iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpo-057464

Ensembl Protein ID

MAPG_08219T0

UniProt Accession

A0A0C4E6S3; A0A0C4E6S3_MAGP6

Genbank Protein ID

KLU89245.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

ADBL01001984

Gene Name

PAN2; MAPG_08219

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MAPG_08219	MAPG_08219T0	MAPG_08219T0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.90e-15	54.5	497	832

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqE.fl 96
           Gl+N+ +  Y NS+LQ+++++p lr+l l++   ++       ++++ll++l  lf  l k k    + +++lk+l +     +    + D +   l
   Q: 497  GLENHIANSYANSLLQVMHFTPILRNLSLQHAATACL------SEQCLLCELGFLFDMLDKAKGATCQATNMLKMLTSHPGVGNlHLLEDDPHAsSL 587
           9*****************************5555554......467***********999999999**********988877554566677764269 PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.....slq 188
           a+++++l + l                   ++ +++  ++ + +++++    + +  +kc +c +++sr ++ +   l  p+ +    +     s++
   Q: 588  AVMIQGLARFL-----------------LDQMCRDYMRTSPEANVMEQATATTAQVLMKCMHCSSETSRSSSSFVNDLVYPQMNYVRGRpptatSFS 667
           99999999999.................12334566788889999**********************888887766666665554333245666*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.....pfcts.......peekqk 273
           d+L++  ++e+       +c++c+++q    + ++k++P+vL  + +  + +++    +   +   +p+e+ +       +c +        +++++
   Q: 668  DILKKSIEREQTAR---GWCTTCRGYQPLATRKTIKSIPQVLAANANISTAEQK----RLWATPGWLPEEIGIIigdehVYCFEgedlklhLQRAKH 757
           ***********995...9************************998887744333....234444444544444333332244333333333223344 PP
   S: 274  ekkkYeLiavvvH..sGslssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
           e + Y+L++vvv    G +++ H +++v+         e+ +W lf+D  V++v+ +e l+++   +t+ +++Y+
   Q: 758  EIYVYSLMGVVVNidRGPPHKPHLISMVNVahsaptppEDSQWHLFNDFLVKPVSSKEALTFNTtwKTPLIVLYQ 832
           59*********9722568999********9999999988999*******************98899999999998 PP

Organism

Magnaporthe poae

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDADWGEVTR FHFQQQRADT FLASTIPTAI AFDTGAELLW VGQDFGRVAS FFHNGNKEME 60
RYTAFKANPH NQGAVRQFLF NERGVICLSP QSVHMALRRG PPLWHINHED MKDLRCMSFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTACCTTGG AGGGAAGCCA CCGGCGCGGC TAATTGGTAC TAATCGGGTA GGTGTGCTTG 60
CTGCTTGTCG AGATGACCAC CTGCCTCCCT CGGCGATGCA GCTGGTGTAT GTACCAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.23	2.00e-143	501.00
IUUC-Apl-003500	Anas platyrhynchos	31.12	2.00e-122	432.00
IUUC-Aca-004930	Anolis carolinensis	31.67	5.00e-142	497.00
IUUC-Acl-008214	Aspergillus clavatus	46.59	0.00e+00	1026.00
IUUC-Afu-009112	Aspergillus fumigatus	46.76	0.00e+00	1013.00
IUUC-Ang-009531	Aspergillus niger	47.13	0.00e+00	1002.00
IUUC-Ame-011259	Astyanax mexicanus	29.36	4.00e-71	261.00
IUUC-Bta-012371	Bos taurus	31.62	1.00e-142	499.00
IUUC-Bci-013684	Botrytis cinerea	51.05	0.00e+00	1141.00
IUUC-Cja-019297	Callithrix jacchus	31.22	4.00e-136	477.00
IUUC-Cfa-020489	Canis familiaris	31.70	1.00e-141	496.00
IUUC-Cpo-022392	Cavia porcellus	31.71	1.00e-138	485.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.89	7.00e-141	493.00
IUUC-Csv-025841	Ciona savignyi	33.60	6.00e-61	227.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	60.92	0.00e+00	1407.00
IUUC-Cne-026932	Cryptococcus neoformans	32.82	6.00e-151	526.00
IUUC-Dre-028482	Danio rerio	29.10	1.00e-69	256.00
IUUC-Dno-029398	Dasypus novemcinctus	32.02	2.00e-140	491.00
IUUC-Dor-030307	Dipodomys ordii	33.04	7.00e-95	340.00
IUUC-Dme-032111	Drosophila melanogaster	27.49	4.00e-70	258.00
IUUC-Eca-033985	Equus caballus	31.53	5.00e-142	497.00
IUUC-Eeu-034928	Erinaceus europaeus	26.68	1.00e-26	113.00
IUUC-Fca-035587	Felis catus	32.15	3.00e-144	504.00
IUUC-Fal-037587	Ficedula albicollis	31.91	3.00e-142	498.00
IUUC-Fso-038133	Fusarium solani	58.63	0.00e+00	774.00
IUUC-Gmo-039076	Gadus morhua	28.65	2.00e-69	256.00
IUUC-Ggr-039957	Gaeumannomyces graminis	95.42	0.00e+00	2227.00
IUUC-Gga-040948	Gallus gallus	31.74	3.00e-141	494.00
IUUC-Gac-042396	Gasterosteus aculeatus	29.46	2.00e-70	259.00
IUUC-Ggo-045412	Gorilla gorilla	31.42	3.00e-140	491.00
IUUC-Hsa-046076	Homo sapiens	31.51	4.00e-141	494.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.36	2.00e-121	428.00
IUUC-Kpa-049178	Komagataella pastoris	31.29	5.00e-161	560.00
IUUC-Lch-050279	Latimeria chalumnae	33.91	4.00e-76	278.00
IUUC-Loc-052872	Lepisosteus oculatus	29.53	2.00e-72	266.00
IUUC-Lma-052986	Leptosphaeria maculans	49.09	0.00e+00	1059.00
IUUC-Laf-054181	Loxodonta africana	32.09	2.00e-136	478.00
IUUC-Mcc-054812	Macaca mulatta	31.35	1.00e-140	492.00
IUUC-Meu-056325	Macropus eugenii	32.29	4.00e-141	494.00
IUUC-Mor-057246	Magnaporthe oryzae	59.49	0.00e+00	1337.00
IUUC-Mla-058911	Melampsora laricipopulina	39.04	2.00e-118	418.00
IUUC-Mga-059335	Meleagris gallopavo	32.03	5.00e-139	487.00
IUUC-Mvi-060461	Microbotryum violaceum	35.56	5.00e-180	623.00
IUUC-Mmr-060636	Microcebus murinus	31.53	1.00e-140	492.00
IUUC-Mmu-063503	Mus musculus	32.40	2.00e-143	501.00
IUUC-Mpu-066670	Mustela putorius furo	31.53	2.00e-141	494.00
IUUC-Mlu-068119	Myotis lucifugus	31.78	1.00e-146	512.00
IUUC-Nfi-068398	Neosartorya fischeri	47.02	0.00e+00	1032.00
IUUC-Ncr-068927	Neurospora crassa	51.29	0.00e+00	1062.00
IUUC-Nle-069651	Nomascus leucogenys	30.29	2.00e-130	458.00
IUUC-Opr-070614	Ochotona princeps	31.62	1.00e-142	499.00
IUUC-Ont-072433	Oreochromis niloticus	29.44	3.00e-73	268.00
IUUC-Oan-073283	Ornithorhynchus anatinus	39.50	2.00e-62	232.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.78	6.00e-136	476.00
IUUC-Ola-087522	Oryzias latipes	30.75	1.00e-135	476.00
IUUC-Oga-088226	Otolemur garnettii	31.96	2.00e-140	492.00
IUUC-Oar-089241	Ovis aries	32.06	2.00e-144	505.00
IUUC-Pan-092297	Papio anubis	31.68	5.00e-133	466.00
IUUC-Psi-094043	Pelodiscus sinensis	31.43	4.00e-129	454.00
IUUC-Pma-094394	Petromyzon marinus	30.04	1.00e-71	263.00
IUUC-Pno-095053	Phaeosphaeria nodorum	48.74	0.00e+00	982.00
IUUC-Ppa-095188	Physcomitrella patens	26.99	2.00e-66	245.00
IUUC-Pfo-097517	Poecilia formosa	31.49	1.00e-139	489.00
IUUC-Pca-100471	Procavia capensis	31.90	3.00e-139	487.00
IUUC-Pva-102805	Pteropus vampyrus	30.46	7.00e-107	380.00
IUUC-Pte-104021	Pyrenophora teres	48.77	0.00e+00	1063.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	48.86	0.00e+00	1056.00
IUUC-Rno-105471	Rattus norvegicus	32.13	4.00e-142	497.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.50	8.00e-120	423.00
IUUC-Sha-106883	Sarcophilus harrisii	31.88	2.00e-134	472.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.83	0.00e+00	655.00
IUUC-Sar-113323	Sorex araneus	33.75	8.00e-115	406.00
IUUC-Sre-115075	Sporisorium reilianum	36.52	5.00e-65	241.00
IUUC-Ssc-116363	Sus scrofa	31.87	9.00e-139	486.00
IUUC-Tru-118427	Takifugu rubripes	29.24	1.00e-72	266.00
IUUC-Tni-120218	Tetraodon nigroviridis	29.52	2.00e-73	269.00
IUUC-Tre-122177	Trichoderma reesei	58.50	0.00e+00	1340.00
IUUC-Tme-127176	Tuber melanosporum	42.97	0.00e+00	826.00
IUUC-Tbe-127641	Tupaia belangeri	24.02	4.00e-22	99.00
IUUC-Ttr-128888	Tursiops truncatus	35.14	1.00e-105	375.00
IUUC-Uma-129361	Ustilago maydis	42.26	3.00e-62	232.00
IUUC-Xtr-132811	Xenopus tropicalis	31.31	3.00e-133	467.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence