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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063201
Ensembl Protein ID ENSMUSP00000027505.6
UniProt Accession Q9D8Y8; Q3UL57; Q6P292; Q9CV64; Q9D9V8; ING5_MOUSE
Genbank Protein ID BAB24580.1; BAB25095.1; BAB26210.1; BAC25697.1; BAE26593.1; AAH64674.1
Protein Name Inhibitor of growth protein 5
Genbank Nucleotide ID AK006421; AK007536; AK009312; AK028010; AK145695; BC064674
Gene Name Ing5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026283.13 ENSMUST00000027505.12 ENSMUSP00000027505.6
ENSMUSG00000026283.13 ENSMUST00000188402.1 ENSMUSP00000140739.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 5.70e-09 37.1 187 234
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C  ewfH+aC+ l+   ++p+ + w+Cp+C +
   Q: 187  TYC-LCHQVSYGE--MIGCDNpdCPiEWFHFACVDLT---TKPKGK-WFCPRCVQ 234
           69*.*******99..*********99***********...999997.******87 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May function as a transcriptional coactivator for RUNX2 (By similarity).
 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May function as a transcriptional coactivator for RUNX2 (By similarity).
Protein Sequence
(Fasta)
MATAMYLEHY LDSIENLPCE LQRNFQLMRE LDQRTEDKKA EIDILAAEYI STVKTLSSAQ 60
RVEHLQKIQS AYSKCKEYSD DKVQLAMQTY EMVDKHIRRL DADLARFEAD LKDRMDGSDF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063201|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
GCCCGCTCGC GCAGACCCCG AGCGTGGCCG AGGCGAAGAT GGCGACTGCC ATGTACTTGG 60
AGCACTATCT GGACAGTAAG CACTCTGGCC GAGCCGCCGC CCGCGCGGGT TCGCGCCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063201|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028638--ING5
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0070776--C:MOZ/MORF histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0043065--P:positive regulation of apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006473--P:protein acetylation
GO:0006351--P:transcription, DNA-templated
KEGG mmu:66262
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002381 Ailuropoda melanoleuca 92.98 3.00e-109 387.00
IUUC-Atr-002906 Amborella trichopoda 34.27 1.00e-32 133.00
IUUC-Apl-003516 Anas platyrhynchos 88.73 7.00e-97 346.00
IUUC-Aca-005009 Anolis carolinensis 85.29 3.00e-111 394.00
IUUC-Ame-011879 Astyanax mexicanus 75.93 2.00e-105 374.00
IUUC-Bta-012590 Bos taurus 93.83 2.00e-114 404.00
IUUC-Cja-019518 Callithrix jacchus 94.17 1.00e-121 428.00
IUUC-Cfa-020620 Canis familiaris 95.00 2.00e-131 461.00
IUUC-Cpo-022085 Cavia porcellus 95.76 8.00e-118 416.00
IUUC-Csa-023421 Chlorocebus sabaeus 94.58 2.00e-118 417.00
IUUC-Dre-027588 Danio rerio 76.45 5.00e-104 370.00
IUUC-Eca-033493 Equus caballus 93.39 2.00e-116 411.00
IUUC-Fca-035635 Felis catus 93.64 1.00e-54 206.00
IUUC-Fal-036998 Ficedula albicollis 89.13 3.00e-111 394.00
IUUC-Gmo-039035 Gadus morhua 76.35 2.00e-103 368.00
IUUC-Gga-040578 Gallus gallus 90.00 1.00e-120 425.00
IUUC-Gac-042172 Gasterosteus aculeatus 75.10 4.00e-105 373.00
IUUC-Hsa-045965 Homo sapiens 94.58 2.00e-118 417.00
IUUC-Loc-052725 Lepisosteus oculatus 82.08 1.00e-103 368.00
IUUC-Mcc-055455 Macaca mulatta 93.45 3.00e-110 390.00
IUUC-Mtr-058089 Medicago truncatula 31.84 5.00e-34 137.00
IUUC-Mga-059312 Meleagris gallopavo 88.61 2.00e-97 347.00
IUUC-Mmr-061351 Microcebus murinus 93.83 9.00e-110 389.00
IUUC-Mdo-062282 Monodelphis domestica 92.50 2.00e-115 407.00
IUUC-Mac-064625 Musa acuminata 34.23 6.00e-37 147.00
IUUC-Mpu-066302 Mustela putorius furo 94.58 3.00e-119 420.00
IUUC-Mlu-068192 Myotis lucifugus 95.42 9.00e-120 422.00
IUUC-Ont-072055 Oreochromis niloticus 76.35 7.00e-101 359.00
IUUC-Oan-073652 Ornithorhynchus anatinus 92.98 1.00e-112 398.00
IUUC-Ocu-073871 Oryctolagus cuniculus 92.95 1.00e-120 425.00
IUUC-Obr-076266 Oryza brachyantha 36.40 3.00e-37 148.00
IUUC-Oin-079049 Oryza indica 34.78 3.00e-35 142.00
IUUC-Oni-082218 Oryza nivara 34.78 3.00e-35 142.00
IUUC-Ola-087103 Oryzias latipes 74.79 8.00e-97 346.00
IUUC-Oga-088066 Otolemur garnettii 84.49 3.00e-102 364.00
IUUC-Ptr-091665 Pan troglodytes 94.58 2.00e-118 417.00
IUUC-Pan-091875 Papio anubis 94.58 2.00e-118 417.00
IUUC-Psi-093904 Pelodiscus sinensis 89.67 5.00e-102 363.00
IUUC-Pfo-096981 Poecilia formosa 76.76 9.00e-101 359.00
IUUC-Ppe-101441 Prunus persica 34.98 6.00e-37 147.00
IUUC-Pva-102282 Pteropus vampyrus 90.00 2.00e-124 437.00
IUUC-Rno-105646 Rattus norvegicus 99.17 2.00e-127 447.00
IUUC-Sha-107031 Sarcophilus harrisii 90.87 1.00e-107 382.00
IUUC-Smo-109441 Selaginella moellendorffii 36.99 5.00e-43 167.00
IUUC-Tgu-116837 Taeniopygia guttata 87.88 9.00e-111 392.00
IUUC-Tru-117974 Takifugu rubripes 76.03 1.00e-98 352.00
IUUC-Tni-120024 Tetraodon nigroviridis 75.52 3.00e-90 324.00
IUUC-Tca-121597 Theobroma cacao 33.20 1.00e-30 126.00
IUUC-Vvi-131487 Vitis vinifera 35.02 4.00e-33 134.00
IUUC-Xtr-132189 Xenopus tropicalis 81.17 3.00e-111 394.00
Created Date 25-Jun-2017

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