iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/ULP	1.40e-34	120.2	13	173

Active Site

Position(s)	Description	Evidence
102	N/A	{ECO:0000250}
119		{ECO:0000250}
163	Nucleophile	ECO:0000250}

Domain Profile

DUB/ULP

   S: 3    vtnedlkcLeegeflnDviidfylkylvlekl..kkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpine....... 82
           ++++d++ L+++++lnD+ii f ++y++ +++  ++++v  i++ +++f+k++++++  ++ ++++++dl +k+++f++in+       
   Q: 13   LRQSDVSLLDPPNWLNDHIIGFAFEYFASSQFhdCSDHVCFISPEVTQFIKCTSSPA--EIAMFLEPLDLPHKRVVFLAINDnsnqaag 99
           7899****************************99999******************99..9***************************98 PP
   S: 83   aaHWslavvcfkkksilllDSlr...gasksnvvkklreylevevkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyves 163
           ++HWsl+v+ ++k+s++++DS++   + ++++v++kl+++l +   k++k  f +e       k p Q+Ns+DCG+yv++++e+
   Q: 100  GTHWSLLVYLQDKNSFFHYDSHSrsnSIHAKQVAEKLKAFLGS---KGDKLVFVEE-------KAPAQQNSYDCGMYVICNTEA 173
           8*********************544444556666666666666...9999999994.......69****************997 PP

Organism

Rattus norvegicus

Functional Description
(View)

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Protein Sequence
(Fasta)

MDPVVLSYMD SLLRQSDVSL LDPPNWLNDH IIGFAFEYFA SSQFHDCSDH VCFISPEVTQ 60
FIKCTSSPAE IAMFLEPLDL PHKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACCGAGATC CCTGAAGGCT GGTTGGGCTG GTGAGGCCTG AGGAATAGGT AAGAAGCCTC 60
CTCCCTACTT AGGTTTGTCT CAGTTTGTGG AAGCAGTGGA TCGCTTTGCA GTCCACGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation

KEGG

rno:315723

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000648	Aegilops tauschii	37.72	1.00e-15	78.20
IUUC-Aml-001531	Ailuropoda melanoleuca	91.94	6.00e-117	412.00
IUUC-Atr-003013	Amborella trichopoda	37.57	1.00e-29	122.00
IUUC-Apl-004195	Anas platyrhynchos	76.89	1.00e-97	348.00
IUUC-Aca-004786	Anolis carolinensis	75.00	1.00e-86	312.00
IUUC-Aly-005844	Arabidopsis lyrata	30.49	2.00e-23	102.00
IUUC-Ath-006941	Arabidopsis thaliana	34.46	4.00e-24	104.00
IUUC-Acl-008184	Aspergillus clavatus	32.89	9.00e-14	70.50
IUUC-Afl-008691	Aspergillus flavus	33.73	2.00e-15	75.90
IUUC-Afu-008846	Aspergillus fumigatus	31.76	2.00e-13	69.70
IUUC-Ani-009338	Aspergillus nidulans	33.53	1.00e-14	73.60
IUUC-Ang-009621	Aspergillus niger	34.50	3.00e-16	79.00
IUUC-Aor-010058	Aspergillus oryzae	33.56	7.00e-14	70.90
IUUC-Ate-010257	Aspergillus terreus	36.02	1.00e-15	76.30
IUUC-Ame-011123	Astyanax mexicanus	64.62	3.00e-71	261.00
IUUC-Bgr-012027	Blumeria graminis	34.01	4.00e-14	71.60
IUUC-Bta-013318	Bos taurus	89.10	3.00e-106	377.00
IUUC-Bci-013780	Botrytis cinerea	36.36	2.00e-16	79.30
IUUC-Bdi-014628	Brachypodium distachyon	35.16	9.00e-18	83.60
IUUC-Bol-015265	Brassica oleracea	36.72	7.00e-29	120.00
IUUC-Bra-017473	Brassica rapa	36.72	4.00e-26	111.00
IUUC-Cel-018221	Caenorhabditis elegans	26.67	1.00e-18	86.30
IUUC-Cja-019384	Callithrix jacchus	90.57	3.00e-114	404.00
IUUC-Cfa-021012	Canis familiaris	92.89	2.00e-118	417.00
IUUC-Cpo-022076	Cavia porcellus	90.05	3.00e-115	407.00
IUUC-Cre-022914	Chlamydomonas reinhardtii	33.17	9.00e-20	90.50
IUUC-Csa-023063	Chlorocebus sabaeus	92.92	8.00e-118	415.00
IUUC-Cin-025409	Ciona intestinalis	42.86	3.00e-29	121.00
IUUC-Csv-025804	Ciona savignyi	44.17	6.00e-35	140.00
IUUC-Cgl-026720	Colletotrichum gloeosporioides	28.16	9.00e-13	67.00
IUUC-Dre-027976	Danio rerio	63.38	2.00e-71	261.00
IUUC-Dno-028918	Dasypus novemcinctus	91.47	2.00e-116	410.00
IUUC-Dor-030731	Dipodomys ordii	85.24	1.00e-107	381.00
IUUC-Dse-031309	Dothistroma septosporum	35.93	7.00e-17	80.90
IUUC-Dme-031655	Drosophila melanogaster	37.50	4.00e-34	137.00
IUUC-Eca-034335	Equus caballus	91.47	2.00e-117	414.00
IUUC-Fca-036443	Felis catus	91.94	3.00e-117	414.00
IUUC-Fal-037240	Ficedula albicollis	73.49	4.00e-93	333.00
IUUC-Fox-037732	Fusarium oxysporum	33.13	4.00e-14	72.40
IUUC-Fso-038212	Fusarium solani	33.13	5.00e-13	68.60
IUUC-Gmo-039320	Gadus morhua	60.10	2.00e-71	261.00
IUUC-Ggr-039866	Gaeumannomyces graminis	27.10	2.00e-07	49.70
IUUC-Gga-040846	Gallus gallus	76.89	4.00e-97	347.00
IUUC-Gac-041495	Gasterosteus aculeatus	59.81	8.00e-66	243.00
IUUC-Gma-043532	Glycine max	33.48	2.00e-29	122.00
IUUC-Ggo-045516	Gorilla gorilla	92.92	4.00e-118	416.00
IUUC-Hsa-046446	Homo sapiens	92.45	2.00e-117	414.00
IUUC-Hvu-047187	Hordeum vulgare	32.58	6.00e-21	94.40
IUUC-Itr-048831	Ictidomys tridecemlineatus	92.42	1.00e-116	411.00
IUUC-Kpa-049383	Komagataella pastoris	30.81	7.00e-16	78.20
IUUC-Lch-049930	Latimeria chalumnae	66.98	5.00e-85	306.00
IUUC-Lpe-051072	Leersia perrieri	35.75	2.00e-11	64.30
IUUC-Loc-052263	Lepisosteus oculatus	63.21	9.00e-77	279.00
IUUC-Lma-053175	Leptosphaeria maculans	34.17	4.00e-13	68.90
IUUC-Laf-053748	Loxodonta africana	88.73	1.00e-113	402.00
IUUC-Mcc-055121	Macaca mulatta	92.92	1.00e-117	415.00
IUUC-Mor-057015	Magnaporthe oryzae	30.72	1.00e-10	60.10
IUUC-Mpo-057551	Magnaporthe poae	29.11	1.00e-09	56.60
IUUC-Mtr-058308	Medicago truncatula	32.74	2.00e-27	115.00
IUUC-Mga-059787	Meleagris gallopavo	77.73	1.00e-91	328.00
IUUC-Mmr-061606	Microcebus murinus	90.52	6.00e-114	402.00
IUUC-Mdo-062222	Monodelphis domestica	83.96	4.00e-108	383.00
IUUC-Mmu-063494	Mus musculus	97.66	8.00e-126	442.00
IUUC-Mac-064771	Musa acuminata	35.29	8.00e-24	103.00
IUUC-Mpu-065843	Mustela putorius furo	91.94	1.00e-116	411.00
IUUC-Mlu-068110	Myotis lucifugus	92.42	8.00e-118	415.00
IUUC-Nfi-068584	Neosartorya fischeri	31.76	1.00e-13	69.70
IUUC-Ncr-068707	Neurospora crassa	28.64	2.00e-13	69.30
IUUC-Nle-069021	Nomascus leucogenys	93.87	7.00e-119	419.00
IUUC-Opr-070594	Ochotona princeps	83.89	5.00e-105	373.00
IUUC-Ont-072612	Oreochromis niloticus	63.08	2.00e-63	235.00
IUUC-Oan-073506	Ornithorhynchus anatinus	81.60	2.00e-98	350.00
IUUC-Ocu-074685	Oryctolagus cuniculus	86.26	2.00e-101	361.00
IUUC-Oba-075541	Oryza barthii	33.70	5.00e-13	68.90
IUUC-Obr-076358	Oryza brachyantha	30.48	4.00e-10	59.30
IUUC-Ogl-077166	Oryza glaberrima	33.51	5.00e-14	71.20
IUUC-Ogu-078617	Oryza glumaepatula	25.00	9.00e-06	45.40
IUUC-Oin-079763	Oryza indica	34.08	4.00e-14	71.60
IUUC-Olo-080606	Oryza longistaminata	34.64	1.00e-18	87.80
IUUC-Ome-081337	Oryza meridionalis	33.70	1.00e-12	68.60
IUUC-Oni-083102	Oryza nivara	34.27	1.00e-12	68.20
IUUC-Oru-084547	Oryza rufipogon	34.08	9.00e-14	71.60
IUUC-Osa-085591	Oryza sativa	34.08	5.00e-14	71.20
IUUC-Ola-087005	Oryzias latipes	61.21	3.00e-61	227.00
IUUC-Oga-088415	Otolemur garnettii	90.05	3.00e-115	407.00
IUUC-Oar-090151	Ovis aries	88.15	6.00e-112	396.00
IUUC-Ptr-091183	Pan troglodytes	93.40	1.00e-118	418.00
IUUC-Pan-092515	Papio anubis	92.89	4.00e-117	413.00
IUUC-Psi-093874	Pelodiscus sinensis	78.30	1.00e-99	355.00
IUUC-Pma-094504	Petromyzon marinus	47.96	3.00e-52	197.00
IUUC-Pno-094778	Phaeosphaeria nodorum	38.82	4.00e-11	61.60
IUUC-Ppa-095729	Physcomitrella patens	33.91	8.00e-28	117.00
IUUC-Pfo-097485	Poecilia formosa	64.15	2.00e-71	261.00
IUUC-Pab-098456	Pongo abelii	92.92	4.00e-118	416.00
IUUC-Pop-099754	Populus trichocarpa	33.61	4.00e-29	121.00
IUUC-Ppe-101897	Prunus persica	40.78	7.00e-32	130.00
IUUC-Pva-103087	Pteropus vampyrus	93.36	9.00e-118	415.00
IUUC-Pte-104338	Pyrenophora teres	32.35	5.00e-19	87.80
IUUC-Pyt-104743	Pyrenophora triticirepentis	29.75	6.00e-15	74.30
IUUC-Sha-107481	Sarcophilus harrisii	82.55	8.00e-108	382.00
IUUC-Sja-107774	Schizosaccharomyces japonicus	30.39	1.00e-16	80.50
IUUC-Spo-108043	Schizosaccharomyces pombe	29.02	3.00e-13	69.70
IUUC-Sit-110301	Setaria italica	32.60	4.00e-17	81.60
IUUC-Sly-110870	Solanum lycopersicum	36.30	3.00e-17	80.50
IUUC-Stu-112872	Solanum tuberosum	35.78	1.00e-26	113.00
IUUC-Sar-113306	Sorex araneus	89.57	4.00e-114	403.00
IUUC-Sbi-113811	Sorghum bicolor	33.33	5.00e-13	68.90
IUUC-Sre-114940	Sporisorium reilianum	24.86	2.00e-09	56.20
IUUC-Ssc-116172	Sus scrofa	93.36	2.00e-118	417.00
IUUC-Tgu-117518	Taeniopygia guttata	73.58	3.00e-91	327.00
IUUC-Tru-118187	Takifugu rubripes	57.51	6.00e-60	223.00
IUUC-Tsy-119532	Tarsius syrichta	92.92	6.00e-118	416.00
IUUC-Tni-119854	Tetraodon nigroviridis	62.26	1.00e-62	232.00
IUUC-Tca-121178	Theobroma cacao	33.48	7.00e-28	117.00
IUUC-Tre-121875	Trichoderma reesei	32.53	1.00e-12	66.20
IUUC-Tvi-122665	Trichoderma virens	32.53	8.00e-14	70.50
IUUC-Tae-123260	Triticum aestivum	35.03	2.00e-20	92.80
IUUC-Tur-126065	Triticum urartu	31.20	5.00e-17	82.40
IUUC-Tme-126891	Tuber melanosporum	35.15	3.00e-18	85.50
IUUC-Tbe-127748	Tupaia belangeri	91.94	1.00e-117	414.00
IUUC-Uma-129463	Ustilago maydis	25.96	8.00e-07	47.40
IUUC-Vda-129820	Verticillium dahliae	31.29	6.00e-11	61.20
IUUC-Vpa-130744	Vicugna pacos	92.38	1.00e-116	411.00
IUUC-Vvi-131735	Vitis vinifera	34.86	2.00e-30	125.00
IUUC-Xtr-132666	Xenopus tropicalis	49.30	1.00e-56	212.00
IUUC-Xma-134199	Xiphophorus maculatus	62.62	3.00e-70	257.00
IUUC-Yli-134333	Yarrowia lipolytica	34.64	7.00e-22	98.60
IUUC-Zma-135340	Zea mays	33.52	1.00e-17	82.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence