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Tag Content
iUUCD ID IUUC-Ncr-068895
Ensembl Protein ID EAA27709
UniProt Accession Q7RY30; LIS11_NEUCR
Genbank Protein ID EAA27709.3
Protein Name Nuclear distribution protein nudF-2; Lissencephaly-1 homolog 1; Nuclear migration protein 1; nudF homolog 2
Genbank Nucleotide ID CM002242
Gene Name nmp-1; lis1-1; mtb4A; nudf-2; pac1-1; ro-15; NCU04534
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
NCU04534 EAA27709 EAA27709
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-47 156.0 199 239
UBD/Beta-Prp 2.20e-67 226.4 111 451
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s++llvs+s+D+t+++WD++tg ++k+
   Q: 199 GHDHSVSAVRFipgSGNLLVSASRDKTLRIWDVSTGYCVKT 239
    8***********7655********************99875 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfs.pdgk.ilvtgseDrtikvw.dlstgkcvhtlkghedsvlslsfsp 104
    ++h ++itcv+f+p s la+gs+d+tik+wd++ g l r+++gh+++v +v++ p+g+ +l+++s+D tik+w +l+++k ++tl gh++sv +++f p
   Q: 111 QSHRDPITCVAFHPVFSSLASGSEDQTIKIWDWELGELERTIKGHTKAVLDVDYGgPRGNtLLASCSSDLTIKLWdPLDSYKNIRTLPGHDHSVSAVRFIP 211
    45777*************************************************7345558**************7789********************** PP
   S: 105 .sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkllrtltgghtdsvysls........fdsng.. 192
    sg+ lvs+s+d+t+r+wd++tg+c++ tl+gh ++v+ v+ + dg+++ s s+D t rlWd+ + + tl g h++ v + +
   Q: 212 gSGNLLVSASRDKTLRIWDVSTGYCVK-TLRGHAEWVRDVCPSLDGKYILSTSDDYTSRLWDVtiTNPEPKVTLIG-HEHVVLCCAiappaayqN---Laa 307
    999************************.***********************************8888888999999.*********666655440...156 PP
   S: 193 .............kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvavlsfgdnv 279
    +++++gs+d++++lwd +g+c++tl gh+++v+ + f+p +++l+s+s+D+++r+Wdl + g+++kt+ + +++ + + ++ v
   Q: 308 magikkppatssaEFMATGSRDKSIRLWDA-RGTCIKTLVGHDNWVRGLVFHPGGKYLLSVSDDKTLRCWDLtQEGKCVKTIGDAHGHFVQCIKWAPS--V 405
    6666666666666****************9.899************************************983679********99665544432332..2 PP
   S: 280 l.................................vlgsedskvniw 292
    + ++gs d +v+i+
   Q: 406 IkdasvngdngepngtpkkggaaatpeaqircviATGSVDLNVRIF 451
    2222334455555555555555555555555555566666666665 PP
   

Organism Neurospora crassa
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSQILTSRQA DELHRALIAY LTAANLPNTA AALREELNLS EEVFDPATAK KYEGLLEKKW 60
TSVVRLQKKI MDLESRNHIL QSELDNATPT SRQNKDPVAW LPRAPPRHTL QSHRDPITCV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ncr-068895|E3,WD_repeat;UBD,Beta-Prp|Neurospora crassa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAGTGGAA GCTGATGCGT TGTTTCGCTG CCCCGCCAAA AGCAAGACAG TCCGCCCACT 60
GAAAGGGAAC CCAAACAAAG TGCTACAGTG GGTGAGCCGT CAGTCTGGCT TTTGAGGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ncr-068895|E3,WD_repeat;UBD,Beta-Prp|Neurospora crassa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG ncr:NCU04534
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 48.12 2.00e-105 374.00
IUUC-Apl-004024 Anas platyrhynchos 48.41 4.00e-109 386.00
IUUC-Aca-004564 Anolis carolinensis 47.92 1.00e-106 378.00
IUUC-Ago-007862 Ashbya gossypii 28.51 1.00e-37 149.00
IUUC-Afl-008502 Aspergillus flavus 66.44 4.00e-175 605.00
IUUC-Afu-008848 Aspergillus fumigatus 70.21 0.00e+00 668.00
IUUC-Ani-009173 Aspergillus nidulans 61.32 2.00e-164 570.00
IUUC-Ang-009873 Aspergillus niger 58.94 3.00e-158 549.00
IUUC-Aor-009973 Aspergillus oryzae 62.42 3.00e-168 582.00
IUUC-Ate-010523 Aspergillus terreus 59.69 5.00e-160 555.00
IUUC-Ame-011154 Astyanax mexicanus 48.66 4.00e-110 389.00
IUUC-Bgr-011972 Blumeria graminis 68.88 0.00e+00 660.00
IUUC-Bta-013106 Bos taurus 48.41 2.00e-109 387.00
IUUC-Bci-013615 Botrytis cinerea 72.96 0.00e+00 685.00
IUUC-Cel-018459 Caenorhabditis elegans 44.85 8.00e-95 338.00
IUUC-Cja-018755 Callithrix jacchus 47.19 7.00e-106 375.00
IUUC-Cfa-020749 Canis familiaris 48.41 2.00e-109 387.00
IUUC-Cpo-022371 Cavia porcellus 48.41 2.00e-109 387.00
IUUC-Csa-023524 Chlorocebus sabaeus 48.82 1.00e-91 327.00
IUUC-Cho-024764 Choloepus hoffmanni 46.26 2.00e-87 313.00
IUUC-Cin-025753 Ciona intestinalis 48.77 9.00e-102 361.00
IUUC-Csv-025817 Ciona savignyi 48.04 1.00e-105 374.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 76.77 0.00e+00 702.00
IUUC-Cne-027087 Cryptococcus neoformans 52.15 2.00e-115 407.00
IUUC-Dre-027554 Danio rerio 48.41 2.00e-107 380.00
IUUC-Dno-029050 Dasypus novemcinctus 48.41 2.00e-109 387.00
IUUC-Dor-030222 Dipodomys ordii 45.23 8.00e-97 345.00
IUUC-Dse-031164 Dothistroma septosporum 67.46 0.00e+00 641.00
IUUC-Dme-031745 Drosophila melanogaster 48.66 4.00e-99 352.00
IUUC-Ete-032508 Echinops telfairi 49.45 2.00e-72 264.00
IUUC-Eca-034288 Equus caballus 47.62 2.00e-104 370.00
IUUC-Eeu-034984 Erinaceus europaeus 44.99 1.00e-95 341.00
IUUC-Fca-036498 Felis catus 48.41 2.00e-109 387.00
IUUC-Fal-036920 Ficedula albicollis 48.41 4.00e-109 386.00
IUUC-Fox-037996 Fusarium oxysporum 71.00 0.00e+00 690.00
IUUC-Fso-038160 Fusarium solani 69.48 0.00e+00 662.00
IUUC-Gmo-038983 Gadus morhua 48.41 2.00e-108 384.00
IUUC-Ggr-040051 Gaeumannomyces graminis 70.63 0.00e+00 670.00
IUUC-Gga-040623 Gallus gallus 48.41 4.00e-109 386.00
IUUC-Gac-041613 Gasterosteus aculeatus 48.53 2.00e-108 384.00
IUUC-Ggo-045410 Gorilla gorilla 44.47 2.00e-89 320.00
IUUC-Hsa-046358 Homo sapiens 48.41 3.00e-109 386.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 48.41 2.00e-109 387.00
IUUC-Kpa-049351 Komagataella pastoris 31.11 5.00e-47 180.00
IUUC-Lch-049936 Latimeria chalumnae 48.17 2.00e-108 384.00
IUUC-Loc-052476 Lepisosteus oculatus 47.87 5.00e-105 372.00
IUUC-Lma-053170 Leptosphaeria maculans 72.63 0.00e+00 659.00
IUUC-Laf-053713 Loxodonta africana 48.25 3.00e-106 376.00
IUUC-Mcc-054628 Macaca mulatta 48.41 4.00e-109 386.00
IUUC-Meu-055927 Macropus eugenii 41.33 2.00e-53 200.00
IUUC-Mor-056962 Magnaporthe oryzae 71.27 0.00e+00 681.00
IUUC-Mpo-057583 Magnaporthe poae 71.06 0.00e+00 652.00
IUUC-Mla-058819 Melampsora laricipopulina 49.35 1.00e-117 414.00
IUUC-Mga-059945 Meleagris gallopavo 48.17 6.00e-109 385.00
IUUC-Mvi-060403 Microbotryum violaceum 51.20 4.00e-130 456.00
IUUC-Mmr-061289 Microcebus murinus 47.67 1.00e-105 374.00
IUUC-Mdo-061912 Monodelphis domestica 48.17 7.00e-109 385.00
IUUC-Mmu-063253 Mus musculus 48.41 2.00e-109 387.00
IUUC-Mpu-066638 Mustela putorius furo 48.41 2.00e-109 387.00
IUUC-Mlu-067267 Myotis lucifugus 47.55 2.00e-106 377.00
IUUC-Nfi-068571 Neosartorya fischeri 65.17 1.00e-176 610.00
IUUC-Nle-069087 Nomascus leucogenys 46.82 5.00e-89 318.00
IUUC-Opr-070579 Ochotona princeps 48.41 2.00e-109 387.00
IUUC-Ont-072432 Oreochromis niloticus 48.77 6.00e-109 385.00
IUUC-Oan-073072 Ornithorhynchus anatinus 48.41 2.00e-109 387.00
IUUC-Ocu-074180 Oryctolagus cuniculus 48.41 2.00e-109 387.00
IUUC-Ola-086815 Oryzias latipes 47.68 2.00e-108 384.00
IUUC-Oga-088219 Otolemur garnettii 47.07 4.00e-106 376.00
IUUC-Oar-090394 Ovis aries 48.41 2.00e-109 387.00
IUUC-Ptr-091517 Pan troglodytes 48.41 2.00e-109 387.00
IUUC-Pan-092421 Papio anubis 48.41 4.00e-109 386.00
IUUC-Psi-093370 Pelodiscus sinensis 48.41 6.00e-109 385.00
IUUC-Pma-094319 Petromyzon marinus 49.56 3.00e-91 326.00
IUUC-Pno-094815 Phaeosphaeria nodorum 71.95 0.00e+00 680.00
IUUC-Pfo-097089 Poecilia formosa 48.77 6.00e-109 385.00
IUUC-Pab-098421 Pongo abelii 48.41 2.00e-109 387.00
IUUC-Pca-100120 Procavia capensis 39.12 1.00e-62 231.00
IUUC-Pva-102960 Pteropus vampyrus 48.17 3.00e-108 383.00
IUUC-Pgr-103538 Puccinia graminis 51.18 3.00e-123 433.00
IUUC-Ptt-103990 Puccinia triticina 44.88 1.00e-46 179.00
IUUC-Pte-104261 Pyrenophora teres 73.55 0.00e+00 685.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 73.76 0.00e+00 687.00
IUUC-Rno-105123 Rattus norvegicus 48.41 2.00e-109 387.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.98 1.00e-36 145.00
IUUC-Sha-107010 Sarcophilus harrisii 48.17 5.00e-109 385.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 75.51 0.00e+00 671.00
IUUC-Sar-113309 Sorex araneus 47.37 9.00e-103 365.00
IUUC-Sre-115003 Sporisorium reilianum 52.41 3.00e-131 459.00
IUUC-Ssc-116148 Sus scrofa 48.41 2.00e-109 387.00
IUUC-Tgu-117299 Taeniopygia guttata 48.41 4.00e-109 386.00
IUUC-Tru-118179 Takifugu rubripes 48.66 5.00e-109 385.00
IUUC-Tsy-119493 Tarsius syrichta 48.66 4.00e-109 385.00
IUUC-Tni-120355 Tetraodon nigroviridis 48.53 3.00e-107 380.00
IUUC-Tre-121977 Trichoderma reesei 67.51 0.00e+00 634.00
IUUC-Tvi-122661 Trichoderma virens 68.52 0.00e+00 626.00
IUUC-Tme-127031 Tuber melanosporum 66.45 4.00e-175 605.00
IUUC-Tbe-127492 Tupaia belangeri 43.02 4.00e-49 186.00
IUUC-Ttr-128929 Tursiops truncatus 48.41 6.00e-109 385.00
IUUC-Uma-129347 Ustilago maydis 53.41 7.00e-132 461.00
IUUC-Vda-129837 Verticillium dahliae 73.33 0.00e+00 660.00
IUUC-Vpa-130532 Vicugna pacos 42.42 4.00e-85 306.00
IUUC-Xtr-131985 Xenopus tropicalis 48.17 5.00e-109 385.00
IUUC-Xma-133314 Xiphophorus maculatus 49.02 4.00e-109 385.00
IUUC-Yli-134403 Yarrowia lipolytica 40.63 6.00e-98 348.00
Created Date 25-Jun-2017

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