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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045679
UUCD1 version UUC-HoS-00117
Ensembl Protein ID ENSP00000364589.4
UniProt Accession Q13619; A2A2W2; O75834; Q589T6; Q5TC62; Q6UP08; Q9UP17; CUL4A_HUMAN
Genbank Protein ID AAD45191.1; AAR13072.1; BAD93235.1; CAM18410.1; CAI13795.1; AAH08308.2; BAA33146.1; AAC50547.1
Protein Name Cullin-4A
Genbank Nucleotide ID AF077188; AY365124; AB178950; AL136221; AL136221; BC008308; AB012193; U58090
Gene Name CUL4A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139842.14 ENST00000375440.8 ENSP00000364589.4
ENSG00000139842.14 ENST00000488558.2 ENSP00000480367.1
ENSG00000139842.14 ENST00000326335.8 ENSP00000322132.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDBSCOP
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 19276361
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 1.80e-220 735.5 65 660
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkifayl 90
           kl+eav+++++++s+++++eely+av+nlc++kv+ +lYk+l++++e+++ +q+   +e+s d+  +Lk++n++W+++++q+ ++r+if++l
   Q: 65   KLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVqAQILPFREDSLDSVlFLKKINTCWQDHCRQMIMIRSIFLFL 156
           5899**********************************************99**************************************** PP
   S: 91   drtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefy 180
           drtyv +++++ ++++++l+l+r++i++d  +++++++ +l lie+eR+geavdr+ll+++  +l++L     ++yk+sFE kfle+t+ +y
   Q: 157  DRTYVLQNSTLPSIWDMGLELFRTHIISDkmVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDL-----QVYKDSFELKFLEETNCLY 243
           ****************************************************************9998.....9****************** PP
   S: 181  kaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlnglee 271
           +ae ++++qe+ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+srv+ g + 
   Q: 244  AAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDHLLDENRVPDLAQMYQLFSRVRGGQQA 335
           **********************************************************9989****************************** PP
   S: 272  llkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.EllAryiDqlLrk 362
           ll++++++ik+ g+a+++++ek+kd   +V++ll++k+k++++++ +F+++++F++ ++++fetf+nk+     +++p El+A+++D++Lr+
   Q: 336  LLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKR-----PNKPaELIAKHVDSKLRA 419
           *************************...*****************************************.....66666************* PP
   S: 363  sskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkee 454
           ++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+d+++S+d++ +Fk++
   Q: 420  GNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQH 511
           ******************************************************************************************** PP
   S: 455  kenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLaf 546
           ++n+++s  ++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+gk+e+qVs fQ++vLL+f
   Q: 512  MQNQSDSGPIDLTVNILTMGYWPTYTPME-VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMF 602
           *************************9999.************************************************************** PP
   S: 547  nnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           n+ + +s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++ke+e++d+f++N ef
   Q: 603  NEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF 660
           *******************************************************998 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
Protein Sequence
(Fasta)
MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ 60
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045679|E3,Cullin|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTCATCCCG CATCCTGCTG GGAAACAGCG TCCATCCGAC ACAGCACCGC CCACAGCGGG 60
CCCTCGGCGT GGCCCGCAGG CCCTTCGGAC CGCCTGGGAG CGCGGCCACA CGTGCCAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045679|E3,Cullin|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0007050--P:cell cycle arrest
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0070911--P:global genome nucleotide-excision repair
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0006293--P:nucleotide-excision repair, preincision complex stabilization
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0016032--P:viral process
KEGG hsa:8451
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001592 Ailuropoda melanoleuca 93.20 0.00e+00 1365.00
IUUC-Apl-003269 Anas platyrhynchos 91.97 0.00e+00 1327.00
IUUC-Afl-008567 Aspergillus flavus 39.16 4.00e-138 485.00
IUUC-Afu-008833 Aspergillus fumigatus 38.46 2.00e-132 466.00
IUUC-Ani-009373 Aspergillus nidulans 39.79 1.00e-138 487.00
IUUC-Ang-009622 Aspergillus niger 39.04 9.00e-138 484.00
IUUC-Aor-010241 Aspergillus oryzae 38.76 1.00e-134 473.00
IUUC-Ate-010251 Aspergillus terreus 39.95 1.00e-142 500.00
IUUC-Bgr-012219 Blumeria graminis 36.79 1.00e-116 414.00
IUUC-Bta-012355 Bos taurus 94.17 0.00e+00 1377.00
IUUC-Bci-013744 Botrytis cinerea 39.61 1.00e-130 460.00
IUUC-Cja-019861 Callithrix jacchus 99.30 0.00e+00 1443.00
IUUC-Cfa-021009 Canis familiaris 93.56 0.00e+00 1426.00
IUUC-Cpo-021867 Cavia porcellus 94.86 0.00e+00 1437.00
IUUC-Csa-024139 Chlorocebus sabaeus 99.74 0.00e+00 1479.00
IUUC-Cho-024899 Choloepus hoffmanni 97.02 0.00e+00 1016.00
IUUC-Cin-025727 Ciona intestinalis 62.70 0.00e+00 770.00
IUUC-Csv-026117 Ciona savignyi 53.89 0.00e+00 867.00
IUUC-Cme-027355 Cyanidioschyzon merolae 34.14 3.00e-117 416.00
IUUC-Dno-028879 Dasypus novemcinctus 87.09 0.00e+00 1333.00
IUUC-Dor-030698 Dipodomys ordii 95.13 0.00e+00 1417.00
IUUC-Dme-031652 Drosophila melanogaster 66.90 0.00e+00 954.00
IUUC-Ete-033101 Echinops telfairi 89.33 0.00e+00 1271.00
IUUC-Eca-033696 Equus caballus 93.78 0.00e+00 1372.00
IUUC-Fca-036333 Felis catus 94.37 0.00e+00 1369.00
IUUC-Fal-036995 Ficedula albicollis 91.93 0.00e+00 1345.00
IUUC-Fox-037854 Fusarium oxysporum 39.30 4.00e-126 445.00
IUUC-Fso-038138 Fusarium solani 39.20 4.00e-130 458.00
IUUC-Gga-040358 Gallus gallus 89.18 0.00e+00 1369.00
IUUC-Gma-043960 Glycine max 59.44 0.00e+00 848.00
IUUC-Itr-048182 Ictidomys tridecemlineatus 95.10 0.00e+00 1303.00
IUUC-Lch-050417 Latimeria chalumnae 86.82 0.00e+00 1333.00
IUUC-Laf-054100 Loxodonta africana 94.03 0.00e+00 1368.00
IUUC-Mcc-055168 Macaca mulatta 99.54 0.00e+00 1322.00
IUUC-Meu-056492 Macropus eugenii 73.71 2.00e-171 596.00
IUUC-Mga-059866 Meleagris gallopavo 92.28 0.00e+00 1336.00
IUUC-Mmr-061551 Microcebus murinus 95.26 0.00e+00 1422.00
IUUC-Mdo-062215 Monodelphis domestica 91.37 0.00e+00 1403.00
IUUC-Mmu-063402 Mus musculus 95.13 0.00e+00 1433.00
IUUC-Mpu-066383 Mustela putorius furo 94.11 0.00e+00 1366.00
IUUC-Mlu-067450 Myotis lucifugus 89.66 0.00e+00 1340.00
IUUC-Ncr-068950 Neurospora crassa 36.33 3.00e-120 426.00
IUUC-Nle-069606 Nomascus leucogenys 99.87 0.00e+00 1481.00
IUUC-Opr-070671 Ochotona princeps 85.21 5.00e-118 418.00
IUUC-Oan-073299 Ornithorhynchus anatinus 88.80 0.00e+00 1354.00
IUUC-Ocu-074731 Oryctolagus cuniculus 94.99 0.00e+00 1442.00
IUUC-Oin-079399 Oryza indica 60.47 0.00e+00 724.00
IUUC-Oar-089346 Ovis aries 93.31 0.00e+00 1367.00
IUUC-Ptr-091177 Pan troglodytes 100.00 0.00e+00 1482.00
IUUC-Pan-092191 Papio anubis 99.08 0.00e+00 1469.00
IUUC-Pab-097622 Pongo abelii 99.47 0.00e+00 1473.00
IUUC-Pca-100391 Procavia capensis 84.63 0.00e+00 999.00
IUUC-Pgr-103334 Puccinia graminis 36.48 4.00e-106 379.00
IUUC-Rno-105829 Rattus norvegicus 94.99 0.00e+00 1439.00
IUUC-Sha-106762 Sarcophilus harrisii 93.61 0.00e+00 1330.00
IUUC-Sre-114943 Sporisorium reilianum 38.75 5.00e-132 465.00
IUUC-Ssc-116133 Sus scrofa 92.51 0.00e+00 1383.00
IUUC-Tgu-116961 Taeniopygia guttata 91.54 0.00e+00 1341.00
IUUC-Tre-121907 Trichoderma reesei 39.53 4.00e-132 465.00
IUUC-Tvi-122568 Trichoderma virens 39.00 1.00e-131 463.00
IUUC-Tme-127162 Tuber melanosporum 40.99 3.00e-140 493.00
IUUC-Ttr-128326 Tursiops truncatus 88.94 0.00e+00 1181.00
IUUC-Uma-129531 Ustilago maydis 39.71 4.00e-114 405.00
IUUC-Vvi-131133 Vitis vinifera 58.91 0.00e+00 855.00
IUUC-Xtr-132761 Xenopus tropicalis 81.94 0.00e+00 1256.00
Created Date 25-Jun-2017

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