iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	23792371

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.50e-19	69.8	198	262
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	4.40e-07	29.2	318	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D++++++ge+f ahk+vLaa+S++F++ f +e+e +  + +v+i+d++p+vf+all+F+Y ++l+e
   Q: 198  SDITFNIAGEKFLAHKLVLAARSPFFKSKFFSEFEAN--NTEVTINDLEPKVFKALLQFMYKDSLPE 262
           69*********************************98..59***********************998 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 5    lgilrfAdlydcpdLkdaaldfil 28
           + il++Ad+y++ +Lk ++l+f+ 
   Q: 318  AKILALADRYNAKELKGVCLKFTA 341
           569*******************75 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSESVIQGSN PDRVLSPTSS KSVTQTVNGS HQFVIQGYSL AKGMGIGKHI ASDNFSVGGY 60
QWGIFFYPDG KNPEDNSSYV SVFIALASEG TEVRALFELA LVDQSGKGKH KVHSHFERSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTCAACAA CACTTTGCCA ATTTTGACTT CTTTCTTCTT CTTTTTCTGC ATAACCTATC 60
AATTAGATAC CATTTAGATT AGCAGCGAAT TTCAAACGGA GATGTCAGAA TCAGTGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR034090--BPM_C
IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0071472--P:cellular response to salt stress
GO:0042631--P:cellular response to water deprivation
GO:0016567--P:protein ubiquitination
GO:0006970--P:response to osmotic stress

KEGG

ath:AT5G21010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005772	Arabidopsis lyrata	96.34	0.00e+00	798.00
IUUC-Bol-015439	Brassica oleracea	89.02	0.00e+00	741.00
IUUC-Bra-017606	Brassica rapa	88.05	0.00e+00	734.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence