iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tre-122177

Ensembl Protein ID

EGR44501

UniProt Accession

G0RWH5; G0RWH5_HYPJQ

Genbank Protein ID

EGR44501.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

GL985089

Gene Name

PAN2; TRIREDRAFT_112211

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIREDRAFT_112211	EGR44501	EGR44501

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.20e-13	47.0	492	821

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee..fsgyeqqDaqE.flaflldqleee 106
             Y NS+LQ ++++p +r+  l+++  ++       ++++ll++l  lf  l+k + +  + +++lk+l++  +   +   e++Da+   l+ +l++l++ 
   Q: 492  NSYANSLLQLMHFVPLIRNIALKHTATSCI------SETCLLCELGFLFDMLQKAEGSICQATNMLKTLSRHPQAgpLGLLEEEDAHAsSLHAMLQGLNRF 586
           56*********************6666665......468*******************************99887556799*****973689999****99 PP
   S: 107  lkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepf..ldlslpvp....gkeetkkeslqdcLesftkeeele 201
           l          +           a++ +    ++ +++++    +s+ikc +c+ + +r  +   +dl  p p    ++  t  ++++++L+s +++e+ +
   Q: 587  L----------LDR-------IAADYATMATAPTSLEETLATMATSNIKCATCKGEWKRPGSTfvNDLLYPAPrppgRNGRTPRTTFSQILKSSVERETTQ 670
           9..........211.......225678888999*********************9996655431257777777767644445567***************9 PP
   S: 202  genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....p.fcts....peekqke........kkkYeLiavv. 284
              k +c  c+k+q ++ + +++++P+vL+l+    s +++       ++   +p+e+ +     + fc +    +               + Y+Li++  
   Q: 671  ---KGWCIGCHKYQPMSTRKTIHSVPKVLMLNTAITSADHR----ALWSTPGWLPEEIGIIveqgQfFCYEgedlK-----LhlqrgihnITVYSLIGMAi 759
           ...59***************************998865554....3445555555554443333332333322220.....1344444449*****98751 PP
   S: 285  .vHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
            + sG+ ++ H va+v+          + +W lf+D  V++v+ +e l+++   + + vl Y
   Q: 760  nIESGQGQKPHLVAMVNVghaepeapAQSQWHLFNDFLVRPVSRDEALSFNTtwKYPSVLAY 821
           14578*************777777766777******************98875555555555 PP

Organism

Trichoderma reesei

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEGWDEVARV QLPPPAVHAL PTRVTTMVFD TIQALLWAGN EFGRVTSFVG NDLQQHTSFK 60
AHQASDGPVR QILVNSKGVL VLGATDVHMA QRGGPPIWHL RHEEMKQLRC MTFTSKGTAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGGAT GGGACGAGGT AAGTGCTCTG CCAACACTGC CGGCCTTCGC TTGTTGTGAT 60
GCATCGATAT GGCGCCGGTT GATGCTAATA CCATGTCTGT CTGCTCTTAC AGGTTGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

tre:TRIREDRAFT_112211

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.91	4.00e-149	520.00
IUUC-Apl-003500	Anas platyrhynchos	30.29	3.00e-127	447.00
IUUC-Aca-004930	Anolis carolinensis	30.71	3.00e-149	521.00
IUUC-Acl-008214	Aspergillus clavatus	49.77	0.00e+00	1136.00
IUUC-Afu-009112	Aspergillus fumigatus	49.40	0.00e+00	1112.00
IUUC-Ang-009531	Aspergillus niger	49.17	0.00e+00	1088.00
IUUC-Ame-011259	Astyanax mexicanus	31.43	4.00e-149	520.00
IUUC-Bta-012371	Bos taurus	31.99	3.00e-148	517.00
IUUC-Bci-013684	Botrytis cinerea	53.22	0.00e+00	1212.00
IUUC-Cja-019297	Callithrix jacchus	31.11	2.00e-144	505.00
IUUC-Cfa-020489	Canis familiaris	31.38	5.00e-146	510.00
IUUC-Cpo-022392	Cavia porcellus	31.33	9.00e-148	516.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.62	3.00e-147	514.00
IUUC-Csv-025841	Ciona savignyi	28.30	7.00e-100	357.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	68.36	0.00e+00	1640.00
IUUC-Cne-026932	Cryptococcus neoformans	32.85	4.00e-163	567.00
IUUC-Dre-028482	Danio rerio	30.93	2.00e-148	518.00
IUUC-Dno-029398	Dasypus novemcinctus	31.68	2.00e-146	511.00
IUUC-Dor-030307	Dipodomys ordii	32.52	2.00e-98	352.00
IUUC-Dme-032111	Drosophila melanogaster	27.11	2.00e-67	249.00
IUUC-Eca-033985	Equus caballus	31.30	8.00e-148	516.00
IUUC-Eeu-034928	Erinaceus europaeus	25.80	2.00e-30	126.00
IUUC-Fca-035587	Felis catus	31.24	3.00e-151	527.00
IUUC-Fal-037587	Ficedula albicollis	30.91	1.00e-148	519.00
IUUC-Fso-038133	Fusarium solani	67.00	0.00e+00	1480.00
IUUC-Gmo-039076	Gadus morhua	44.07	8.00e-74	270.00
IUUC-Ggr-039957	Gaeumannomyces graminis	58.48	0.00e+00	1323.00
IUUC-Gga-040948	Gallus gallus	31.62	2.00e-149	521.00
IUUC-Gac-042396	Gasterosteus aculeatus	28.24	3.00e-77	282.00
IUUC-Ggo-045412	Gorilla gorilla	31.54	3.00e-147	514.00
IUUC-Hsa-046076	Homo sapiens	31.45	1.00e-146	512.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	29.93	8.00e-126	443.00
IUUC-Kpa-049178	Komagataella pastoris	33.16	5.00e-177	613.00
IUUC-Lch-050279	Latimeria chalumnae	28.74	2.00e-118	419.00
IUUC-Loc-052872	Lepisosteus oculatus	29.02	1.00e-76	280.00
IUUC-Lma-052986	Leptosphaeria maculans	52.55	0.00e+00	1174.00
IUUC-Laf-054181	Loxodonta africana	30.98	7.00e-143	499.00
IUUC-Mcc-054812	Macaca mulatta	31.57	1.00e-146	513.00
IUUC-Meu-056325	Macropus eugenii	30.97	5.00e-146	510.00
IUUC-Mor-057246	Magnaporthe oryzae	50.00	0.00e+00	1096.00
IUUC-Mpo-057464	Magnaporthe poae	58.18	0.00e+00	1326.00
IUUC-Mla-058911	Melampsora laricipopulina	39.67	3.00e-124	438.00
IUUC-Mga-059335	Meleagris gallopavo	31.65	4.00e-147	514.00
IUUC-Mvi-060461	Microbotryum violaceum	36.28	0.00e+00	644.00
IUUC-Mmr-060636	Microcebus murinus	31.56	2.00e-144	505.00
IUUC-Mmu-063503	Mus musculus	31.21	2.00e-148	518.00
IUUC-Mpu-066670	Mustela putorius furo	31.91	4.00e-148	517.00
IUUC-Mlu-068119	Myotis lucifugus	31.77	2.00e-151	528.00
IUUC-Nfi-068398	Neosartorya fischeri	49.77	0.00e+00	1139.00
IUUC-Ncr-068927	Neurospora crassa	51.26	0.00e+00	1089.00
IUUC-Nle-069651	Nomascus leucogenys	30.45	5.00e-139	487.00
IUUC-Opr-070614	Ochotona princeps	30.64	2.00e-143	501.00
IUUC-Ont-072433	Oreochromis niloticus	31.84	3.00e-154	538.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.89	1.00e-65	243.00
IUUC-Ocu-074401	Oryctolagus cuniculus	28.07	1.00e-74	273.00
IUUC-Ola-087522	Oryzias latipes	30.62	1.00e-150	525.00
IUUC-Oga-088226	Otolemur garnettii	31.37	5.00e-147	513.00
IUUC-Oar-089241	Ovis aries	31.74	3.00e-151	527.00
IUUC-Pan-092297	Papio anubis	31.88	1.00e-136	479.00
IUUC-Psi-094043	Pelodiscus sinensis	29.49	1.00e-132	466.00
IUUC-Pma-094394	Petromyzon marinus	43.26	3.00e-70	258.00
IUUC-Pno-095053	Phaeosphaeria nodorum	53.10	0.00e+00	1078.00
IUUC-Ppa-095188	Physcomitrella patens	26.26	2.00e-66	245.00
IUUC-Pfo-097517	Poecilia formosa	31.13	5.00e-155	540.00
IUUC-Pca-100471	Procavia capensis	30.97	6.00e-147	513.00
IUUC-Pva-102805	Pteropus vampyrus	32.93	3.00e-98	351.00
IUUC-Pte-104021	Pyrenophora teres	53.46	0.00e+00	1191.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	53.36	0.00e+00	1177.00
IUUC-Rno-105471	Rattus norvegicus	31.26	2.00e-149	521.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.41	4.00e-124	437.00
IUUC-Sha-106883	Sarcophilus harrisii	31.31	8.00e-142	496.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.76	0.00e+00	686.00
IUUC-Sar-113323	Sorex araneus	32.85	3.00e-122	431.00
IUUC-Sre-115075	Sporisorium reilianum	43.53	1.00e-66	246.00
IUUC-Ssc-116363	Sus scrofa	28.91	1.00e-75	276.00
IUUC-Tru-118427	Takifugu rubripes	28.87	5.00e-80	291.00
IUUC-Tni-120218	Tetraodon nigroviridis	28.93	7.00e-80	290.00
IUUC-Tme-127176	Tuber melanosporum	45.68	0.00e+00	904.00
IUUC-Tbe-127641	Tupaia belangeri	23.48	2.00e-23	103.00
IUUC-Ttr-128888	Tursiops truncatus	35.23	3.00e-111	395.00
IUUC-Uma-129361	Ustilago maydis	44.08	6.00e-67	248.00
IUUC-Xtr-132811	Xenopus tropicalis	27.91	3.00e-73	268.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence