iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006896

UUCD1 version

UUC-ArT-01591

Ensembl Protein ID

AT5G62540.1

UniProt Accession

P42746; Q4TZ06; Q8H1P1; Q94AD2; UBC3_ARATH

Genbank Protein ID

AAA32898.1; AAY44844.1; BAB11504.1; AED97620.1; AAK63955.1; AAN28744.1; AAK82529.1; AAM62597.1

Protein Name

Ubiquitin-conjugating enzyme E2 3; E2 ubiquitin-conjugating enzyme 3; Ubiquitin carrier protein 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase 3

Genbank Nucleotide ID

L19352; DQ027018; AB015469; CP002688; AY039851; AY143805; AY048267; AY085367

Gene Name

UBC3; At5g62540; K19B1.15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G62540	AT5G62540.1	AT5G62540.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20663873; 16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	6.10e-52	176.0	8	141

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           Rl+ ++k+l+kdpp gis  p+d+ ++++w++li+Gpedtp++gg+Fkl+++f+edYP kPP v+f++++fhPn+y++G++Cl+il+  ++Wsp ++v
   Q: 8    RLMWDFKRLQKDPPVGISGAPQDN-NIMHWNALIFGPEDTPWDGGTFKLTLHFTEDYPNKPPIVRFVSRMFHPNIYADGSICLDILQ--NQWSPIYDV 102
           8999*******************9.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           + vl+siqsll++pnp+sp+n+eaa+l+++n++ey++kv
   Q: 103  AAVLTSIQSLLCDPNPDSPANAEAARLFSENKREYNRKV 141
           ************************************998 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MTTPAKKRLM WDFKRLQKDP PVGISGAPQD NNIMHWNALI FGPEDTPWDG GTFKLTLHFT 60
EDYPNKPPIV RFVSRMFHPN IYADGSICLD ILQNQWSPIY DVAAVLTSIQ SLLCDPNPDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTATTTT CTTAAAATAG TATATGATTT TTTCATTTTA AACTTTCTTT GTGTTTTCTT 60
CTTCTCTTCC TTTATTTGGT GAAGAAAAAG GAAAGAAAAA TCTCAACTTT GATTCTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G62540

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006563	Arabidopsis lyrata	96.67	2.00e-85	306.00
IUUC-Bol-015664	Brassica oleracea	91.33	5.00e-83	298.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence