iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012141.1	ENSSHAT00000014319.1	ENSSHAP00000014201.1
ENSSHAG00000012141.1	ENSSHAT00000014320.1	ENSSHAP00000014202.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-69	234.3	1905	2250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           +Gl+Nlg+tCY+ S++Q+L++ipe r+++++ k++e+++       +++ l +lqk+f+ l++s+ ka++pr + k+  + ++ +++
   Q: 1905 VGLTNLGATCYLASTIQQLYMIPEARQAIFTaKYSEDIK-------HKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNT 1984
           6*****************************945555554.......568899*********************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            eq+D  Ef++ l+ ++ee                               + k++++ lF+g ++++++ l+c++vs++ e+f+++ 
   Q: 1985 GEQKDMTEFFTDLITKIEEMS----------------------------PELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVR 2043
           *****************9977............................567899******************************** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           ++v + +     ++ ++L++ t +++leg+n+y c++c kk++aek+  +kklP++L+++ +R++f+  ++++ek+n++++fpl+Ld
   Q: 2044 CQVADMK-----NIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLD 2125
           *******.....9************************************************************************** PP
   S: 261  lspfcts...................peekqkekkkYeLiavvvHsGslssGHYvayvkn.......ekgkWllfdDskVtevkeee 321
           ++p++++                   +   ++e+++Y+Li+v vH+G++++GHY++++++       +++kW+lf+D +V++ + ++
   Q: 2126 MTPYTEDflmgkcdrkegfkeevdlgK---ETESYEYDLIGVTVHTGTADGGHYYSFIRDivnphayKNNKWYLFNDAEVKPFDSAQ 2209
           *******99999998888887774422...3449**************************99999988999**************** PP
   S: 322  vleetg........................staYvlfYkrr 338
             +e+                         ++aY+lfYkr+
   Q: 2210 LASECFggemttktydsvtdkfmdfsfektHSAYMLFYKRM 2250
           **97779********************************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LCFEVSFIFL TLNFISDIEG GDGLQLRKEH TLKIFAYINS WTQRQCLCCF KEYKHLEIFN 60
QVVCALINLV IAQVQALRDQ LCKHCTINID STWQDQNNQA EEPLNVERES HEEENIERQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATGTTTTG AGGTTTCATT CATATTTTTG ACATTAAATT TTAGTAAAAT ATGTTTGGAG 60
TTAATAGTTT AAATTATTCA ATTTTTTAAT TTTTAAGTAA ATATTGCTGT GTGCTCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR011030--Vitellinogen_superhlx

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002257	Ailuropoda melanoleuca	95.01	0.00e+00	6610.00
IUUC-Apl-003284	Anas platyrhynchos	95.49	0.00e+00	6332.00
IUUC-Aca-004415	Anolis carolinensis	93.67	0.00e+00	6490.00
IUUC-Acl-008140	Aspergillus clavatus	29.22	7.00e-64	240.00
IUUC-Afl-008381	Aspergillus flavus	28.76	3.00e-63	238.00
IUUC-Afu-008857	Aspergillus fumigatus	28.48	3.00e-64	241.00
IUUC-Ani-009257	Aspergillus nidulans	28.49	2.00e-55	212.00
IUUC-Ang-009759	Aspergillus niger	28.20	2.00e-63	238.00
IUUC-Aor-009931	Aspergillus oryzae	28.76	5.00e-63	237.00
IUUC-Ame-011219	Astyanax mexicanus	64.73	0.00e+00	2479.00
IUUC-Bgr-012195	Blumeria graminis	27.32	2.00e-66	249.00
IUUC-Bta-012989	Bos taurus	95.01	0.00e+00	6576.00
IUUC-Bci-013798	Botrytis cinerea	32.68	5.00e-58	221.00
IUUC-Cja-018974	Callithrix jacchus	91.29	0.00e+00	773.00
IUUC-Cfa-021214	Canis familiaris	95.21	0.00e+00	6629.00
IUUC-Cpo-021912	Cavia porcellus	93.71	0.00e+00	4566.00
IUUC-Csa-023658	Chlorocebus sabaeus	94.24	0.00e+00	6559.00
IUUC-Cho-024971	Choloepus hoffmanni	82.90	0.00e+00	2836.00
IUUC-Cgl-026466	Colletotrichum gloeosporioides	28.44	8.00e-64	240.00
IUUC-Dre-027428	Danio rerio	85.79	0.00e+00	4662.00
IUUC-Dno-029690	Dasypus novemcinctus	94.42	0.00e+00	6458.00
IUUC-Dor-030817	Dipodomys ordii	86.20	0.00e+00	2095.00
IUUC-Dse-031423	Dothistroma septosporum	26.75	2.00e-35	145.00
IUUC-Dme-032102	Drosophila melanogaster	54.53	0.00e+00	856.00
IUUC-Ete-032552	Echinops telfairi	91.81	0.00e+00	2924.00
IUUC-Eca-033457	Equus caballus	95.24	0.00e+00	6346.00
IUUC-Eeu-035118	Erinaceus europaeus	91.55	0.00e+00	2990.00
IUUC-Fca-036213	Felis catus	93.55	0.00e+00	4943.00
IUUC-Fal-037643	Ficedula albicollis	93.05	0.00e+00	6447.00
IUUC-Fox-037971	Fusarium oxysporum	27.59	4.00e-63	237.00
IUUC-Fso-038108	Fusarium solani	27.54	2.00e-59	225.00
IUUC-Ggr-040075	Gaeumannomyces graminis	33.10	3.00e-62	234.00
IUUC-Gga-040511	Gallus gallus	93.05	0.00e+00	6501.00
IUUC-Gac-042024	Gasterosteus aculeatus	88.24	0.00e+00	5051.00
IUUC-Ggo-044924	Gorilla gorilla	90.95	0.00e+00	6059.00
IUUC-Hsa-046913	Homo sapiens	94.27	0.00e+00	6593.00
IUUC-Itr-048626	Ictidomys tridecemlineatus	94.84	0.00e+00	6596.00
IUUC-Lch-049675	Latimeria chalumnae	86.89	0.00e+00	4924.00
IUUC-Loc-052832	Lepisosteus oculatus	86.88	0.00e+00	5983.00
IUUC-Lma-053130	Leptosphaeria maculans	27.06	1.00e-59	226.00
IUUC-Laf-054169	Loxodonta africana	94.08	0.00e+00	6583.00
IUUC-Mcc-055847	Macaca mulatta	93.65	0.00e+00	6470.00
IUUC-Meu-056327	Macropus eugenii	86.98	0.00e+00	1588.00
IUUC-Mor-057152	Magnaporthe oryzae	28.35	3.00e-61	231.00
IUUC-Mpo-057310	Magnaporthe poae	26.47	1.00e-60	229.00
IUUC-Mmr-060780	Microcebus murinus	94.52	0.00e+00	6603.00
IUUC-Mdo-062308	Monodelphis domestica	95.71	0.00e+00	6358.00
IUUC-Mmu-063457	Mus musculus	93.14	0.00e+00	6514.00
IUUC-Mpu-066917	Mustela putorius furo	92.62	0.00e+00	6403.00
IUUC-Mlu-067696	Myotis lucifugus	94.64	0.00e+00	6567.00
IUUC-Nfi-068259	Neosartorya fischeri	27.44	1.00e-63	239.00
IUUC-Ncr-068911	Neurospora crassa	25.94	1.00e-59	226.00
IUUC-Nle-069586	Nomascus leucogenys	94.42	0.00e+00	6607.00
IUUC-Opr-070447	Ochotona princeps	91.25	0.00e+00	2803.00
IUUC-Ont-072396	Oreochromis niloticus	82.44	0.00e+00	5519.00
IUUC-Oan-073147	Ornithorhynchus anatinus	95.80	0.00e+00	6639.00
IUUC-Ocu-074324	Oryctolagus cuniculus	94.61	0.00e+00	6571.00
IUUC-Ola-086312	Oryzias latipes	83.00	0.00e+00	5330.00
IUUC-Oga-088878	Otolemur garnettii	94.36	0.00e+00	6586.00
IUUC-Oar-089919	Ovis aries	94.77	0.00e+00	6559.00
IUUC-Ptr-090713	Pan troglodytes	94.84	0.00e+00	6070.00
IUUC-Pan-091957	Papio anubis	95.73	0.00e+00	4980.00
IUUC-Psi-093240	Pelodiscus sinensis	94.51	0.00e+00	6534.00
IUUC-Pma-094469	Petromyzon marinus	73.14	0.00e+00	4103.00
IUUC-Pno-095059	Phaeosphaeria nodorum	32.56	3.00e-56	215.00
IUUC-Pfo-097159	Poecilia formosa	79.96	0.00e+00	5571.00
IUUC-Pab-098003	Pongo abelii	94.20	0.00e+00	6271.00
IUUC-Pca-100799	Procavia capensis	95.63	0.00e+00	1463.00
IUUC-Pva-103226	Pteropus vampyrus	89.86	0.00e+00	6177.00
IUUC-Pte-104235	Pyrenophora teres	27.19	9.00e-60	226.00
IUUC-Pyt-104803	Pyrenophora triticirepentis	27.51	5.00e-60	226.00
IUUC-Rno-105389	Rattus norvegicus	93.76	0.00e+00	5393.00
IUUC-Sar-113444	Sorex araneus	88.17	0.00e+00	5779.00
IUUC-Ssc-115815	Sus scrofa	94.39	0.00e+00	5481.00
IUUC-Tgu-117470	Taeniopygia guttata	94.84	0.00e+00	6263.00
IUUC-Tru-118543	Takifugu rubripes	84.81	0.00e+00	5392.00
IUUC-Tsy-119081	Tarsius syrichta	87.05	0.00e+00	4746.00
IUUC-Tni-120294	Tetraodon nigroviridis	83.21	2.00e-165	574.00
IUUC-Tre-122057	Trichoderma reesei	28.11	3.00e-60	228.00
IUUC-Tvi-122570	Trichoderma virens	35.62	1.00e-58	223.00
IUUC-Tme-127154	Tuber melanosporum	26.95	9.00e-62	232.00
IUUC-Tbe-127801	Tupaia belangeri	89.51	0.00e+00	2888.00
IUUC-Ttr-129262	Tursiops truncatus	90.45	0.00e+00	6240.00
IUUC-Vda-129686	Verticillium dahliae	28.55	2.00e-61	232.00
IUUC-Vpa-130484	Vicugna pacos	93.15	0.00e+00	5147.00
IUUC-Xtr-131769	Xenopus tropicalis	87.19	0.00e+00	6131.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence