iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035754

Ensembl Protein ID

ENSFCAP00000024617.1

UniProt Accession

M3XDB1; M3XDB1_FELCA

Genbank Protein ID

ENSFCAP00000024617

Protein Name

Non-specific serine/threonine protein kinase

Genbank Nucleotide ID

AANG02176537

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000023817.1	ENSFCAT00000025149.1	ENSFCAP00000024617.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	50.67	1.00e-111	400.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	39.12	3.00e-95	343.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Felis catus

Protein Sequence
(Fasta)

MSSTDTHLSE EDITSWRKMA TAEKQKHDGR VKIGHYILGD TLGVGTFGKV KVGKHELTGH 60
KVAVKILNRQ KIRSLDVVGK IRREIQNLKL FRHPHIIKLY QVISTPSDIF MVMEYVSGGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCTCCA CAGACACACA TCTGAGCGAA GAGGACATCA CTTCCTGGAG AGCAGCTTGA 60
AGACCCTCAA TATTCTTCCC TCTCTCCCCA GGTGCCTCCC CCTTCCAAAA CAGTAGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	45.55	4.00e-117	415.00
IUUC-Aml-001907	Ailuropoda melanoleuca	94.22	0.00e+00	1038.00
IUUC-Atr-002770	Amborella trichopoda	47.04	2.00e-122	432.00
IUUC-Apl-003395	Anas platyrhynchos	72.30	0.00e+00	793.00
IUUC-Aca-004480	Anolis carolinensis	72.76	0.00e+00	817.00
IUUC-Aly-006289	Arabidopsis lyrata	50.67	1.00e-120	426.00
IUUC-Ath-007014	Arabidopsis thaliana	51.12	6.00e-122	431.00
IUUC-Ago-007957	Ashbya gossypii	40.80	4.00e-111	395.00
IUUC-Acl-008103	Aspergillus clavatus	56.66	4.00e-97	349.00
IUUC-Afl-008555	Aspergillus flavus	55.97	2.00e-97	350.00
IUUC-Afu-008949	Aspergillus fumigatus	56.31	5.00e-97	348.00
IUUC-Ani-009408	Aspergillus nidulans	56.90	2.00e-97	349.00
IUUC-Ang-009551	Aspergillus niger	56.66	3.00e-98	352.00
IUUC-Aor-010176	Aspergillus oryzae	55.97	2.00e-97	350.00
IUUC-Ate-010287	Aspergillus terreus	57.95	6.00e-97	348.00
IUUC-Ame-011019	Astyanax mexicanus	71.78	0.00e+00	831.00
IUUC-Bgr-012045	Blumeria graminis	55.29	1.00e-96	347.00
IUUC-Bta-012786	Bos taurus	96.32	0.00e+00	1042.00
IUUC-Bci-013774	Botrytis cinerea	54.22	5.00e-99	355.00
IUUC-Bdi-014319	Brachypodium distachyon	45.71	2.00e-118	419.00
IUUC-Bol-016242	Brassica oleracea	50.46	2.00e-123	436.00
IUUC-Bra-016750	Brassica rapa	51.36	8.00e-124	437.00
IUUC-Cel-018518	Caenorhabditis elegans	56.97	3.00e-178	618.00
IUUC-Cja-019386	Callithrix jacchus	73.02	0.00e+00	850.00
IUUC-Cfa-020177	Canis familiaris	94.18	0.00e+00	992.00
IUUC-Cpo-021805	Cavia porcellus	72.84	0.00e+00	846.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	52.98	2.00e-94	338.00
IUUC-Csa-024267	Chlorocebus sabaeus	73.02	0.00e+00	848.00
IUUC-Cho-024859	Choloepus hoffmanni	96.99	0.00e+00	1026.00
IUUC-Cin-025550	Ciona intestinalis	58.19	0.00e+00	653.00
IUUC-Csv-026139	Ciona savignyi	57.19	0.00e+00	654.00
IUUC-Cne-027044	Cryptococcus neoformans	45.25	3.00e-103	369.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.03	1.00e-108	386.00
IUUC-Dre-027749	Danio rerio	80.65	0.00e+00	939.00
IUUC-Dno-030006	Dasypus novemcinctus	93.70	0.00e+00	1030.00
IUUC-Dor-030578	Dipodomys ordii	72.84	0.00e+00	847.00
IUUC-Dse-031507	Dothistroma septosporum	59.01	1.00e-101	364.00
IUUC-Dme-031704	Drosophila melanogaster	55.63	1.00e-175	609.00
IUUC-Ete-033055	Echinops telfairi	98.06	0.00e+00	1090.00
IUUC-Eca-034239	Equus caballus	94.17	0.00e+00	989.00
IUUC-Fal-037363	Ficedula albicollis	91.17	0.00e+00	996.00
IUUC-Fox-038073	Fusarium oxysporum	53.07	6.00e-99	355.00
IUUC-Fso-038236	Fusarium solani	55.00	2.00e-95	343.00
IUUC-Gmo-039633	Gadus morhua	79.90	0.00e+00	964.00
IUUC-Ggr-039987	Gaeumannomyces graminis	48.15	1.00e-98	354.00
IUUC-Gga-040546	Gallus gallus	73.37	0.00e+00	844.00
IUUC-Gac-041822	Gasterosteus aculeatus	71.23	0.00e+00	804.00
IUUC-Gma-042712	Glycine max	46.40	8.00e-122	430.00
IUUC-Ggo-044797	Gorilla gorilla	94.05	0.00e+00	1036.00
IUUC-Hsa-045867	Homo sapiens	94.22	0.00e+00	1036.00
IUUC-Hvu-047406	Hordeum vulgare	45.69	2.00e-119	422.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	73.02	0.00e+00	850.00
IUUC-Kpa-049190	Komagataella pastoris	42.15	1.00e-113	403.00
IUUC-Lch-049623	Latimeria chalumnae	86.22	0.00e+00	946.00
IUUC-Lpe-051392	Leersia perrieri	50.45	1.00e-122	433.00
IUUC-Loc-052362	Lepisosteus oculatus	87.81	0.00e+00	927.00
IUUC-Lma-053054	Leptosphaeria maculans	56.03	2.00e-103	370.00
IUUC-Laf-053799	Loxodonta africana	93.87	0.00e+00	1068.00
IUUC-Mcc-055862	Macaca mulatta	73.02	0.00e+00	851.00
IUUC-Mor-057170	Magnaporthe oryzae	47.94	3.00e-99	356.00
IUUC-Mpo-057302	Magnaporthe poae	47.45	6.00e-99	355.00
IUUC-Mtr-058309	Medicago truncatula	47.17	1.00e-122	433.00
IUUC-Mla-059058	Melampsora laricipopulina	40.90	1.00e-101	363.00
IUUC-Mga-059206	Meleagris gallopavo	72.39	0.00e+00	787.00
IUUC-Mvi-060337	Microbotryum violaceum	48.27	4.00e-97	348.00
IUUC-Mmr-061761	Microcebus murinus	94.40	0.00e+00	1038.00
IUUC-Mdo-062160	Monodelphis domestica	73.90	0.00e+00	845.00
IUUC-Mmu-063406	Mus musculus	72.66	0.00e+00	843.00
IUUC-Mac-064518	Musa acuminata	47.50	8.00e-116	410.00
IUUC-Mpu-066326	Mustela putorius furo	71.88	0.00e+00	787.00
IUUC-Mlu-068227	Myotis lucifugus	93.42	0.00e+00	983.00
IUUC-Nfi-068493	Neosartorya fischeri	56.31	4.00e-97	349.00
IUUC-Ncr-068665	Neurospora crassa	56.52	2.00e-101	363.00
IUUC-Nle-070158	Nomascus leucogenys	73.02	0.00e+00	852.00
IUUC-Opr-070272	Ochotona princeps	98.25	0.00e+00	1072.00
IUUC-Ont-072027	Oreochromis niloticus	81.36	0.00e+00	938.00
IUUC-Oan-073322	Ornithorhynchus anatinus	88.81	0.00e+00	992.00
IUUC-Ocu-074188	Oryctolagus cuniculus	96.46	0.00e+00	1049.00
IUUC-Oba-075436	Oryza barthii	46.79	1.00e-123	437.00
IUUC-Obr-076507	Oryza brachyantha	46.72	6.00e-124	437.00
IUUC-Ogl-077718	Oryza glaberrima	50.22	2.00e-119	422.00
IUUC-Ogu-078349	Oryza glumaepatula	46.20	1.00e-123	436.00
IUUC-Oin-079889	Oryza indica	45.54	6.00e-120	424.00
IUUC-Olo-080521	Oryza longistaminata	46.79	1.00e-123	436.00
IUUC-Ome-081630	Oryza meridionalis	46.59	3.00e-123	434.00
IUUC-Oni-082211	Oryza nivara	46.79	5.00e-124	437.00
IUUC-Opu-083617	Oryza punctata	46.08	1.00e-122	433.00
IUUC-Oru-084252	Oryza rufipogon	46.79	1.00e-123	436.00
IUUC-Osa-085548	Oryza sativa	46.79	1.00e-123	436.00
IUUC-Ola-086366	Oryzias latipes	82.17	0.00e+00	955.00
IUUC-Olu-087861	Ostreococcus lucimarinus	47.14	3.00e-115	408.00
IUUC-Oga-088003	Otolemur garnettii	94.40	0.00e+00	1039.00
IUUC-Oar-089933	Ovis aries	96.32	0.00e+00	1042.00
IUUC-Ptr-090718	Pan troglodytes	94.22	0.00e+00	1036.00
IUUC-Pan-092526	Papio anubis	94.05	0.00e+00	1035.00
IUUC-Psi-094034	Pelodiscus sinensis	90.23	0.00e+00	992.00
IUUC-Pno-095030	Phaeosphaeria nodorum	55.23	2.00e-101	362.00
IUUC-Ppa-095615	Physcomitrella patens	49.56	9.00e-121	427.00
IUUC-Pfo-097050	Poecilia formosa	81.55	0.00e+00	939.00
IUUC-Pab-098519	Pongo abelii	94.22	0.00e+00	1036.00
IUUC-Pop-099781	Populus trichocarpa	52.16	9.00e-124	436.00
IUUC-Pca-101104	Procavia capensis	98.55	0.00e+00	796.00
IUUC-Ppe-101642	Prunus persica	47.96	4.00e-121	428.00
IUUC-Pva-102470	Pteropus vampyrus	73.02	0.00e+00	846.00
IUUC-Pgr-103406	Puccinia graminis	55.52	3.00e-88	319.00
IUUC-Ptt-103713	Puccinia triticina	48.50	2.00e-69	256.00
IUUC-Pte-104259	Pyrenophora teres	53.87	2.00e-101	363.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	54.29	3.00e-102	366.00
IUUC-Rno-104960	Rattus norvegicus	72.66	0.00e+00	847.00
IUUC-Sce-106290	Saccharomyces cerevisiae	40.33	3.00e-109	389.00
IUUC-Sha-107603	Sarcophilus harrisii	92.29	0.00e+00	1023.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	49.47	8.00e-106	377.00
IUUC-Spo-108202	Schizosaccharomyces pombe	39.50	2.00e-104	372.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	54.55	2.00e-98	353.00
IUUC-Smo-109309	Selaginella moellendorffii	44.90	6.00e-120	424.00
IUUC-Sit-109745	Setaria italica	51.36	1.00e-124	440.00
IUUC-Sly-110890	Solanum lycopersicum	51.36	2.00e-122	432.00
IUUC-Stu-112144	Solanum tuberosum	44.78	4.00e-114	405.00
IUUC-Sar-113521	Sorex araneus	96.12	0.00e+00	834.00
IUUC-Sbi-114764	Sorghum bicolor	46.92	8.00e-126	443.00
IUUC-Sre-115141	Sporisorium reilianum	63.07	2.00e-110	393.00
IUUC-Ssc-115732	Sus scrofa	94.17	0.00e+00	989.00
IUUC-Tgu-117190	Taeniopygia guttata	90.64	0.00e+00	989.00
IUUC-Tru-118735	Takifugu rubripes	71.55	0.00e+00	822.00
IUUC-Tsy-119503	Tarsius syrichta	69.03	0.00e+00	741.00
IUUC-Tni-119833	Tetraodon nigroviridis	82.00	0.00e+00	935.00
IUUC-Tca-121386	Theobroma cacao	46.41	6.00e-123	434.00
IUUC-Tre-122070	Trichoderma reesei	53.94	8.00e-101	361.00
IUUC-Tvi-122305	Trichoderma virens	50.87	1.00e-99	357.00
IUUC-Tae-123515	Triticum aestivum	46.09	1.00e-122	433.00
IUUC-Tur-126416	Triticum urartu	45.24	2.00e-118	419.00
IUUC-Tme-127174	Tuber melanosporum	37.77	2.00e-65	243.00
IUUC-Tbe-127791	Tupaia belangeri	73.06	4.00e-100	358.00
IUUC-Ttr-129224	Tursiops truncatus	97.37	0.00e+00	1083.00
IUUC-Uma-129372	Ustilago maydis	62.72	1.00e-109	390.00
IUUC-Vda-129819	Verticillium dahliae	50.67	6.00e-84	305.00
IUUC-Vpa-130220	Vicugna pacos	71.46	0.00e+00	781.00
IUUC-Vvi-131649	Vitis vinifera	47.13	6.00e-123	434.00
IUUC-Xtr-132954	Xenopus tropicalis	73.25	0.00e+00	847.00
IUUC-Xma-134082	Xiphophorus maculatus	81.73	0.00e+00	865.00
IUUC-Yli-134422	Yarrowia lipolytica	42.10	7.00e-113	400.00
IUUC-Zma-135621	Zea mays	51.40	1.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence