iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058680

Ensembl Protein ID

AES66750

UniProt Accession

G7IR70; A0A0C3V5W0; G7IR70_MEDTR

Genbank Protein ID

AES66750.2

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CM001218

Gene Name

MTR_2g081180

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_2g081180	AES66751	AES66751
MTR_2g081180	KEH38823	KEH38823
MTR_2g081180	KEH38822	KEH38822
MTR_2g081180	AES66750	AES66750

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-51	176.7	308	801
UBD/Alpha-Helix/UBA	4.20e-16	59.9	619	658

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
764	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelre.lllekkkeklneenpkepkgellkslqklfeel......................wkskkkavsprellkalk 78
           tGl NlgN+CY+ +++Q+ ++ +++ + ++ ++  +k  ee+p +p+ +l ++l+kl + l                      ++ +++ + pr++++ ++
   Q: 308  TGLVNLGNSCYLAATMQAVFSARSFSSrYYINQSLKKAFEEAPADPTVDLNMQLTKLAHGLlsgkysvpqvenddnknvattpTSAEQEGIPPRMFKTLVA 408
           7************************762445567778888899******************9999999999999888887655589999************ PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           + ++efs+++qqDa Ef+ ++ldq+e++                              k++    + F++ ++++i c + +  ++r+ + + lsl++p +
   Q: 409  ASHPEFSTMRQQDALEFFLHFLDQVERSN---------------------------AGKTELDPARSFKFGVEDRILCSSGKVAYNRR-NDYILSLNIPLH 481
           **************************988...........................45566667899***********8777666444.557788888877 PP
   S: 180  eetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
           e t+ke                              l+ cL+sf+++ee+++   +y++  + k++a+k+ +l+++P++L+lh+ +f + ee+++++k++ 
   Q: 482  EATNKEelelfhklkaeklsegkevsgdevvrprvPLEACLASFSAPEEVHD---FYSTALQMKTTAVKSAGLTSFPDYLVLHMRKF-VMEEGWVPKKLDV 578
           77777778******************************************97...********************************.67889******** PP
   S: 252  kvefpleLdlspfcts................................................................................peekq 272
           +v++p+ +d+s++ ++                                                                                +    
   Q: 579  YVDVPDIIDISHMRSKghqpgeellpdgvpieddseiplanedivaqlvsmgfnqihcqkaaintsnagveeamtwllahmedpdidapilrgrgsE---- 675
           ***********99999777777777777777777777777777777777777766666666666666666666666666555555555555555550.... PP
   S: 273  ke...................................................................kkkYeLiavvvHsG.slssGHYvayvknekgk 305
            +                                                                     +Y+L+++v+H G s+++GHYva++ + +g+
   Q: 676  -SvdqskvdmllsfgfqddvarkaliasggdiekatdwifsnpdasvsnmdatasnttsgpndadlpdgGGRYRLMGIVSHIGtSTHCGHYVAHILK-DGR 774
           .055555566666666666666666666666666666666666666677777777888888888999999***************************.9** PP
   S: 306  WllfdDskVtevkeeevleetgstaYvlfYkr 337
           W+ f+D+kV ++   +  +   + +Y++f++r
   Q: 775  WVIFNDNKVGAS--INPPK---DMGYLYFFER 801
           *********988..34455...7888888876 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +ed+++qlv+MGF++ ++++a  ++ n  +e+A+++Ll +
   Q: 619  NEDIVAQLVSMGFNQIHCQKAAINTsNAGVEEAMTWLLAH 658
           89***********************************976 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MDLLRSNLSR VRIPEPTNRV YKQECCLSFD TPMSEGGLFI DMFNFLAFGK DYVGWNFEKT 60
GNPVYLHVKK TKKPVPEDRP LKKPTLLAIG IDGGFDNNEA DYEETHNIVI LPDYVSLSYP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAAGATAG GACAAAAGAG AGTATATTAG CTTGATTTCT TTCTTCTCCA AAGGATACGA 60
TACACTAATT GATCGGTTAG GGCAAACACT GATTCTCTCT CTAAAACCCT TCCTTTCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mtr:MTR_2g081180

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	62.45	0.00e+00	1005.00
IUUC-Aml-002104	Ailuropoda melanoleuca	47.96	0.00e+00	741.00
IUUC-Atr-002580	Amborella trichopoda	69.63	0.00e+00	1208.00
IUUC-Apl-003774	Anas platyrhynchos	48.01	0.00e+00	724.00
IUUC-Aca-005368	Anolis carolinensis	48.98	0.00e+00	763.00
IUUC-Aly-005727	Arabidopsis lyrata	75.37	0.00e+00	1239.00
IUUC-Ath-006974	Arabidopsis thaliana	75.25	0.00e+00	1242.00
IUUC-Ago-007890	Ashbya gossypii	27.04	1.00e-69	257.00
IUUC-Acl-008057	Aspergillus clavatus	36.69	1.00e-123	436.00
IUUC-Afl-008547	Aspergillus flavus	37.41	6.00e-115	407.00
IUUC-Afu-008805	Aspergillus fumigatus	33.16	2.00e-107	382.00
IUUC-Ani-009441	Aspergillus nidulans	35.71	7.00e-99	354.00
IUUC-Ang-009720	Aspergillus niger	35.14	2.00e-114	405.00
IUUC-Aor-010111	Aspergillus oryzae	35.32	3.00e-125	442.00
IUUC-Ate-010531	Aspergillus terreus	33.54	4.00e-101	361.00
IUUC-Ame-011470	Astyanax mexicanus	42.03	0.00e+00	652.00
IUUC-Bgr-012183	Blumeria graminis	33.17	2.00e-107	382.00
IUUC-Bta-013179	Bos taurus	47.67	0.00e+00	746.00
IUUC-Bci-013858	Botrytis cinerea	34.50	6.00e-122	431.00
IUUC-Bdi-014904	Brachypodium distachyon	67.57	0.00e+00	1108.00
IUUC-Bol-015296	Brassica oleracea	75.47	0.00e+00	1240.00
IUUC-Bra-017619	Brassica rapa	73.61	0.00e+00	1227.00
IUUC-Cel-018625	Caenorhabditis elegans	33.58	4.00e-115	408.00
IUUC-Cja-019063	Callithrix jacchus	47.61	0.00e+00	739.00
IUUC-Cfa-020976	Canis familiaris	49.52	0.00e+00	763.00
IUUC-Cpo-022265	Cavia porcellus	49.34	0.00e+00	763.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.42	3.00e-115	408.00
IUUC-Csa-024078	Chlorocebus sabaeus	43.51	0.00e+00	676.00
IUUC-Cho-024702	Choloepus hoffmanni	42.39	1.00e-115	409.00
IUUC-Cin-025411	Ciona intestinalis	42.70	3.00e-175	608.00
IUUC-Csv-026347	Ciona savignyi	40.98	5.00e-170	590.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.20	4.00e-106	378.00
IUUC-Cne-026831	Cryptococcus neoformans	35.42	5.00e-121	427.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.84	8.00e-55	208.00
IUUC-Dre-027982	Danio rerio	44.77	0.00e+00	659.00
IUUC-Dno-029034	Dasypus novemcinctus	48.30	0.00e+00	748.00
IUUC-Dor-030130	Dipodomys ordii	41.95	3.00e-98	352.00
IUUC-Dse-031467	Dothistroma septosporum	35.76	2.00e-116	412.00
IUUC-Dme-032075	Drosophila melanogaster	44.01	0.00e+00	654.00
IUUC-Ete-032865	Echinops telfairi	44.91	0.00e+00	665.00
IUUC-Eca-034059	Equus caballus	48.08	0.00e+00	744.00
IUUC-Eeu-035304	Erinaceus europaeus	45.73	0.00e+00	669.00
IUUC-Fca-035515	Felis catus	48.19	0.00e+00	747.00
IUUC-Fal-037271	Ficedula albicollis	48.43	0.00e+00	715.00
IUUC-Fox-037745	Fusarium oxysporum	35.42	2.00e-118	419.00
IUUC-Fso-038158	Fusarium solani	35.38	1.00e-116	413.00
IUUC-Gmo-039071	Gadus morhua	44.26	0.00e+00	658.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.22	7.00e-110	390.00
IUUC-Gga-040635	Gallus gallus	47.68	0.00e+00	756.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.83	0.00e+00	674.00
IUUC-Gma-043614	Glycine max	81.55	0.00e+00	1326.00
IUUC-Ggo-044602	Gorilla gorilla	48.19	0.00e+00	748.00
IUUC-Hsa-045959	Homo sapiens	48.19	0.00e+00	748.00
IUUC-Hvu-047563	Hordeum vulgare	66.61	0.00e+00	870.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.95	0.00e+00	751.00
IUUC-Kpa-049156	Komagataella pastoris	31.57	1.00e-104	374.00
IUUC-Lch-049648	Latimeria chalumnae	48.50	0.00e+00	753.00
IUUC-Lpe-051523	Leersia perrieri	66.91	0.00e+00	1126.00
IUUC-Loc-052072	Lepisosteus oculatus	43.11	0.00e+00	670.00
IUUC-Lma-053216	Leptosphaeria maculans	34.69	1.00e-107	385.00
IUUC-Laf-054327	Loxodonta africana	48.07	0.00e+00	747.00
IUUC-Mcc-055443	Macaca mulatta	48.07	0.00e+00	744.00
IUUC-Meu-056298	Macropus eugenii	51.03	2.00e-157	549.00
IUUC-Mor-057106	Magnaporthe oryzae	34.87	1.00e-117	416.00
IUUC-Mpo-057589	Magnaporthe poae	34.02	2.00e-111	396.00
IUUC-Mla-058903	Melampsora laricipopulina	34.34	1.00e-110	393.00
IUUC-Mga-059669	Meleagris gallopavo	47.26	0.00e+00	713.00
IUUC-Mvi-060476	Microbotryum violaceum	33.69	2.00e-103	369.00
IUUC-Mmr-060575	Microcebus murinus	48.30	0.00e+00	747.00
IUUC-Mdo-062183	Monodelphis domestica	47.91	0.00e+00	748.00
IUUC-Mmu-063592	Mus musculus	48.30	0.00e+00	751.00
IUUC-Mac-065446	Musa acuminata	67.29	0.00e+00	1158.00
IUUC-Mpu-066082	Mustela putorius furo	49.28	0.00e+00	755.00
IUUC-Mlu-067345	Myotis lucifugus	47.31	0.00e+00	734.00
IUUC-Nfi-068558	Neosartorya fischeri	34.32	1.00e-118	419.00
IUUC-Ncr-068960	Neurospora crassa	32.08	2.00e-104	372.00
IUUC-Nle-070173	Nomascus leucogenys	49.40	0.00e+00	759.00
IUUC-Opr-070556	Ochotona princeps	48.30	0.00e+00	759.00
IUUC-Ont-071502	Oreochromis niloticus	45.58	0.00e+00	677.00
IUUC-Oan-072959	Ornithorhynchus anatinus	55.11	2.00e-70	258.00
IUUC-Ocu-074861	Oryctolagus cuniculus	49.52	0.00e+00	770.00
IUUC-Oba-075109	Oryza barthii	66.75	0.00e+00	1113.00
IUUC-Obr-076292	Oryza brachyantha	67.99	0.00e+00	1106.00
IUUC-Ogl-077065	Oryza glaberrima	67.99	0.00e+00	1149.00
IUUC-Ogu-078776	Oryza glumaepatula	66.38	0.00e+00	1127.00
IUUC-Oin-080048	Oryza indica	67.86	0.00e+00	1141.00
IUUC-Olo-080711	Oryza longistaminata	65.10	0.00e+00	1030.00
IUUC-Ome-081506	Oryza meridionalis	66.54	0.00e+00	1043.00
IUUC-Oni-082320	Oryza nivara	64.90	0.00e+00	1104.00
IUUC-Opu-083801	Oryza punctata	68.11	0.00e+00	1105.00
IUUC-Oru-085139	Oryza rufipogon	64.78	0.00e+00	1098.00
IUUC-Osa-085713	Oryza sativa	68.11	0.00e+00	1153.00
IUUC-Ola-086951	Oryzias latipes	44.08	0.00e+00	651.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.24	2.00e-164	572.00
IUUC-Oga-088625	Otolemur garnettii	47.78	0.00e+00	742.00
IUUC-Oar-089995	Ovis aries	46.92	0.00e+00	734.00
IUUC-Ptr-090640	Pan troglodytes	47.25	0.00e+00	746.00
IUUC-Pan-091974	Papio anubis	47.49	0.00e+00	737.00
IUUC-Psi-093957	Pelodiscus sinensis	48.02	0.00e+00	766.00
IUUC-Pma-094242	Petromyzon marinus	49.36	3.00e-107	381.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.34	2.00e-104	373.00
IUUC-Ppa-095901	Physcomitrella patens	63.86	0.00e+00	1083.00
IUUC-Pfo-097148	Poecilia formosa	44.51	0.00e+00	679.00
IUUC-Pab-098068	Pongo abelii	43.22	2.00e-178	619.00
IUUC-Pop-098855	Populus trichocarpa	80.65	0.00e+00	1283.00
IUUC-Pca-100738	Procavia capensis	45.30	4.00e-143	501.00
IUUC-Ppe-101315	Prunus persica	80.97	0.00e+00	1328.00
IUUC-Pva-102154	Pteropus vampyrus	47.54	0.00e+00	737.00
IUUC-Pgr-103343	Puccinia graminis	33.63	3.00e-99	355.00
IUUC-Ptt-103928	Puccinia triticina	30.34	4.00e-97	348.00
IUUC-Pte-104306	Pyrenophora teres	33.65	5.00e-101	361.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.33	2.00e-106	379.00
IUUC-Rno-105801	Rattus norvegicus	48.30	0.00e+00	753.00
IUUC-Sce-106304	Saccharomyces cerevisiae	30.34	3.00e-68	252.00
IUUC-Sha-107635	Sarcophilus harrisii	48.67	0.00e+00	751.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.80	2.00e-95	343.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.98	2.00e-113	402.00
IUUC-Smo-108848	Selaginella moellendorffii	61.00	0.00e+00	964.00
IUUC-Sit-110728	Setaria italica	68.77	0.00e+00	1173.00
IUUC-Sly-111523	Solanum lycopersicum	74.88	0.00e+00	1268.00
IUUC-Sar-113733	Sorex araneus	46.23	4.00e-97	348.00
IUUC-Sbi-114419	Sorghum bicolor	69.55	0.00e+00	1160.00
IUUC-Sre-115225	Sporisorium reilianum	34.09	2.00e-110	392.00
IUUC-Ssc-115686	Sus scrofa	47.61	0.00e+00	749.00
IUUC-Tgu-117346	Taeniopygia guttata	47.73	0.00e+00	743.00
IUUC-Tru-118350	Takifugu rubripes	43.84	0.00e+00	667.00
IUUC-Tsy-119278	Tarsius syrichta	39.95	5.00e-165	574.00
IUUC-Tni-120658	Tetraodon nigroviridis	44.38	0.00e+00	651.00
IUUC-Tca-121585	Theobroma cacao	80.79	0.00e+00	1291.00
IUUC-Tre-122043	Trichoderma reesei	35.50	4.00e-116	411.00
IUUC-Tvi-122303	Trichoderma virens	35.17	9.00e-118	417.00
IUUC-Tae-123798	Triticum aestivum	66.34	0.00e+00	1118.00
IUUC-Tur-126732	Triticum urartu	62.38	0.00e+00	1049.00
IUUC-Tme-126909	Tuber melanosporum	34.62	2.00e-105	375.00
IUUC-Tbe-127261	Tupaia belangeri	40.03	5.00e-116	411.00
IUUC-Ttr-128295	Tursiops truncatus	38.25	5.00e-161	561.00
IUUC-Uma-129599	Ustilago maydis	33.90	9.00e-114	404.00
IUUC-Vda-129688	Verticillium dahliae	34.90	4.00e-113	401.00
IUUC-Vpa-130170	Vicugna pacos	38.14	4.00e-147	514.00
IUUC-Vvi-131116	Vitis vinifera	80.79	0.00e+00	1275.00
IUUC-Xtr-131953	Xenopus tropicalis	46.28	0.00e+00	711.00
IUUC-Xma-133837	Xiphophorus maculatus	44.75	0.00e+00	682.00
IUUC-Yli-134510	Yarrowia lipolytica	35.48	7.00e-110	390.00
IUUC-Zma-135786	Zea mays	68.81	0.00e+00	1122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence