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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063964
UUCD1 version UUC-MuM-00555
Ensembl Protein ID ENSMUSP00000078795.6
UniProt Accession Q71FD5; ZNRF2_MOUSE
Genbank Protein ID AAQ08116.1
Protein Name E3 ubiquitin-protein ligase ZNRF2; RING-type E3 ubiquitin transferase ZNRF2; Zinc/RING finger protein 2
Genbank Nucleotide ID AF513708
Gene Name Znrf2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000058446.14 ENSMUST00000079869.12 ENSMUSP00000078795.6
ENSMUSG00000058446.14 ENSMUST00000148425.1 ENSMUSP00000145276.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 88.36 5.00e-62 234.00 IUUC-Hsa-046291
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
 May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MGAKQSGPAA NGRTRAYSGS DLPSGTGSGG GGADGARAAR FAAPVSGAQQ PSASAGAAAA 60
AAAAASAPAA PRSRSLGGAV GSASGGRAAQ SAFSIPSAGG GGGPYGSQDS VHSSPEDSVG 120
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Protein Fasta Sequence


>IUUC-Mmu-063964|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCGCGTCCG CACGGCTACC TGAGCGGCAG CCGCGAGCTG CGTCCCGCCT CTCTCGCTTG 60
CTCGCTCGCT CGCTCGCTCG CGGCCCGGGG CGGCGCGGAC ATGGGCGCCA AGCAGAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063964|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0010008--C:endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:387524
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002006 Ailuropoda melanoleuca 98.10 9.00e-62 227.00
IUUC-Apl-003883 Anas platyrhynchos 96.63 2.00e-49 186.00
IUUC-Aca-004497 Anolis carolinensis 78.26 2.00e-62 231.00
IUUC-Acl-008261 Aspergillus clavatus 47.17 5.00e-10 59.70
IUUC-Afl-008724 Aspergillus flavus 57.14 3.00e-11 63.20
IUUC-Afu-008835 Aspergillus fumigatus 47.17 6.00e-10 59.30
IUUC-Ang-009666 Aspergillus niger 48.15 3.00e-11 63.50
IUUC-Ate-010331 Aspergillus terreus 48.15 3.00e-10 60.50
IUUC-Ame-011041 Astyanax mexicanus 87.50 3.00e-54 204.00
IUUC-Bgr-012049 Blumeria graminis 43.48 6.00e-07 49.30
IUUC-Bta-013206 Bos taurus 73.98 1.00e-73 268.00
IUUC-Cel-018347 Caenorhabditis elegans 62.14 3.00e-35 141.00
IUUC-Cja-019912 Callithrix jacchus 91.85 8.00e-60 223.00
IUUC-Cpo-021391 Cavia porcellus 97.73 2.00e-49 186.00
IUUC-Csa-023094 Chlorocebus sabaeus 91.85 3.00e-60 224.00
IUUC-Cin-025162 Ciona intestinalis 60.40 2.00e-36 145.00
IUUC-Csv-026373 Ciona savignyi 59.41 1.00e-36 146.00
IUUC-Dre-027399 Danio rerio 72.64 6.00e-47 179.00
IUUC-Dno-029420 Dasypus novemcinctus 93.33 2.00e-60 225.00
IUUC-Dme-031584 Drosophila melanogaster 73.47 9.00e-41 160.00
IUUC-Eca-034068 Equus caballus 98.84 1.00e-50 190.00
IUUC-Fca-035770 Felis catus 96.59 3.00e-51 192.00
IUUC-Gmo-039148 Gadus morhua 61.34 2.00e-65 241.00
IUUC-Gga-041010 Gallus gallus 84.25 3.00e-60 224.00
IUUC-Gac-041711 Gasterosteus aculeatus 94.17 3.00e-56 211.00
IUUC-Hsa-046291 Homo sapiens 74.39 4.00e-64 237.00
IUUC-Lch-049870 Latimeria chalumnae 94.12 3.00e-45 174.00
IUUC-Loc-052877 Lepisosteus oculatus 93.20 3.00e-56 211.00
IUUC-Lma-053072 Leptosphaeria maculans 43.64 2.00e-08 54.30
IUUC-Laf-054451 Loxodonta africana 93.33 3.00e-61 228.00
IUUC-Mcc-055078 Macaca mulatta 90.37 2.00e-63 235.00
IUUC-Mmr-061658 Microcebus murinus 97.73 2.00e-49 186.00
IUUC-Mdo-062052 Monodelphis domestica 80.13 3.00e-64 238.00
IUUC-Mlu-067009 Myotis lucifugus 97.09 8.00e-57 211.00
IUUC-Nfi-068593 Neosartorya fischeri 47.17 4.00e-10 59.70
IUUC-Ncr-068662 Neurospora crassa 48.98 9.00e-09 55.50
IUUC-Nle-069306 Nomascus leucogenys 86.03 4.00e-61 227.00
IUUC-Oga-088009 Otolemur garnettii 75.20 3.00e-65 241.00
IUUC-Ptr-091609 Pan troglodytes 87.92 6.00e-62 230.00
IUUC-Pan-092598 Papio anubis 90.37 2.00e-63 235.00
IUUC-Psi-093749 Pelodiscus sinensis 98.82 3.00e-50 188.00
IUUC-Pma-094361 Petromyzon marinus 77.01 1.00e-39 153.00
IUUC-Ppa-095396 Physcomitrella patens 36.49 3.00e-08 53.50
IUUC-Pfo-096340 Poecilia formosa 85.59 8.00e-57 213.00
IUUC-Pab-097603 Pongo abelii 90.37 2.00e-63 235.00
IUUC-Pva-102216 Pteropus vampyrus 98.82 3.00e-48 184.00
IUUC-Pte-104063 Pyrenophora teres 37.70 3.00e-08 53.50
IUUC-Pyt-104423 Pyrenophora triticirepentis 37.70 3.00e-08 53.50
IUUC-Rno-104829 Rattus norvegicus 97.71 8.00e-63 233.00
IUUC-Ssl-108602 Sclerotinia sclerotiorum 46.00 7.00e-08 52.40
IUUC-Ssc-116023 Sus scrofa 96.59 4.00e-49 185.00
IUUC-Tru-117571 Takifugu rubripes 57.02 2.00e-62 231.00
IUUC-Tni-120337 Tetraodon nigroviridis 88.35 9.00e-54 202.00
IUUC-Tbe-127983 Tupaia belangeri 93.33 2.00e-62 232.00
IUUC-Ttr-129090 Tursiops truncatus 87.92 5.00e-65 240.00
Created Date 25-Jun-2017

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