iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-24	86.1	327	360
UBD/Beta-Prp	4.10e-42	145.3	238	500

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd..tllvsGsdDgtikvWD 29
           gHt+ vt++af   ++    l+s+sdDgt+++WD
   Q: 327  GHTGAVTAIAFsprPGspYQLLSSSDDGTCRIWD 360
           8************9555356************** PP

UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           ik l+gh+ +v +++   +++++++tgs+d+ +kvw+++t  +l+s  ghe+ +t++  s++  +++++s+D +i+vw l +g +v++l+gh+  v++
   Q: 238  IKRLRGHRNAVYCAIL-DRSGRYVITGSDDRLVKVWSMDTAYCLASCRGHEGDITDLAVSSNNIFIASASNDCVIRVWRLPDGLPVSVLRGHTGAVTA 334
           5678889998888655.59*******************************************99********************************** PP
   S: 100  lsfsp...sgdklvsGshdrtirvwdletgqclee..................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.......... 166
           ++fsp   s + l+s s+d t r+wd +  q                       ++++++ + c +++ +g+++v+Gs D+  r++++          
   Q: 335  IAFSPrpgSPYQLLSSSDDGTCRIWDARGAQFAPRiyvprppspdgknsgpssSNAQQSHQIFCCAFNASGSVFVTGSSDTLARVYSVwsanktntdd 432
           *****98777**********************999******************9999999*****************************999999998 PP
   S: 167  ..ktgkllrtltgghtdsvyslsfdsng..........................kelvsgsldgtvklw 207
             + +  ++ l g h+++v+ ++f+                               +v++s+dg+ ++w
   Q: 433  peQPNHEMDVLAG-HENDVNYVQFSGCAagskfsvtdyskdenvpkfknswfchDNIVTCSRDGSAIIW 500
           8544555555566.*********665555566666666677799999999***99************** PP

Organism

Arabidopsis thaliana

Protein Sequence
(Fasta)

MALRKNTPKG DSVSLPMKPL NFSRKLPGNV QIPDPDIVQS VAPNIDLDLR EVYFLMLHLL 60
SSGPCQKTYA LLRHELLEHE LLPRRYHAWY SRSGLPSGDE NDDGNSFPLN YTELAKRYSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTGCG TTGTGCTCTG TTTCTTCCCT TCTCTCTCTA TCCAGTGCGT TTCTCCACAA 60
TCCTTTCGCC TTCTTCTGCC GAAATTTTGT CTTGCCCAAA AAACACTAAA AAACCGAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	55.69	0.00e+00	866.00
IUUC-Aml-002299	Ailuropoda melanoleuca	32.25	5.00e-73	269.00
IUUC-Atr-002600	Amborella trichopoda	68.50	0.00e+00	1093.00
IUUC-Apl-003700	Anas platyrhynchos	31.52	2.00e-65	244.00
IUUC-Aca-004474	Anolis carolinensis	32.78	2.00e-80	294.00
IUUC-Aly-006406	Arabidopsis lyrata	97.29	0.00e+00	2914.00
IUUC-Ame-010718	Astyanax mexicanus	30.94	5.00e-81	296.00
IUUC-Bdi-014797	Brachypodium distachyon	52.86	0.00e+00	776.00
IUUC-Bol-015737	Brassica oleracea	86.60	0.00e+00	2586.00
IUUC-Bra-017961	Brassica rapa	86.54	0.00e+00	2580.00
IUUC-Cja-018868	Callithrix jacchus	32.84	4.00e-81	296.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	33.44	5.00e-33	135.00
IUUC-Csa-023618	Chlorocebus sabaeus	32.69	9.00e-81	295.00
IUUC-Cho-024690	Choloepus hoffmanni	28.57	1.00e-35	145.00
IUUC-Csv-025813	Ciona savignyi	27.16	1.00e-58	220.00
IUUC-Dre-028205	Danio rerio	32.54	4.00e-81	296.00
IUUC-Dno-030048	Dasypus novemcinctus	32.56	4.00e-73	270.00
IUUC-Dor-030195	Dipodomys ordii	35.52	2.00e-32	134.00
IUUC-Eeu-034688	Erinaceus europaeus	33.06	1.00e-38	155.00
IUUC-Gmo-039116	Gadus morhua	28.89	2.00e-22	102.00
IUUC-Gac-042435	Gasterosteus aculeatus	30.64	6.00e-62	233.00
IUUC-Gma-043340	Glycine max	56.52	0.00e+00	1680.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	27.30	1.00e-22	100.00
IUUC-Lch-049662	Latimeria chalumnae	31.36	2.00e-78	287.00
IUUC-Lpe-051619	Leersia perrieri	49.82	0.00e+00	1315.00
IUUC-Loc-052672	Lepisosteus oculatus	32.69	3.00e-79	290.00
IUUC-Meu-056321	Macropus eugenii	29.47	2.00e-54	208.00
IUUC-Mtr-058094	Medicago truncatula	56.65	0.00e+00	1625.00
IUUC-Mlu-067928	Myotis lucifugus	32.20	5.00e-73	269.00
IUUC-Ont-072221	Oreochromis niloticus	33.53	1.00e-80	295.00
IUUC-Oba-075709	Oryza barthii	50.57	0.00e+00	1382.00
IUUC-Obr-076619	Oryza brachyantha	50.23	0.00e+00	1404.00
IUUC-Ogl-077493	Oryza glaberrima	48.40	0.00e+00	1134.00
IUUC-Ogu-078641	Oryza glumaepatula	47.32	0.00e+00	984.00
IUUC-Oin-079669	Oryza indica	69.27	0.00e+00	700.00
IUUC-Olo-080755	Oryza longistaminata	48.29	0.00e+00	1093.00
IUUC-Oni-082991	Oryza nivara	47.28	0.00e+00	1073.00
IUUC-Opu-083233	Oryza punctata	50.63	0.00e+00	1406.00
IUUC-Oru-085195	Oryza rufipogon	50.46	0.00e+00	1384.00
IUUC-Ola-086648	Oryzias latipes	33.53	5.00e-81	296.00
IUUC-Oga-088578	Otolemur garnettii	32.84	2.00e-70	261.00
IUUC-Oar-090214	Ovis aries	31.14	7.00e-69	256.00
IUUC-Pma-094427	Petromyzon marinus	31.71	3.00e-37	148.00
IUUC-Pfo-096191	Poecilia formosa	33.13	2.00e-80	294.00
IUUC-Pab-098402	Pongo abelii	32.69	8.00e-81	295.00
IUUC-Pop-099185	Populus trichocarpa	58.10	0.00e+00	1722.00
IUUC-Pca-101128	Procavia capensis	31.80	1.00e-66	248.00
IUUC-Ppe-101849	Prunus persica	55.07	0.00e+00	1671.00
IUUC-Sar-113004	Sorex araneus	31.04	1.00e-65	245.00
IUUC-Ssc-115461	Sus scrofa	31.68	2.00e-71	264.00
IUUC-Tru-117625	Takifugu rubripes	33.84	4.00e-80	293.00
IUUC-Tni-120716	Tetraodon nigroviridis	33.23	1.00e-80	295.00
IUUC-Tca-121098	Theobroma cacao	57.60	0.00e+00	1753.00
IUUC-Tae-125478	Triticum aestivum	63.88	0.00e+00	1029.00
IUUC-Tur-126809	Triticum urartu	61.73	0.00e+00	1014.00
IUUC-Tbe-127479	Tupaia belangeri	44.14	3.00e-30	127.00
IUUC-Ttr-128427	Tursiops truncatus	32.58	1.00e-72	268.00
IUUC-Vpa-130160	Vicugna pacos	32.62	2.00e-71	264.00
IUUC-Vvi-131362	Vitis vinifera	58.78	0.00e+00	1759.00
IUUC-Xtr-132717	Xenopus tropicalis	32.59	3.00e-81	297.00
IUUC-Xma-134120	Xiphophorus maculatus	33.59	1.00e-81	296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence