iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052149

Ensembl Protein ID

ENSLOCP00000018299.1

UniProt Accession

W5NCE0; W5NCE0_LEPOC

Genbank Protein ID

ENSLOCP00000018299

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01004900

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000014851.1	ENSLOCT00000018331.1	ENSLOCP00000018299.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.50e-10	39.3	3423	3455
E3 activity/HECT	3.40e-92	309.6	4472	4806

Active Site

Position(s)	Description	Evidence
4775	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v  + + +  +ll+++++Dgt++vW++++
   Q: 3423 HQSRVITCGWcNKkGLLATSGNDGTVRVWNVTK 3455
           899988889*9778****************986 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4472 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4558
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+ ++l ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4559 PLDLHLAPMVWKQLCCVPLILEDLEEVDLLYVQTLNSILHIEDSGITEENFHDMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4645
           ****************************************************9999999887777666666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4646 EYVDRAIEYRLHE-MDRQVAAVREGMSWIIPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWQTLEEFSN 4730
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4731 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDM 4806
           *****************6.899999.679999956666***********************************99987 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MALMIPPVKL KWLEHLNSSW IMEDSESIAT REGVSVLYSK LVANKEVVLL PQQVLCLKGP 60
QLPDFERESL SSDEQEHYLD ALLGSQLALA KMVCSDSPFA AALRKRLLVL QRIFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGATGGC ACCCAAGTGA TCCAACATGG CCCTGATGAT CCCTCCTGTG AAGCTGAAAT 60
GGCTGGAGCA CCTCAACAGC TCCTGGATCA TGGAGGACAG CGAGTCCATC GCGACGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	84.31	0.00e+00	7521.00
IUUC-Apl-003461	Anas platyrhynchos	84.46	0.00e+00	7580.00
IUUC-Aca-004452	Anolis carolinensis	79.06	0.00e+00	4856.00
IUUC-Bta-013213	Bos taurus	84.64	0.00e+00	7533.00
IUUC-Bra-017584	Brassica rapa	34.96	7.00e-50	192.00
IUUC-Cja-019298	Callithrix jacchus	84.48	0.00e+00	7527.00
IUUC-Cfa-021213	Canis familiaris	84.51	0.00e+00	7599.00
IUUC-Cpo-021674	Cavia porcellus	82.72	0.00e+00	5044.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.76	5.00e-50	191.00
IUUC-Csa-023341	Chlorocebus sabaeus	84.66	0.00e+00	7557.00
IUUC-Cho-024567	Choloepus hoffmanni	84.05	0.00e+00	1545.00
IUUC-Dre-028289	Danio rerio	81.77	0.00e+00	7296.00
IUUC-Dno-029988	Dasypus novemcinctus	84.50	0.00e+00	7526.00
IUUC-Dor-030636	Dipodomys ordii	77.44	0.00e+00	1925.00
IUUC-Ete-032598	Echinops telfairi	82.25	0.00e+00	1335.00
IUUC-Eca-033754	Equus caballus	84.46	0.00e+00	7536.00
IUUC-Eeu-034702	Erinaceus europaeus	80.64	0.00e+00	1311.00
IUUC-Fca-035900	Felis catus	84.59	0.00e+00	7556.00
IUUC-Fal-037034	Ficedula albicollis	82.95	0.00e+00	6506.00
IUUC-Gmo-038634	Gadus morhua	92.54	0.00e+00	1241.00
IUUC-Gga-040321	Gallus gallus	84.40	0.00e+00	7626.00
IUUC-Gma-043808	Glycine max	33.68	5.00e-46	180.00
IUUC-Ggo-045134	Gorilla gorilla	81.41	0.00e+00	4103.00
IUUC-Hsa-046516	Homo sapiens	84.49	0.00e+00	7525.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	83.45	0.00e+00	2149.00
IUUC-Lch-049903	Latimeria chalumnae	86.24	0.00e+00	7743.00
IUUC-Lpe-051165	Leersia perrieri	34.32	9.00e-52	197.00
IUUC-Laf-053426	Loxodonta africana	84.41	0.00e+00	7579.00
IUUC-Mcc-055826	Macaca mulatta	84.32	0.00e+00	7540.00
IUUC-Meu-056521	Macropus eugenii	75.54	0.00e+00	1981.00
IUUC-Mga-059567	Meleagris gallopavo	91.87	0.00e+00	2032.00
IUUC-Mmr-061512	Microcebus murinus	83.88	0.00e+00	7447.00
IUUC-Mdo-062177	Monodelphis domestica	82.28	0.00e+00	7318.00
IUUC-Mmu-064373	Mus musculus	84.85	0.00e+00	5395.00
IUUC-Mpu-066148	Mustela putorius furo	85.09	0.00e+00	7607.00
IUUC-Mlu-067680	Myotis lucifugus	84.30	0.00e+00	7500.00
IUUC-Nle-069633	Nomascus leucogenys	84.18	0.00e+00	7455.00
IUUC-Opr-070609	Ochotona princeps	84.67	0.00e+00	1213.00
IUUC-Ont-071249	Oreochromis niloticus	84.24	0.00e+00	7588.00
IUUC-Oan-073157	Ornithorhynchus anatinus	84.21	0.00e+00	7467.00
IUUC-Ocu-074841	Oryctolagus cuniculus	85.02	0.00e+00	7637.00
IUUC-Oba-075262	Oryza barthii	34.65	3.00e-50	192.00
IUUC-Obr-076115	Oryza brachyantha	34.85	2.00e-49	189.00
IUUC-Ogl-077586	Oryza glaberrima	34.65	2.00e-50	192.00
IUUC-Ogu-078796	Oryza glumaepatula	34.41	1.00e-49	190.00
IUUC-Oin-079298	Oryza indica	34.41	1.00e-49	190.00
IUUC-Ome-081908	Oryza meridionalis	33.92	2.00e-48	186.00
IUUC-Oni-082049	Oryza nivara	34.41	1.00e-49	190.00
IUUC-Opu-083608	Oryza punctata	34.25	1.00e-50	194.00
IUUC-Oru-084712	Oryza rufipogon	34.41	1.00e-49	190.00
IUUC-Osa-086078	Oryza sativa	34.41	1.00e-49	190.00
IUUC-Ola-086889	Oryzias latipes	82.69	0.00e+00	5290.00
IUUC-Oga-088459	Otolemur garnettii	83.52	0.00e+00	7455.00
IUUC-Oar-089888	Ovis aries	84.62	0.00e+00	7509.00
IUUC-Ptr-091114	Pan troglodytes	84.44	0.00e+00	7536.00
IUUC-Pan-092442	Papio anubis	84.46	0.00e+00	7547.00
IUUC-Psi-093833	Pelodiscus sinensis	83.02	0.00e+00	4920.00
IUUC-Pma-094275	Petromyzon marinus	78.96	0.00e+00	1762.00
IUUC-Ppa-095790	Physcomitrella patens	35.87	5.00e-55	208.00
IUUC-Pfo-097262	Poecilia formosa	82.77	0.00e+00	5135.00
IUUC-Pab-097760	Pongo abelii	83.23	0.00e+00	4207.00
IUUC-Pca-100465	Procavia capensis	82.72	0.00e+00	3873.00
IUUC-Ppe-101345	Prunus persica	34.27	2.00e-52	201.00
IUUC-Pva-102950	Pteropus vampyrus	85.10	0.00e+00	3640.00
IUUC-Rno-104892	Rattus norvegicus	84.96	0.00e+00	5387.00
IUUC-Sha-106633	Sarcophilus harrisii	83.92	0.00e+00	7368.00
IUUC-Smo-108827	Selaginella moellendorffii	35.73	2.00e-53	204.00
IUUC-Sly-111155	Solanum lycopersicum	35.94	5.00e-53	202.00
IUUC-Stu-112166	Solanum tuberosum	31.97	7.00e-49	189.00
IUUC-Sar-113251	Sorex araneus	77.58	0.00e+00	2152.00
IUUC-Ssc-116391	Sus scrofa	84.40	0.00e+00	7541.00
IUUC-Tgu-116554	Taeniopygia guttata	84.09	0.00e+00	7548.00
IUUC-Tru-118695	Takifugu rubripes	83.52	0.00e+00	7522.00
IUUC-Tsy-119647	Tarsius syrichta	78.99	0.00e+00	3723.00
IUUC-Tni-120707	Tetraodon nigroviridis	83.37	0.00e+00	7492.00
IUUC-Tbe-127346	Tupaia belangeri	76.07	0.00e+00	2150.00
IUUC-Ttr-128542	Tursiops truncatus	78.15	0.00e+00	4822.00
IUUC-Vpa-130611	Vicugna pacos	85.97	0.00e+00	3548.00
IUUC-Xtr-131933	Xenopus tropicalis	80.96	0.00e+00	7166.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence