iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fox-037745

Ensembl Protein ID

FOXG_10614P0

UniProt Accession

A0A0D2Y2W5; A0A0D2Y2W5_FUSO4

Genbank Protein ID

KNB10390.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DS231708

Gene Name

FOXG_10614

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FOXG_10614	FOXG_10614T0	FOXG_10614P0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-52	179.1	301	773
UBD/Alpha-Helix/UBA	1.30e-20	72.6	582	619

Active Site

Position(s)	Description	Evidence
310	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
728	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel............w...kskkkavsprellkalkkeae 82
           tGlkNlgN+CY+ S++QcL+ +p++++ +++  + +l+    +ep +++ ++l+k    l                 +++k  +p +l++ +++ +e
   Q: 301  TGLKNLGNSCYLASIIQCLFDMPSFQDRYFR-PNDDLPIV--PEPAADIETQLRKTADGLlsgryskpdadvAgegITHQKGLAPAMLKHLIGRGHE 394
           7******************************.66666655..456666666666666666333333333332355566777**************** PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           efs+++qqDa Efl++l++ + ++                           +     +  ++ F++ l+++++cl c++v  + ++   + ++vp +
   Q: 395  EFSTMRQQDALEFLQHLFKLITRSP--------------------------H--PDGKDPTQPFRFVLEQRLQCLGCHKVRYSSNEQDNIFIDVPLE 463
           *********************9988..........................2..23334689*******************8888888899999988 PP
   S: 180  eetkke...........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspf 264
           +   +e           sl++cL++ft +e++e    + c+ c +k   +k+  +k++P++L+++  ++  +  +++++k++  v +p+e ++l+++
   Q: 464  KLPREEgsegpdaykpvSLKECLDNFTGAEKVE----LTCSACGSKDGFTKRSLFKTFPDTLVVNARKM--TVVNWVPIKVDVPVLVPDEpFNLDEY 554
           88777789999*********************9....9*******************************..6678********************** PP
   S: 265  cts.............................................................................................. 267
           +++                                                                                              
   Q: 555  LSRglqpgeeqlpdepevkapafepdaaalaqleamgfprnrceralhatgnsdanaamewlfghmedpdidapldlgaqsgdantadpekiemlga 651
           ***9999988888888888888888888888888888877777777777777776666666666666666666666666666655555555555555 PP
   S: 268  .....peekqke.................................................kkkYeLiavvvHsG.slssGHYvayvknekgk.... 305
                p     +                                                 + +++L ++v+H+G s++ GHYva++++  g+    
   Q: 652  mgfgaP-----QakkalketggdveravewlfshpddqgifdddapaeaaapkepagsadlPATFQLRSIVCHKGtSIHAGHYVAFIRKALGDanvp 743
           555550.....05555566666666677777777777777777777777777788888888****************************55556678 PP
   S: 306  .WllfdDskVtevkeeevleetgstaYvlfYkr 337
            W+lf+D+kV e +  +v e++ + aYv+f+kr
   Q: 744  tWVLFNDEKVVEAH--DVDEMR-KFAYVYFFKR 773
           8*********9985..555533.79******97 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
            +l+ql++MGF+r+++ +aL a+ n +++aA+e+L+ +
   Q: 582  AALAQLEAMGFPRNRCERALHATgNSDANAAMEWLFGH 619
           589********************************976 PP

Organism

Fusarium oxysporum

Protein Sequence
(Fasta)

MACQHLDLIG LTPPNPSQSV YREDCTQCFD SIDDPAGLDV CLQCFNGGCA GDRNHNRLHY 60
ALTQHPLALN IRRTRKIVER DEPPTKMSKL AIAAETEEDR YDTALTVKCL DCNTELDRTH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTGCC AGCATCTCGA CTTGATCGGT ACGTGAATCT TCAAAATTGA CCCCGCCATT 60
TGATCGACCA CCAGTCATGA TAGTTGCGAC AAGCTCGTGG TCGACCTCGT TAGAACTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	33.33	3.00e-98	351.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.77	4.00e-128	450.00
IUUC-Atr-002580	Amborella trichopoda	33.72	4.00e-104	370.00
IUUC-Apl-003774	Anas platyrhynchos	35.88	2.00e-127	447.00
IUUC-Aca-005368	Anolis carolinensis	35.92	6.00e-133	466.00
IUUC-Aly-005727	Arabidopsis lyrata	36.49	2.00e-124	438.00
IUUC-Ath-006974	Arabidopsis thaliana	36.61	3.00e-124	437.00
IUUC-Ago-007890	Ashbya gossypii	31.93	2.00e-111	394.00
IUUC-Acl-008057	Aspergillus clavatus	56.77	0.00e+00	906.00
IUUC-Afl-008547	Aspergillus flavus	58.08	0.00e+00	792.00
IUUC-Afu-008805	Aspergillus fumigatus	54.86	0.00e+00	800.00
IUUC-Ani-009441	Aspergillus nidulans	54.97	0.00e+00	729.00
IUUC-Ang-009720	Aspergillus niger	57.82	0.00e+00	907.00
IUUC-Aor-010111	Aspergillus oryzae	58.95	0.00e+00	953.00
IUUC-Ate-010531	Aspergillus terreus	53.38	0.00e+00	826.00
IUUC-Ame-011893	Astyanax mexicanus	35.91	3.00e-110	390.00
IUUC-Bgr-012183	Blumeria graminis	61.34	0.00e+00	977.00
IUUC-Bta-013179	Bos taurus	34.77	7.00e-127	446.00
IUUC-Bci-013858	Botrytis cinerea	66.67	0.00e+00	1097.00
IUUC-Bdi-014904	Brachypodium distachyon	34.54	2.00e-102	365.00
IUUC-Bol-015296	Brassica oleracea	35.66	3.00e-122	431.00
IUUC-Bra-017939	Brassica rapa	35.83	2.00e-122	431.00
IUUC-Cel-018625	Caenorhabditis elegans	29.86	1.00e-81	295.00
IUUC-Cja-019063	Callithrix jacchus	34.22	2.00e-125	441.00
IUUC-Cfa-020976	Canis familiaris	35.89	7.00e-131	459.00
IUUC-Cpo-022265	Cavia porcellus	35.48	1.00e-129	455.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	35.23	2.00e-64	238.00
IUUC-Csa-024177	Chlorocebus sabaeus	36.64	1.00e-120	425.00
IUUC-Cho-024702	Choloepus hoffmanni	34.09	8.00e-80	290.00
IUUC-Cin-025411	Ciona intestinalis	35.10	1.00e-104	372.00
IUUC-Csv-026347	Ciona savignyi	32.62	2.00e-101	361.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	76.11	0.00e+00	1152.00
IUUC-Cne-026831	Cryptococcus neoformans	47.96	0.00e+00	673.00
IUUC-Cme-027335	Cyanidioschyzon merolae	33.26	2.00e-55	209.00
IUUC-Dre-027982	Danio rerio	33.10	7.00e-109	386.00
IUUC-Dno-029034	Dasypus novemcinctus	35.01	2.00e-128	451.00
IUUC-Dor-030479	Dipodomys ordii	37.33	1.00e-62	233.00
IUUC-Dse-031467	Dothistroma septosporum	56.29	0.00e+00	886.00
IUUC-Dme-032075	Drosophila melanogaster	34.39	5.00e-116	410.00
IUUC-Ete-032865	Echinops telfairi	32.10	1.00e-107	382.00
IUUC-Eca-034059	Equus caballus	34.77	1.00e-126	445.00
IUUC-Eeu-035304	Erinaceus europaeus	35.38	6.00e-117	413.00
IUUC-Fca-035515	Felis catus	34.66	8.00e-127	446.00
IUUC-Fal-037271	Ficedula albicollis	37.28	6.00e-124	436.00
IUUC-Fso-038158	Fusarium solani	89.19	0.00e+00	1387.00
IUUC-Gmo-039071	Gadus morhua	34.61	6.00e-114	403.00
IUUC-Ggr-040098	Gaeumannomyces graminis	70.58	0.00e+00	1078.00
IUUC-Gga-040635	Gallus gallus	35.47	8.00e-130	456.00
IUUC-Gac-042528	Gasterosteus aculeatus	35.86	4.00e-116	410.00
IUUC-Gma-043614	Glycine max	34.50	7.00e-110	389.00
IUUC-Ggo-044602	Gorilla gorilla	34.66	9.00e-127	446.00
IUUC-Hsa-045959	Homo sapiens	34.66	9.00e-127	446.00
IUUC-Hvu-047563	Hordeum vulgare	38.13	1.00e-101	361.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.85	1.00e-127	448.00
IUUC-Kpa-049156	Komagataella pastoris	41.72	9.00e-178	615.00
IUUC-Lch-049648	Latimeria chalumnae	34.78	3.00e-121	427.00
IUUC-Lpe-051523	Leersia perrieri	33.62	2.00e-103	368.00
IUUC-Loc-052072	Lepisosteus oculatus	31.44	7.00e-107	379.00
IUUC-Lma-053216	Leptosphaeria maculans	61.79	0.00e+00	973.00
IUUC-Laf-054327	Loxodonta africana	35.16	2.00e-127	448.00
IUUC-Mcc-055443	Macaca mulatta	34.66	3.00e-127	447.00
IUUC-Meu-056298	Macropus eugenii	35.24	2.00e-85	308.00
IUUC-Mor-057106	Magnaporthe oryzae	72.17	0.00e+00	1126.00
IUUC-Mpo-057589	Magnaporthe poae	70.83	0.00e+00	1078.00
IUUC-Mtr-058680	Medicago truncatula	35.71	9.00e-114	402.00
IUUC-Mla-058903	Melampsora laricipopulina	44.81	0.00e+00	638.00
IUUC-Mga-059669	Meleagris gallopavo	35.12	2.00e-123	434.00
IUUC-Mvi-060476	Microbotryum violaceum	44.38	1.00e-176	611.00
IUUC-Mmr-060575	Microcebus murinus	34.77	2.00e-126	445.00
IUUC-Mdo-062183	Monodelphis domestica	34.84	5.00e-127	446.00
IUUC-Mmu-063592	Mus musculus	34.89	4.00e-127	447.00
IUUC-Mac-065634	Musa acuminata	31.74	9.00e-103	366.00
IUUC-Mpu-066082	Mustela putorius furo	36.00	1.00e-130	458.00
IUUC-Mlu-067345	Myotis lucifugus	34.62	2.00e-128	451.00
IUUC-Nfi-068558	Neosartorya fischeri	57.36	0.00e+00	857.00
IUUC-Ncr-068960	Neurospora crassa	71.39	0.00e+00	1080.00
IUUC-Nle-070173	Nomascus leucogenys	35.65	1.00e-129	455.00
IUUC-Opr-070556	Ochotona princeps	35.20	5.00e-127	446.00
IUUC-Ont-071502	Oreochromis niloticus	35.11	2.00e-119	421.00
IUUC-Oan-072959	Ornithorhynchus anatinus	39.82	1.00e-43	167.00
IUUC-Ocu-074861	Oryctolagus cuniculus	36.36	1.00e-130	458.00
IUUC-Oba-075109	Oryza barthii	33.75	3.00e-107	380.00
IUUC-Obr-076292	Oryza brachyantha	34.58	6.00e-106	376.00
IUUC-Ogl-077065	Oryza glaberrima	35.24	6.00e-115	406.00
IUUC-Ogu-078776	Oryza glumaepatula	34.00	3.00e-111	394.00
IUUC-Oin-080048	Oryza indica	35.11	5.00e-114	403.00
IUUC-Olo-080711	Oryza longistaminata	33.80	1.00e-101	362.00
IUUC-Ome-081506	Oryza meridionalis	34.55	1.00e-102	365.00
IUUC-Oni-082320	Oryza nivara	33.05	4.00e-106	377.00
IUUC-Opu-083801	Oryza punctata	34.62	3.00e-102	364.00
IUUC-Oru-085139	Oryza rufipogon	33.41	2.00e-106	378.00
IUUC-Osa-085713	Oryza sativa	35.36	1.00e-115	409.00
IUUC-Ola-086951	Oryzias latipes	33.65	1.00e-110	392.00
IUUC-Olu-087822	Ostreococcus lucimarinus	32.64	1.00e-101	362.00
IUUC-Oga-088625	Otolemur garnettii	34.31	8.00e-127	446.00
IUUC-Oar-089995	Ovis aries	34.66	2.00e-128	451.00
IUUC-Ptr-090640	Pan troglodytes	35.51	2.00e-129	454.00
IUUC-Pan-091974	Papio anubis	34.50	3.00e-128	450.00
IUUC-Psi-093957	Pelodiscus sinensis	35.54	8.00e-133	466.00
IUUC-Pma-094242	Petromyzon marinus	39.95	2.00e-71	261.00
IUUC-Pno-094835	Phaeosphaeria nodorum	62.23	0.00e+00	883.00
IUUC-Ppa-095901	Physcomitrella patens	36.63	1.00e-125	442.00
IUUC-Pfo-097148	Poecilia formosa	34.95	2.00e-118	417.00
IUUC-Pab-098068	Pongo abelii	32.71	2.00e-108	385.00
IUUC-Pop-098943	Populus trichocarpa	35.64	3.00e-115	407.00
IUUC-Pca-100738	Procavia capensis	36.66	2.00e-96	345.00
IUUC-Ppe-101315	Prunus persica	34.85	3.00e-111	394.00
IUUC-Pva-102154	Pteropus vampyrus	34.66	2.00e-126	444.00
IUUC-Pgr-103343	Puccinia graminis	42.75	1.00e-150	524.00
IUUC-Ptt-103928	Puccinia triticina	37.80	2.00e-144	504.00
IUUC-Pte-104306	Pyrenophora teres	63.81	0.00e+00	934.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	62.92	0.00e+00	951.00
IUUC-Rno-105801	Rattus norvegicus	34.89	2.00e-127	447.00
IUUC-Sce-106304	Saccharomyces cerevisiae	33.79	1.00e-116	412.00
IUUC-Sha-107635	Sarcophilus harrisii	35.05	8.00e-129	452.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	43.24	3.00e-177	613.00
IUUC-Spo-108144	Schizosaccharomyces pombe	42.37	3.00e-177	613.00
IUUC-Smo-108848	Selaginella moellendorffii	36.89	2.00e-116	411.00
IUUC-Sit-110728	Setaria italica	34.66	2.00e-115	408.00
IUUC-Sly-111523	Solanum lycopersicum	37.25	1.00e-124	438.00
IUUC-Sar-113733	Sorex araneus	38.46	3.00e-54	204.00
IUUC-Sbi-114419	Sorghum bicolor	34.70	2.00e-112	397.00
IUUC-Sre-115225	Sporisorium reilianum	44.55	0.00e+00	645.00
IUUC-Ssc-115686	Sus scrofa	34.62	9.00e-127	446.00
IUUC-Tgu-117346	Taeniopygia guttata	35.54	7.00e-125	439.00
IUUC-Tru-118350	Takifugu rubripes	33.22	1.00e-114	405.00
IUUC-Tsy-119278	Tarsius syrichta	33.66	8.00e-90	323.00
IUUC-Tni-120658	Tetraodon nigroviridis	34.24	1.00e-109	389.00
IUUC-Tca-121585	Theobroma cacao	35.07	3.00e-113	400.00
IUUC-Tre-122043	Trichoderma reesei	80.46	0.00e+00	1224.00
IUUC-Tvi-122303	Trichoderma virens	80.10	0.00e+00	1232.00
IUUC-Tae-123798	Triticum aestivum	34.95	1.00e-111	395.00
IUUC-Tur-126732	Triticum urartu	32.79	8.00e-101	359.00
IUUC-Tme-126909	Tuber melanosporum	61.59	0.00e+00	924.00
IUUC-Tbe-127261	Tupaia belangeri	31.91	5.00e-76	277.00
IUUC-Ttr-129119	Tursiops truncatus	36.76	2.00e-58	219.00
IUUC-Uma-129599	Ustilago maydis	45.39	0.00e+00	682.00
IUUC-Vda-129688	Verticillium dahliae	77.65	0.00e+00	1175.00
IUUC-Vpa-130170	Vicugna pacos	39.26	8.00e-44	170.00
IUUC-Vvi-131116	Vitis vinifera	35.39	1.00e-114	405.00
IUUC-Xtr-131953	Xenopus tropicalis	34.31	5.00e-113	400.00
IUUC-Xma-133837	Xiphophorus maculatus	34.62	4.00e-118	417.00
IUUC-Yli-134510	Yarrowia lipolytica	45.87	5.00e-179	619.00
IUUC-Zma-135786	Zea mays	35.45	1.00e-106	379.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence