iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007508

UUCD1 version

UUC-ArT-01716

Ensembl Protein ID

AT5G65450.2

UniProt Accession

Q9FKP5; UBP17_ARATH

Genbank Protein ID

BAB11567.1; AED98058.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme 17; Ubiquitin thioesterase 17; Ubiquitin-specific-processing protease 17

Genbank Nucleotide ID

AF302667; CP002688

Gene Name

UBP17; At5g65450; MNA5.19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G65450	AT5G65450.2	AT5G65450.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-70	239.5	348	651

Active Site

Position(s)	Description	Evidence
338	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092}
592	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           +Gl NlgN+CY N+vLQcL+++++l ++l +  +++++++     ++ ++++++++l+ +   + ++  sp ++l++l+k+ +++   +++Da+Efl+
   Q: 348  FGLVNLGNSCYANAVLQCLAFTRPLISYLIRgLHSKTCRK-----KSWCFVCEFEHLILKA-RGGESPLSPIKILSKLQKIGKHLGPGKEEDAHEFLR 439
           6******************************666666655.....578**********988.9999******************************** PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesft 195
           + +d++++ +                  l++     +  ++++l+  +F+g l+s+ikc +c ++s+r e ++dl++++ g+      sl+++L++ft
   Q: 440  CAVDTMQSVF------------------LKEAPAAGPFAEETTLVGLTFGGYLHSKIKCMACLHKSERPELMMDLTVEIDGDIG----SLEEALAQFT 515
           **********..................22334456778889****************************************95....8********* PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG...sl 290
           + e l+gen+y+c +ck++q+a+kkl++ + P++L++ LkRf+ ++      k++k ++fp+ Ld+sp++++p+ ++  +  Y+L+avvvH     +l
   Q: 516  AYEVLDGENRYFCGRCKSYQKAKKKLMILEGPNILTVVLKRFQSDN----FGKLSKPIHFPELLDISPYMSDPNHGD--HPVYSLYAVVVHLDamsTL 607
           ******************************************5544....369**********************99..9***********6522367 PP
   S: 291  ssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            sGHYv+y+k  +g+W+++dDs+V +v+ e+vl    + aY+l+Y r
   Q: 608  FSGHYVCYIKTLDGDWFKIDDSNVFPVQLETVLL---EGAYMLLYAR 651
           79********************************...********87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MPVSLESETL GFRCLLIGCM MLVFLLIRRQ WRSASVRREE VIRLIALATE ESYLAEEVRP 60
ATVDYGGDSV SDVYRCAVCL YPTTTRCSQC KSVRYCSSKC QILHWRRGHK EECRSPDYDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCACTTTCT CTCTCTAACA ACACACCATT CTTTCTGATT TCTTCTTCTT CTTCTTTTCT 60
CTCTCTCTAG CTTTAATCTC TCCAGATGCC CAAATCCTTT ACCCGCCGTC GCTTCTCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS00972--USP_1
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G65450

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	57.77	1.00e-124	440.00
IUUC-Atr-002920	Amborella trichopoda	63.10	9.00e-135	474.00
IUUC-Aly-006266	Arabidopsis lyrata	91.36	0.00e+00	1201.00
IUUC-Bol-015937	Brassica oleracea	73.18	0.00e+00	960.00
IUUC-Bra-017119	Brassica rapa	75.95	0.00e+00	1018.00
IUUC-Gma-043931	Glycine max	57.23	7.00e-149	520.00
IUUC-Mtr-058108	Medicago truncatula	64.47	9.00e-147	513.00
IUUC-Oba-075877	Oryza barthii	62.87	7.00e-121	427.00
IUUC-Obr-076357	Oryza brachyantha	63.59	3.00e-126	445.00
IUUC-Oin-079111	Oryza indica	65.17	2.00e-123	436.00
IUUC-Olo-080489	Oryza longistaminata	60.45	3.00e-118	418.00
IUUC-Ome-081510	Oryza meridionalis	45.21	4.00e-124	438.00
IUUC-Oni-082699	Oryza nivara	62.72	2.00e-120	426.00
IUUC-Opu-083249	Oryza punctata	60.27	3.00e-122	432.00
IUUC-Oru-084225	Oryza rufipogon	62.72	2.00e-120	426.00
IUUC-Osa-085422	Oryza sativa	60.12	6.00e-113	401.00
IUUC-Ppe-101893	Prunus persica	50.00	4.00e-168	584.00
IUUC-Sit-109941	Setaria italica	43.73	9.00e-121	427.00
IUUC-Tca-121704	Theobroma cacao	65.96	5.00e-156	544.00
IUUC-Tae-125414	Triticum aestivum	58.65	5.00e-125	441.00
IUUC-Tur-126736	Triticum urartu	58.65	7.00e-125	441.00
IUUC-Vvi-131703	Vitis vinifera	50.43	2.00e-174	605.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence