iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10898935; 9268021

Classification

Family	E-value	Score	Start	End
DUB/USP	5.30e-98	329.2	23	361

Active Site

Position(s)	Description	Evidence
32	Nucleophile
310	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEfl 96
           +G++N+gNtCY+NSvLQ+L+++ ++re+lle++ ++     + + +++ll++l++lf+++   k+k+++++p+++++ lkk +e f++y++qDa+Efl
   Q: 23   FGFENFGNTCYCNSVLQALYFCAPFREQLLEHYANN-----KADAEENLLTCLADLFSQISsqKKKTGVIAPKRFVQRLKKQNELFRSYMHQDAHEFL 115
           69*****************************33332.....246789*************98899999****************************** PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsde.........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke 185
           ++ll++l e l+ke++ +k + e    s+++++         a+  +k+   ++++++Fqg l+++++cl+c++v+ r+e+fldlsl++++++     
   Q: 116  NYLLNELVEILEKETQATKADNET---SSSPEKianvlkaplANGVHKEPIVTWVHKIFQGILTNETRCLRCETVTARDETFLDLSLDIEQNS----- 205
           ***********6633333333333...3333335668998888888888899*****************************************..... PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiav 283
           s+++cL++f+++e+l+ e+k++c+kc+++qea+k++k+kk P++L++hLkRf++ e+ ++ +k++ +v fpleL+ls+ + +      ++ +Y+L+av
   Q: 206  SITSCLKNFSSTETLHAEDKFFCDKCCSLQEAQKRMKIKKPPHILVIHLKRFKYMEQLGRYKKLSYRVVFPLELKLSNTVDE-----YVDIEYSLFAV 298
           9****************************************************************************88877.....3489******* PP
   S: 284  vvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           vvH G ++++GHYv++vk+ +++Wl fdD++V+ ++e+ v+++ g         + +Y+l+Y++
   Q: 299  VVHVGsGPNHGHYVSLVKS-HNHWLFFDDESVEIIEESAVQTFFGssqeyssntDHGYILLYES 361
           *******************.889*******************999*****************85 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Required for the correct development of pollen.

Protein Sequence
(Fasta)

MGAAGSKLEK ALGDQFPEGE RYFGFENFGN TCYCNSVLQA LYFCAPFREQ LLEHYANNKA 60
DAEENLLTCL ADLFSQISSQ KKKTGVIAPK RFVQRLKKQN ELFRSYMHQD AHEFLNYLLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTATTCGCG AGGAACAGAA ATTTCAGTAT CGATCTTCTT CTTCTTCTTC TTCGCCAATT 60
TCAACACTTT CGAAATCTGA GAATCTTCTG TGTGAATCGG AACGAAATTA ACGGTGTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0519--Myristate
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G22310

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000934	Aegilops tauschii	76.75	2.00e-174	605.00
IUUC-Aml-002353	Ailuropoda melanoleuca	59.07	1.00e-123	435.00
IUUC-Apl-003380	Anas platyrhynchos	58.24	3.00e-121	427.00
IUUC-Aca-005031	Anolis carolinensis	58.11	7.00e-125	439.00
IUUC-Ago-007871	Ashbya gossypii	35.41	2.00e-48	186.00
IUUC-Acl-008239	Aspergillus clavatus	47.00	1.00e-72	267.00
IUUC-Afl-008602	Aspergillus flavus	47.33	9.00e-74	271.00
IUUC-Afu-008816	Aspergillus fumigatus	47.00	3.00e-73	269.00
IUUC-Ani-009137	Aspergillus nidulans	47.51	2.00e-71	263.00
IUUC-Ang-009703	Aspergillus niger	46.56	4.00e-74	271.00
IUUC-Aor-009901	Aspergillus oryzae	47.00	6.00e-74	271.00
IUUC-Ate-010431	Aspergillus terreus	45.85	1.00e-71	263.00
IUUC-Bgr-012071	Blumeria graminis	45.34	4.00e-78	285.00
IUUC-Bta-013023	Bos taurus	58.95	3.00e-123	434.00
IUUC-Bdi-014887	Brachypodium distachyon	84.20	0.00e+00	628.00
IUUC-Cja-018956	Callithrix jacchus	58.95	7.00e-123	432.00
IUUC-Cfa-021064	Canis familiaris	58.40	4.00e-120	423.00
IUUC-Cpo-022443	Cavia porcellus	58.95	6.00e-123	433.00
IUUC-Csa-023841	Chlorocebus sabaeus	59.07	1.00e-123	435.00
IUUC-Csv-025828	Ciona savignyi	44.95	3.00e-98	351.00
IUUC-Cne-026900	Cryptococcus neoformans	39.72	1.00e-52	200.00
IUUC-Dre-028230	Danio rerio	59.34	1.00e-125	442.00
IUUC-Dno-029209	Dasypus novemcinctus	58.95	9.00e-123	432.00
IUUC-Dme-032038	Drosophila melanogaster	59.22	7.00e-72	263.00
IUUC-Eeu-034916	Erinaceus europaeus	59.67	1.00e-100	358.00
IUUC-Fca-036299	Felis catus	58.95	9.00e-123	432.00
IUUC-Gga-041157	Gallus gallus	58.52	7.00e-122	429.00
IUUC-Ggo-044659	Gorilla gorilla	58.95	8.00e-123	432.00
IUUC-Hsa-046156	Homo sapiens	59.07	1.00e-123	435.00
IUUC-Itr-048157	Ictidomys tridecemlineatus	59.07	1.00e-123	435.00
IUUC-Kpa-049250	Komagataella pastoris	43.19	5.00e-68	251.00
IUUC-Lch-049969	Latimeria chalumnae	58.79	1.00e-121	428.00
IUUC-Loc-052479	Lepisosteus oculatus	59.34	2.00e-124	438.00
IUUC-Lma-053300	Leptosphaeria maculans	44.41	5.00e-74	271.00
IUUC-Laf-054085	Loxodonta africana	59.07	1.00e-123	435.00
IUUC-Mcc-055566	Macaca mulatta	58.95	4.00e-123	433.00
IUUC-Mla-059142	Melampsora laricipopulina	52.12	2.00e-93	336.00
IUUC-Mga-059575	Meleagris gallopavo	58.40	8.00e-121	426.00
IUUC-Mvi-060357	Microbotryum violaceum	53.31	5.00e-77	282.00
IUUC-Mdo-062579	Monodelphis domestica	59.07	4.00e-124	436.00
IUUC-Mmu-063611	Mus musculus	59.07	1.00e-123	435.00
IUUC-Mac-064964	Musa acuminata	83.11	0.00e+00	630.00
IUUC-Mpu-066038	Mustela putorius furo	58.95	8.00e-123	432.00
IUUC-Mlu-068183	Myotis lucifugus	58.95	5.00e-123	433.00
IUUC-Nfi-068611	Neosartorya fischeri	47.00	4.00e-73	268.00
IUUC-Nle-069330	Nomascus leucogenys	59.07	1.00e-123	435.00
IUUC-Opr-070980	Ochotona princeps	58.95	7.00e-123	432.00
IUUC-Ont-072134	Oreochromis niloticus	59.07	2.00e-125	441.00
IUUC-Ocu-074923	Oryctolagus cuniculus	58.68	9.00e-122	429.00
IUUC-Oba-075620	Oryza barthii	83.92	8.00e-180	622.00
IUUC-Obr-076208	Oryza brachyantha	83.92	8.00e-180	622.00
IUUC-Ogl-077763	Oryza glaberrima	83.92	8.00e-180	622.00
IUUC-Ogu-078571	Oryza glumaepatula	84.20	1.00e-180	625.00
IUUC-Oin-080002	Oryza indica	84.74	0.00e+00	640.00
IUUC-Opu-084002	Oryza punctata	83.65	1.00e-179	621.00
IUUC-Oru-084226	Oryza rufipogon	84.74	0.00e+00	640.00
IUUC-Osa-085453	Oryza sativa	84.74	0.00e+00	640.00
IUUC-Ola-086546	Oryzias latipes	58.95	1.00e-124	438.00
IUUC-Olu-087809	Ostreococcus lucimarinus	51.10	3.00e-94	337.00
IUUC-Oar-089248	Ovis aries	58.95	8.00e-123	432.00
IUUC-Ptr-090814	Pan troglodytes	59.07	1.00e-123	435.00
IUUC-Pan-091753	Papio anubis	59.07	1.00e-123	435.00
IUUC-Psi-094012	Pelodiscus sinensis	58.40	7.00e-121	426.00
IUUC-Ppa-095275	Physcomitrella patens	82.56	0.00e+00	630.00
IUUC-Pfo-097369	Poecilia formosa	59.34	6.00e-126	443.00
IUUC-Pab-098594	Pongo abelii	59.07	1.00e-123	435.00
IUUC-Pva-102892	Pteropus vampyrus	58.95	1.00e-122	432.00
IUUC-Pgr-103306	Puccinia graminis	51.13	7.00e-94	338.00
IUUC-Rno-104909	Rattus norvegicus	59.07	8.00e-124	436.00
IUUC-Sce-106367	Saccharomyces cerevisiae	38.73	6.00e-61	228.00
IUUC-Sha-107400	Sarcophilus harrisii	58.95	3.00e-123	434.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	41.14	2.00e-62	232.00
IUUC-Sit-109700	Setaria italica	85.01	0.00e+00	627.00
IUUC-Sbi-114562	Sorghum bicolor	85.56	0.00e+00	642.00
IUUC-Sre-115197	Sporisorium reilianum	45.23	2.00e-76	280.00
IUUC-Ssc-115550	Sus scrofa	58.95	6.00e-123	432.00
IUUC-Tgu-116800	Taeniopygia guttata	58.52	8.00e-122	429.00
IUUC-Tru-118212	Takifugu rubripes	59.07	3.00e-125	440.00
IUUC-Tni-120071	Tetraodon nigroviridis	59.07	1.00e-125	442.00
IUUC-Tae-125756	Triticum aestivum	83.92	0.00e+00	625.00
IUUC-Tur-126331	Triticum urartu	83.92	0.00e+00	626.00
IUUC-Tme-126890	Tuber melanosporum	46.04	7.00e-88	317.00
IUUC-Vda-129736	Verticillium dahliae	38.76	3.00e-58	219.00
IUUC-Vpa-130590	Vicugna pacos	56.04	2.00e-112	398.00
IUUC-Xma-133111	Xiphophorus maculatus	59.34	7.00e-126	442.00
IUUC-Yli-134632	Yarrowia lipolytica	43.91	4.00e-75	275.00
IUUC-Zma-135752	Zea mays	84.74	0.00e+00	625.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence