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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106303
Ensembl Protein ID YBL047C
UniProt Accession P34216; D6VPV1; EDE1_YEAST
Genbank Protein ID CAA84867.1; CAA55048.1; CAA80797.1; DAA07071.1
Protein Name EH domain-containing and endocytosis protein 1; Bud site selection protein 15
Genbank Nucleotide ID Z35808; X78214; Z23261; BK006936
Gene Name EDE1; BUD15; YBL047C; YBL0501; YBL0520
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBL047C YBL047C YBL047C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 12529323; 16563434
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 3.90e-09 34.8 1345 1379
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 6    kleqlveMGFdreealqaLraannnleaAveyLld 40
           ++e+l  MGF++eea  aL+ +n++leaA+++Lld
   Q: 1345 AVEELSGMGFTEEEAHNALEKCNWDLEAATNFLLD 1379
           6899999**************************98 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner.
 Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner.
Protein Sequence
(Fasta)
MASITFRTPL SSQEQAFYNQ KFHQLDTEDL GVVTGEAVRP LFASSGLPGQ LLSQVWATVD 60
IDNKGFLNLN EFSAALRMIA QLQNAPNQPI SAALYESTPT QLASFSINQN PAPMQSGSAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106303|UBD,UBA|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGCATCTA TTACTTTTAG AACTCCATTA TCCTCTCAGG AACAAGCCTT TTATAATCAG 60
AAATTTCACC AATTGGATAC GGAAGATCTC GGGGTGGTCA CTGGCGAGGC AGTCAGACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106303|UBD,UBA|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50030--UBA
Pfam

PF12763--EF-hand_4
PF00627--UBA
SMART

SM00054--EFh
SM00027--EH
SM00165--UBA
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005935--C:cellular bud neck
GO:0005934--C:cellular bud tip
GO:0005737--C:cytoplasm
GO:0005509--F:calcium ion binding
GO:0043130--F:ubiquitin binding
GO:0044396--P:actin cortical patch organization
GO:0006897--P:endocytosis
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032467--P:positive regulation of cytokinesis
GO:0032880--P:regulation of protein localization
KEGG sce:YBL047C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000722 Aegilops tauschii 28.57 2.00e-11 63.50
IUUC-Aml-001596 Ailuropoda melanoleuca 32.09 5.00e-25 107.00
IUUC-Atr-002491 Amborella trichopoda 30.72 1.00e-12 67.40
IUUC-Apl-003288 Anas platyrhynchos 27.54 2.00e-32 132.00
IUUC-Aca-005333 Anolis carolinensis 29.48 5.00e-38 150.00
IUUC-Aly-005557 Arabidopsis lyrata 29.67 2.00e-10 59.70
IUUC-Ath-007330 Arabidopsis thaliana 27.78 1.00e-09 57.00
IUUC-Ago-007867 Ashbya gossypii 49.32 6.00e-115 407.00
IUUC-Acl-008193 Aspergillus clavatus 34.05 1.00e-27 116.00
IUUC-Afl-008603 Aspergillus flavus 32.80 1.00e-47 183.00
IUUC-Afu-008916 Aspergillus fumigatus 33.51 4.00e-48 185.00
IUUC-Ani-009469 Aspergillus nidulans 33.15 7.00e-49 187.00
IUUC-Ang-009642 Aspergillus niger 32.47 7.00e-51 194.00
IUUC-Aor-009997 Aspergillus oryzae 32.10 3.00e-47 182.00
IUUC-Ate-010517 Aspergillus terreus 32.63 2.00e-48 186.00
IUUC-Ame-011472 Astyanax mexicanus 26.72 5.00e-32 130.00
IUUC-Bgr-012135 Blumeria graminis 31.86 7.00e-50 191.00
IUUC-Bta-013028 Bos taurus 28.24 1.00e-35 143.00
IUUC-Bci-013666 Botrytis cinerea 32.55 1.00e-51 196.00
IUUC-Bdi-014016 Brachypodium distachyon 31.25 3.00e-12 65.90
IUUC-Bol-015187 Brassica oleracea 27.34 3.00e-10 58.50
IUUC-Bra-017706 Brassica rapa 28.12 1.00e-10 60.10
IUUC-Cel-018490 Caenorhabditis elegans 26.74 7.00e-19 87.80
IUUC-Cja-019821 Callithrix jacchus 28.24 2.00e-35 142.00
IUUC-Cfa-020227 Canis familiaris 26.60 1.00e-26 113.00
IUUC-Cpo-021877 Cavia porcellus 31.89 8.00e-20 90.50
IUUC-Cre-022691 Chlamydomonas reinhardtii 37.78 2.00e-03 35.00
IUUC-Csa-024072 Chlorocebus sabaeus 28.61 9.00e-36 143.00
IUUC-Cho-025000 Choloepus hoffmanni 28.66 2.00e-32 132.00
IUUC-Cin-025645 Ciona intestinalis 26.21 1.00e-20 93.20
IUUC-Csv-025925 Ciona savignyi 37.35 8.00e-14 67.80
IUUC-Cgl-026390 Colletotrichum gloeosporioides 31.31 4.00e-39 155.00
IUUC-Cne-027039 Cryptococcus neoformans 45.12 1.00e-16 80.90
IUUC-Cme-027270 Cyanidioschyzon merolae 26.40 2.00e-10 59.30
IUUC-Dre-027504 Danio rerio 30.46 6.00e-36 144.00
IUUC-Dno-029498 Dasypus novemcinctus 30.17 1.00e-36 146.00
IUUC-Dor-030630 Dipodomys ordii 27.54 9.00e-35 140.00
IUUC-Dse-031409 Dothistroma septosporum 30.91 4.00e-42 165.00
IUUC-Dme-031851 Drosophila melanogaster 25.56 9.00e-19 87.40
IUUC-Eca-033328 Equus caballus 28.37 1.00e-36 146.00
IUUC-Fca-035511 Felis catus 27.46 2.00e-34 139.00
IUUC-Fal-036796 Ficedula albicollis 29.77 3.00e-37 148.00
IUUC-Fox-037755 Fusarium oxysporum 31.30 2.00e-47 182.00
IUUC-Fso-038230 Fusarium solani 30.15 3.00e-44 172.00
IUUC-Gmo-038482 Gadus morhua 28.04 6.00e-32 130.00
IUUC-Ggr-039734 Gaeumannomyces graminis 30.96 1.00e-38 153.00
IUUC-Gga-040315 Gallus gallus 30.35 4.00e-38 151.00
IUUC-Gac-042109 Gasterosteus aculeatus 28.44 2.00e-19 89.40
IUUC-Gma-043381 Glycine max 28.77 3.00e-12 65.90
IUUC-Ggo-044868 Gorilla gorilla 25.69 7.00e-26 110.00
IUUC-Hsa-046286 Homo sapiens 28.32 9.00e-36 143.00
IUUC-Hvu-047530 Hordeum vulgare 29.73 2.00e-13 69.30
IUUC-Itr-048698 Ictidomys tridecemlineatus 25.62 3.00e-16 77.00
IUUC-Kpa-049396 Komagataella pastoris 40.96 2.00e-72 265.00
IUUC-Lch-049746 Latimeria chalumnae 26.88 2.00e-30 125.00
IUUC-Lpe-051250 Leersia perrieri 33.33 2.00e-12 66.20
IUUC-Loc-052757 Lepisosteus oculatus 26.43 7.00e-31 127.00
IUUC-Lma-053198 Leptosphaeria maculans 28.88 2.00e-41 163.00
IUUC-Laf-054158 Loxodonta africana 28.32 5.00e-34 137.00
IUUC-Mcc-055325 Macaca mulatta 28.61 1.00e-35 143.00
IUUC-Meu-056373 Macropus eugenii 30.00 3.00e-29 121.00
IUUC-Mor-056953 Magnaporthe oryzae 32.18 6.00e-41 161.00
IUUC-Mpo-057429 Magnaporthe poae 31.03 2.00e-20 92.80
IUUC-Mtr-057705 Medicago truncatula 29.41 4.00e-12 65.10
IUUC-Mla-059188 Melampsora laricipopulina 31.55 8.00e-45 173.00
IUUC-Mga-060058 Meleagris gallopavo 30.64 3.00e-38 151.00
IUUC-Mvi-060354 Microbotryum violaceum 30.05 6.00e-44 171.00
IUUC-Mmr-061060 Microcebus murinus 28.90 4.00e-36 144.00
IUUC-Mdo-063032 Monodelphis domestica 28.77 3.00e-29 122.00
IUUC-Mmu-064091 Mus musculus 27.75 7.00e-32 130.00
IUUC-Mac-065649 Musa acuminata 28.38 3.00e-12 65.90
IUUC-Mpu-065932 Mustela putorius furo 28.61 3.00e-35 142.00
IUUC-Mlu-067488 Myotis lucifugus 28.90 3.00e-36 144.00
IUUC-Nfi-068419 Neosartorya fischeri 33.87 8.00e-48 184.00
IUUC-Ncr-068851 Neurospora crassa 32.32 1.00e-45 176.00
IUUC-Nle-068996 Nomascus leucogenys 28.32 3.00e-35 141.00
IUUC-Opr-070476 Ochotona princeps 24.11 7.00e-17 80.90
IUUC-Ont-071313 Oreochromis niloticus 25.44 3.00e-29 122.00
IUUC-Oan-073390 Ornithorhynchus anatinus 32.45 5.00e-13 68.90
IUUC-Ocu-074170 Oryctolagus cuniculus 28.81 2.00e-32 132.00
IUUC-Oba-075548 Oryza barthii 32.77 2.00e-15 76.60
IUUC-Obr-076871 Oryza brachyantha 30.90 2.00e-14 73.20
IUUC-Ogl-077317 Oryza glaberrima 32.77 2.00e-15 76.60
IUUC-Ogu-078849 Oryza glumaepatula 34.57 1.00e-12 67.00
IUUC-Oin-079539 Oryza indica 32.20 6.00e-15 74.70
IUUC-Olo-080259 Oryza longistaminata 34.57 2.00e-12 66.60
IUUC-Ome-081199 Oryza meridionalis 34.57 9.00e-13 67.40
IUUC-Oni-082167 Oryza nivara 34.57 2.00e-12 66.60
IUUC-Opu-084149 Oryza punctata 32.43 2.00e-14 73.20
IUUC-Oru-084541 Oryza rufipogon 34.57 2.00e-12 66.60
IUUC-Osa-085387 Oryza sativa 32.20 4.00e-15 74.70
IUUC-Ola-086518 Oryzias latipes 26.94 6.00e-27 114.00
IUUC-Olu-087698 Ostreococcus lucimarinus 30.21 1.00e-08 53.10
IUUC-Oga-088628 Otolemur garnettii 26.53 3.00e-27 115.00
IUUC-Oar-089833 Ovis aries 28.53 6.00e-35 140.00
IUUC-Ptr-090733 Pan troglodytes 28.61 9.00e-36 143.00
IUUC-Pan-092868 Papio anubis 26.61 2.00e-27 115.00
IUUC-Psi-094063 Pelodiscus sinensis 31.91 4.00e-23 101.00
IUUC-Pma-094451 Petromyzon marinus 26.90 4.00e-30 123.00
IUUC-Pno-094814 Phaeosphaeria nodorum 29.86 4.00e-39 155.00
IUUC-Ppa-095426 Physcomitrella patens 29.79 2.00e-10 59.30
IUUC-Pfo-096780 Poecilia formosa 29.41 5.00e-20 91.70
IUUC-Pab-098749 Pongo abelii 28.61 9.00e-36 143.00
IUUC-Pop-098963 Populus trichocarpa 32.63 2.00e-10 59.70
IUUC-Pca-100272 Procavia capensis 26.85 8.00e-12 63.90
IUUC-Ppe-101928 Prunus persica 28.97 5.00e-12 65.10
IUUC-Pva-102739 Pteropus vampyrus 28.03 3.00e-33 135.00
IUUC-Pgr-103392 Puccinia graminis 30.09 6.00e-44 171.00
IUUC-Ptt-103746 Puccinia triticina 28.70 4.00e-26 111.00
IUUC-Pte-104059 Pyrenophora teres 29.75 2.00e-41 162.00
IUUC-Pyt-104816 Pyrenophora triticirepentis 30.03 9.00e-42 164.00
IUUC-Rno-105042 Rattus norvegicus 28.08 2.00e-34 139.00
IUUC-Sha-106549 Sarcophilus harrisii 28.29 1.00e-29 123.00
IUUC-Sja-107675 Schizosaccharomyces japonicus 27.97 8.00e-41 160.00
IUUC-Spo-108370 Schizosaccharomyces pombe 29.70 2.00e-24 106.00
IUUC-Ssl-108463 Sclerotinia sclerotiorum 31.40 6.00e-48 184.00
IUUC-Smo-108995 Selaginella moellendorffii 36.84 1.00e-09 56.20
IUUC-Sit-110414 Setaria italica 33.33 4.00e-12 65.50
IUUC-Sly-111403 Solanum lycopersicum 34.02 8.00e-12 64.30
IUUC-Stu-112258 Solanum tuberosum 36.90 2.00e-09 55.50
IUUC-Sar-113358 Sorex araneus 33.66 1.00e-29 122.00
IUUC-Sbi-114170 Sorghum bicolor 33.67 5.00e-14 71.60
IUUC-Sre-114981 Sporisorium reilianum 32.17 2.00e-48 186.00
IUUC-Ssc-115746 Sus scrofa 27.67 3.00e-34 138.00
IUUC-Tgu-117351 Taeniopygia guttata 30.06 7.00e-36 144.00
IUUC-Tru-118540 Takifugu rubripes 29.15 2.00e-37 149.00
IUUC-Tsy-118873 Tarsius syrichta 24.21 2.00e-21 95.90
IUUC-Tni-119871 Tetraodon nigroviridis 27.49 3.00e-32 131.00
IUUC-Tca-121631 Theobroma cacao 29.27 3.00e-08 52.40
IUUC-Tre-122064 Trichoderma reesei 30.48 3.00e-38 152.00
IUUC-Tvi-122351 Trichoderma virens 32.02 1.00e-47 183.00
IUUC-Tae-123242 Triticum aestivum 33.33 4.00e-12 65.50
IUUC-Tur-126623 Triticum urartu 32.10 2.00e-11 63.20
IUUC-Tme-126877 Tuber melanosporum 31.17 3.00e-50 192.00
IUUC-Tbe-127307 Tupaia belangeri 25.72 4.00e-26 111.00
IUUC-Ttr-128775 Tursiops truncatus 31.91 3.00e-25 108.00
IUUC-Uma-129336 Ustilago maydis 34.08 8.00e-50 191.00
IUUC-Vda-129921 Verticillium dahliae 32.86 5.00e-37 148.00
IUUC-Vpa-130684 Vicugna pacos 27.95 8.00e-36 143.00
IUUC-Vvi-130856 Vitis vinifera 28.26 2.00e-08 53.10
IUUC-Xtr-132716 Xenopus tropicalis 28.84 1.00e-36 146.00
IUUC-Xma-133907 Xiphophorus maculatus 29.41 8.00e-21 94.00
IUUC-Yli-134577 Yarrowia lipolytica 38.17 1.00e-64 240.00
IUUC-Zma-134872 Zea mays 31.01 3.00e-15 74.70
Created Date 25-Jun-2017

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