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Tag Content
UUCD2 ID IUUC-Bta-012964
UUCD1 version UUC-BoT-00978
Ensembl Protein ID ENSBTAP00000025423.4
UniProt Accession Q58D20; NLE1_BOVIN
Genbank Protein ID AAX46624.1
Protein Name Notchless protein homolog 1
Genbank Nucleotide ID BT021777
Gene Name NLE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000019094.4 ENSBTAT00000025423.4 ENSBTAP00000025423.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-66 217.3 198 242
UBD/Beta-Prp 1.50e-79 267.4 107 303
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g+++++
   Q: 198  GHSKWITALSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCERT 242
           8***************9889**********************985 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +   
   Q: 107  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRA 195
           6789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++ +++     +p++++++s+s+D+ vr+Wd   g++ rtltg h +sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 196  LTGHSKWITALSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERTLTG-HAQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 282
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlv 238
           tl+gh  +v+ +++s  d  l 
   Q: 283  TLQGHGHWVNTMALS-TDYALR 303
           **************9.444444 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
 Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
Protein Sequence
(Fasta)
MAAAAAADEA ATRDVQRLLV QFQDEGGQLL GSPFDVPVDI TPDKLQLVCN ALLAQEDPLP 60
LAFYVHDAEI VSSLGRTLES QAVETEKVLD IIYQPQAIFR VRAVTRCTSS LEGHSEAVIS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012964|E3,WD_repeat;UBD,Beta-Prp|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGCGG CGGCGGCGGC GGTGGGTGTG CGTGAGTGCG GGCGGGGCCC GCGGACGGGC 60
TCTCCCGCCG GCTTTCCCGA GGCCGTAGGG AGGCGGGAGT GGGGGCCCTC GGGTAACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012964|E3,WD_repeat;UBD,Beta-Prp|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis
KEGG bta:509793
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000437 Aegilops tauschii 58.58 1.00e-170 592.00
IUUC-Aml-001793 Ailuropoda melanoleuca 96.62 0.00e+00 944.00
IUUC-Atr-002507 Amborella trichopoda 58.42 2.00e-167 582.00
IUUC-Apl-003964 Anas platyrhynchos 83.04 0.00e+00 803.00
IUUC-Aly-006396 Arabidopsis lyrata 54.22 8.00e-161 560.00
IUUC-Ath-007278 Arabidopsis thaliana 54.43 8.00e-161 560.00
IUUC-Ago-007951 Ashbya gossypii 47.85 1.00e-129 456.00
IUUC-Acl-008298 Aspergillus clavatus 47.08 2.00e-119 422.00
IUUC-Afl-008581 Aspergillus flavus 51.94 7.00e-109 386.00
IUUC-Afu-008906 Aspergillus fumigatus 46.07 3.00e-119 422.00
IUUC-Ani-009189 Aspergillus nidulans 44.83 2.00e-116 412.00
IUUC-Ang-009630 Aspergillus niger 47.61 8.00e-123 433.00
IUUC-Aor-010038 Aspergillus oryzae 47.20 1.00e-126 446.00
IUUC-Ate-010278 Aspergillus terreus 46.40 3.00e-121 429.00
IUUC-Ame-011890 Astyanax mexicanus 80.76 0.00e+00 823.00
IUUC-Bgr-012011 Blumeria graminis 48.24 7.00e-130 457.00
IUUC-Bci-013592 Botrytis cinerea 44.53 5.00e-119 421.00
IUUC-Bdi-015035 Brachypodium distachyon 58.67 9.00e-172 596.00
IUUC-Bol-015501 Brassica oleracea 55.56 6.00e-161 560.00
IUUC-Bra-017642 Brassica rapa 55.34 2.00e-160 558.00
IUUC-Cel-018430 Caenorhabditis elegans 58.03 6.00e-167 580.00
IUUC-Cja-019125 Callithrix jacchus 95.36 0.00e+00 937.00
IUUC-Cfa-021013 Canis familiaris 95.15 0.00e+00 854.00
IUUC-Cpo-021743 Cavia porcellus 94.71 0.00e+00 934.00
IUUC-Cre-022973 Chlamydomonas reinhardtii 47.56 5.00e-123 434.00
IUUC-Csa-024270 Chlorocebus sabaeus 95.78 0.00e+00 941.00
IUUC-Cin-025795 Ciona intestinalis 66.31 0.00e+00 684.00
IUUC-Csv-025953 Ciona savignyi 67.38 0.00e+00 684.00
IUUC-Cgl-026517 Colletotrichum gloeosporioides 51.99 1.00e-108 386.00
IUUC-Cne-026901 Cryptococcus neoformans 49.70 6.00e-140 490.00
IUUC-Cme-027281 Cyanidioschyzon merolae 47.91 5.00e-116 411.00
IUUC-Dre-028515 Danio rerio 77.59 0.00e+00 799.00
IUUC-Dno-029596 Dasypus novemcinctus 96.41 0.00e+00 940.00
IUUC-Dor-030494 Dipodomys ordii 94.70 0.00e+00 927.00
IUUC-Dse-031538 Dothistroma septosporum 48.03 5.00e-130 457.00
IUUC-Dme-031974 Drosophila melanogaster 59.17 6.00e-168 583.00
IUUC-Ete-032948 Echinops telfairi 97.13 1.00e-118 419.00
IUUC-Eca-033399 Equus caballus 97.24 0.00e+00 946.00
IUUC-Eeu-035013 Erinaceus europaeus 94.26 4.00e-116 411.00
IUUC-Fca-035860 Felis catus 96.41 0.00e+00 941.00
IUUC-Fal-037069 Ficedula albicollis 86.40 2.00e-130 457.00
IUUC-Fox-038059 Fusarium oxysporum 46.56 7.00e-125 440.00
IUUC-Fso-038445 Fusarium solani 46.76 3.00e-125 442.00
IUUC-Gmo-039319 Gadus morhua 75.74 0.00e+00 733.00
IUUC-Ggr-040095 Gaeumannomyces graminis 47.39 4.00e-122 431.00
IUUC-Gga-040303 Gallus gallus 84.00 3.00e-128 450.00
IUUC-Gac-042267 Gasterosteus aculeatus 78.15 0.00e+00 764.00
IUUC-Gma-043974 Glycine max 57.02 2.00e-169 588.00
IUUC-Ggo-044637 Gorilla gorilla 95.54 0.00e+00 929.00
IUUC-Hsa-046128 Homo sapiens 95.99 0.00e+00 943.00
IUUC-Hvu-047373 Hordeum vulgare 58.03 5.00e-170 590.00
IUUC-Itr-048070 Ictidomys tridecemlineatus 95.19 0.00e+00 937.00
IUUC-Kpa-049274 Komagataella pastoris 44.69 2.00e-127 449.00
IUUC-Lch-049907 Latimeria chalumnae 82.18 0.00e+00 822.00
IUUC-Lpe-050778 Leersia perrieri 53.65 1.00e-152 532.00
IUUC-Loc-051889 Lepisosteus oculatus 80.76 0.00e+00 824.00
IUUC-Lma-053041 Leptosphaeria maculans 49.18 2.00e-116 412.00
IUUC-Laf-053598 Loxodonta africana 97.05 0.00e+00 950.00
IUUC-Mcc-055660 Macaca mulatta 95.57 0.00e+00 939.00
IUUC-Meu-056197 Macropus eugenii 79.53 0.00e+00 771.00
IUUC-Mor-056949 Magnaporthe oryzae 45.96 1.00e-118 420.00
IUUC-Mpo-057571 Magnaporthe poae 53.70 3.00e-63 235.00
IUUC-Mtr-058530 Medicago truncatula 58.30 2.00e-166 578.00
IUUC-Mla-059133 Melampsora laricipopulina 46.08 3.00e-125 441.00
IUUC-Mga-059252 Meleagris gallopavo 83.29 0.00e+00 655.00
IUUC-Mvi-060522 Microbotryum violaceum 50.00 4.00e-137 481.00
IUUC-Mmr-061117 Microcebus murinus 96.21 0.00e+00 936.00
IUUC-Mdo-062892 Monodelphis domestica 89.01 0.00e+00 888.00
IUUC-Mmu-064108 Mus musculus 95.35 0.00e+00 911.00
IUUC-Mac-064430 Musa acuminata 59.10 2.00e-172 598.00
IUUC-Mpu-065882 Mustela putorius furo 95.77 0.00e+00 935.00
IUUC-Mlu-068123 Myotis lucifugus 96.41 0.00e+00 945.00
IUUC-Nfi-068484 Neosartorya fischeri 46.76 2.00e-119 422.00
IUUC-Ncr-068649 Neurospora crassa 43.66 7.00e-115 407.00
IUUC-Nle-069140 Nomascus leucogenys 95.75 0.00e+00 932.00
IUUC-Opr-070220 Ochotona princeps 87.47 0.00e+00 812.00
IUUC-Ont-072643 Oreochromis niloticus 79.62 0.00e+00 815.00
IUUC-Ocu-074007 Oryctolagus cuniculus 95.98 0.00e+00 911.00
IUUC-Oba-075904 Oryza barthii 59.10 8.00e-173 599.00
IUUC-Obr-076280 Oryza brachyantha 58.67 5.00e-172 597.00
IUUC-Ogl-077425 Oryza glaberrima 59.10 6.00e-173 600.00
IUUC-Ogu-078586 Oryza glumaepatula 59.10 5.00e-173 600.00
IUUC-Oin-079489 Oryza indica 56.96 6.00e-164 570.00
IUUC-Olo-080766 Oryza longistaminata 58.97 9.00e-173 599.00
IUUC-Ome-081905 Oryza meridionalis 59.10 6.00e-173 600.00
IUUC-Oni-083022 Oryza nivara 59.10 3.00e-173 601.00
IUUC-Opu-083615 Oryza punctata 59.10 6.00e-173 600.00
IUUC-Oru-085076 Oryza rufipogon 59.10 3.00e-173 601.00
IUUC-Osa-085744 Oryza sativa 59.31 1.00e-173 602.00
IUUC-Ola-087290 Oryzias latipes 77.73 0.00e+00 800.00
IUUC-Olu-087898 Ostreococcus lucimarinus 52.93 4.00e-144 504.00
IUUC-Oga-088980 Otolemur garnettii 95.75 0.00e+00 934.00
IUUC-Oar-089580 Ovis aries 98.78 0.00e+00 837.00
IUUC-Ptr-090845 Pan troglodytes 95.33 0.00e+00 926.00
IUUC-Pan-092836 Papio anubis 95.36 0.00e+00 939.00
IUUC-Psi-093965 Pelodiscus sinensis 83.33 2.00e-56 210.00
IUUC-Pno-095052 Phaeosphaeria nodorum 46.50 4.00e-122 431.00
IUUC-Ppa-095432 Physcomitrella patens 59.28 1.00e-171 596.00
IUUC-Pfo-096963 Poecilia formosa 71.22 0.00e+00 699.00
IUUC-Pab-097716 Pongo abelii 91.93 0.00e+00 886.00
IUUC-Pop-099224 Populus trichocarpa 58.30 1.00e-170 592.00
IUUC-Pca-100682 Procavia capensis 91.55 0.00e+00 670.00
IUUC-Ppe-101819 Prunus persica 58.21 2.00e-168 585.00
IUUC-Pva-102338 Pteropus vampyrus 97.77 0.00e+00 724.00
IUUC-Pgr-103583 Puccinia graminis 54.74 3.00e-132 465.00
IUUC-Ptt-103737 Puccinia triticina 44.34 4.00e-99 355.00
IUUC-Pte-104150 Pyrenophora teres 49.55 2.00e-121 429.00
IUUC-Pyt-104606 Pyrenophora triticirepentis 49.32 3.00e-121 428.00
IUUC-Rno-105987 Rattus norvegicus 95.13 0.00e+00 933.00
IUUC-Sce-106315 Saccharomyces cerevisiae 47.46 9.00e-131 460.00
IUUC-Sha-107273 Sarcophilus harrisii 90.06 0.00e+00 899.00
IUUC-Sja-107677 Schizosaccharomyces japonicus 46.75 8.00e-119 420.00
IUUC-Spo-108092 Schizosaccharomyces pombe 48.97 9.00e-124 437.00
IUUC-Ssl-108442 Sclerotinia sclerotiorum 44.28 9.00e-116 410.00
IUUC-Smo-108855 Selaginella moellendorffii 56.47 6.00e-164 570.00
IUUC-Sit-110329 Setaria italica 59.31 8.00e-173 600.00
IUUC-Sly-111830 Solanum lycopersicum 59.96 1.00e-174 605.00
IUUC-Stu-112603 Solanum tuberosum 59.96 2.00e-174 605.00
IUUC-Sar-113504 Sorex araneus 92.96 1.00e-74 273.00
IUUC-Sbi-114560 Sorghum bicolor 58.24 1.00e-169 589.00
IUUC-Sre-115133 Sporisorium reilianum 41.62 1.00e-123 436.00
IUUC-Ssc-115903 Sus scrofa 97.47 0.00e+00 950.00
IUUC-Tgu-116798 Taeniopygia guttata 84.14 0.00e+00 850.00
IUUC-Tru-118361 Takifugu rubripes 78.36 0.00e+00 803.00
IUUC-Tsy-118849 Tarsius syrichta 96.60 0.00e+00 937.00
IUUC-Tni-120094 Tetraodon nigroviridis 78.48 0.00e+00 799.00
IUUC-Tca-121634 Theobroma cacao 57.87 7.00e-168 583.00
IUUC-Tre-122051 Trichoderma reesei 46.67 1.00e-119 423.00
IUUC-Tvi-122322 Trichoderma virens 47.50 5.00e-123 434.00
IUUC-Tae-125822 Triticum aestivum 58.46 1.00e-170 592.00
IUUC-Tur-126766 Triticum urartu 52.19 2.00e-162 565.00
IUUC-Tme-127175 Tuber melanosporum 52.00 1.00e-132 466.00
IUUC-Tbe-127779 Tupaia belangeri 94.38 0.00e+00 824.00
IUUC-Ttr-128224 Tursiops truncatus 92.99 0.00e+00 815.00
IUUC-Uma-129537 Ustilago maydis 41.99 7.00e-125 441.00
IUUC-Vda-129927 Verticillium dahliae 45.40 3.00e-111 395.00
IUUC-Vpa-130658 Vicugna pacos 84.71 0.00e+00 798.00
IUUC-Vvi-131659 Vitis vinifera 58.00 4.00e-170 590.00
IUUC-Xtr-132918 Xenopus tropicalis 76.47 0.00e+00 784.00
IUUC-Xma-133700 Xiphophorus maculatus 79.41 0.00e+00 810.00
IUUC-Yli-134478 Yarrowia lipolytica 49.90 4.00e-139 488.00
IUUC-Zma-135835 Zea mays 55.78 1.00e-166 579.00
Created Date 25-Jun-2017

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