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Tag Content
iUUCD ID IUUC-Lch-049936
Ensembl Protein ID ENSLACP00000020703.2
UniProt Accession H3BFN2; H3BFN2_LATCH
Genbank Protein ID ENSLACP00000020703
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AFYH01008545
Gene Name PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLACG00000018191.2 ENSLACT00000020843.2 ENSLACP00000020703.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-57 188.8 190 229
UBD/Beta-Prp 2.80e-95 319.1 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH v+++a ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 190 GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 229
    899*******99777********************99875 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v ++p +++++s+++D+++r+Wd++++
   Q: 283 SWAPESsfptileatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLVHPGGKFILSCADDKTLRVWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s+++ + + + +v+gs d++v++w+++
   Q: 372 CMKTLNAHEHFVTSMDF-HKTAPFVVSGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Latimeria chalumnae
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGVPFGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Lch-049936|E3,WD_repeat;UBD,Beta-Prp|Latimeria chalumnae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCGCGCTGG TGAGCTCGGT GACTGAAAGC ATAGGGAGAC CGGCTGAAAG GAAAGAGAGA 60
AGCGAGAGGG GAAAATAACA CATTTTTAAG CCCAAATAAC TCTCCGAAGC CACCCCTGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Lch-049936|E3,WD_repeat;UBD,Beta-Prp|Latimeria chalumnae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

KEGG lcm:102358277
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 96.74 0.00e+00 811.00
IUUC-Apl-004024 Anas platyrhynchos 96.59 0.00e+00 830.00
IUUC-Aca-004564 Anolis carolinensis 96.10 0.00e+00 824.00
IUUC-Ago-007862 Ashbya gossypii 26.61 2.00e-38 152.00
IUUC-Acl-008360 Aspergillus clavatus 46.04 7.00e-105 374.00
IUUC-Afl-008502 Aspergillus flavus 44.91 2.00e-93 335.00
IUUC-Afu-008848 Aspergillus fumigatus 45.52 2.00e-106 379.00
IUUC-Ani-009173 Aspergillus nidulans 42.79 1.00e-89 323.00
IUUC-Ang-009873 Aspergillus niger 44.81 4.00e-94 338.00
IUUC-Aor-009973 Aspergillus oryzae 43.69 2.00e-91 328.00
IUUC-Ate-010523 Aspergillus terreus 42.46 3.00e-90 325.00
IUUC-Ame-010969 Astyanax mexicanus 95.12 0.00e+00 823.00
IUUC-Bgr-011972 Blumeria graminis 47.49 6.00e-105 374.00
IUUC-Bta-013106 Bos taurus 96.83 0.00e+00 833.00
IUUC-Bci-013615 Botrytis cinerea 44.82 1.00e-99 356.00
IUUC-Cel-018459 Caenorhabditis elegans 57.18 6.00e-148 516.00
IUUC-Cja-018755 Callithrix jacchus 94.39 0.00e+00 813.00
IUUC-Cfa-020749 Canis familiaris 96.83 0.00e+00 833.00
IUUC-Cpo-022371 Cavia porcellus 96.83 0.00e+00 833.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 35.76 2.00e-50 192.00
IUUC-Csa-023524 Chlorocebus sabaeus 95.65 0.00e+00 697.00
IUUC-Cho-024764 Choloepus hoffmanni 85.98 0.00e+00 657.00
IUUC-Cin-025753 Ciona intestinalis 70.56 5.00e-180 623.00
IUUC-Csv-025817 Ciona savignyi 69.27 0.00e+00 637.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 46.57 6.00e-98 350.00
IUUC-Cne-027087 Cryptococcus neoformans 50.39 5.00e-111 394.00
IUUC-Dre-027554 Danio rerio 94.88 0.00e+00 817.00
IUUC-Dno-029050 Dasypus novemcinctus 96.59 0.00e+00 832.00
IUUC-Dor-030222 Dipodomys ordii 88.54 0.00e+00 750.00
IUUC-Dse-031164 Dothistroma septosporum 43.10 3.00e-101 362.00
IUUC-Dme-031745 Drosophila melanogaster 69.83 8.00e-172 596.00
IUUC-Ete-032508 Echinops telfairi 80.00 0.00e+00 668.00
IUUC-Eca-034288 Equus caballus 96.24 0.00e+00 806.00
IUUC-Eeu-034984 Erinaceus europaeus 88.29 0.00e+00 746.00
IUUC-Fca-036498 Felis catus 96.83 0.00e+00 833.00
IUUC-Fal-036920 Ficedula albicollis 96.59 0.00e+00 830.00
IUUC-Fox-037996 Fusarium oxysporum 45.57 6.00e-103 367.00
IUUC-Fso-038160 Fusarium solani 43.36 3.00e-98 352.00
IUUC-Gmo-038983 Gadus morhua 93.66 0.00e+00 812.00
IUUC-Ggr-040051 Gaeumannomyces graminis 44.39 7.00e-98 350.00
IUUC-Gga-040623 Gallus gallus 96.59 0.00e+00 830.00
IUUC-Gac-041363 Gasterosteus aculeatus 92.68 0.00e+00 810.00
IUUC-Ggo-045410 Gorilla gorilla 85.96 0.00e+00 702.00
IUUC-Hsa-046358 Homo sapiens 96.59 0.00e+00 830.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 96.83 0.00e+00 833.00
IUUC-Kpa-049351 Komagataella pastoris 29.07 7.00e-43 168.00
IUUC-Loc-052476 Lepisosteus oculatus 95.74 0.00e+00 805.00
IUUC-Lma-053170 Leptosphaeria maculans 46.43 2.00e-100 358.00
IUUC-Laf-053713 Loxodonta africana 94.87 0.00e+00 813.00
IUUC-Mcc-054628 Macaca mulatta 96.34 0.00e+00 830.00
IUUC-Meu-055927 Macropus eugenii 82.31 8.00e-135 472.00
IUUC-Mor-056962 Magnaporthe oryzae 44.36 6.00e-98 350.00
IUUC-Mpo-057583 Magnaporthe poae 44.34 2.00e-93 335.00
IUUC-Mla-058819 Melampsora laricipopulina 48.09 1.00e-117 416.00
IUUC-Mga-059945 Meleagris gallopavo 96.34 0.00e+00 830.00
IUUC-Mvi-060403 Microbotryum violaceum 49.66 9.00e-129 453.00
IUUC-Mmr-061289 Microcebus murinus 96.74 0.00e+00 810.00
IUUC-Mdo-061912 Monodelphis domestica 96.10 0.00e+00 826.00
IUUC-Mmu-063253 Mus musculus 96.83 0.00e+00 833.00
IUUC-Mpu-066638 Mustela putorius furo 96.83 0.00e+00 833.00
IUUC-Mlu-067267 Myotis lucifugus 95.34 0.00e+00 816.00
IUUC-Nfi-068571 Neosartorya fischeri 44.18 4.00e-99 354.00
IUUC-Ncr-068895 Neurospora crassa 48.17 5.00e-105 374.00
IUUC-Nle-069087 Nomascus leucogenys 97.31 0.00e+00 682.00
IUUC-Opr-070579 Ochotona princeps 96.59 0.00e+00 832.00
IUUC-Ont-072432 Oreochromis niloticus 93.66 0.00e+00 812.00
IUUC-Oan-073072 Ornithorhynchus anatinus 96.83 0.00e+00 833.00
IUUC-Ocu-074180 Oryctolagus cuniculus 96.59 0.00e+00 832.00
IUUC-Ola-086772 Oryzias latipes 94.88 0.00e+00 817.00
IUUC-Oga-088219 Otolemur garnettii 94.62 0.00e+00 812.00
IUUC-Oar-090394 Ovis aries 96.83 0.00e+00 833.00
IUUC-Ptr-091517 Pan troglodytes 96.83 0.00e+00 833.00
IUUC-Pan-092421 Papio anubis 96.34 0.00e+00 830.00
IUUC-Psi-093370 Pelodiscus sinensis 96.34 0.00e+00 830.00
IUUC-Pma-094319 Petromyzon marinus 87.68 0.00e+00 639.00
IUUC-Pno-094815 Phaeosphaeria nodorum 47.02 7.00e-104 370.00
IUUC-Pfo-097089 Poecilia formosa 94.39 0.00e+00 817.00
IUUC-Pab-098421 Pongo abelii 96.83 0.00e+00 833.00
IUUC-Pca-100120 Procavia capensis 70.79 9.00e-160 556.00
IUUC-Pva-102960 Pteropus vampyrus 96.59 0.00e+00 828.00
IUUC-Pgr-103538 Puccinia graminis 47.20 4.00e-117 414.00
IUUC-Ptt-103990 Puccinia triticina 42.06 7.00e-44 172.00
IUUC-Pte-104261 Pyrenophora teres 47.26 6.00e-104 370.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.49 3.00e-104 372.00
IUUC-Rno-105123 Rattus norvegicus 96.83 0.00e+00 833.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.53 2.00e-36 146.00
IUUC-Sha-107010 Sarcophilus harrisii 95.85 0.00e+00 825.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.80 5.00e-67 248.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.95 3.00e-100 358.00
IUUC-Sar-113309 Sorex araneus 95.99 0.00e+00 801.00
IUUC-Sre-115003 Sporisorium reilianum 49.54 2.00e-124 439.00
IUUC-Ssc-116148 Sus scrofa 96.83 0.00e+00 833.00
IUUC-Tgu-117299 Taeniopygia guttata 96.34 0.00e+00 828.00
IUUC-Tru-117721 Takifugu rubripes 93.17 0.00e+00 805.00
IUUC-Tsy-119493 Tarsius syrichta 95.61 0.00e+00 817.00
IUUC-Tni-120355 Tetraodon nigroviridis 93.17 0.00e+00 780.00
IUUC-Tre-121977 Trichoderma reesei 42.58 1.00e-100 360.00
IUUC-Tvi-122661 Trichoderma virens 43.01 2.00e-99 356.00
IUUC-Tme-127031 Tuber melanosporum 48.14 4.00e-104 371.00
IUUC-Tbe-127492 Tupaia belangeri 62.60 2.00e-123 435.00
IUUC-Ttr-128929 Tursiops truncatus 96.83 0.00e+00 831.00
IUUC-Uma-129347 Ustilago maydis 47.49 6.00e-122 430.00
IUUC-Vda-129837 Verticillium dahliae 45.19 5.00e-99 354.00
IUUC-Vpa-130532 Vicugna pacos 82.64 0.00e+00 644.00
IUUC-Xtr-131985 Xenopus tropicalis 95.61 0.00e+00 827.00
IUUC-Xma-133314 Xiphophorus maculatus 94.88 0.00e+00 820.00
IUUC-Yli-134403 Yarrowia lipolytica 38.39 2.00e-75 275.00
Created Date 25-Jun-2017

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