iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062475

UUCD1 version

UUC-MoD-00140

Ensembl Protein ID

ENSMODP00000014282.3

UniProt Accession

F6RKH2; F6RKH2_MONDO

Protein Name

Uncharacterized protein

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000011425.3	ENSMODT00000014546.3	ENSMODP00000014282.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.70e-12	46.4	298	340

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkC 51
            C+vC++gge    l++C+ C ++fH aCl+++  ++ p+   w C  C
   Q: 298  ECAVCRDGGE----LICCDGCPRAFHLACLEPP-LTDIPSGM-WRCGCC 340
           6*********....*******************.*******7.****99 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MLPGPASHRM SSSDRPSGET DVRQLLKLYR TEISMAVDDT FPLLHGLADH DVIPEDKFKE 60
TQSLREKDGC HKALHALLSW LLGRDSASIR GFWTVLFKDY NLERYGRLQA IRSSFPKDVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGACCAGAG AAGCCGCTGA GGTCAGCTAG CTCCCCATGC TCCCTGGCCC TGCCTCTCAC 60
AGGATGTCCA GCTCAGACCG ACCCTCGGGG GAGACGGATG TCCGGCAGCT CCTGAAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0006955--P:immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	49.37	2.00e-123	436.00
IUUC-Aca-004543	Anolis carolinensis	64.52	2.00e-22	96.70
IUUC-Bgr-012025	Blumeria graminis	37.50	1.00e-09	59.30
IUUC-Bta-012988	Bos taurus	49.20	3.00e-121	428.00
IUUC-Cja-019486	Callithrix jacchus	43.71	9.00e-59	220.00
IUUC-Cfa-021069	Canis familiaris	50.27	5.00e-121	427.00
IUUC-Cpo-021649	Cavia porcellus	47.29	3.00e-99	355.00
IUUC-Csa-023960	Chlorocebus sabaeus	48.32	2.00e-109	389.00
IUUC-Dre-028583	Danio rerio	35.17	8.00e-78	284.00
IUUC-Dno-029869	Dasypus novemcinctus	43.53	5.00e-45	175.00
IUUC-Dor-030263	Dipodomys ordii	64.84	1.00e-32	133.00
IUUC-Ete-032778	Echinops telfairi	69.16	1.00e-41	164.00
IUUC-Eca-034328	Equus caballus	47.29	5.00e-114	404.00
IUUC-Fca-035400	Felis catus	48.19	1.00e-111	396.00
IUUC-Fal-036644	Ficedula albicollis	50.27	6.00e-75	274.00
IUUC-Fox-038014	Fusarium oxysporum	38.00	3.00e-08	54.70
IUUC-Fso-038262	Fusarium solani	41.18	2.00e-08	55.10
IUUC-Ggo-045250	Gorilla gorilla	51.23	1.00e-120	427.00
IUUC-Hsa-046603	Homo sapiens	50.28	6.00e-123	434.00
IUUC-Hvu-047073	Hordeum vulgare	52.63	2.00e-13	71.60
IUUC-Itr-048977	Ictidomys tridecemlineatus	48.65	5.00e-120	424.00
IUUC-Lch-050310	Latimeria chalumnae	43.98	4.00e-108	385.00
IUUC-Lpe-050827	Leersia perrieri	33.83	5.00e-11	63.50
IUUC-Loc-052508	Lepisosteus oculatus	41.65	4.00e-107	381.00
IUUC-Laf-054028	Loxodonta africana	58.01	6.00e-99	354.00
IUUC-Mcc-054935	Macaca mulatta	49.43	2.00e-118	419.00
IUUC-Mga-059318	Meleagris gallopavo	57.53	1.00e-15	77.40
IUUC-Mmr-061557	Microcebus murinus	45.64	3.00e-97	348.00
IUUC-Mmu-063994	Mus musculus	49.17	2.00e-129	456.00
IUUC-Mpu-066347	Mustela putorius furo	47.86	2.00e-123	436.00
IUUC-Mlu-068239	Myotis lucifugus	43.90	1.00e-66	246.00
IUUC-Nle-069544	Nomascus leucogenys	54.44	3.00e-22	98.60
IUUC-Opr-071199	Ochotona princeps	67.59	5.00e-38	152.00
IUUC-Ont-072571	Oreochromis niloticus	31.93	2.00e-56	213.00
IUUC-Oan-073739	Ornithorhynchus anatinus	62.52	2.00e-176	612.00
IUUC-Ogl-077865	Oryza glaberrima	60.87	7.00e-13	70.10
IUUC-Olo-080499	Oryza longistaminata	60.87	7.00e-13	70.50
IUUC-Opu-083209	Oryza punctata	60.87	9.00e-13	70.10
IUUC-Ola-086528	Oryzias latipes	36.34	3.00e-47	182.00
IUUC-Oga-088353	Otolemur garnettii	52.16	3.00e-121	428.00
IUUC-Oar-090065	Ovis aries	55.21	3.00e-101	361.00
IUUC-Ptr-091347	Pan troglodytes	50.09	2.00e-115	409.00
IUUC-Pan-092423	Papio anubis	47.57	8.00e-112	397.00
IUUC-Psi-093798	Pelodiscus sinensis	54.93	2.00e-143	502.00
IUUC-Pfo-096145	Poecilia formosa	38.13	4.00e-38	152.00
IUUC-Pab-098369	Pongo abelii	58.43	1.00e-89	323.00
IUUC-Pop-099262	Populus trichocarpa	55.77	2.00e-12	68.20
IUUC-Pca-100537	Procavia capensis	44.61	4.00e-113	401.00
IUUC-Ppe-101215	Prunus persica	56.25	1.00e-12	68.90
IUUC-Pva-102639	Pteropus vampyrus	49.26	4.00e-110	391.00
IUUC-Rno-105285	Rattus norvegicus	52.21	4.00e-135	474.00
IUUC-Sha-107159	Sarcophilus harrisii	75.82	0.00e+00	739.00
IUUC-Sit-110355	Setaria italica	58.33	4.00e-12	67.80
IUUC-Sbi-113930	Sorghum bicolor	58.33	3.00e-12	67.80
IUUC-Ssc-115773	Sus scrofa	48.85	3.00e-115	409.00
IUUC-Tgu-116922	Taeniopygia guttata	48.67	2.00e-76	279.00
IUUC-Tru-118263	Takifugu rubripes	33.51	2.00e-62	233.00
IUUC-Tsy-119270	Tarsius syrichta	49.60	2.00e-50	193.00
IUUC-Tni-120138	Tetraodon nigroviridis	33.45	1.00e-66	247.00
IUUC-Tca-121757	Theobroma cacao	45.83	2.00e-13	72.00
IUUC-Tre-121959	Trichoderma reesei	41.67	5.00e-09	57.00
IUUC-Tvi-122553	Trichoderma virens	41.67	4.00e-09	57.80
IUUC-Tae-124715	Triticum aestivum	60.87	3.00e-13	71.60
IUUC-Tbe-128077	Tupaia belangeri	46.57	4.00e-112	398.00
IUUC-Ttr-128781	Tursiops truncatus	67.30	1.00e-54	207.00
IUUC-Xtr-132665	Xenopus tropicalis	33.54	1.00e-14	73.90
IUUC-Xma-133054	Xiphophorus maculatus	32.91	2.00e-64	240.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence