iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062183

UUCD1 version

UUC-MoD-01149

Ensembl Protein ID

ENSMODP00000022630.2

UniProt Accession

F7CWU5; F7CWU5_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018148.2	ENSMODT00000023028.2	ENSMODP00000022630.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-63	213.6	337	856
UBD/Alpha-Helix/UBA	2.80e-23	81.5	725	763

Active Site

Position(s)	Description	Evidence
346	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
819	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...........wkskkk............ 66
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                +            
   Q: 337  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPSDPTQDFSTQVAKLGHGLlsgeyskpapeS----Gdgeqvpeqkgiq 420
           7******************************.99999999********************555555555550....0555555555555 PP
   S: 67   .avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
             ++pr++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ ++++i
   Q: 421  dGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKI 480
           5*****************************************.............................6788899*********** PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqe 216
           kcl+ ++v+ ++   + ++lpvp++   +ke                            +++cLe+f ++e++++   ++++  ++k+ 
   Q: 481  KCLATEKVKYTQRVDYIMQLPVPMDAALNKEelleyeerkrqaeeekqplpelvraqvPFSSCLEAFGAPEQVDD---FWSTALQAKSV 566
           **************************999989*****************************************97...*********** PP
   S: 217  aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................................... 267
           a+k++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+                                          
   Q: 567  AVKTTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGAglqpgeeelpdiapplvtpdepkgswmtpvypppptap 654
           ***********************997.*******************9888888888888888888888888888888888888888888 PP
   S: 268  ....................................................................................peekq 272
                                                                                               +    
   Q: 655  mldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplvlpgssgpgststvadppsedcvativsmgfsR---- 739
           8877777777777777777777777777777777777777777777766666666666666666666655555555555555550.... PP
   S: 273  ke..........................................................kkkYeLiavvvHsG.slssGHYvayvkne 302
            +                                                          + kY+L+a ++H+G s+ +GHYv+++k+ 
   Q: 740  -DqamkalratnnnleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK- 826
           .05555555555666666777777777777777777777777778888888888888888****************************. PP
   S: 303  kgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 827  EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 856
           9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nnnle+Av++++++
   Q: 725  SEDCVATIVSMGFSRDQAMKALRATNNNLERAVDWIFSH 763
           699**********************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

VGVAGAVLCG SAAAGVMAEL SEEALLSVLP TIRVPKAGDR VHKDECAFSF DTPESEGGLY 60
ICMNTFLGFG KQYVEKHYCR TGQRVYLHLQ RTRRPKEDDS TSGTGDPPRK KPTRLAIGVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGAGTCG CGGGAGCCGT TCTGTGTGGA AGCGCTGCTG CCGGTGTCAT GGCGGAGCTG 60
AGTGAGGAGG CGCTGCTATC TGTATTACCG ACTATCCGGG TCCCCAAGGC CGGAGATCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.39	0.00e+00	661.00
IUUC-Aml-002104	Ailuropoda melanoleuca	91.99	0.00e+00	1534.00
IUUC-Atr-002580	Amborella trichopoda	45.82	0.00e+00	740.00
IUUC-Apl-003774	Anas platyrhynchos	88.86	0.00e+00	1472.00
IUUC-Aca-005368	Anolis carolinensis	87.97	0.00e+00	1523.00
IUUC-Aly-005727	Arabidopsis lyrata	47.88	0.00e+00	748.00
IUUC-Ath-006974	Arabidopsis thaliana	47.87	0.00e+00	749.00
IUUC-Ago-007890	Ashbya gossypii	29.33	4.00e-82	299.00
IUUC-Acl-008057	Aspergillus clavatus	34.84	9.00e-127	447.00
IUUC-Afl-008547	Aspergillus flavus	35.96	5.00e-118	418.00
IUUC-Afu-008805	Aspergillus fumigatus	34.54	6.00e-119	421.00
IUUC-Ani-009441	Aspergillus nidulans	33.12	4.00e-103	369.00
IUUC-Ang-009720	Aspergillus niger	34.58	4.00e-122	432.00
IUUC-Aor-010111	Aspergillus oryzae	33.77	1.00e-128	454.00
IUUC-Ate-010531	Aspergillus terreus	32.71	1.00e-103	370.00
IUUC-Ame-011893	Astyanax mexicanus	66.80	0.00e+00	1001.00
IUUC-Bgr-012183	Blumeria graminis	33.81	4.00e-124	439.00
IUUC-Bta-013179	Bos taurus	92.21	0.00e+00	1540.00
IUUC-Bci-013858	Botrytis cinerea	34.95	8.00e-132	464.00
IUUC-Bdi-014904	Brachypodium distachyon	47.46	0.00e+00	727.00
IUUC-Bol-015296	Brassica oleracea	48.40	0.00e+00	758.00
IUUC-Bra-017939	Brassica rapa	48.04	0.00e+00	761.00
IUUC-Cel-018625	Caenorhabditis elegans	35.00	6.00e-134	471.00
IUUC-Cja-019063	Callithrix jacchus	90.47	0.00e+00	1504.00
IUUC-Cfa-020976	Canis familiaris	92.83	0.00e+00	1545.00
IUUC-Cpo-022265	Cavia porcellus	92.60	0.00e+00	1537.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.76	2.00e-118	419.00
IUUC-Csa-024177	Chlorocebus sabaeus	91.65	0.00e+00	1402.00
IUUC-Cho-024702	Choloepus hoffmanni	85.24	0.00e+00	930.00
IUUC-Cin-025411	Ciona intestinalis	50.48	0.00e+00	833.00
IUUC-Csv-026347	Ciona savignyi	46.60	0.00e+00	795.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.55	2.00e-113	403.00
IUUC-Cne-026831	Cryptococcus neoformans	35.61	2.00e-128	453.00
IUUC-Dre-027982	Danio rerio	64.46	0.00e+00	1081.00
IUUC-Dno-029034	Dasypus novemcinctus	92.33	0.00e+00	1550.00
IUUC-Dor-030479	Dipodomys ordii	91.42	0.00e+00	658.00
IUUC-Dse-031467	Dothistroma septosporum	36.66	2.00e-134	473.00
IUUC-Dme-032075	Drosophila melanogaster	50.35	0.00e+00	835.00
IUUC-Ete-032865	Echinops telfairi	82.26	0.00e+00	1369.00
IUUC-Eca-034059	Equus caballus	92.06	0.00e+00	1548.00
IUUC-Eeu-035304	Erinaceus europaeus	86.89	0.00e+00	1399.00
IUUC-Fca-035515	Felis catus	92.56	0.00e+00	1547.00
IUUC-Fal-037271	Ficedula albicollis	89.65	0.00e+00	1447.00
IUUC-Fox-037745	Fusarium oxysporum	35.60	3.00e-130	459.00
IUUC-Fso-038158	Fusarium solani	36.06	1.00e-130	461.00
IUUC-Gmo-039071	Gadus morhua	66.59	0.00e+00	1100.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.63	4.00e-123	435.00
IUUC-Gga-040635	Gallus gallus	89.39	0.00e+00	1551.00
IUUC-Gac-042528	Gasterosteus aculeatus	65.64	0.00e+00	1115.00
IUUC-Gma-043614	Glycine max	46.86	0.00e+00	722.00
IUUC-Ggo-044602	Gorilla gorilla	91.62	0.00e+00	1529.00
IUUC-Hsa-045959	Homo sapiens	91.62	0.00e+00	1529.00
IUUC-Hvu-047563	Hordeum vulgare	47.63	2.00e-173	602.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	91.27	0.00e+00	1536.00
IUUC-Kpa-049156	Komagataella pastoris	33.64	2.00e-117	417.00
IUUC-Lch-049648	Latimeria chalumnae	82.68	0.00e+00	1388.00
IUUC-Lpe-051523	Leersia perrieri	47.60	0.00e+00	736.00
IUUC-Lma-053216	Leptosphaeria maculans	34.79	9.00e-115	409.00
IUUC-Laf-054327	Loxodonta africana	91.38	0.00e+00	1526.00
IUUC-Mcc-055443	Macaca mulatta	91.50	0.00e+00	1525.00
IUUC-Meu-056298	Macropus eugenii	97.39	0.00e+00	1107.00
IUUC-Mor-057106	Magnaporthe oryzae	36.76	7.00e-133	468.00
IUUC-Mpo-057589	Magnaporthe poae	35.27	2.00e-126	446.00
IUUC-Mtr-058680	Medicago truncatula	48.40	0.00e+00	749.00
IUUC-Mla-058903	Melampsora laricipopulina	32.18	1.00e-116	414.00
IUUC-Mga-059669	Meleagris gallopavo	88.61	0.00e+00	1470.00
IUUC-Mvi-060476	Microbotryum violaceum	34.18	5.00e-119	421.00
IUUC-Mmr-060575	Microcebus murinus	92.21	0.00e+00	1541.00
IUUC-Mmu-063592	Mus musculus	91.97	0.00e+00	1536.00
IUUC-Mac-065634	Musa acuminata	43.62	0.00e+00	711.00
IUUC-Mpu-066082	Mustela putorius furo	92.23	0.00e+00	1533.00
IUUC-Mlu-067345	Myotis lucifugus	89.65	0.00e+00	1507.00
IUUC-Nfi-068558	Neosartorya fischeri	35.29	4.00e-127	448.00
IUUC-Ncr-068960	Neurospora crassa	35.93	8.00e-119	421.00
IUUC-Nle-070173	Nomascus leucogenys	92.23	0.00e+00	1530.00
IUUC-Opr-070556	Ochotona princeps	91.50	0.00e+00	1545.00
IUUC-Ont-071502	Oreochromis niloticus	66.47	0.00e+00	1092.00
IUUC-Ocu-074861	Oryctolagus cuniculus	92.35	0.00e+00	1553.00
IUUC-Oba-075109	Oryza barthii	47.44	0.00e+00	737.00
IUUC-Obr-076292	Oryza brachyantha	48.64	0.00e+00	733.00
IUUC-Ogl-077065	Oryza glaberrima	48.75	0.00e+00	768.00
IUUC-Ogu-078776	Oryza glumaepatula	47.44	0.00e+00	750.00
IUUC-Oin-080048	Oryza indica	48.28	0.00e+00	761.00
IUUC-Olo-080711	Oryza longistaminata	45.61	0.00e+00	679.00
IUUC-Ome-081506	Oryza meridionalis	46.58	0.00e+00	691.00
IUUC-Oni-082320	Oryza nivara	46.53	0.00e+00	731.00
IUUC-Opu-083801	Oryza punctata	47.56	0.00e+00	727.00
IUUC-Oru-085139	Oryza rufipogon	46.53	0.00e+00	733.00
IUUC-Osa-085713	Oryza sativa	48.87	0.00e+00	771.00
IUUC-Ola-086951	Oryzias latipes	65.26	0.00e+00	1057.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.92	0.00e+00	634.00
IUUC-Oga-088625	Otolemur garnettii	91.39	0.00e+00	1523.00
IUUC-Oar-089995	Ovis aries	89.41	0.00e+00	1511.00
IUUC-Ptr-090640	Pan troglodytes	89.14	0.00e+00	1521.00
IUUC-Pan-091974	Papio anubis	90.59	0.00e+00	1508.00
IUUC-Psi-093957	Pelodiscus sinensis	88.37	0.00e+00	1563.00
IUUC-Pma-094242	Petromyzon marinus	72.97	2.00e-172	598.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.84	6.00e-108	385.00
IUUC-Ppa-095901	Physcomitrella patens	50.23	0.00e+00	812.00
IUUC-Pfo-097148	Poecilia formosa	67.50	0.00e+00	1098.00
IUUC-Pab-098068	Pongo abelii	84.32	0.00e+00	1353.00
IUUC-Pop-098943	Populus trichocarpa	47.51	0.00e+00	736.00
IUUC-Pca-100738	Procavia capensis	84.42	0.00e+00	1378.00
IUUC-Ppe-101315	Prunus persica	48.05	0.00e+00	743.00
IUUC-Pva-102154	Pteropus vampyrus	90.67	0.00e+00	1511.00
IUUC-Pgr-103343	Puccinia graminis	33.94	3.00e-110	392.00
IUUC-Ptt-103928	Puccinia triticina	30.69	2.00e-109	390.00
IUUC-Pte-104306	Pyrenophora teres	33.41	5.00e-107	382.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.43	9.00e-110	391.00
IUUC-Rno-105801	Rattus norvegicus	92.09	0.00e+00	1536.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.09	4.00e-74	272.00
IUUC-Sha-107635	Sarcophilus harrisii	96.29	0.00e+00	1592.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.43	5.00e-108	385.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.94	1.00e-114	407.00
IUUC-Smo-108848	Selaginella moellendorffii	48.26	0.00e+00	754.00
IUUC-Sit-110728	Setaria italica	48.28	0.00e+00	784.00
IUUC-Sly-111523	Solanum lycopersicum	47.93	0.00e+00	782.00
IUUC-Sbi-114419	Sorghum bicolor	47.82	0.00e+00	766.00
IUUC-Sre-115225	Sporisorium reilianum	34.75	2.00e-127	450.00
IUUC-Ssc-115686	Sus scrofa	90.45	0.00e+00	1529.00
IUUC-Tgu-117346	Taeniopygia guttata	89.17	0.00e+00	1522.00
IUUC-Tru-118350	Takifugu rubripes	63.91	0.00e+00	1078.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.97	0.00e+00	1069.00
IUUC-Tca-121585	Theobroma cacao	48.35	0.00e+00	746.00
IUUC-Tre-122043	Trichoderma reesei	34.67	6.00e-120	424.00
IUUC-Tvi-122303	Trichoderma virens	35.97	5.00e-126	445.00
IUUC-Tae-125686	Triticum aestivum	47.32	0.00e+00	743.00
IUUC-Tur-126732	Triticum urartu	44.80	0.00e+00	698.00
IUUC-Tme-126909	Tuber melanosporum	35.02	6.00e-123	434.00
IUUC-Tbe-127261	Tupaia belangeri	85.86	0.00e+00	964.00
IUUC-Uma-129599	Ustilago maydis	33.70	1.00e-129	457.00
IUUC-Vda-129688	Verticillium dahliae	34.33	8.00e-124	437.00
IUUC-Vvi-131116	Vitis vinifera	47.81	0.00e+00	718.00
IUUC-Xtr-131953	Xenopus tropicalis	77.40	0.00e+00	1319.00
IUUC-Xma-133837	Xiphophorus maculatus	67.73	0.00e+00	1103.00
IUUC-Yli-134510	Yarrowia lipolytica	35.89	7.00e-131	461.00
IUUC-Zma-135786	Zea mays	47.58	0.00e+00	732.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence