria maculans 37.62 9.00e-15 70.90
IUUC-Laf-053596 Loxodonta africana 53.47 1.00e-26 110.00
IUUC-Mcc-054845 Macaca mulatta 54.44 3.00e-25 105.00
IUUC-Meu-055968 Macropus eugenii 54.55 1.00e-28 117.00
IUUC-Mor-057126 Magnaporthe oryzae 35.92 2.00e-13 67.00
IUUC-Mpo-057311 Magnaporthe poae 34.95 5.00e-14 69.30
IUUC-Mtr-058266 Medicago truncatula 78.16 4.00e-36 141.00
IUUC-Mla-058847 Melampsora laricipopulina 34.29 3.00e-08 49.70
IUUC-Mga-059468 Meleagris gallopavo 58.06 6.00e-28 114.00
IUUC-Mvi-060235 Microbotryum violaceum 33.33 3.00e-17 80.10
IUUC-Mdo-061948 Monodelphis domestica 54.55 1.00e-28 116.00
IUUC-Mmu-063946 Mus musculus 54.64 1.00e-27 113.00
IUUC-Mac-064812 Musa acuminata 74.12 2.00e-33 132.00
IUUC-Mpu-066763 Mustela putorius furo 53.54 4.00e-28 114.00
IUUC-Mlu-066970 Myotis lucifugus 52.63 1.00e-19 86.30
IUUC-Ncr-068824 Neurospora crassa 36.63 2.00e-15 73.60
IUUC-Nle-069849 Nomascus leucogenys 51.32 4.00e-19 86.30
IUUC-Opr-070227 Ochotona princeps 54.55 3.00e-28 115.00
IUUC-Ont-072530 Oreochromis niloticus 56.57 5.00e-29 117.00
IUUC-Oan-073191 Ornithorhynchus anatinus 56.04 1.00e-26 109.00
IUUC-Ocu-074460 Oryctolagus cuniculus 54.55 5.00e-28 114.00
IUUC-Oba-075499 Oryza barthii 69.05 7.00e-30 122.00
IUUC-Obr-076896 Oryza brachyantha 69.05 6.00e-30 123.00
IUUC-Ogl-077834 Oryza glaberrima 69.05 3.00e-30 122.00
IUUC-Ogu-078622 Oryza glumaepatula 69.05 3.00e-30 122.00
IUUC-Oin-079358 Oryza indica 69.05 7.00e-30 122.00
IUUC-Olo-081035 Oryza longistaminata 67.68 2.00e-32 130.00
IUUC-Oni-082425 Oryza nivara 69.05 3.00e-30 122.00
IUUC-Opu-083461 Oryza punctata 68.67 2.00e-29 120.00
IUUC-Oru-084875 Oryza rufipogon 71.83 9.00e-25 103.00
IUUC-Oga-089128 Otolemur garnettii 53.54 3.00e-28 115.00
IUUC-Oar-089896 Ovis aries 55.56 2.00e-28 115.00
IUUC-Ptr-091618 Pan troglodytes 51.32 4.00e-14 69.70
IUUC-Pan-092238 Papio anubis 51.32 3.00e-19 86.30
IUUC-Psi-093879 Pelodiscus sinensis 55.56 1.00e-28 117.00
IUUC-Pma-094484 Petromyzon marinus 56.00 4.00e-22 95.10
IUUC-Ppa-095801 Physcomitrella patens 65.66 2.00e-26 109.00
IUUC-Pfo-097192 Poecilia formosa 56.84 4.00e-28 114.00
IUUC-Pab-098203 Pongo abelii 53.54 4.00e-23 98.20
IUUC-Pop-099614 Populus trichocarpa 76.47 8.00e-35 137.00
IUUC-Pca-100507 Procavia capensis 53.95 1.00e-19 86.70
IUUC-Ppe-101174 Prunus persica 82.83 3.00e-46 175.00
IUUC-Pva-102735 Pteropus vampyrus 53.54 3.00e-25 105.00
IUUC-Pgr-103510 Puccinia graminis 40.74 8.00e-11 58.20
IUUC-Ptt-103918 Puccinia triticina 36.19 2.00e-10 57.00
IUUC-Pte-104173 Pyrenophora teres 36.89 4.00e-16 75.50
IUUC-Pyt-104806 Pyrenophora triticirepentis 36.63 1.00e-16 77.00
IUUC-Rno-105820 Rattus norvegicus 56.84 2.00e-28 115.00
IUUC-Sce-106366 Saccharomyces cerevisiae 35.64 2.00e-15 72.80
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.80 8.00e-13 64.70
IUUC-Spo-108074 Schizosaccharomyces pombe 41.18 5.00e-09 51.60
IUUC-Smo-108944 Selaginella moellendorffii 60.44 8.00e-27 110.00
IUUC-Sit-110277 Setaria italica 71.08 8.00e-31 124.00
IUUC-Sly-111505 Solanum lycopersicum 76.47 3.00e-35 138.00
IUUC-Stu-112076 Solanum tuberosum 76.47 2.00e-35 139.00
IUUC-Sbi-114274 Sorghum bicolor 68.09 2.00e-30 122.00
IUUC-Sre-114953 Sporisorium reilianum 45.10 3.00e-21 92.80
IUUC-Ssc-115418 Sus scrofa 53.54 6.00e-28 114.00
IUUC-Tgu-117311 Taeniopygia guttata 55.91 2.00e-26 108.00
IUUC-Tru-118598 Takifugu rubripes 56.04 6.00e-26 107.00
IUUC-Tni-120109 Tetraodon nigroviridis 56.25 8.00e-26 107.00
IUUC-Tre-122099 Trichoderma reesei 38.71 9.00e-11 57.00
IUUC-Tvi-122285 Trichoderma virens 37.62 2.00e-13 66.60
IUUC-Tae-125193 Triticum aestivum 69.05 1.00e-30 123.00
IUUC-Tur-126677 Triticum urartu 61.46 4.00e-28 115.00
IUUC-Tme-127120 Tuber melanosporum 37.25 2.00e-16 77.00
IUUC-Tbe-128050 Tupaia belangeri 40.40 4.00e-15 72.00
IUUC-Ttr-129019 Tursiops truncatus 51.52 1.00e-27 113.00
IUUC-Uma-129483 Ustilago maydis 44.12 3.00e-21 92.40
IUUC-Vda-129690 Verticillium dahliae 57.89 4.00e-09 52.40
IUUC-Vvi-131174 Vitis vinifera 81.93 9.00e-37 143.00
IUUC-Xma-133862 Xiphophorus maculatus 56.84 4.00e-28 114.00
IUUC-Yli-134398 Yarrowia lipolytica 43.56 3.00e-18 82.40
IUUC-Zma-134964 Zea mays 72.62 2.00e-31 125.00
Created Date 25-Jun-2017

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